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1. 发明授权

US5098659A Apparatus for continuously monitoring a plurality of chemical analytes through a single optical fiber and method of making 失效
标题翻译：通过单光纤连续监测化学分析物的多样性的装置和制备方法
公开(公告)号：US5098659A
公开(公告)日：1992-03-24
申请号：US587234
申请日：1990-09-24
申请人： Jeffrey B. Yim , Gamal-Eddin Khalil , Roger J. Pihl , Bradley D. Huss , Gerald G. Vurek
发明人： Jeffrey B. Yim , Gamal-Eddin Khalil , Roger J. Pihl , Bradley D. Huss , Gerald G. Vurek
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1459 , G01N21/31 , G01N21/64 , G01N21/76 , G01N21/77 , G01N21/80 , G01N33/49
CPC分类号： G01N21/643 , A61B5/14539 , A61B5/1459 , G01N21/7703 , G01N2021/6434 , G01N2021/773 , G01N2021/7793 , G01N21/80
摘要： A CO.sub.2 /O.sub.2 or pH/O.sub.2 gas sensor comprising a single optical fiber and a method for making the same. The optical fiber carries light signals at different wavelengths for monitoring either CO.sub.2 concentration or pH level, in combination with O.sub.2 concentration. Attached to the distal end of the fiber-optic probe is a cylindrical pellet that has one surface covered by a light reflective material (gold foil) and the other surface attached adjacent to the distal end of the optical fiber. Depending on whether the sensor is to monitor either CO.sub.2 or pH, the pellet comprises either a CO.sub.2 analyte indicator molecule or a pH analyte indicator molecule covalently bonded to a polymer matrix material. Also adjacent to the distal end of the optical fiber is disposed a second polymer matrix material which is codissolved with an O.sub.2 analyte reactive indicator molecule. The second polymer matrix material is either interposed between the cylindrical pellet and the distal end of the optical fiber or surrounds the cylindrical pellet. If pH is being measured, the distal end of the optical fiber is coated with a hydrophilic material that is permeable to water. Conversely, if CO.sub.2 is being monitored, the distal end is coated with a hydrophobic material.

2. 发明授权

US5043286A Method and sensor for measuring oxygen concentration 失效
标题翻译：测量氧浓度的方法和传感器
公开(公告)号：US5043286A
公开(公告)日：1991-08-27
申请号：US267231
申请日：1988-12-14
申请人： Gamal-Eddin Khalil , Martin P. Gouterman , Edmond Green
发明人： Gamal-Eddin Khalil , Martin P. Gouterman , Edmond Green
IPC分类号： A61K49/00 , G01N21/64
CPC分类号： G01N21/643 , A61K49/0013 , A61K49/0015 , A61K49/0021 , G01N2021/6432 , Y10T436/207497 , Y10T436/209163 , Y10T436/255
摘要： Methods of and luminescent substances for measuring oxygen concentration of a test fluid. A test fluid is contacted with a plastic film containing a luminescent substance, the luminescent emission intensity of which is quenched in the presence of oxygen. The film is subjected to irradiation by light that is strongly absorbed by the luminescent substance, and a measure of the time dependence of luminescent emission intensity I(t) is obtained. Three modes of measuring quenching, and thus the oxygen concentration, from I(t) are described. These modes are insensitive to variation in plastic thickness, concentration of the luminescent substance, and take into account the non-exponential decay of the emission, thereby extending the range over which the film is sensitive. The luminescent substances include metallo derivatives of partially or fully fluorinated porphyrins which are photostable due to the fluorination of the porphyrin ring.
摘要翻译：用于测量测试液体氧浓度的方法和发光物质。将测试流体与含有发光物质的塑料膜接触，其发光强度在氧气存在下淬灭。通过被发光物质强烈吸收的光进行照射，得到发光强度I（t）的时间依赖性的度量。描述了从I（t）测量淬火，因此氧浓度的三种模式。这些模式对塑料厚度的变化，发光物质的浓度不敏感，并且考虑到发射的非指数衰减，从而延长了膜的敏感范围。发光物质包括部分或完全氟化的卟啉的金属衍生物，其由于卟啉环的氟化而是光稳定的。

