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1. 发明授权

US5971948A Apparatus for collection, washing, and reinfusion of shed blood 失效
标题翻译：用于收集，洗涤和输送流血的装置
公开(公告)号：US5971948A
公开(公告)日：1999-10-26
申请号：US818314
申请日：1997-03-14
申请人： Etienne Pages , Jean Papillon
发明人： Etienne Pages , Jean Papillon
IPC分类号： A61M1/02 , A61M1/00 , A61M1/36 , A61M37/00
CPC分类号： A61M1/3693 , A61M1/3621 , A61M1/3692 , A61M1/3696 , A61M1/0011 , A61M2205/3306 , A61M2205/3344 , A61M2205/3351 , A61M2205/3393 , B04B2005/0478
摘要： An integrated, vacuum-driven shed blood processing system that collects, dilutes, filters and washes postoperatively shed blood and concentrates red blood cells for reinfusion to the patient. The location of the centrifuge bowl between the surgical site and the vacuum source used to clean the site allows the immediate collection of shed blood in the bowl without an intermediate reservoir or an additional pump. In conjunction with a modified centrifuge bowl having a sealed aperture in its floor that permits reinfusion directly from the bowl without an additional reinfusion bag or reverse pump, this configuration processes blood for reinfusion using fewer steps and components yet without loss of functionality. Dilution of the blood upon its introduction into the system reduces the tendency to coagulate and allows the use of lower bowl rotation speeds. Slower rotation reduces red blood cell damage and lowers power requirements, which improves portability.
摘要翻译：一个集成的真空驱动的棚式血液处理系统，在术后收集，稀释，过滤和洗涤血液，并将红血细胞浓缩至患者的再灌注。手术部位和用于清洁部位的真空源之间的离心机碗的位置允许在碗中立即收集流出的血液，而不需要中间储存器或额外的泵。结合具有在其地板中具有密封孔的修改的离心机碗，其允许直接从碗再灌输而不需要额外的再灌注袋或反向泵，该配置使用较少的步骤和组件处理血液用于再灌注而不失去功能。血液在引入系统时的稀释降低了凝结的倾向，并允许使用较低的碗转速。较慢的旋转可减少红细胞损伤并降低功率需求，从而提高便携性。

2. 发明授权

US5643193A Apparatus for collection washing and reinfusion of shed blood 失效
标题翻译：用于收集洗涤和输出流血的装置
公开(公告)号：US5643193A
公开(公告)日：1997-07-01
申请号：US571496
申请日：1995-12-13
申请人： Jean Papillon , Etienne Pages
发明人： Jean Papillon , Etienne Pages
IPC分类号： A61M1/02 , A61M1/00 , A61M1/36 , A61M37/00
CPC分类号： A61M1/3693 , A61M1/3621 , A61M1/3692 , A61M1/3696 , A61M1/0011 , A61M2205/3306 , A61M2205/3344 , A61M2205/3351 , A61M2205/3393 , B04B2005/0478
摘要： An integrated, vacuum-driven shed blood processing system that collects, dilutes, filters and washes postoperatively shed blood and concentrates red blood cells for reinfusion to the patient. The location of the centrifuge bowl between the surgical site and the vacuum source used to clean the site allows the immediate collection of shed blood in the bowl without an intermediate reservoir or an additional pump. In conjunction with a modified centrifuge bowl having a sealed aperture in its floor that permits reinfusion directly from the bowl without an additional reinfusion bag or reverse pump, this configuration processes blood for reinfusion using fewer steps and components yet without loss of functionality. Dilution of the blood upon its introduction into the system reduces the tendency to coagulate and allows the use of lower bowl rotation speeds. Slower rotation reduces red blood cell damage and lowers power requirements, which improves portability.
摘要翻译：一个集成的真空驱动的棚式血液处理系统，在术后收集，稀释，过滤和洗涤血液，并将红血细胞浓缩至患者的再灌注。手术部位和用于清洁部位的真空源之间的离心机碗的位置允许在碗中立即收集流出的血液，而不需要中间储存器或额外的泵。结合具有在其地板中具有密封孔的修改的离心机碗，其允许直接从碗再灌输而不需要额外的再灌注袋或反向泵，该配置使用较少的步骤和组件处理血液用于再灌注而不失去功能。血液在引入系统时的稀释降低了凝结的倾向，并允许使用较低的碗转速。较慢的旋转可减少红细胞损伤并降低功率需求，从而提高便携性。

