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1. 发明授权

US5127077A Fiber-optic physiological probes 失效
标题翻译：光纤生理探针
公开(公告)号：US5127077A
公开(公告)日：1992-06-30
申请号：US629988
申请日：1990-12-18
申请人： Lokanathan M. Iyer , Jeffrey B. Yim , Kenneth S. Lyon
发明人： Lokanathan M. Iyer , Jeffrey B. Yim , Kenneth S. Lyon
IPC分类号： A61B5/00 , G01N21/03 , G01N21/64 , G01N21/77 , G01N21/78 , G01N21/80 , G01N21/85
CPC分类号： A61B5/14539 , A61B5/1459 , G01N21/6428 , G01N2021/0385 , G01N2021/6434 , G01N21/77 , G01N21/783 , G01N21/80 , G01N21/8507
摘要： Fiber optic sensors suitable for monitoring physiological analyte concentrations are described. The sensors include analyte permeable matrices disposed in a light path defined by the axial core at one end of an optical fiber segment. The matrix contains an indicator molecule covalently linked to a polymer or admixed with the polymer. The indicator molecule may be an absorptive molecule or a luminescent molecule. pH, PCO.sub.2, and PO.sub.2 sensors are described and may be disposed together in substantially coterminal arrangement to make a multivariable probe.
摘要翻译：描述了适用于监测生理分析物浓度的光纤传感器。这些传感器包括分析物可渗透的基质，其设置在由光纤段的一端由轴向芯限定的光路中。基质含有与聚合物共价连接或与聚合物混合的指示剂分子。指示剂分子可以是吸收分子或发光分子。描述了pH，PCO2和PO2传感器，并且可以以基本上共同的方式布置在一起以形成多变量探针。

2. 发明授权

US5047627A Configuration fiber-optic blood gas sensor bundle and method of making 失效
标题翻译：配置光纤血气传感器束及其制作方法
公开(公告)号：US5047627A
公开(公告)日：1991-09-10
申请号：US526185
申请日：1990-05-18
申请人： Jeffrey B. Yim , Todd W. Hubbard , Lori D. Melkerson , Michael A. Sexton , Bruce M. Fieggen
发明人： Jeffrey B. Yim , Todd W. Hubbard , Lori D. Melkerson , Michael A. Sexton , Bruce M. Fieggen
IPC分类号： A61B5/145 , A61B5/1459 , G01N21/31 , G01N21/55 , G01N21/64 , G01N21/77 , G01N21/78 , G01N21/80 , G01N33/49 , G01N33/84
CPC分类号： G01N21/7703 , G01N33/84 , G01N2021/3181 , G01N2021/6434 , G01N2021/772 , G01N21/783 , G01N21/80
摘要： A bundle of fiber-optic sensors that resist breakage, for use in measuring pH, CO.sub.2, and O.sub.2 concentration, and a method of making the same. Three otpical fibers are enclosed in a common polyimide sheath and extend parallel to one another toward a distal end of the sensor, where they are bonded together in a mutually supportive array. At the distal end of one of these optical fibers is disposed a pellet comprising a CO.sub.2 analyte indicator molecule codissolved within a polymer matrix. A thin reflective surface of gold foil is provided on the pellet such that incident light transmitted through the optical fiber and polymer matrix is reflected back into the optical fiber. The CO.sub.2 polymer matrix absorbs light of a given wavelength to an extent dependent upon the level of CO.sub.2 present. Similarly, on the distal end of a second optical fiber is disposed a pH pellet comprising a pH analyte indicator matrix with a thin reflective gold foil attached for reflecting light that has passed through the pH analyte indicator matrix back into the optical fiber. The pH analyte indicator matrix absorbs light of a given wavelenth to an extent dependent upon the hydrogen ion concentration (pH level) of a surrounding fluid. The third optical fiber is used for measuring oxygen concentration. An O.sub.2 indicator matrix covers the distal ends of at least two of the three optical fibers; however, at least a portion of the pH optical fiber and the pH pellet are free of the O.sub.2 indicator matrix, which is hydrophobic. The oxygen indicator matrix phosphoresces for an interval of time that decreases in proportion to the surrounding oxygen gas concentration. The phosphorescent and reflected light signals are transmitted to light detectors through the optical fibers for comparison to reference signals, so that the analyte concentrations can be determined.

