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1. 发明申请

US20050245892A1 Apparatus and method for inserting an intra-aorta catheter through a delivery sheath 有权
标题翻译：用于通过输送鞘插入主动脉内导管的装置和方法
公开(公告)号：US20050245892A1
公开(公告)日：2005-11-03
申请号：US11084295
申请日：2005-03-18
申请人： Jeffrey Elkins , Harry Goodson , Mark Maguire , Aurelio Valencia , Samir Patel
发明人： Jeffrey Elkins , Harry Goodson , Mark Maguire , Aurelio Valencia , Samir Patel
IPC分类号： A61M25/00 , A61M25/01 , A61M25/06 , A61M31/00
CPC分类号： A61M25/0043 , A61M25/0662 , A61M39/06
摘要： An introducer system delivers therapy locally to a renal system in a patient. A proximal coupler assembly is coupled to an introducer sheath that delivers multiple devices simultaneously into a location within an abdominal aorta associated with first and second renal artery ostia. The coupler assembly has a network of branch lumens arranged to allow for smooth slideable engagement of multiple coupled devices without substantial interference therebetween. A first branch lumen typically introduces a percutaneous translumenal interventional device such as an angiography or guiding catheter into the introducer sheath and is substantially aligned with a longitudinal axis of the sheath. One or more other branch lumen are off-axis from the longitudinal axis by about 30 degrees or less and introduce components of a bilateral renal delivery assembly into the introducer sheath in conjunction with the other device. Novel insertion devices are provided to coordinate the coupling of the multiple devices.
摘要翻译：导引器系统将局部给予患者的肾系统治疗。近端联接器组件联接到导引器鞘，其将多个装置同时输送到与第一和第二肾动脉口相关联的腹主动脉内的位置。耦合器组件具有布置成允许多个耦合器件的平滑可滑动接合而没有实质干涉的分支腔的网络。第一分支腔通常将经皮腔内介入装置（例如血管造影或引导导管）引入导引器鞘并且基本上与护套的纵向轴线对准。一个或多个其它分支腔从纵向轴线偏离约30度或更小，并且将双侧肾递送组件的组件与另一装置一起引入导引鞘中。提供了新的插入装置来协调多个装置的耦合。

2. 发明申请

US20060047266A1 Apparatus and method for inserting an intra-aorta catheter through a delivery sheath 有权
公开(公告)号：US20060047266A1
公开(公告)日：2006-03-02
申请号：US11259187
申请日：2005-10-25
申请人： Jeffrey Elkins , Harry Goodson , Mark Maguire , Aurelio Valencia , Samir Patel
发明人： Jeffrey Elkins , Harry Goodson , Mark Maguire , Aurelio Valencia , Samir Patel
IPC分类号： A61M25/01
CPC分类号： A61M25/0043 , A61M25/0662 , A61M39/06
摘要： An introducer system delivers therapy locally to a renal system in a patient. A proximal coupler assembly is coupled to an introducer sheath that delivers multiple devices simultaneously into a location within an abdominal aorta associated with first and second renal artery ostia. The coupler assembly has a network of branch lumens arranged to allow for smooth slideable engagement of multiple coupled devices without substantial interference therebetween. A first branch lumen typically introduces a percutaneous translumenal interventional device such as an angiography or guiding catheter into the introducer sheath and is substantially aligned with a longitudinal axis of the sheath. One or more other branch lumen are off-axis from the longitudinal axis by about 30 degrees or less and introduce components of a bilateral renal delivery assembly into the introducer sheath in conjunction with the other device. Novel insertion devices are provided to coordinate the coupling of the multiple devices.