3. 发明申请

US20090259164A1 System and Method for Optimized Apheresis Draw and Return 有权
标题翻译：优化抽选和回报的系统和方法
公开(公告)号：US20090259164A1
公开(公告)日：2009-10-15
申请号：US12102427
申请日：2008-04-14
申请人： Etienne Pages , Michael Ragusa
发明人： Etienne Pages , Michael Ragusa
IPC分类号： A61M1/34
CPC分类号： A61M1/30 , A61M1/024 , A61M1/0245 , A61M1/14 , A61M1/1601 , A61M1/1603 , A61M1/1613 , A61M1/3472 , A61M1/36 , A61M1/3607 , A61M1/3621 , A61M1/3639 , A61M1/3663 , A61M1/3679 , A61M1/382 , A61M2205/3306 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3379 , A61M2205/3393
摘要： A blood processing device for collecting and exchanging blood components includes a venous-access device for drawing whole blood from a subject and returning unused blood components to the subject. The system may also include a blood component separation device that separates the drawn whole blood into a first blood component and a second blood component. The blood component separation device may also be configured to send the second blood component to a second blood component storage container. The system may use a return line that fluidly connects the venous-access device and the blood component separation device to return the first blood component to the subject. The system may also have a first and second pressure sensor located on the return line. The first pressure sensor may be located between the blood component separation device and the venous-access device and may determine a first pressure within the return line. The second pressure sensor may be located on the return line between the first pressure sensor and the venous-access device and may determine a second pressure within the return line. A pump connected to the return line may control the return flow rate within the return line based on a subject access pressure determined based on the first pressure and the second pressure.
摘要翻译：用于收集和交换血液成分的血液处理装置包括用于从对象抽取全血并将未使用的血液成分返回给对象的静脉通路装置。该系统还可以包括血液成分分离装置，其将抽取的全血分离成第一血液成分和第二血液成分。血液成分分离装置也可以构成为将第二血液成分送到第二血液成分储存容器。系统可以使用流体连接静脉通路装置和血液成分分离装置的返回管线，以将第一血液成分返回给对象。系统还可以具有位于返回管线上的第一和第二压力传感器。第一压力传感器可以位于血液成分分离装置和静脉通路装置之间，并且可以确定回流管线内的第一压力。第二压力传感器可以位于第一压力传感器和静脉通路装置之间的返回管线上，并且可以确定返回管线内的第二压力。连接到返回管路的泵可以基于基于第一压力和第二压力确定的对象进入压力来控制返回管线内的返回流量。

4. 发明授权

US5954971A Pumped-filter blood-processing apparatus and methods 失效
标题翻译：抽滤式血液处理装置及方法
公开(公告)号：US5954971A
公开(公告)日：1999-09-21
申请号：US779912
申请日：1997-01-07
申请人： Etienne Pages , Alain Dransart , Yair Egozy , Yves Baratelli
发明人： Etienne Pages , Alain Dransart , Yair Egozy , Yves Baratelli
IPC分类号： A61K35/14 , A61M1/02 , A61M1/36 , B01D37/00 , B01D36/00
CPC分类号： A61M1/3639 , A61M1/0218 , A61M1/0231 , A61M1/3641 , A61M1/3646 , A61M1/3696 , A61M1/0222 , A61M2205/331
摘要： Automated filtration of whole blood or blood components is accomplished in a manner that ensures consistent flow or pressure characteristics through the filter. A feedback circuit monitors pressure in the vicinity of the filter inlet and controls operation of a fluid pump that sends one or more unfiltered blood components into the filter. Using this arrangement, a variety of parameters relating to filtration efficacy can be precisely controlled, including flow rate, flow pressure, and average pressure over a predetermined volume. The system may provide an alarm or automatic cut-off in the event a maximum value of one of the parameters is reached or exceeded. The system is also capable of serially filtering multiple blood products through the single filter and accommodating different flow or pressure characteristics associated with each such product.
摘要翻译：全血或血液成分的自动过滤是通过过滤器确保一致的流量或压力特性的方式完成的。反馈电路监测过滤器入口附近的压力，并控制将一个或多个未过滤的血液成分送入过滤器的流体泵的操作。使用这种布置，可以精确地控制与过滤效能相关的各种参数，包括流量，流量压力和超过预定体积的平均压力。在达到或超过其中一个参数的最大值的情况下，系统可能会提供报警或自动切断。该系统还能够通过单个过滤器串联过滤多个血液产品并且适应与每个这样的产品相关联的不同的流动或压力特性。