3. 发明授权

US5284139A Hemometrix temperature compensation 失效
标题翻译：血液半球温度补偿
公开(公告)号：US5284139A
公开(公告)日：1994-02-08
申请号：US815925
申请日：1991-12-30
申请人： Gamal-Eddin Khalil , David P. Brown
发明人： Gamal-Eddin Khalil , David P. Brown
IPC分类号： G01N21/27 , G01N21/31 , A61B5/00 , A61B5/02 , F21V9/16 , G01N33/48
CPC分类号： G01N21/27 , G01N2021/3144 , G01N2201/1211 , G01N2201/126
摘要： A method for converting a value for the partial pressure of oxygen (pO.sub.2) in blood at a measurement temperature to a corresponding value at a reference temperature (37.degree. C.). A value for pO.sub.2 is determined by measurements made in a patient's blood stream using a phosphorescent compound that is sensitive to the concentration of oxygen. The phosphorescent compound is illuminated with a short pulse of light, causing it to produce a phosphorescent emission having a rate of decay that varies as the function of the partial pressure of oxygen in the blood surrounding the phosphorescent compound. A detector produces an electrical signal corresponding to the intensity of the phosphorescent emission, and the electrical signal is converted to a corresponding digital value for input to a microcomputer. Also supplied to the microcomputer in digital form is a signal indicative of the temperature at the measurement site where the phosphorescent compound is disposed. The microcomputer determines the phosphorescent decay rate and from that value, determines the pO.sub.2 at the measurement site for the temperature at which the measurement was made. An initial estimate of a corresponding value for pO.sub.2 at the reference temperature is made as a function of the measurement temperature and the pO.sub.2 at that temperature. A more accurate estimate of pO.sub.2 at the reference temperature is iteratively determined by successively evaluating an expression that is a function of the initial measurement and a previous more accurate estimate. If the measurement temperature is less than the reference temperature, the current more accurate estimate is replaced by the average of the previous two estimates. A final more accurate estimate representing the value for pO.sub.2 at the reference temperature is then displayed.
摘要翻译：将测定温度的血液中的氧分压值（pO2）转换为基准温度（37℃）下的对应值的方法。通过使用对氧浓度敏感的磷光化合物在患者血液中进行的测量来确定pO2的值。用短脉冲光照射磷光化合物，使其产生具有随着磷光化合物周围的血液中的氧分压的函数而变化的衰减速率的磷光发射。检测器产生对应于磷光发射强度的电信号，并且将电信号转换成相应的数字值以输入微计算机。还以数字形式提供给微型计算机是指示设置磷光化合物的测量部位处的温度的信号。微型计算机确定磷光衰减速率，从该值确定在测量部位进行测量的温度下的pO2。在参考温度下对pO2的相应值的初始估计作为测量温度和该温度下的pO2的函数。通过连续评估作为初始测量的函数的表达式和先前的更准确的估计，迭代地确定参考温度下pO2的更准确的估计。如果测量温度低于参考温度，则当前更准确的估计值将被前两次估计值的平均值所替代。然后显示表示参考温度下pO2值的最终更准确的估计。

4. 发明申请

US20070105235A1 Osmium-based oxygen sensor and pressure-sensitive paint 审中-公开
标题翻译：锇基氧传感器和压敏漆
公开(公告)号：US20070105235A1
公开(公告)日：2007-05-10
申请号：US11355504
申请日：2006-02-16
申请人： William Carlson , Gregory Phelan , Jason Benedict , Werner Kaminsky , Gamal-Eddin Khalil , Martin Gouterman , Larry Dalton
发明人： William Carlson , Gregory Phelan , Jason Benedict , Werner Kaminsky , Gamal-Eddin Khalil , Martin Gouterman , Larry Dalton
IPC分类号： G01N21/75
CPC分类号： C07F15/0026
摘要： Osmium-based oxygen sensor, pressure-sensitive paint that includes the osmium-based oxygen sensor, and method for measuring the pressure of an oxygen-containing fluid on a surface using the pressure-sensitive paint.
摘要翻译：锇基氧传感器，包括锇基氧传感器的压敏涂料以及使用压敏涂料测量表面上的含氧流体的压力的方法。

5. 发明申请

US20060160241A1 Dual-luminophor compositions and related methods 审中-公开
标题翻译：双发光组合物及相关方法
公开(公告)号：US20060160241A1
公开(公告)日：2006-07-20
申请号：US11134080
申请日：2005-05-19
申请人： Gamal-Eddin Khalil , Martin Gouterman , Colin Costin , James Callis , Sang Im , Younan Xia
发明人： Gamal-Eddin Khalil , Martin Gouterman , Colin Costin , James Callis , Sang Im , Younan Xia
IPC分类号： G01N21/64
CPC分类号： G01N21/76
摘要： A dual-luminophor compositions that include a first luminescent compound having a luminescent emission that is sensitive to oxygen concentration, a second luminescent compound having a luminescent emission that is insensitive to oxygen concentration, and an oxygen-permeable host material; and method for measuring the pressure of an oxygen-containing fluid using the dual-luminophor composition.
摘要翻译：一种双发光组合物，其包含具有对氧浓度敏感的发光发射的第一发光化合物，具有对氧浓度不敏感的发光发射的第二发光化合物和透氧性主体材料; 以及使用双发光体组合物测量含氧流体的压力的方法。

