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1. 发明申请

US20070248972A1 Page-4, an X-linked gage-like gene expressed in normal and neoplastic prostate, testis and uterus, and uses therefor 审中-公开
标题翻译：第4页，在正常和肿瘤前列腺，睾丸和子宫中表达的X连接的量规样基因，并用于其
公开(公告)号：US20070248972A1
公开(公告)日：2007-10-25
申请号：US11704714
申请日：2007-02-09
申请人： Ira Pastan , Ulrich Brinkmann , George Vasmatzis , Byungkook Lee
发明人： Ira Pastan , Ulrich Brinkmann , George Vasmatzis , Byungkook Lee
IPC分类号： C12Q1/68 , C07H21/00 , C12N1/00 , C12N1/21 , C12N15/00 , C12N5/00
CPC分类号： C07K14/4748 , A61K39/00
摘要： PAGE-4 is a gene preferentially expressed in normal male and female reproductive tissues, prostate, testis, fallopian tube, uterus and placenta, as well as in prostate cancer, testicular cancer and uterine cancer. This expression pattern makes it a target for diagnosis and for vaccine based therapy of neoplasms of prostate, testis and uterus. The invention provides immunogenic compositions comprising PAGE-4 protein or immunogenic peptides thereof, methods of inhibiting the growth of malignant cells expressing PAGE-4, and methods of inducing an enhanced immune response to PAGE-4-expressing cancers.
摘要翻译： PAGE-4是在正常男性和女性生殖组织，前列腺，睾丸，输卵管，子宫和胎盘以及前列腺癌，睾丸癌和子宫癌中优先表达的基因。这种表达模式使其成为诊断和基于疫苗的前列腺，睾丸和子宫肿瘤的治疗的目标。本发明提供包含PAGE-4蛋白或其免疫原性肽的免疫原性组合物，抑制表达PAGE-4的恶性细胞生长的方法，以及诱导对表达PAGE-4的癌症增强的免疫应答的方法。

2. 发明授权

US07052703B1 T-cell receptorγ alternate reading frame protein, (TARP) and uses thereof 有权
标题翻译： T细胞接受体交替阅读框蛋白（TARP）及其用途
公开(公告)号：US07052703B1
公开(公告)日：2006-05-30
申请号：US10031158
申请日：2000-07-12
申请人： Ira Pastan , Magnus Essand , Byungkook Lee , George Vasmatzis , Curt Wolfgang , Ulrich Brinkmann
发明人： Ira Pastan , Magnus Essand , Byungkook Lee , George Vasmatzis , Curt Wolfgang , Ulrich Brinkmann
IPC分类号： A61K39/00
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00
摘要： This invention provides nucleic acids containing sequences from a TCRγ transcript from prostate epithelial cells and many breast cancer cells and a T-cell receptor gamma Alternate Reading frame Protein (“TARP”) expressed from the translation of those sequences. Vaccines made from TARP are useful in raising immune responses to cells in which the protein is expressed, including prostate cancer cells and cells of many breast cancers. The invention also provides methods for diagnosing the presence of prostate cancer and TARP-expressing breast cancers, as well as methods of administering TARP and nucleic acids encoding TARP to subjects.
摘要翻译：本发明提供了含有来自前列腺上皮细胞的TCRγ转录物和许多乳腺癌细胞的序列的核酸，以及从这些序列翻译表达的T细胞受体γ替代阅读框架蛋白（“TARP”）。由TARP制成的疫苗可用于提高蛋白质表达细胞的免疫应答，包括前列腺癌细胞和许多乳腺癌细胞。本发明还提供了用于诊断前列腺癌和TARP表达乳腺癌的存在的方法，以及将TARP和编码TARP的核酸给予受试者的方法。