5. 发明授权

US06629919B2 Core for blood processing apparatus 有权
标题翻译：核心为血液处理设备
公开(公告)号：US06629919B2
公开(公告)日：2003-10-07
申请号：US09764702
申请日：2001-01-18
申请人： Yáir Egozy , Paul J. Vernucci , Lelie E. Rose , Etienne Pages
发明人： Yáir Egozy , Paul J. Vernucci , Lelie E. Rose , Etienne Pages
IPC分类号： B04B104
CPC分类号： B04B7/08 , B04B5/0442 , B04B2005/0464 , B04B2005/0478
摘要： The invention is directed to a centrifugation bowl with a rotating core. The centrifugation bowl includes a rotating bowl body which defines a primary separation chamber. The core, which is generally cylindrically shaped and is disposed within the bowl body, defines a secondary separation chamber. A stationary header assembly may be mounted on top of the bowl body through a rotating seal. The stationary header assembly includes an inlet port for receiving whole blood and an outlet port from which one or more blood components are withdrawn. The inlet port is in fluid communication with a feed tube that extends into the primary separation chamber. The outlet port is in fluid communication with an effluent tube that extends into the bowl body. The effluent tube includes an entryway at a first radial position relative to a central, rotating axis of the bowl. The core is arranged at a second radial position that is outboard from the entryway to the effluent tube and includes one or more core passageways for providing fluid communication between the primary and secondary separation chambers. A sealed region is formed at the upper edge of the core relative to its attachment point to the bowl body. Also provided is a method for recovering a whole blood fraction from a donor using the core of the present invention.
摘要翻译：本发明涉及具有旋转芯的离心碗。离心碗包括限定一次分离室的旋转碗体。通常为圆柱形且设置在碗体内的芯部限定了二次分离室。固定的头部组件可以通过旋转的密封件安装在碗体的顶部上。固定头部组件包括用于接收全血的入口和一个或多个血液成分被从其中排出的出口。入口与进入主分离室的进料管流体连通。出口端口与延伸到碗体内的流出物管道流体连通。流出管包括相对于碗的中心旋转轴线的第一径向位置处的入口。芯部布置在第二径向位置，该第二径向位置从出入口管的入口处外侧，并且包括一个或多个用于在初级分离室和第二分离室之间提供流体连通的芯通道。在芯的上边缘处相对于其与碗体的附接点形成密封区域。还提供了使用本发明的核心从供体中回收全血部分的方法。

6. 发明授权

US5514070A Plural collector centrifuge bowl for blood processing 失效
标题翻译：多收集离心机碗用于血液加工
公开(公告)号：US5514070A
公开(公告)日：1996-05-07
申请号：US184677
申请日：1994-01-21
申请人： Etienne Pages
发明人： Etienne Pages
IPC分类号： A61M1/02 , B04B1/02 , B04B5/04 , B04B7/08
CPC分类号： B04B7/08 , A61M1/3693 , B04B5/0442 , B04B2005/0464
摘要： A centrifuge bowl for separating whole blood into less dense and more dense components and for collecting both less dense and more dense components without stopping bowl rotation. The fluid pathway from an inlet port to a separation chamber comprises an inlet tube and an introduction passageway. The fluid pathway from the separation chamber to an outlet port comprises a collection passageway. The introduction and collection passageways are nonrotatable. The more dense blood components can be extracted from the bowl during rotation by applying suction at the inlet port or pressure at the outlet port.
摘要翻译：一个离心机碗，用于将全血分离成更密集和更致密的组分，并收集较少密度和更致密的组分，而不会停止碗旋转。从入口到分离室的流体路径包括入口管和引入通道。从分离室到出口的流体路径包括收集通道。导入和收集通道是不可旋转的。通过在入口处施加吸力或在出口处的压力，可以在旋转期间从碗中提取更浓密的血液成分。

7. 发明申请

US20090259162A1 System and Method for Plasma Reduced Platelet Collection 有权
标题翻译：血浆减少血小板收集的系统和方法
公开(公告)号：US20090259162A1
公开(公告)日：2009-10-15
申请号：US12102486
申请日：2008-04-14
申请人： Toshiyasu Ohashi , Etienne Pages , Dominique Uhlmann , Pascal Maillard , Michael Ragusa
发明人： Toshiyasu Ohashi , Etienne Pages , Dominique Uhlmann , Pascal Maillard , Michael Ragusa
IPC分类号： A61M1/38
CPC分类号： A61M1/0263 , A61M1/0209 , A61M1/0218 , A61M1/0259 , A61M1/0272 , A61M1/029 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M1/382 , A61M2202/0413 , A61M2202/0427
摘要： A method and apparatus for collecting plasma reduced platelets potentially suspended in a synthetic solution from a donor. Whole blood is drawn from the donor and introduced into a separation chamber. Platelets are extracted from the separation chamber into a container, using, for example, surge (with anticoagulated plasma or a synthetic solution) or push methodologies. The remaining blood components in the separation chamber are returned back to the donor. The steps of drawing whole blood and introducing the whole blood into the separation chamber, extracting platelets from the separation chamber into the container, and returning the remaining components in the chamber back to the donor are repeated. The sequestered platelets in the container are reintroduced into the separation chamber, whereupon a plasma reduced platelet product is extracted.
摘要翻译：一种用于收集可能悬浮在来自供体的合成溶液中的血浆还原血小板的方法和装置。从供体抽出全血并引入分离室。使用例如喘振（具有抗凝血浆或合成溶液）或推进方法将血小板从分离室提取到容器中。分离室中的剩余血液成分返回给供体。将全血全血引入分离室，将分离室中的血小板从容器中取出并将其中的剩余组分重新送回供体的步骤。将容器中的隔离血小板重新引入分离室，从而提取血浆减少的血小板产物。

