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1. 发明授权

US5536719A Benzothiadiazine compound 失效
标题翻译：苯并噻二嗪化合物
公开(公告)号：US5536719A
公开(公告)日：1996-07-16
申请号：US500609
申请日：1995-07-11
申请人： Alex Cordi , Michael Spedding , Bernard Serkiz , Jean Lepagnol , Patrice Desos , Philippe Morain
发明人： Alex Cordi , Michael Spedding , Bernard Serkiz , Jean Lepagnol , Patrice Desos , Philippe Morain
IPC分类号： A61K31/54 , A61K31/549 , A61P25/00 , A61P25/18 , A61P25/20 , A61P25/28 , A61P43/00 , C07B53/00 , C07B57/00 , C07B61/00 , C07D513/04
CPC分类号： C07D513/04
摘要： A compound of formula (I): ##STR1## in the form of its S enantiomer, its addition salts with a pharmaceutically acceptable acid or base and medicinal product containing the same are useful for the treatment or prevention of pathologies associated with dysfunction of glutamatergic neurotransmission.
摘要翻译：式（I）化合物：其S对映异构体形式的其（I）化合物，其与药学上可接受的酸或碱的加成盐和含有其的药物可用于治疗或预防与功能障碍相关的病理学谷氨酸能神经传递。

2. 发明授权

US08778932B2 Dihydro-oxazolobenzodiazepinone compounds, a process for there preparation and pharmaceutical compositions containing them 有权
标题翻译：二氢 - 恶唑基二氮杂二氮杂酮化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US08778932B2
公开(公告)日：2014-07-15
申请号：US13413977
申请日：2012-03-07
申请人： István Ling , József Barkóczy , Ferenc Antoni , István Gascályi , György Lévay , Michael Spedding , László Hársing
发明人： István Ling , József Barkóczy , Ferenc Antoni , István Gascályi , György Lévay , Michael Spedding , László Hársing
IPC分类号： A61K31/551 , C07D498/04 , C07D519/00
CPC分类号： C07D498/04 , A61K31/551 , C07D519/00
摘要： Compounds of formula (I): wherein: R1 represents a hydrogen atom or an alkyl group; R2 represents an alkyl group; R3 represents an aryl or heteroaryl group. Medicinal products containing the same which are useful in the treatment or prevention of psychiatric and neurological disorders characterized by cognitive deficits.
摘要翻译：式（I）化合物：其中：R1表示氢原子或烷基; R2表示烷基; R3表示芳基或杂芳基。含有该物质的药物可用于治疗或预防以认知缺陷为特征的精神和神经障碍。

3. 发明授权

US4956365A Decahydro-8H-isoquino(2,1-g)(1,6)naphthyridine derivatives and related compounds 失效
标题翻译：十氢-8H-异喹啉（2,1-g）（1,6）萘啶衍生物和相关化合物
公开(公告)号：US4956365A
公开(公告)日：1990-09-11
申请号：US257372
申请日：1988-10-12
申请人： Robin D. Clark , Andrew T. Kilpatrick , Michael Spedding
发明人： Robin D. Clark , Andrew T. Kilpatrick , Michael Spedding
IPC分类号： C07D471/14 , C07D491/22
CPC分类号： C07D471/14
摘要： Compounds of formulas (1) and (2): ##STR1## in which: X and Y are independently hydrogen, hydroxy, lower alkyl, lower alkoxy or halo, or X and Y taken together is methylenedioxy or ethylene-1,2-dioxy;W is oxygen or sulfur; andZ is --R.sup.1, --OR.sup.2 or --NR.sup.3 R.sup.4, whereinR.sup.1 is lower alkyl, lower haloalkyl, cycloalkyl, optionally substituted phenyl or phenyl lower alkyl, or heteroaryl;R.sup.2 is lower alkyl, optionally substituted phenyl or phenyl lower alkyl;R.sup.3 and R.sup.4 are independently hydrogen, alkyl, optionally substituted phenyl or phenyl lower alkyl; orR.sup.3 and R.sup.4 taken together with the nitrogen to which they are attached represent a heterocycle of the formula: ##STR2## wherein A is --(CH.sub.2).sub.m, --N(R.sup.5)-- or oxygen, in which m is an integer of 0-2 and R.sup.5 is hydrogen or lower alkyl;or a pharmaceutically acceptable salt thereof, are useful as .alpha..sub.2 -blockers.
摘要翻译：（1）和（2）的化合物：其中：X和Y独立地是氢，羟基，低级烷基，低级烷氧基或卤素，或X和Y一起是亚甲二氧基或亚乙基-1,2-二氧基; W是氧或硫; 且Z为-R1，-OR2或-NR3R4，其中R1为低级烷基，低级卤代烷基，环烷基，任选取代的苯基或苯基低级烷基或杂芳基; R2是低级烷基，任意取代的苯基或苯基低级烷基; R3和R4独立地是氢，烷基，任选取代的苯基或苯基低级烷基; 或者R 3和R 4与它们所连接的氮一起代表下式的杂环：其中A是 - （CH 2）m，-N（R 5） - 或氧，其中m是整数0 -2和R5是氢或低级烷基; 或其药学上可接受的盐可用作α2-受体阻滞剂。