3. 发明授权

US07399827B1 Page-4, an x-linked gage-like gene expressed in normal and neoplastic prostate, testis and uterus, and uses therefor 失效
标题翻译：第4页，在正常和肿瘤前列腺，睾丸和子宫中表达的x连接的量规样基因，并用于其
公开(公告)号：US07399827B1
公开(公告)日：2008-07-15
申请号：US09763393
申请日：1999-08-31
申请人： Ira Pastan , Ulrich Brinkmann , George Vasmatzis , Byungkook Lee
发明人： Ira Pastan , Ulrich Brinkmann , George Vasmatzis , Byungkook Lee
IPC分类号： C07K14/00
CPC分类号： C07K14/4748 , A61K39/00
摘要： PAGE-4 is a gene preferentially expressed in normal male and female reproductive tissues, prostate, testis, fallopian tube, uterus and placenta, as well as in prostate cancer, testicular cancer and uterine cancer. This expression pattern makes it a target for diagnosis and for vaccine based therapy of neoplasms of prostate, testis and uterus. The invention provides immunogenic compositions comprising PAGE-4 protein or immunogenic peptides thereof, methods of inhibiting the growth of malignant cells expressing PAGE-4, and methods of inducing an enhanced immune response to PAGE-4-expressing cancers.
摘要翻译： PAGE-4是在正常男性和女性生殖组织，前列腺，睾丸，输卵管，子宫和胎盘以及前列腺癌，睾丸癌和子宫癌中优先表达的基因。这种表达模式使其成为诊断和基于疫苗的前列腺，睾丸和子宫肿瘤的治疗的目标。本发明提供包含PAGE-4蛋白或其免疫原性肽的免疫原性组合物，抑制表达PAGE-4的恶性细胞生长的方法，以及诱导对表达PAGE-4的癌症增强的免疫应答的方法。

4. 发明申请

US20090304702A1 GENE EXPRESSED IN PROSTATE CANCER AND METHODS OF USE 审中-公开
标题翻译：前列腺癌中表达的基因和使用方法
公开(公告)号：US20090304702A1
公开(公告)日：2009-12-10
申请号：US12497382
申请日：2009-07-02
申请人： Ira Pastan , Tapan K. Bera , Byungkook Lee
发明人： Ira Pastan , Tapan K. Bera , Byungkook Lee
IPC分类号： A61K39/395 , G01N33/53 , C12N5/02 , C07K16/00
CPC分类号： A61K38/168 , A61K38/164 , A61K47/64 , C07K14/47 , C07K14/4748 , C12Q1/6886 , C12Q2600/106 , G01N33/57434 , G01N2500/00
摘要： A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugates are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.
摘要翻译：公开了在前列腺细胞中特异性检测到的多肽，称为前列腺中表达的剪接变体 - 新型基因（SV-NGEP）。还公开了编码SV-NGEP的多核苷酸，以及包括这些多核苷酸的载体。还公开了用这些多核苷酸转化的宿主细胞。公开了特异性结合SV-NGEP的抗体和免疫偶联物。公开了使用NGEP多肽，特异性结合SV-NGEP的抗体或编码SV-NGEP的多核苷酸的方法。公开了检测前列腺癌的检测。还公开了包含SV-NGEP多肽，特异性结合SV-NGEP的抗体或编码SV-NGEP的多核苷酸的药物组合物。这些药物组合物可用于治疗前列腺癌。

5. 发明授权

US08623828B2 Blocking mesothelin peptide fragments 失效
标题翻译：阻断间皮素肽片段
公开(公告)号：US08623828B2
公开(公告)日：2014-01-07
申请号：US13133136
申请日：2008-12-05
申请人： Mitchell Ho , Ira Pastan , Osamu Kaneko , Byungkook Lee
发明人： Mitchell Ho , Ira Pastan , Osamu Kaneko , Byungkook Lee
IPC分类号： C07K5/00
CPC分类号： C07K14/47 , C07K2319/30
摘要： The present invention provides mesothelin peptide fragments corresponding to the CA125 binding site of mesothelin. The peptide fragments find use in disrupting the binding interaction between mesothelin and CA 125, for example, in the treatment and prevention of cancers that require the interaction of mesothelin and CA125 for growth, progression and/or metastasis.
摘要翻译：本发明提供对应于间皮素的CA125结合位点的间皮素肽片段。肽片段用于破坏间皮素和CA125之间的结合相互作用，例如在治疗和预防需要间皮素和CA125与生长，进展和/或转移相互作用的癌症中。