8. 再颁专利

USRE39449E1 Apparatus for cryopreservation and recovery of red blood cells 有权
公开(公告)号：USRE39449E1
公开(公告)日：2006-12-26
申请号：US10929151
申请日：2004-08-27
申请人： Etienne Pages
发明人： Etienne Pages
IPC分类号： A16K35/14
CPC分类号： A01N1/0247 , A01N1/02
摘要： A system dynamically adjusts the delivery rate of a cryopreservation solution to red blood cells to permit freezing. The delivery rate is preferably determined according to an equation that maintains a linear change of red blood cell osmolarity over time so as to prevent osmolarity shock of the red blood cells. In the preferred embodiment, the system includes a controller that is preconfigured to automatically deliver the cryopreservation solution to the red blood cells in accordance with the equation. The system may also support the recovery of thawed red blood cells by diluting the red blood cells and washing them of the cryopreservative. Again, the system preferably adjusts the delivery rate of a dilution solution so as to prevent osmolarity shock of the red blood cells during the recovery phase. The recovered red blood cells may be suspended in a preservation solution to further increase their shelf-life following the recovery phase.

9. 发明申请

US20060058167A1 Blood component separation system with stationary separation chamber 审中-公开
标题翻译：血液成分分离系统与固定分离室
公开(公告)号：US20060058167A1
公开(公告)日：2006-03-16
申请号：US11167784
申请日：2005-06-27
申请人： Michael Ragusa , Gary Stacey , Etienne Pages
发明人： Michael Ragusa , Gary Stacey , Etienne Pages
IPC分类号： B04B11/02
CPC分类号： G02B27/42 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , G02B21/32 , G02B27/4205
摘要： Provided is a blood processing system having a stationary component separation chamber. Individual blood components as well as other particles and contaminates are separated from blood flowing through the separation chamber by optical traps configured to manipulate specific components are projected into the flow field of the chamber. Cells or particles of the selected components that are manipulated by the optical traps then may be directed from the flow field to individual reservoirs to collect quantities of the selected components.
摘要翻译：提供了一种具有静止部件分离室的血液处理系统。单独的血液成分以及其它颗粒和污染物与通过配置成操纵特定组分的光学捕集器流经分离室的血液分离，投射到腔室的流场中。然后由光学捕集器操纵的所选择的组分的细胞或颗粒可以从流场引导到各个储存器以收集大量的所选择的组分。

10. 发明授权

US06464624B2 Blood processing method and apparatus using a centrifugation bowl with filter core 有权
标题翻译：血液处理方法和装置，使用带滤芯的离心碗
公开(公告)号：US06464624B2
公开(公告)日：2002-10-15
申请号：US09879550
申请日：2001-06-12
申请人： Etienne Pages
发明人： Etienne Pages
IPC分类号： B04B716
CPC分类号： B04B7/08 , B04B5/0442 , B04B2005/0464 , B04B2005/0478
摘要： The invention is directed to blood processing method and apparatus utilizing a centrifugation bowl with a filter core disposed within the bowl. The centrifugation bowl includes a rotating bowl body defining an enclosed separation chamber. A generally cylindrical filter core is disposed inside the separation chamber. The filter core includes a filter membrane that is sized to block at least white blood cells, but to allow plasma to pass through. The filter core is generally arranged within the separation chamber such that plasma is forced to pass through the filter core before being removed from the centrifugation bowl. The addition of the filter core provides an efficient, low-cost method for recovering a “purer” plasma fraction from a donor.
摘要翻译：本发明涉及使用具有设置在碗内的过滤芯的离心钵的血液处理方法和装置。离心碗包括限定封闭分离室的旋转碗体。大致圆柱形的过滤芯设置在分离室的内部。过滤芯包括过滤膜，其尺寸至少能够阻挡至少白细胞，但允许血浆通过。过滤器芯通常布置在分离室内，使得等离子体在从离心碗移除之前被迫通过过滤芯。过滤芯的添加为从供体中回收“更纯”的血浆级分提供了一种有效的低成本方法。

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