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    • 3. 发明授权
    • Hemometrix temperature compensation
    • 血液半球温度补偿
    • US5284139A
    • 1994-02-08
    • US815925
    • 1991-12-30
    • Gamal-Eddin KhalilDavid P. Brown
    • Gamal-Eddin KhalilDavid P. Brown
    • G01N21/27G01N21/31A61B5/00A61B5/02F21V9/16G01N33/48
    • G01N21/27G01N2021/3144G01N2201/1211G01N2201/126
    • A method for converting a value for the partial pressure of oxygen (pO.sub.2) in blood at a measurement temperature to a corresponding value at a reference temperature (37.degree. C.). A value for pO.sub.2 is determined by measurements made in a patient's blood stream using a phosphorescent compound that is sensitive to the concentration of oxygen. The phosphorescent compound is illuminated with a short pulse of light, causing it to produce a phosphorescent emission having a rate of decay that varies as the function of the partial pressure of oxygen in the blood surrounding the phosphorescent compound. A detector produces an electrical signal corresponding to the intensity of the phosphorescent emission, and the electrical signal is converted to a corresponding digital value for input to a microcomputer. Also supplied to the microcomputer in digital form is a signal indicative of the temperature at the measurement site where the phosphorescent compound is disposed. The microcomputer determines the phosphorescent decay rate and from that value, determines the pO.sub.2 at the measurement site for the temperature at which the measurement was made. An initial estimate of a corresponding value for pO.sub.2 at the reference temperature is made as a function of the measurement temperature and the pO.sub.2 at that temperature. A more accurate estimate of pO.sub.2 at the reference temperature is iteratively determined by successively evaluating an expression that is a function of the initial measurement and a previous more accurate estimate. If the measurement temperature is less than the reference temperature, the current more accurate estimate is replaced by the average of the previous two estimates. A final more accurate estimate representing the value for pO.sub.2 at the reference temperature is then displayed.
    • 将测定温度的血液中的氧分压值(pO2)转换为基准温度(37℃)下的对应值的方法。 通过使用对氧浓度敏感的磷光化合物在患者血液中进行的测量来确定pO2的值。 用短脉冲光照射磷光化合物,使其产生具有随着磷光化合物周围的血液中的氧分压的函数而变化的衰减速率的磷光发射。 检测器产生对应于磷光发射强度的电信号,并且将电信号转换成相应的数字值以输入微计算机。 还以数字形式提供给微型计算机是指示设置磷光化合物的测量部位处的温度的信号。 微型计算机确定磷光衰减速率,从该值确定在测量部位进行测量的温度下的pO2。 在参考温度下对pO2的相应值的初始估计作为测量温度和该温度下的pO2的函数。 通过连续评估作为初始测量的函数的表达式和先前的更准确的估计,迭代地确定参考温度下pO2的更准确的估计。 如果测量温度低于参考温度,则当前更准确的估计值将被前两次估计值的平均值所替代。 然后显示表示参考温度下pO2值的最终更准确的估计。
    • 7. 发明授权
    • Oxygen monitoring methods and apparatus (I)
    • 氧气监测方法及装置(一)
    • US06815211B1
    • 2004-11-09
    • US09128897
    • 1998-08-04
    • Perry R. BlazewiczLeslie E. MaceJerry R. AppersonGamal-Eddin Khalil
    • Perry R. BlazewiczLeslie E. MaceJerry R. AppersonGamal-Eddin Khalil
    • G01N2175
    • G01N21/6408A61B5/0833G01N21/6428G01N21/645G01N31/225G01N33/497
    • Apparatus or systems which employ luminescence quenching to produce an oxygen concentration indicative signal. Components of such systems include: (1) an airway adapter, sampling cell, or the like having a sensor which is excited into luminescence with the luminescence decaying in a manner reflecting the concentration of oxygen in gases flowing through the airway adapter or other flow device; (2) a transducer which has a light source for exciting a luminescable composition in the sensor into luminescence and a light sensitive detector for converting energy emitted from the luminescing composition as that composition is quenched into an electrical signal indicative of oxygen concentration in the gases being monitored; and (3) subsystems for maintaining the sensor temperature constant and for processing the signal generated by the light sensitive detector. Sensors for systems of the character just described, methods of fabricating those sensors, and methods for installing the sensors in the flow device.
    • 采用发光淬灭以产生氧浓度指示信号的装置或系统。 这种系统的组件包括:(1)具有传感器的气道适配器,采样单元等,其被激发成发光,发光以反映气道适配器或其它流动装置中流动的气体中的氧浓度的方式衰减 ; (2)具有用于将传感器中的可发光组合物激发成发光的光源的传感器和用于转换从发光组合物发射的能量的光敏检测器,该组合物被猝灭成指示气体中的氧浓度的电信号 监控 和(3)用于维持传感器温度恒定并用于处理由光敏检测器产生的信号的子系统。 用于刚刚描述的角色的系统的传感器,制造这些传感器的方法,以及用于将传感器安装在流动装置中的方法。