6. 发明申请

US20060194204A1 Gene expressed in prostate cancer, methods and use thereof 失效
标题翻译：在前列腺癌中表达的基因，其方法和用途
公开(公告)号：US20060194204A1
公开(公告)日：2006-08-31
申请号：US10552515
申请日：2004-04-05
申请人： Ira Pastan , Tapan Bera , Byungkook Lee
发明人： Ira Pastan , Tapan Bera , Byungkook Lee
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30
CPC分类号： A61K38/168 , A61K38/164 , A61K47/64 , C07K14/47 , C07K14/4748 , C12Q1/6886 , C12Q2600/106 , G01N33/57434 , G01N2500/00
摘要： A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these poynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugages are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection of prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NEGP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.
摘要翻译：公开了在前列腺细胞中特异性检测到的多肽，称为前列腺中表达的剪接变体 - 新型基因（SV-NGEP）。还公开了编码SV-NGEP的多核苷酸，以及包括这些寡核苷酸的载体也是如此。还公开了用这些多核苷酸转化的宿主细胞。公开了特异性结合SV-NGEP的抗体和免疫结合物。公开了使用NGEP多肽，特异性结合SV-NGEP的抗体或编码SV-NGEP的多核苷酸的方法。公开了检测前列腺癌的测定。还公开了包含SV-NGEP多肽，特异性结合SV-NEGP的抗体或编码SV-NGEP的多核苷酸的药物组合物。这些药物组合物可用于治疗前列腺癌。

7. 发明授权

US5889157A Humanized B3 antibody fragments, fusion proteins, and uses thereof 失效
标题翻译：人源化B3抗体片段，融合蛋白及其用途
公开(公告)号：US5889157A
公开(公告)日：1999-03-30
申请号：US331396
申请日：1994-10-28
申请人： Ira Pastan , Itai Benhar , Eduardo A. Padlan , Sun-Hee Jung , Byungkook Lee
发明人： Ira Pastan , Itai Benhar , Eduardo A. Padlan , Sun-Hee Jung , Byungkook Lee
IPC分类号： A61K38/00 , A61K47/48 , A61P35/00 , C07K14/21 , C07K16/18 , C07K16/30 , C07K16/34 , C07K19/00 , G01N33/574 , C07K16/00 , A61K39/395
CPC分类号： G01N33/57419 , A61K47/48569 , C07K14/21 , C07K16/18 , C07K16/30 , C07K16/34 , C07K19/00 , G01N33/57446 , G01N33/57449 , G01N33/57492 , A61K38/00 , C07K2317/24 , C07K2317/56 , C07K2317/622 , C07K2319/00
摘要： This invention provides for recombinant single chain antibodies capable of specifically binding to a Lewis.sup.Y -related carbohydrate antigen and fusion proteins comprising these antibodies. More particularly, the invention provides for humanized chain Fv regions of the monoclonal antibodies B1, B3 and B5 and fusion proteins incorporating these humanized antibodies. The antibodies may comprise humanized variable heavy (V.sub.H) chains, humanized variable light (V.sub.L) chains, or both. The invention also provides for DNA sequences encoding the various humanized antibodies. In addition, the invention provides for methods of detecting cells bearing a Lewis.sup.Y antigen in a patient and for methods of killing or inhibiting the growth of cells bearing a Lewis.sup.Y antigen in a patient.
摘要翻译：本发明提供能够特异性结合LewisY相关糖类抗原的重组单链抗体和包含这些抗体的融合蛋白。更具体地，本发明提供了单克隆抗体B1，B3和B5的人源化链Fv区域以及掺入了这些人源化抗体的融合蛋白质。抗体可以包含人源化可变重链（VH）链，人源化可变光（VL）链或两者。本发明还提供编码各种人源化抗体的DNA序列。此外，本发明提供了检测患者中携带LewisY抗原的细胞的方法，以及用于杀死或抑制患有LewisY抗原的细胞的生长的方法。

8. 发明授权

US07572887B2 Gene expressed in prostate cancer, methods and use thereof 失效
标题翻译：在前列腺癌中表达的基因，其方法和用途
公开(公告)号：US07572887B2
公开(公告)日：2009-08-11
申请号：US10552515
申请日：2004-04-05
申请人： Ira Pastan , Tapan K. Bera , Byungkook Lee
发明人： Ira Pastan , Tapan K. Bera , Byungkook Lee
IPC分类号： C07K14/00 , C07H21/04 , C12N15/00 , C12Q1/68
CPC分类号： A61K38/168 , A61K38/164 , A61K47/64 , C07K14/47 , C07K14/4748 , C12Q1/6886 , C12Q2600/106 , G01N33/57434 , G01N2500/00
摘要： A polypeptide is disclosed that is specifically detected in the cells of the prostate, termed Splice Variant-Novel Gene Expressed in Prostate (SV-NGEP). Polynucleotides encoding SV-NGEP are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugages are disclosed that specifically bind SV-NGEP. Methods are disclosed for using an NGEP polypeptide, an antibody that specifically binds SV-NGEP, or a polynucleotide encoding SV-NGEP. Assays are disclosed for the detection of prostate cancer. Pharmaceutical compositions including an SV-NGEP polypeptide, an antibody that specifically binds SV-NEGP, or a polynucleotide encoding SV-NGEP are also disclosed. These pharmaceutical compositions are of use in the treatment of prostate cancer.
摘要翻译：公开了在前列腺细胞中特异性检测到的多肽，称为前列腺中表达的剪接变体 - 新型基因（SV-NGEP）。还公开了编码SV-NGEP的多核苷酸，以及包括这些多核苷酸的载体。还公开了用这些多核苷酸转化的宿主细胞。公开了特异性结合SV-NGEP的抗体和免疫结合物。公开了使用NGEP多肽，特异性结合SV-NGEP的抗体或编码SV-NGEP的多核苷酸的方法。公开了检测前列腺癌的测定。还公开了包含SV-NGEP多肽，特异性结合SV-NEGP的抗体或编码SV-NGEP的多核苷酸的药物组合物。这些药物组合物可用于治疗前列腺癌。

