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1. 发明授权

US08095214B2 Perivascular leak repair system 有权
标题翻译：血管周围渗漏修复系统
公开(公告)号：US08095214B2
公开(公告)日：2012-01-10
申请号：US12502294
申请日：2009-07-14
申请人： Jeffrey Allen , David Brin , Chris Coppin
发明人： Jeffrey Allen , David Brin , Chris Coppin
IPC分类号： A61N1/30 , A61M31/00 , A61B17/06 , A61F2/24
CPC分类号： A61B17/00491 , A61B2017/00243 , A61B2017/00783 , A61F2/2409
摘要： The perivascular leak repair system, and method of using the same, of the present invention provides a sealant reservoir 102 with a repair catheter 104 operably attached; a flow control device 106 disposed between the sealant reservoir 102 and the repair catheter 104, and the flow control device 106 responsive to a flow control signal 108; a heart phase detector 114 generating a diastole phase signal 112; an injection switch 122 generating a injection signal 120; and a flow controller 110 responsive to the diastole phase signal 112 and the injection signal 120, and generating the flow control signal 108. A method of sealing a perivascular leak comprises identifying the perivascular leak 140; inserting a repair catheter to the perivascular leak 142; injecting sealant at the perivascular leak 144; and removing the repair catheter 146. The sealant can be injected when the heart is in diastole to sweep the sealant into the perivascular leak.
摘要翻译：本发明的血管周围泄漏修复系统及其使用方法提供了具有可操作地附接的修复导管104的密封剂储存器102; 布置在密封剂储存器102和修复导管104之间的流量控制装置106以及响应于流量控制信号108的流量控制装置106; 产生舒张期相位信号112的心脏相位检测器114; 产生喷射信号120的喷射开关122; 以及响应于舒张期相位信号112和注射信号120的流量控制器110，以及产生流量控制信号108.密封血管周围的泄漏的方法包括识别血管周围的泄漏140; 将维修导管插入血管周围的泄漏142; 在血管周围泄漏144处注射密封剂; 并且移除修复导管146.当心脏舒适时可以注射密封剂以将密封剂扫过血管周围的泄漏。

2. 发明授权

US08588900B2 Perivascular leak repair system 有权
公开(公告)号：US08588900B2
公开(公告)日：2013-11-19
申请号：US13312635
申请日：2011-12-06
申请人： Jeffrey Allen , David Brin , Chris Coppin
发明人： Jeffrey Allen , David Brin , Chris Coppin
IPC分类号： A61N1/30 , A61M31/00 , A61M5/00 , A61B17/06 , A61F2/24
CPC分类号： A61B17/00491 , A61B2017/00243 , A61B2017/00783 , A61F2/2409
摘要： The perivascular leak repair system, and method of using the same, of the present invention provides a sealant reservoir with a repair catheter operably attached; a flow control device disposed between the sealant reservoir and the repair catheter, and the flow control device responsive to a flow control signal; a heart phase detector generating a diastole phase signal; an injection switch generating a injection signal; and a flow controller responsive to the diastole phase signal and the injection signal, and generating the flow control signal. A method of sealing a perivascular leak comprises identifying the perivascular leak; inserting a repair catheter to the perivascular leak; injecting sealant at the perivascular leak; and removing the repair catheter. The sealant can be injected when the heart is in diastole to sweep the sealant into the perivascular leak.

3. 发明申请

US20090240248A1 Methods and Apparatus for Ablation of Cardiac Tissue 审中-公开
标题翻译：心脏组织消融的方法和装置
公开(公告)号：US20090240248A1
公开(公告)日：2009-09-24
申请号：US12087176
申请日：2006-12-29
申请人： John A. Deford , Charles Krauss , David Brin
发明人： John A. Deford , Charles Krauss , David Brin
IPC分类号： A61B18/14 , A61B17/00
CPC分类号： A61B18/1492 , A61B2018/00214 , A61B2018/00375
摘要： Embodiments of the invention relate to electrophysiology catheters and methods of using the same. According to one embodiment, a method of treating a cardiac arrhythmia comprises forming a first lesion about a source of an electrical signal in the heart, the first lesion having an open first perimeter, and forming a second lesion about the source of the electrical signal in the heart. The second lesion has an open second perimeter and is located closer to the source of the electrical signal than the first lesion. The first lesion is discontinuous from the second lesion, and at least the first and second lesions together form a closed, at least substantially complete conduction block. According to other embodiments, catheters are provided for performing this and other methods.
摘要翻译：本发明的实施例涉及电生理学导管及其使用方法。根据一个实施方案，治疗心律失常的方法包括在心脏中形成关于电信号源的第一病变，所述第一病变具有开放的第一周界，以及围绕所述电信号源形成第二病变心脏第二病变具有开放的第二周界，并且位于比第一病变更靠近电信号源的位置。第一病变与第二病变不连续，并且至少第一和第二病变一起形成封闭的，至少基本完全的传导阻滞。根据其他实施例，提供了用于执行该方法和其它方法的导管。

4. 发明申请

US20050266043A1 Methods and compounds for treatment of aneurysmal tissue 审中-公开
标题翻译：用于治疗动脉瘤组织的方法和化合物
公开(公告)号：US20050266043A1
公开(公告)日：2005-12-01
申请号：US10946939
申请日：2004-09-22
申请人： David Tseng , Jack Chu , Michel LeTort , Brian Raze , David Brin
发明人： David Tseng , Jack Chu , Michel LeTort , Brian Raze , David Brin
IPC分类号： A61B17/12 , A61F2/02 , A61F2/06 , A61L24/00 , A61L24/04 , A61L24/06 , A61L31/12 , A61L31/16 , A61F2/00
CPC分类号： A61L31/041 , A61B17/12022 , A61B17/12118 , A61B17/12186 , A61F2/07 , A61F2/89 , A61F2002/065 , A61F2002/077 , A61F2230/0054 , A61F2250/0003 , A61L24/0015 , A61L24/043 , A61L31/16 , A61L2300/406 , A61L2300/41 , A61L2300/432 , C08L31/04 , C08L67/04 , C08L33/10
摘要： Methods and apparatus for minimizing the risks inherent in endovascular grafting for aneurysm repair are provided, including the implantation and time-controlled release of at least one bioactive agent at the aneurysmal site.
摘要翻译：提供了用于最小化动脉瘤修复的血管内移植固有的风险的方法和装置，包括在动脉瘤部位植入和时间控制释放至少一种生物活性剂。