3. 发明申请

US20070167913A1 VASCULAR SHEATH WITH VARIABLE LUMEN CONSTRUCTION 审中-公开
标题翻译：具有可变的建筑结构的血管
公开(公告)号：US20070167913A1
公开(公告)日：2007-07-19
申请号：US11548565
申请日：2006-10-11
申请人： Jeffrey Elkins , Harry Goodson , Craig Ball , Aurelio Valencia , Samir Patel , Neema Hekmat
发明人： Jeffrey Elkins , Harry Goodson , Craig Ball , Aurelio Valencia , Samir Patel , Neema Hekmat
IPC分类号： A61M5/178 , A61F2/06 , A61M31/00
CPC分类号： A61M25/0662 , A61F2/07 , A61F2002/065 , A61M25/0668 , A61M2025/0024 , A61M2025/0183 , A61M2025/0188 , A61M2025/0681
摘要： A system for delivering a renal treatment and a peripheral treatment includes a renal catheter, a peripheral catheter, and an introducer sheath having first and second lumens. The first lumen is configured to receive the renal catheter and is sized to extend from a patient insertion site to a femoral or iliac artery location near or distal to a patient aortic branch. The second lumen is configured to receive the peripheral catheter and is sized to extend from the patient insertion site to an opposite femoral or iliac artery location near or distal to the patient aortic branch. A method of delivering a renal treatment and a peripheral treatment includes positioning an introducer sheath in an iliac artery, advancing a renal catheter and a peripheral catheter through the introducer sheath, where the renal catheter is separated from the peripheral catheter within the introducer sheath by a flap.
摘要翻译：用于递送肾脏治疗和外周治疗的系统包括肾导管，外周导管和具有第一和第二腔的导引鞘。第一管腔被配置为接纳肾导管，其尺寸设计成从患者插入位置延伸到患者主动脉分支附近或远侧的股骨或髂动脉位置。第二管腔构造成接收外周导管，其尺寸设计成从患者插入位置延伸到患者主动脉分支附近或远侧的相对的股骨或髂动脉位置。递送肾脏治疗和周边治疗的方法包括将引导器鞘定位在髂动脉中，使肾导管和外周导管穿过导引鞘，其中肾导管与导引鞘内的周围导管分开一个皮瓣

4. 发明申请

US20060036218A1 Method and apparatus for selective material delivery via an intra-renal catheter 有权
标题翻译：通过肾内导管选择性物质输送的方法和装置
公开(公告)号：US20060036218A1
公开(公告)日：2006-02-16
申请号：US11084738
申请日：2005-03-16
申请人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
发明人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
IPC分类号： A61M25/00
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.
摘要翻译：两个肾递送部件具有两个远端端口，其适于通过其腹主动脉壁的独特位置处经由其相应的肾口位于两个肾动脉内。近端联接器组件在身体外部并且联接以将材料递送到两个远端端口用于双侧肾疗法。递送部件中的一个或两个可以是自插管到相应的肾口中，或者可以被可控制地引导到相应的口中。非闭塞性锚固件可以与肾动脉或腹主动脉中的锚定位置处的一个或两个递送构件联接，以将肾递送构件固定在肾动脉内。肾活性流体剂联接到双向递送系统。另一种肾脏治疗系统将来自腔静脉的肾静脉插管并控制向相应肾脏逆行递送药剂。

5. 发明申请

US20070249997A1 METHOD AND APPARATUS FOR SELECTIVE MATERIAL DELIVERY VIA AN INTRA-RENAL CATHETER 有权
标题翻译：通过内镜导管选择性材料输送的方法和装置
公开(公告)号：US20070249997A1
公开(公告)日：2007-10-25
申请号：US11768390
申请日：2007-06-26
申请人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
发明人： Harry Goodson , Jeffrey Elkins , Samir Patel , Aurelio Valencia , Ricardo Aboytes , Craig Ball , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
IPC分类号： A61M31/00 , A61F2/06
CPC分类号： A61M25/04 , A61M25/0029 , A61M25/0054 , A61M25/0147 , A61M25/0152 , A61M29/02 , A61M39/06 , A61M2025/0008 , A61M2025/0034 , A61M2025/0037 , A61M2025/0161 , A61M2025/0188 , A61M2025/1004 , A61M2025/1047 , A61M2025/1052
摘要： Two renal delivery members have two distal ports that are adapted to be positioned within two renal arteries via their corresponding renal ostia at unique locations along an abdominal aortic wall. A proximal coupler assembly is outside the body and is coupled to deliver material to the two distal ports for bi-lateral renal therapy. One or both of the delivery members may be self-cannulating into the corresponding renal ostium, or may be controllably steered into the respective ostium. Non-occlusive anchors may be coupled with one or both of the delivery members at anchoring positions in the renal artery or abdominal aorta to secure the renal delivery member within the renal artery. Renal-active fluid agents are coupled to the bi-lateral delivery system. Another renal therapy system cannulates a renal vein from the vena cava and controls a retrograde delivery of agents to the respective kidney.
摘要翻译：两个肾递送部件具有两个远端端口，其适于通过其腹主动脉壁的独特位置处经由其相应的肾口位于两个肾动脉内。近端联接器组件在身体外部并且联接以将材料递送到两个远端端口用于双侧肾疗法。递送部件中的一个或两个可以是自套管到相应的肾口中，或者可以被可控制地引导到相应的口中。非闭塞性锚固件可以与肾动脉或腹主动脉中的锚定位置处的一个或两个递送构件联接，以将肾递送构件固定在肾动脉内。肾活性流体剂联接到双向递送系统。另一种肾脏治疗系统将来自腔静脉的肾静脉插管并控制向相应肾脏逆行递送药剂。