9. 发明申请

US20110236385A1 BLOCKING MESOTHELIN PEPTIDE FRAGMENTS 失效
标题翻译：阻塞MESOTHELIN胶囊片
公开(公告)号：US20110236385A1
公开(公告)日：2011-09-29
申请号：US13133136
申请日：2008-12-05
申请人： Mitchell Ho , Ira Pastan , Osamu Kaneko , Byungkook Lee
发明人： Mitchell Ho , Ira Pastan , Osamu Kaneko , Byungkook Lee
IPC分类号： A61K39/395 , C07K2/00 , C07K14/47 , C07K19/00 , C12N9/00 , A61K39/00 , C12N5/071 , A61P35/00 , A61P37/04
CPC分类号： C07K14/47 , C07K2319/30
摘要： The present invention provides mesothelin peptide fragments corresponding to the CA125 binding site of mesothelin. The peptide fragments find use in disrupting the binding interaction between mesothelin and CA 125, for example, in the treatment and prevention of cancers that require the interaction of mesothelin and CA125 for growth, progression and/or metastasis.
摘要翻译：本发明提供对应于间皮素的CA125结合位点的间皮素肽片段。肽片段用于破坏间皮素和CA125之间的结合相互作用，例如在治疗和预防需要间皮素和CA125与生长，进展和/或转移相互作用的癌症中。

10. 发明申请

US20050053988A1 Gene expressed in breast cancer and methods of use 审中-公开
标题翻译：乳腺癌基因表达及使用方法
公开(公告)号：US20050053988A1
公开(公告)日：2005-03-10
申请号：US10913196
申请日：2004-08-05
申请人： Ira Pastan , Kristi Egland , Byungkook Lee , James Vincent
发明人： Ira Pastan , Kristi Egland , Byungkook Lee , James Vincent
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C07K14/705 , C12Q1/00 , C12Q1/68 , G01N33/574
CPC分类号： C07K14/47 , A61K38/00 , A61K39/00 , C07K14/705
摘要： A polypeptide is disclosed that is detected in the breast cancer cells termed 68h05. Polynucleotides encoding 68h05 are also disclosed, as are vectors including these polynucleotides. Host cells transformed with these polynucleotides are also disclosed. Antibodies and immunoconjugates are disclosed that specifically bind 68h05. Methods are disclosed for using a 68h05 polypeptide, an antibody that specifically binds 68h05, or a polynucleotide encoding 68h05, such as in the treatment of breast cancer or prostate cancer. Assays are disclosed for the detection breast or prostate cancer. Pharmaceutical compositions including a 68h05 polypeptide, an antibody that specifically binds 68h05, or a polynucleotide encoding 68h05 are also disclosed. These pharmaceutical compositions are of use in the treatment of breast or prostate cancer.
摘要翻译：公开了在称为68h05的乳腺癌细胞中检测到的多肽。还公开了编码68h05的多核苷酸，以及包括这些多核苷酸的载体也是公开的。还公开了用这些多核苷酸转化的宿主细胞。公开了特异性结合68h05的抗体和免疫偶联物。公开了使用68h05多肽，特异性结合68h05的抗体或编码68h05的多核苷酸的方法，例如用于治疗乳腺癌或前列腺癌。公开了检测乳腺癌或前列腺癌的检测。还公开了包含68h05多肽，特异性结合68h05的抗体或编码68h05的多核苷酸的药物组合物。这些药物组合物可用于治疗乳腺癌或前列腺癌。

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