6. 发明授权

US06815211B1 Oxygen monitoring methods and apparatus (I) 失效
标题翻译：氧气监测方法及装置（一）
公开(公告)号：US06815211B1
公开(公告)日：2004-11-09
申请号：US09128897
申请日：1998-08-04
申请人： Perry R. Blazewicz , Leslie E. Mace , Jerry R. Apperson , Gamal-Eddin Khalil
发明人： Perry R. Blazewicz , Leslie E. Mace , Jerry R. Apperson , Gamal-Eddin Khalil
IPC分类号： G01N2175
CPC分类号： G01N21/6408 , A61B5/0833 , G01N21/6428 , G01N21/645 , G01N31/225 , G01N33/497
摘要： Apparatus or systems which employ luminescence quenching to produce an oxygen concentration indicative signal. Components of such systems include: (1) an airway adapter, sampling cell, or the like having a sensor which is excited into luminescence with the luminescence decaying in a manner reflecting the concentration of oxygen in gases flowing through the airway adapter or other flow device; (2) a transducer which has a light source for exciting a luminescable composition in the sensor into luminescence and a light sensitive detector for converting energy emitted from the luminescing composition as that composition is quenched into an electrical signal indicative of oxygen concentration in the gases being monitored; and (3) subsystems for maintaining the sensor temperature constant and for processing the signal generated by the light sensitive detector. Sensors for systems of the character just described, methods of fabricating those sensors, and methods for installing the sensors in the flow device.
摘要翻译：采用发光淬灭以产生氧浓度指示信号的装置或系统。这种系统的组件包括：（1）具有传感器的气道适配器，采样单元等，其被激发成发光，发光以反映气道适配器或其它流动装置中流动的气体中的氧浓度的方式衰减 ; （2）具有用于将传感器中的可发光组合物激发成发光的光源的传感器和用于转换从发光组合物发射的能量的光敏检测器，该组合物被猝灭成指示气体中的氧浓度的电信号监控和（3）用于维持传感器温度恒定并用于处理由光敏检测器产生的信号的子系统。用于刚刚描述的角色的系统的传感器，制造这些传感器的方法，以及用于将传感器安装在流动装置中的方法。

7. 发明授权

US4810655A Method for measuring oxygen concentration 失效
标题翻译：氧浓度测定方法
公开(公告)号：US4810655A
公开(公告)日：1989-03-07
申请号：US931746
申请日：1986-09-11
申请人： Gamal-Eddin Khalil , Martin P. Gouterman , Edmond Green
发明人： Gamal-Eddin Khalil , Martin P. Gouterman , Edmond Green
IPC分类号： A61K49/00 , G01N21/64 , G01N21/76 , A61B5/00 , G01N33/52
CPC分类号： G01N21/643 , A61K49/0013 , A61K49/0015 , A61K49/0021 , A61K49/0036 , G01N2021/6432 , Y10T436/207497 , Y10T436/209163 , Y10T436/255
摘要： Methods and compositions are described for measuring oxygen concentration, particularly for monitoring oxygen in the blood with a fiber optic catheter. Oxygen concentration is determined by observing quenching of the emission from a luminescent (phosphorescent of fluorescent) molecule embedded in an oxygen-permeable matrix. A test fluid of unknown oxygen concentration is contacted with the matrix containing at least one luminescent substance. The matrix is subjected to irradiation over some period of time by light of a wavelength that is strongly absorbed by the luminescent substance, and a measure of the time dependence of luminescent emission intensity I(t) is obtained. Three modes of determining oxygen concentration from I(t) are described.
摘要翻译： PCT No.PCT / US86 / 01362 Sec。 371日期1986年9月11日 102（e）1986年9月11日PCT PCT。1986年6月27日PCT公布。第WO87 / 00023号公报日期：1987年1月15日。描述了用于测量氧浓度的方法和组合物，特别是用于使用光纤导管监测血液中的氧。氧浓度通过观察从透氧基质中包含的发光（荧光磷光体）分子发射的猝灭来确定。未知氧浓度的测试流体与含有至少一种发光物质的基质接触。通过被发光物质强烈吸收的波长的光，在一段时间内对基质进行照射，得到发光强度I（t）的时间依赖性的度量。描述了从I（t）确定氧浓度的三种模式。

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