5. 发明申请

US20050149113A1 Temporary intraluminal filter guidewire and methods of use 失效
公开(公告)号：US20050149113A1
公开(公告)日：2005-07-07
申请号：US11053368
申请日：2005-02-08
申请人： Nareak Douk , Nasser Rafiee , David Brin , Peter Strickler
发明人： Nareak Douk , Nasser Rafiee , David Brin , Peter Strickler
IPC分类号： A61B17/00 , A61B17/22 , A61F2/01 , A61F2/82 , A61M25/00 , A61M29/00
CPC分类号： A61F2/013 , A61B2017/1205 , A61B2017/12095 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/0069 , A61F2230/0071 , A61F2230/008
摘要： The present invention is a temporary intraluminal filter guidewire for use during interventional procedures, such as angioplasty or stent deployment. A braided filter is mounted near the distal end of a steerable guidewire, which guides a therapeutic catheter. An actuator rod slides over the guidewire and is removably connected to the filter. The rod controls relative displacement of the filter ends, causing transformation of the filter between a deployed configuration and a collapsed configuration. Wire having enhanced radiopacity is included in the filter to provide visualization under fluoroscopy.

6. 发明申请

US20050043786A1 Methods and apparatus for treatment of aneurysmal tissue 审中-公开
标题翻译：用于治疗动脉瘤组织的方法和装置
公开(公告)号：US20050043786A1
公开(公告)日：2005-02-24
申请号：US10643649
申请日：2003-08-18
申请人： Jack Chu , Scott Doig , David Brin
发明人： Jack Chu , Scott Doig , David Brin
IPC分类号： A61F2/00 , A61F2/06 , A61F2/88
CPC分类号： A61F2/88 , A61F2250/0067
摘要： Methods and apparatus for aiding aneurysm repair are provided. Such apparatus is constructed to support or bolster the aneurysmal site initially, while contracting if the aneurysmal site shrinks or contracts. The apparatus also supplies a pharmaceutical agent to aid in healing the surrounding aneurysmal tissue. The apparatus may comprise a drug eluting polymer or may have a passive coating which can be selectively deployed by adding an activation agent after deployment. The device can be used alone or in conjunction with a AAA stent graft that isolates the aneurysmal sac from the vascular system.
摘要翻译：提供了辅助动脉瘤修复的方法和装置。这种装置被构造成最初支撑或支撑动脉瘤部位，同时如果动脉瘤部位缩小或收缩则承包。该装置还提供药剂以帮助愈合周围的动脉瘤组织。该装置可以包括药物洗脱聚合物或可以具有被动涂层，其可以在部署之后通过添加活化剂来选择性地部署。该装置可以单独使用或与用于将动脉瘤囊与血管系统隔离的AAA支架移植物结合使用。

7. 发明申请

US20060141006A1 Methods and apparatus for treatment of aneurysmal tissue 审中-公开
标题翻译：用于治疗动脉瘤组织的方法和装置
公开(公告)号：US20060141006A1
公开(公告)日：2006-06-29
申请号：US11358653
申请日：2006-02-21
申请人： David Brin , David Tseng
发明人： David Brin , David Tseng
IPC分类号： A61F2/00 , A61K31/65
CPC分类号： A61L31/16 , A61F2/07 , A61F2/90 , A61F2002/067 , A61F2250/0067 , A61L31/10 , A61L2300/602
摘要： The present invention encompasses methods and apparatus for aiding aneurysm repair.
摘要翻译：本发明包括用于辅助动脉瘤修复的方法和装置。

8. 发明申请

US20070231361A1 Use of Fatty Acids to Inhibit the Growth of Aneurysms 审中-公开
标题翻译：使用脂肪酸抑制动脉瘤的生长
公开(公告)号：US20070231361A1
公开(公告)日：2007-10-04
申请号：US11277637
申请日：2006-03-28
申请人： David Brin , Jack Chu , Prema Ganesan , Dianne Judd , Michel Letort , Patrice Tremble , Eugene Tedeschi
发明人： David Brin , Jack Chu , Prema Ganesan , Dianne Judd , Michel Letort , Patrice Tremble , Eugene Tedeschi
IPC分类号： A61K31/202
CPC分类号： A61K31/202
摘要： Methods of treating an aneurysm in a patient in need thereof are provided. The methods comprise delivering to a treatment site an effective amount of a fatty acid inhibitor of a matrix metalloproteinase (MMP) such that the fatty acid inhibitor of the MMP causes the regression of a pre-existing aneurysm. Additionally, an implantable medical device is provided for implanting in a vessel wall of a patient comprising a structural support and a fatty acid inhibitor of an MMP.
摘要翻译：提供了在有需要的患者中治疗动脉瘤的方法。所述方法包括向治疗部位递送有效量的基质金属蛋白酶（MMP）的脂肪酸抑制剂，使得MMP的脂肪酸抑制剂导致预先存在的动脉瘤的消退。另外，可植入医疗装置用于植入患者的血管壁，包括结构支持物和MMP的脂肪酸抑制剂。

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