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1. 发明申请

US20230010020A1 AUTOMATED TALENT USAGE RIGHTS NEGOTIATION & MANAGEMENT TOOL 有权
公开(公告)号：US20230010020A1
公开(公告)日：2023-01-12
申请号：US17734711
申请日：2022-05-02
申请人： Mark Willingham
发明人： Mark Willingham
IPC分类号： G06Q50/18 , G06Q10/10
摘要： A system and method for managing usage rights, and autonomous creation of a usage rights and release agreement between a client and a talent for usage rights of job materials. The system includes an interface module for generating a client interface and a talent interface; a negotiation module for generating usage rights charge based on the price, the details of the client, and the details of the job; a contract module to generate a usage rights and release agreement based on the details of a talent, the usage rights charge, the details of the client, and the details of the job to; and generating a contract between the client and a talent based on the usage rights and release agreement.

2. 发明申请

US20070113298A1 Genetically determined mouse model of resistance to transplantable cancers 审中-公开
标题翻译：遗传决定的抗移植癌的小鼠模型
公开(公告)号：US20070113298A1
公开(公告)日：2007-05-17
申请号：US11586227
申请日：2006-10-25
申请人： Zheng Cui , Mark Willingham
发明人： Zheng Cui , Mark Willingham
IPC分类号： A01K67/027 , C12N5/06
CPC分类号： A61K49/0008 , A01K67/027 , A01K2227/105 , A01K2267/02 , A01K2267/0331 , A01K2267/0337
摘要： We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is age-dependent spontaneous regression of advanced cancers. This powerful resistance segregates as a single-locus dominant trait, is independent of tumor burden and is effective against cell lines from multiple types of cancer. During spontaneous regression or immediately following exposure, cancer cells provoke a massive infiltration of host leukocytes which form aggregates and rosettes with tumor cells. The cytolytic destruction of cancer cells by innate leukocytes is rapid and specific without apparent damage to normal cells. The mice are healthy, cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance that may have potential for therapy or prevention of cancer.
摘要翻译：我们建立并研究了一种具有宿主对宿主对移植细胞诱导的腹水和固体癌症的独特性状的小鼠集落。这种特征的一个戏剧性表现是晚期癌症的年龄依赖性自发性消退。这种强大的抗性作为单基因座的主要特征分离，与肿瘤负荷无关，对多种类型癌症的细胞系有效。在自发消退或暴露后立即，癌细胞引起宿主白细胞的大量浸润，其与肿瘤细胞形成聚集体和玫瑰花结。先天性白细胞对癌细胞的细胞溶解破坏是快速且特异的，没有对正常细胞的明显损伤。小鼠健康，无癌症，寿命长。这些观察结果表明，以前无法识别的可能具有治疗或预防癌症潜力的免疫监测机制。

3. 发明授权

US5990296A Single chain B3 antibody fusion proteins and their uses 失效
标题翻译：单链B3抗体融合蛋白及其用途
公开(公告)号：US5990296A
公开(公告)日：1999-11-23
申请号：US759804
申请日：1996-12-03
申请人： Ira Pastan , Mark Willingham , David Fitzgerald , Ulrich Brinkmann , Lee Pai
发明人： Ira Pastan , Mark Willingham , David Fitzgerald , Ulrich Brinkmann , Lee Pai
IPC分类号： A61K38/00 , A61K47/48 , A61P35/00 , C07K14/21 , C07K16/18 , C07K16/30 , C07K16/34 , C07K19/00 , G01N33/574 , C07H21/04
CPC分类号： A61K47/48569 , C07K14/21 , C07K16/18 , C07K16/30 , C07K16/34 , C07K19/00 , G01N33/57419 , G01N33/57446 , G01N33/57449 , G01N33/57492 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/622 , C07K2319/00 , Y10S530/866 , Y10S530/867
摘要： This invention provides for recombinant single chain antibodies capable of specifically binding to a Lewis.sup.Y -related carbohydrate antigen and fusion proteins comprising these antibodies. More particularly, the invention provides for single chain Fv regions of the monoclonal antibody B3. The invention also provides for a method of improving the binding affinity of antibodies lacking a serine at position 95 of the V.sub.H region that involves mutating position 95 to a serine.
摘要翻译：本发明提供能够特异性结合LewisY相关糖类抗原的重组单链抗体和包含这些抗体的融合蛋白。更具体地，本发明提供单克隆抗体B3的单链Fv区。本发明还提供了一种方法，其将VH区域的95位缺失丝氨酸的抗体与包含突变位置95的丝氨酸相结合。