6. 发明申请

US20060079859A1 Renal infusion systems and methods 有权
标题翻译：肾输液系统及方法
公开(公告)号：US20060079859A1
公开(公告)日：2006-04-13
申请号：US11241749
申请日：2005-09-29
申请人： Jeffrey Elkins , Harry Goodson , Craig Ball , Aurelio Valencia , Samir Patel , Neema Hekmat
发明人： Jeffrey Elkins , Harry Goodson , Craig Ball , Aurelio Valencia , Samir Patel , Neema Hekmat
IPC分类号： A61M31/00
CPC分类号： A61M25/00 , A61M25/0068 , A61M25/0074 , A61M25/008 , A61M25/0662 , A61M25/10 , A61M25/1002 , A61M2025/0057 , A61M2025/0183 , A61M2025/0681 , A61M2025/1045 , A61M2025/105 , A61M2025/1052 , A61M2025/1095 , A61M2029/025 , A61M2210/127
摘要： Systems, devices, and methods for delivering treatment to the renal arteries are provided. Exemplary systems include a delivery catheter having a distal bifurcation, an introducer assembly comprising an introducer sheath in operative association with a Y-hub, wherein Y-hub includes a first port for receiving the delivery catheter and a second port for receiving a second catheter, and a constraint assembly for holding the distal bifurcation of the delivery catheter in a low-profile configuration when it is advanced distally beyond the introducer sheath.
摘要翻译：提供了用于将治疗递送到肾动脉的系统，装置和方法。示例性系统包括具有远端分叉的输送导管，导引器组件，其包括与Y型轮毂可操作地相关联的引导器护套，其中Y型毂包括用于接收输送导管的第一端口和用于接收第二导管的第二端口，以及约束组件，当约束组件向远侧远离导引鞘时，用于将输送导管的远端分叉保持在低轮廓构型。

7. 发明申请

US20060030814A1 Method and apparatus for selective drug infusion via an intra-aortic flow diverter delivery catheter 审中-公开
标题翻译：通过主动脉内分流器输送导管选择性药物输注的方法和装置
公开(公告)号：US20060030814A1
公开(公告)日：2006-02-09
申请号：US11083802
申请日：2005-03-18
申请人： Aurelio Valencia , Ricardo Aboytes , Jeffrey Elkins , Harry Goodson , Samir Patel , Craig Ball , Trevor Greenan , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
发明人： Aurelio Valencia , Ricardo Aboytes , Jeffrey Elkins , Harry Goodson , Samir Patel , Craig Ball , Trevor Greenan , Randy Kesten , Andrew Kramer , Sam Payne , Sophia Pesotchinsky , Michael Rosenthal
IPC分类号： A61M31/00
CPC分类号： A61M25/1002 , A61M25/00 , A61M25/0074 , A61M25/0082 , A61M25/04 , A61M29/02 , A61M39/06 , A61M2025/0073 , A61M2025/1052
摘要： A local renal delivery system includes a flow isolation assembly and a local injection assembly. The flow isolation assembly in one mode is adapted to isolate only a partial flow region along the outer circumference along the aorta wall such that fluids inject there are maintained to flow substantially into the renal arteries. Various types of flow isolation assemblies and local injection assemblies are described.
摘要翻译：局部肾递送系统包括流动隔离组件和局部注射组件。在一种模式中的流动隔离组件适于仅沿着沿着主动脉壁的外周隔离部分流动区域，使得在其中注入的流体被维持以基本上流入肾动脉。描述了各种类型的流动隔离组件和局部注射组件。

8. 发明申请

US20060069323A1 Systems and methods for bi-lateral guidewire cannulation of branched body lumens 审中-公开
标题翻译：分支体腔双向导丝套管的系统和方法
公开(公告)号：US20060069323A1
公开(公告)日：2006-03-30
申请号：US11233562
申请日：2005-09-22
申请人： Jeffrey Elkins , Harry Goodson , Aurelio Valencia , Richard Aboytes , Samir Patel
发明人： Jeffrey Elkins , Harry Goodson , Aurelio Valencia , Richard Aboytes , Samir Patel
IPC分类号： A61M25/00
CPC分类号： A61M25/0172 , A61M25/01 , A61M25/0105 , A61M25/0662 , A61M25/09
摘要： A system and method is provided that is adapted to allow for rapid cannulation of a guidewire into a branch lumen extending from a main lumen in a body of a patient, and in particular into two renal arteries extending from an abdominal aorta wall. A dual lumen catheter shaft delivers first and second pre-shaped guidewires to the location of the renal arteries in the aorta, such that the first and second pre-shaped guidewires self-cannulate within the renal arteries. Additional guidewires and/or interventional devices may be incorporated into the system and method for use with the catheter shaft, or over the two pre-shaped guidewires, to meet a particular need for a particular patient or intended procedure.
摘要翻译：提供了一种系统和方法，其适于允许将导丝快速插入到从患者体内的主腔延伸的分支腔中，特别是从腹主动脉壁延伸的两个肾动脉中。双腔导管轴将第一和第二预形状导丝导管到主动脉中肾动脉的位置，使得第一和第二预成形导丝在肾动脉内自我插管。额外的导线和/或介入装置可以并入用于导管轴或两个预成形导丝线上的系统和方法，以满足特定患者或预期程序的特定需要。