4. 发明授权

US07435850B2 Naphthalene compounds 失效
公开(公告)号：US07435850B2
公开(公告)日：2008-10-14
申请号：US11824392
申请日：2007-06-29
申请人： Said Yous , Basile Peres , Ahmed Sabaouni , Pascal Berthelot , Michael Spedding , Philippe Delagrange , Daniel-Henri Caignard , Mark Millan
发明人： Said Yous , Basile Peres , Ahmed Sabaouni , Pascal Berthelot , Michael Spedding , Philippe Delagrange , Daniel-Henri Caignard , Mark Millan
IPC分类号： C07C233/00 , C07C235/00 , C07C237/00 , C07C239/00
CPC分类号： C07C233/18
摘要： A compound selected from those of formula (I): Medicinal products containing the same which are useful in the treatment of disorders of the melatoninergic system.

5. 发明授权

US5733871A Methods for the treatment of neuronal damage associated with ischemia, hypoxia or neurodegeneration 失效
标题翻译：治疗与缺血，缺氧或神经变性相关的神经元损伤的方法
公开(公告)号：US5733871A
公开(公告)日：1998-03-31
申请号：US30429
申请日：1995-03-16
申请人： Brian J. Alps , Christine Mary Brown , Franklin D. Collins , Caroline J. Emmett , Michael Spedding , Deborah Russell , Seth P. Finklestein , Michael A. Moskowitz , Roger Lewis Whiting
发明人： Brian J. Alps , Christine Mary Brown , Franklin D. Collins , Caroline J. Emmett , Michael Spedding , Deborah Russell , Seth P. Finklestein , Michael A. Moskowitz , Roger Lewis Whiting
IPC分类号： A61K38/18 , A61K38/00 , A61K38/16 , A61K38/27 , A61K38/28
CPC分类号： A61K38/185 , A61K38/1825
摘要： Intravenous administration and pharmaceutically acceptable compositions of neurotrophic factors for treating neuronal damage in the central nervous system of individuals in need of such treatment are disclosed. The neuronal damage associated with ischemia, hypoxia, or neurodegeneration may result from stroke or cardiac arrest. This invention provides for the intravenous administration of neurotrophic factors such as bFGF, aFGF, NGF, CNTF, BDNF, NT3, NT4, IGF-I and IGF-II.
摘要翻译： PCT No.PCT / US92 / 09618 Sec。 371日期1995年3月16日 102（e）1995年3月16日PCT PCT 1991年11月6日PCT公布。出版物WO93 / 08828 日期：1993年5月13日公开了用于治疗需要这种治疗的个体的中枢神经系统中神经元损伤的神经营养因子的静脉内给药和药学上可接受的组合物。与缺血，缺氧或神经变性相关的神经元损伤可能是由卒中或心脏停搏引起的。本发明提供神经营养因子如bFGF，aFGF，NGF，CNTF，BDNF，NT3，NT4，IGF-1和IGF-II的静脉内施用。

6. 发明授权

US4529733A Antihypertensive 3-furoyl-1,4-dihydropyridines 失效
标题翻译：抗高血压3-糠酰-1,4-二氢吡啶
公开(公告)号：US4529733A
公开(公告)日：1985-07-16
申请号：US592184
申请日：1984-03-22
申请人： Maurice W. Gittos , Michael Spedding
发明人： Maurice W. Gittos , Michael Spedding
IPC分类号： C07D307/46 , A61K31/435 , A61K31/44 , A61K31/443 , A61P3/00 , A61P3/14 , A61P9/08 , A61P9/10 , A61P9/12 , C07D405/06 , A61K31/455
CPC分类号： C07D405/06 , Y10S514/929
摘要： Novel 1,4-dihydropyridine derivatives have the following general Formula: ##STR1## and are calcium antagonists, useful for treating cardiovascular diseases.
摘要翻译：新的1,4-二氢吡啶衍生物具有以下通式：并且是用于治疗心血管疾病的钙拮抗剂。