3. 发明授权

US5000901A Fiber-optic physiological probes 失效
标题翻译：光纤生理探针
公开(公告)号：US5000901A
公开(公告)日：1991-03-19
申请号：US491336
申请日：1990-03-09
申请人： Lokanathan M. Iyer , Jeffrey B. Yim , Kenneth S. Lyon
发明人： Lokanathan M. Iyer , Jeffrey B. Yim , Kenneth S. Lyon
IPC分类号： A61B5/00 , G01N21/03 , G01N21/64 , G01N21/77 , G01N21/78 , G01N21/80 , G01N21/85
CPC分类号： G01N21/7703 , A61B5/14539 , A61B5/1459 , G01N21/6428 , G01N2021/0385 , G01N2021/6434 , G01N2021/772 , G01N2021/7786 , G01N21/783 , G01N21/80 , G01N21/8507
摘要： Methods of monitoring analyte concentration in fluids using fiber optic sensors that include analyte permeable matrices disposed in a light path at one end of an optical fiber waveguide. The analyte permeable matrix includes an indicator molecular capable of responding to the analyte in an optically detectable manner. The absorbance or emission from the analyte permeable matrix after irradiation is used to determine the concentration of the analyte in the fluid as a function of the measured absorbance or emission. Methods for manufacturing fiber optic sensors useful in a method of monitoring analyte concentration in a fluid include casting a polymer film that includes an indicator molecule capable of responding to the analyte in an optically detectable manner. Disks or pellets are punched from the film and applied to the end of an optical fiber waveguide.
摘要翻译：使用光纤传感器监测流体中的分析物浓度的方法，其包括设置在光纤波导的一端的光路中的分析物可渗透的基质。分析物可渗透基质包括能以光学可检测方式响应分析物的指示剂分子。照射后来自分析物可渗透基质的吸收或发射用于确定流体中分析物的浓度作为测量的吸光度或发射的函数。用于制造用于监测流体中分析物浓度的方法的光纤传感器的方法包括浇铸聚合物膜，该聚合物膜包括能够以可光学检测的方式响应分析物的指示剂分子。将磁片或丸片从薄膜冲压并施加到光纤波导的末端。

4. 发明授权

US4925268A Fiber-optic physiological probes 失效
标题翻译：光纤生理探针
公开(公告)号：US4925268A
公开(公告)日：1990-05-15
申请号：US224620
申请日：1988-07-25
申请人： Lokanathan M. Iyer , Jeffrey B. Yim , Kenneth S. Lyon
发明人： Lokanathan M. Iyer , Jeffrey B. Yim , Kenneth S. Lyon
IPC分类号： G01N33/49 , A61B5/00 , G01N21/03 , G01N21/64 , G01N21/76 , G01N21/77 , G01N21/78 , G01N21/80 , G01N21/85
CPC分类号： G01N21/7703 , A61B5/14539 , A61B5/1459 , G01N21/6428 , G01N2021/0385 , G01N2021/6434 , G01N2021/772 , G01N2021/7786 , G01N21/783 , G01N21/80 , G01N21/8507
摘要： Fiber-optic sensors suitable for monitoring physiological analyte concentration. An analyte-permeable matrix is disposed in the light path defined by the axial core at one end of an optical fiber segment. The matrix contains an indicator molecule covalently linked to a polymer, preferably methyl methacrylate/methacrylamidopropyltrimethylammonium chloride, N-vinylpyrrolidone/p-aminostyrene, methyl methacrylate/hydroxymethyl methacrylate, methyl methacrylate/N-vinylpyrrolidone, or methyl methacrylate/acrylic acid. In representative embodiments, the polymer is approximately 94:6 mole/mole percent of either methyl methacrylate/methacrylamidopropyltrimethylammonium chloride or N-vinylpyrrolidone/p-aminostyrene copolymer. Drift-free performance is obtained with such sensors having analyte-permeable matrices of significantly less than about 70 microns in thickness. The indicator molecule may be covalently linked to the polymer through an aminoarylalkylamine, such as 4-(aminophenyl)-ethylamine or 4-(aminophenyl)-propylamine.

5. 发明授权

US5300769A Method and system of compensating for signal artifacts in a fiber-optic sensing system 失效
标题翻译：补偿光纤传感系统中信号伪影的方法和系统
公开(公告)号：US5300769A
公开(公告)日：1994-04-05
申请号：US999495
申请日：1992-12-29
申请人： Jeffrey J. Dahlin , John F. Holic, Jr. , William G. Lundell , Steven B. Duke , Jeffrey B. Yim
发明人： Jeffrey J. Dahlin , John F. Holic, Jr. , William G. Lundell , Steven B. Duke , Jeffrey B. Yim
IPC分类号： G01D5/26 , G01N21/77 , G01N33/48 , A61B5/00
CPC分类号： G01D5/268 , G01N21/7703 , G01N2021/772
摘要： A method and system for controlling the intervals during which light signals are sampled in a fiber-optic sensing system compensates for signal artifacts that are caused by movement of the fiber-optic waveguide during the sampling. The method and system sample the light signals at intervals that are shorter than the intervals during which displacement of the optical waveguide occurs in normal use. The short-sampling intervals result in the individual sampling of different wavelengths of light being exposed to the same changes in transmission characteristics of the optical waveguide which causes signal artifacts. Accordingly, when subsequent processing of the collected signals occurs, the effects of the signal artifacts are compensated for.
摘要翻译：用于控制光信号在光纤感测系统中采样的间隔的方法和系统补偿由采样期间光纤波导的移动引起的信号伪影。该方法和系统以比在正常使用中发生光波导位移的间隔短的间隔对光信号进行采样。短采样间隔导致不同波长的光的单独采样被暴露于导致信号伪影的光波导的传输特性的相同变化。因此，当收集的信号的后续处理发生时，补偿信号伪像的影响。