4. 发明授权

US5608039A Single chain B3 antibody fusion proteins and their uses 失效
标题翻译：单链B3抗体融合蛋白及其用途
公开(公告)号：US5608039A
公开(公告)日：1997-03-04
申请号：US331398
申请日：1994-10-28
申请人： Ira Pastan , Mark Willingham , David Fitzgerald , Ulrich Brinkmann , Lee Pai
发明人： Ira Pastan , Mark Willingham , David Fitzgerald , Ulrich Brinkmann , Lee Pai
IPC分类号： A61K38/00 , A61K47/48 , A61P35/00 , C07K14/21 , C07K16/18 , C07K16/30 , C07K16/34 , C07K19/00 , G01N33/574 , C12N15/62 , A61K39/00 , A61K51/10 , C07K16/28
CPC分类号： A61K47/48569 , C07K14/21 , C07K16/18 , C07K16/30 , C07K16/34 , C07K19/00 , G01N33/57419 , G01N33/57446 , G01N33/57449 , G01N33/57492 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/622 , C07K2319/00 , Y10S530/866 , Y10S530/867
摘要： This invention provides for recombinant single chain antibodies capable of specifically binding to a Lewis.sup.Y -related carbohydrate antigen and fusion proteins comprising these antibodies. More particularly, the invention provides for single chain Fv regions of the monoclonal antibody B3. The invention also provides for a method of improving the binding affinity of antibodies lacking a serine at position 95 of the V.sub.H region that involves mutating position 95 to a serine.
摘要翻译：本发明提供能够特异性结合LewisY相关糖类抗原的重组单链抗体和包含这些抗体的融合蛋白。更具体地，本发明提供单克隆抗体B3的单链Fv区。本发明还提供了一种方法，其将VH区域的95位缺失丝氨酸的抗体与包含突变位置95的丝氨酸相结合。

5. 发明授权

US4806494A Monoclonal antibody against ovarian cancer cells (OVB-3) 失效
标题翻译：针对卵巢癌细胞的单克隆抗体（OVB-3）
公开(公告)号：US4806494A
公开(公告)日：1989-02-21
申请号：US888960
申请日：1986-07-24
申请人： Ira Pastan , David J. Fitzgerald , Mark Willingham
发明人： Ira Pastan , David J. Fitzgerald , Mark Willingham
IPC分类号： A61K38/00 , A61K47/48 , C07K16/30 , G01N33/53 , A61K39/00 , A61K45/02 , G01N33/543
CPC分类号： C07K16/30 , A61K47/48484 , A61K47/48584 , A61K38/00
摘要： Monoclonal antibodies are produced which specifically bind to human ovarian cancer cells. These antibodies are conjugated to Pseudomonas exotoxin in order to produce an immunotoxin suitable for the chemotherapeutic treatment of human ovarian cancer.
摘要翻译：产生特异性结合人卵巢癌细胞的单克隆抗体。这些抗体与假单胞菌外毒素结合，以产生适用于人卵巢癌化学治疗的免疫毒素。

6. 发明申请

US20100300804A1 Di-Electric Harness For Fall Arrest Systems 审中-公开
标题翻译：用于秋季避雷系统的电力线束
公开(公告)号：US20100300804A1
公开(公告)日：2010-12-02
申请号：US12787692
申请日：2010-05-26
申请人： Mark Willingham
发明人： Mark Willingham
IPC分类号： A62B35/00
CPC分类号： A62B35/0025 , A62B35/0018
摘要： The di-electric harness for fall arrest systems includes a full body harness having first and second webbings extending through a chest plate and back plate. The first and second webbings cross at the chest plate and at the back plate and form a loop at the back plate in which is disposed a D-ring. The first and second webbings each extend through a hip plate to form a leg strap. The chest plate, back plate and hip plates are made of non-metal.
摘要翻译：用于防坠落系统的双电源线束包括全身线束，其具有延伸穿过胸板和后板的第一和第二网带。第一和第二网带在胸板和背板处交叉，并在背板上形成环，其中设置有D形环。第一和第二网带每个延伸穿过髋板以形成腿带。胸板，背板和髋板由非金属制成。