7. 发明授权

US07947852B2 Naphthalene compounds, a process for their preparation and pharmaceutical compositions containing them 失效
标题翻译：萘化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US07947852B2
公开(公告)日：2011-05-24
申请号：US12452429
申请日：2008-07-01
申请人： Said Yous , Mohamed Ettaoussi , Ahmed Sabaouni , Pascal Berthelot , Michael Spedding , Philippe Delagrange , Daniel-Henri Caignard , Mark Millan
发明人： Said Yous , Mohamed Ettaoussi , Ahmed Sabaouni , Pascal Berthelot , Michael Spedding , Philippe Delagrange , Daniel-Henri Caignard , Mark Millan
IPC分类号： C07C233/233 , A61K31/16
CPC分类号： C07C251/48
摘要： Compounds of formula (I): wherein: R1 represents alkyl, alkenyl, haloalkyl, polyhaloalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, X represents a group N—OR2 wherein R2 represents a hydrogen atom or an alkyl group. Medicinal products containing the same which are useful in treating disorders of the melatoninergic system.
摘要翻译：式（I）的化合物：其中：R 1表示烷基，烯基，卤代烷基，多卤代烷基，环烷基，环烷基烷基，芳基，芳烷基，杂芳基或杂芳基烷基，X表示基团N-OR 2，其中R 2表示氢原子或烷基。含有该药物的药物可用于治疗褪黑激素系统的疾病。

8. 发明申请

US20100168244A1 NAPHTHALENE COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 失效
标题翻译：萘磺酸化合物，其制备方法和含有它们的药物组合物
公开(公告)号：US20100168244A1
公开(公告)日：2010-07-01
申请号：US12452429
申请日：2008-07-01
申请人： Said Yous , Mohamed Ettaoussi , Ahmed Sabaouni , Pascal Berthelot , Michael Spedding , Philippe Delagrange , Daniel-Henri Caignard , Mark Millan
发明人： Said Yous , Mohamed Ettaoussi , Ahmed Sabaouni , Pascal Berthelot , Michael Spedding , Philippe Delagrange , Daniel-Henri Caignard , Mark Millan
IPC分类号： A61K31/16 , C07C233/02 , A61P25/00 , A61P25/28 , A61P25/18 , A61P9/00 , A61P25/24 , A61P3/10 , A61P35/04 , A61P37/00 , A61P15/00 , A61P25/06
CPC分类号： C07C251/48
摘要： Compounds of formula (I): wherein: R1 represents alkyl, alkenyl, haloalkyl, polyhaloalkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl, X represents a group N—OR2 wherein R2 represents a hydrogen atom or an alkyl group. Medicinal products containing the same which are useful in treating disorders of the melatoninergic system.
摘要翻译：式（I）的化合物：其中：R 1表示烷基，烯基，卤代烷基，多卤代烷基，环烷基，环烷基烷基，芳基，芳烷基，杂芳基或杂芳基烷基，X表示基团N-OR 2，其中R 2表示氢原子或烷基。含有该药物的药物可用于治疗褪黑激素系统的疾病。

9. 发明授权

US07462741B2 Naphthalene compounds 失效
标题翻译：萘化合物
公开(公告)号：US07462741B2
公开(公告)日：2008-12-09
申请号：US11823771
申请日：2007-06-28
申请人： Said Yous , Basile Peres , Ahmed Sabaouni , Pascal Berthelot , Michael Spedding , Philippe Delagrange , Daniel-Henri Caignard , Mark Millan
发明人： Said Yous , Basile Peres , Ahmed Sabaouni , Pascal Berthelot , Michael Spedding , Philippe Delagrange , Daniel-Henri Caignard , Mark Millan
IPC分类号： C07C233/17 , A61K31/165
CPC分类号： C07C233/18
摘要： A compound selected from those of formula (I): Medicinal products containing the same which are useful in the treatment of disorders of the melatoninergic system.
摘要翻译：选自式（I）的化合物：含有该化合物的药物，其可用于治疗褪黑激素系统的病症。

10. 发明申请

US20080004350A1 Naphthalene compounds 失效
公开(公告)号：US20080004350A1
公开(公告)日：2008-01-03
申请号：US11824392
申请日：2007-06-29
申请人： Said Yous , Basile Peres , Ahmed Sabaouni , Pascal Berthelot , Michael Spedding , Philippe Delagrange , Daniel-Henri Caignard , Mark Millan
发明人： Said Yous , Basile Peres , Ahmed Sabaouni , Pascal Berthelot , Michael Spedding , Philippe Delagrange , Daniel-Henri Caignard , Mark Millan
IPC分类号： A61K31/16 , C07C235/32
CPC分类号： C07C233/18
摘要： A compound selected from those of formula (I): Medicinal products containing the same which are useful in the treatment of disorders of the melatoninergic system.

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