9. 发明申请

US20050245882A1 Method and apparatus for intra-aortic substance delivery to a branch vessel 有权
标题翻译：用于主动脉内物质输送到分支血管的方法和装置
公开(公告)号：US20050245882A1
公开(公告)日：2005-11-03
申请号：US11084434
申请日：2005-03-18
申请人： Jeffrey Elkins , Aurelio Valencia , Samir Patel , Ricardo Aboytes , Harry Goodson , Craig Ball
发明人： Jeffrey Elkins , Aurelio Valencia , Samir Patel , Ricardo Aboytes , Harry Goodson , Craig Ball
IPC分类号： A61M20060101 , A61M5/31 , A61M25/00 , A61M37/00
CPC分类号： A61M25/0068 , A61M25/00 , A61M25/0041 , A61M25/007 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/0082 , A61M39/06 , A61M2025/0073 , A61M2025/105
摘要： A renal flow system injects a volume of fluid agent into a location within an abdominal aorta in a manner that flows bi-laterally into each of two renal arteries via their respectively spaced ostia along the abdominal aorta wall. A local injection assembly includes two injection members, each having an injection port that couples to a source of fluid agent externally of the patient. The injection ports may be positioned with an outer region of blood flow along the abdominal aorta wall perfusing the two renal arteries. A flow isolation assembly may isolate flow of the injected agent within the outer region and into the renals. The injection members are delivered to the location in a first radially collapsed condition, and bifurcate across the aorta to inject into the spaced renal ostia. A delivery catheter for upstream interventions is used as a chassis to deliver a bilateral local renal injection assembly to the location within the abdominal aorta.
摘要翻译：肾流系统以一定的方式将一定体积的流体药剂注入腹主动脉内的一个位置，这两种方式通过沿着腹主动脉壁的分别间隔开的两个肾动脉双向流入两个肾动脉。局部注射组件包括两个注射构件，每个注射构件具有连接到病人外部的流体剂源的注射口。注射口可以沿着灌注两个肾动脉的腹主动脉壁的外侧血流区域定位。流动隔离组件可以隔离外部区域内的注射药剂流入肾脏。注射构件在第一径向折叠状态下被输送到该位置，并且跨越主动脉分叉以注入间隔开的肾口。用于上游干预的输送导管用作底架以将双侧局部肾注射组件递送至腹主动脉内的位置。

10. 发明申请

US20070287967A1 SELECTIVE RENAL CANNULATION AND INFUSION SYSTEMS AND METHODS 失效
标题翻译：选择性肾移植和输注系统和方法
公开(公告)号：US20070287967A1
公开(公告)日：2007-12-13
申请号：US11758417
申请日：2007-06-05
申请人： Neema Hekmat , Harry Goodson , Aurelio Valencia , Jeffrey Elkins
发明人： Neema Hekmat , Harry Goodson , Aurelio Valencia , Jeffrey Elkins
IPC分类号： A61M25/00
CPC分类号： A61M25/0068 , A61M25/0028 , A61M25/0029 , A61M25/0071 , A61M25/0074 , A61M25/0075 , A61M25/008 , A61M25/02 , A61M2025/0034 , A61M2025/0037 , A61M2025/0073 , A61M2025/024 , A61M2025/1045
摘要： Renal infusion systems include an infusion catheter having a bifurcated distal end with a first branch and second branch, the branches being biased to deploy laterally when unconstrained. Systems also include a delivery sheath having a lumen which receives the infusion catheter and constrains the first branch and second branch. A distal opening of the delivery sheath is formed asymmetrically to allow one of the first and second branches to open laterally while the other of the branches remains constrained. Methods of using renal infusion systems are also provided.
摘要翻译：肾输液系统包括具有分叉远端的输注导管，其具有第一分支和第二分支，所述分支被偏置以在无约束时横向展开。系统还包括具有接收输注导管并限制第一分支和第二分支的内腔的输送鞘。输送护套的远端开口不对称地形成，以允许第一和第二分支中的一个横向打开，而另一个分支保持约束。还提供了使用肾输注系统的方法。

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