7. 发明申请

US20080089875A1 METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER 审中-公开
标题翻译：治疗癌症的方法和组合
公开(公告)号：US20080089875A1
公开(公告)日：2008-04-17
申请号：US11870768
申请日：2007-10-11
申请人： Zheng Cui , Mark Willingham
发明人： Zheng Cui , Mark Willingham
IPC分类号： A61K35/00 , A61P43/00
CPC分类号： A61K35/17 , A61K35/15 , A61K2300/00
摘要： A method of treating cancer comprises: (a) providing allogenic or autologous white blood cells from a suitable donor; and then (b) administering the white blood cells to the subject in an amount effective to treat the cancer. Preferably the white blood cells comprise innate immune cells. Preferably the white blood cells comprise less than 10% by number of cytotoxic T lymphocytes. Preferably the white blood cells, or more particularly the innate immune cells, are preselected in vitro to kill cancer cells in vitro (for example, by collecting white blood cells from the patient and determining that the white blood cells kill cancer cells in vitro before and thereby pre-selecting the donor, before collecting a subsequent population of cells from the donor for administration).
摘要翻译：治疗癌症的方法包括：（a）从合适的供体提供同种异体或自体白细胞; 然后（b）以有效治疗癌症的量给受试者施用白细胞。优选地，白细胞包含先天免疫细胞。优选地，白细胞包含少于10个数量的细胞毒性T淋巴细胞。优选地，在体外预先选择白细胞，或更特别是先天免疫细胞，以在体外杀死癌细胞（例如，通过从患者中收集白细胞并确定白细胞在体外杀死癌细胞，从而在从供体施用之前收集随后的细胞群体之前预先选择供体）。

8. 发明申请

US20050022258A1 Genetically determined mouse model of resistance to transplantable cancers 审中-公开
标题翻译：遗传决定的抗移植癌的小鼠模型
公开(公告)号：US20050022258A1
公开(公告)日：2005-01-27
申请号：US10827654
申请日：2004-04-19
申请人： Zheng Cui , Mark Willingham
发明人： Zheng Cui , Mark Willingham
IPC分类号： A01K67/027 , A61K49/00 , C12N5/06
CPC分类号： A61K49/0008 , A01K67/027 , A01K2227/105 , A01K2267/02 , A01K2267/0331 , A01K2267/0337
摘要： We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is age-dependent spontaneous regression of advanced cancers. This powerful resistance segregates as a single-locus dominant trait, is independent of tumor burden and is effective against cell lines from multiple types of cancer. During spontaneous regression or immediately following exposure, cancer cells provoke a massive infiltration of host leukocytes which form aggregates and rosettes with tumor cells. The cytolytic destruction of cancer cells by innate leukocytes is rapid and specific without apparent damage to normal cells. The mice are healthy, cancer-free and have a normal life span. These observations suggest a previously unrecognized mechanism of immune surveillance that may have potential for therapy or prevention of cancer.
摘要翻译：我们建立并研究了一种具有宿主对宿主对移植细胞诱导的腹水和固体癌症的独特性状的小鼠集落。这种特征的一个戏剧性表现是晚期癌症的年龄依赖性自发性消退。这种强大的抗性作为单基因座的主要特征分离，与肿瘤负荷无关，对多种类型癌症的细胞系有效。在自发消退或暴露后立即，癌细胞引起宿主白细胞的大量浸润，其与肿瘤细胞形成聚集体和玫瑰花结。先天性白细胞对癌细胞的细胞溶解破坏是快速且特异的，没有对正常细胞的明显损伤。小鼠健康，无癌症，寿命长。这些观察结果表明，以前无法识别的可能具有治疗或预防癌症潜力的免疫监测机制。

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