6. 发明授权

US5098659A Apparatus for continuously monitoring a plurality of chemical analytes through a single optical fiber and method of making 失效
标题翻译：通过单光纤连续监测化学分析物的多样性的装置和制备方法
公开(公告)号：US5098659A
公开(公告)日：1992-03-24
申请号：US587234
申请日：1990-09-24
申请人： Jeffrey B. Yim , Gamal-Eddin Khalil , Roger J. Pihl , Bradley D. Huss , Gerald G. Vurek
发明人： Jeffrey B. Yim , Gamal-Eddin Khalil , Roger J. Pihl , Bradley D. Huss , Gerald G. Vurek
IPC分类号： A61B5/145 , A61B5/00 , A61B5/1459 , G01N21/31 , G01N21/64 , G01N21/76 , G01N21/77 , G01N21/80 , G01N33/49
CPC分类号： G01N21/643 , A61B5/14539 , A61B5/1459 , G01N21/7703 , G01N2021/6434 , G01N2021/773 , G01N2021/7793 , G01N21/80
摘要： A CO.sub.2 /O.sub.2 or pH/O.sub.2 gas sensor comprising a single optical fiber and a method for making the same. The optical fiber carries light signals at different wavelengths for monitoring either CO.sub.2 concentration or pH level, in combination with O.sub.2 concentration. Attached to the distal end of the fiber-optic probe is a cylindrical pellet that has one surface covered by a light reflective material (gold foil) and the other surface attached adjacent to the distal end of the optical fiber. Depending on whether the sensor is to monitor either CO.sub.2 or pH, the pellet comprises either a CO.sub.2 analyte indicator molecule or a pH analyte indicator molecule covalently bonded to a polymer matrix material. Also adjacent to the distal end of the optical fiber is disposed a second polymer matrix material which is codissolved with an O.sub.2 analyte reactive indicator molecule. The second polymer matrix material is either interposed between the cylindrical pellet and the distal end of the optical fiber or surrounds the cylindrical pellet. If pH is being measured, the distal end of the optical fiber is coated with a hydrophilic material that is permeable to water. Conversely, if CO.sub.2 is being monitored, the distal end is coated with a hydrophobic material.

7. 发明授权

US5304495A Method for determining flush interference in measurement of chemical and physical parameters with indwelling probe 失效
标题翻译：用留置探针测定化学和物理参数的冲洗干扰的方法
公开(公告)号：US5304495A
公开(公告)日：1994-04-19
申请号：US997863
申请日：1992-12-29
申请人： Jeffrey B. Yim
发明人： Jeffrey B. Yim
IPC分类号： A61B5/00 , G01N25/20 , A61B5/02 , G01N33/48 , G01N33/50
CPC分类号： A61B5/14539 , A61B5/1455
摘要： A system (10) for in vivo measuring chemical and physical parameters of a patient's blood includes a probe (12), a sensing system (14), and flush interference warning devices (20). The system measures pH, pCO.sub.2, and temperature values, and determines a base excess value using the measured pH and pCO.sub.2. The time rate of change of the base excess value is also determined, as is the time rate of change of temperature. The warning devices are activated, indicating that the measured parameters are likely affected by the presence of flush solution flowing past the probe, when either: (a) the base excess value is less than a predefined threshold base excess; (b) the absolute value of the time rate of change of the base excess value is greater than a predefined threshold time rate of change of base excess; or, (c) the absolute value of the time rate of change of temperature is greater than a predefined threshold time rate of change of temperature.
摘要翻译：用于体内测量患者血液的化学和物理参数的系统（10）包括探针（12），感测系统（14）和冲洗干扰警告装置（20）。该系统测量pH，pCO2和温度值，并使用测量的pH和pCO2确定碱度过量值。还要确定基础过剩值的时间变化率，以及温度变化的时间速率。警告装置被激活，表明测量的参数可能受到流过探头的冲洗液的存在的影响，当时：（a）基础过量值小于预定义的阈值基础过剩; （b）基本超额值的时间变化率的绝对值大于基准过剩的预定阈值时间变化率; 或者，（c）温度变化时间率的绝对值大于预定的阈值时间温度变化率。

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