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1. 发明申请

US20060058167A1 Blood component separation system with stationary separation chamber 审中-公开
标题翻译：血液成分分离系统与固定分离室
公开(公告)号：US20060058167A1
公开(公告)日：2006-03-16
申请号：US11167784
申请日：2005-06-27
申请人： Michael Ragusa , Gary Stacey , Etienne Pages
发明人： Michael Ragusa , Gary Stacey , Etienne Pages
IPC分类号： B04B11/02
CPC分类号： G02B27/42 , A61M1/30 , A61M1/302 , A61M1/303 , A61M1/308 , A61M1/3693 , A61M1/3696 , G02B21/32 , G02B27/4205
摘要： Provided is a blood processing system having a stationary component separation chamber. Individual blood components as well as other particles and contaminates are separated from blood flowing through the separation chamber by optical traps configured to manipulate specific components are projected into the flow field of the chamber. Cells or particles of the selected components that are manipulated by the optical traps then may be directed from the flow field to individual reservoirs to collect quantities of the selected components.
摘要翻译：提供了一种具有静止部件分离室的血液处理系统。单独的血液成分以及其它颗粒和污染物与通过配置成操纵特定组分的光学捕集器流经分离室的血液分离，投射到腔室的流场中。然后由光学捕集器操纵的所选择的组分的细胞或颗粒可以从流场引导到各个储存器以收集大量的所选择的组分。

2. 发明申请

US20100234788A1 System and Method for the Re-Anticoagulation of Platelet Rich Plasma 有权
标题翻译：血小板富血浆再凝固系统与方法
公开(公告)号：US20100234788A1
公开(公告)日：2010-09-16
申请号：US12402565
申请日：2009-03-12
申请人： Etienne Pages , Michael Ragusa
发明人： Etienne Pages , Michael Ragusa
IPC分类号： A61M37/00
CPC分类号： A61M1/3672 , A61M1/0209 , A61M1/0218 , A61M1/288 , A61M1/3603 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3693 , A61M1/38 , A61M1/382 , A61M2005/1402 , A61M2005/1403 , A61M2202/0071 , A61M2202/0413 , A61M2202/0415 , A61M2202/0427 , A61M2205/3379 , A61M2205/75 , B01D2221/10
摘要： A method for the re-anticoagulation of platelet rich plasma in a blood apheresis system includes priming the blood apheresis system with anticoagulant, such that a volume of anticoagulant is transferred to a PRP container. The method may then transfer the anticoagulant within the PRP container to a red blood cell container, and collect a volume of platelet rich plasma within the PRP container. The platelet rich plasma may be collected in a plurality of cycles. Between collection cycles, the method may transfer a portion of the volume of anticoagulant from the red blood cell container to the PRP container.
摘要翻译：用于在血液分离系统中重新抗凝血小板血浆的方法包括用抗凝血剂引发血液分离系统，使得一定量的抗凝血剂转移到PRP容器中。然后，该方法可以将PRP容器内的抗凝血剂转移到红细胞容器中，并在PRP容器内收集一定体积的富含血小板的血浆。可以以多个周期收集富血小板血浆。在收集周期之间，该方法可以将抗凝血剂的一部分从红细胞容器转移到PRP容器。

3. 发明申请

US20090259163A1 Three-Line Apheresis System and Method 有权
标题翻译：三线单采系统与方法
公开(公告)号：US20090259163A1
公开(公告)日：2009-10-15
申请号：US12102407
申请日：2008-04-14
申请人： Etienne Pages , Michael Ragusa
发明人： Etienne Pages , Michael Ragusa
IPC分类号： A61M1/14
CPC分类号： A61M1/367 , A61M1/0209 , A61M1/0218 , A61M1/30 , A61M1/303 , A61M1/304 , A61M1/3601 , A61M1/3603 , A61M1/3604 , A61M1/3621 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M1/387 , A61M2202/0071
摘要： A blood processing system for collecting and exchanging blood components includes a venous-access device for drawing whole blood from a subject and returning blood components to the subject. The system may also include three lines connecting the venous access device to a blood component separation device and an anticoagulant source. A blood draw line fluidly connects to the venous-access device to the blood component separation device. An anticoagulant line connected to an anticoagulant source, introduces anticoagulant into the drawn whole blood. A return line, fluidly connected to the venous-access device and the blood component separation device, and returns uncollected blood component to the subject. A draw pump, an anticoagulant pump, and a return pump, respectively control the flows through the draw line, anticoagulant line, and the return line. The blood component separation device separates the drawn blood into a first blood component and a second blood component. The blood component separation device also may be configured to send the first blood component to a first blood component bag.
摘要翻译：用于收集和交换血液成分的血液处理系统包括用于从对象抽取全血并将血液成分返回到受试者的静脉通路装置。该系统还可以包括将静脉进入装置连接到血液成分分离装置和抗凝血剂源的三条线。血液抽吸管线与静脉通路装置流体连接到血液成分分离装置。连接抗凝血源的抗凝血剂线，将抗凝血剂引入到全血中。流体地连接到静脉通路装置和血液成分分离装置的返回管线，并将未收集的血液成分返回给受试者。抽水泵，抗凝血泵和回流泵分别控制通过牵引线，抗凝血线和回流管线的流量。血液成分分离装置将抽取的血液分离为第一血液成分和第二血液成分。血液成分分离装置还可以构造成将第一血液成分发送到第一血液成分袋。

4. 发明申请

US20090259162A1 System and Method for Plasma Reduced Platelet Collection 有权
标题翻译：血浆减少血小板收集的系统和方法
公开(公告)号：US20090259162A1
公开(公告)日：2009-10-15
申请号：US12102486
申请日：2008-04-14
申请人： Toshiyasu Ohashi , Etienne Pages , Dominique Uhlmann , Pascal Maillard , Michael Ragusa
发明人： Toshiyasu Ohashi , Etienne Pages , Dominique Uhlmann , Pascal Maillard , Michael Ragusa
IPC分类号： A61M1/38
CPC分类号： A61M1/0263 , A61M1/0209 , A61M1/0218 , A61M1/0259 , A61M1/0272 , A61M1/029 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M1/382 , A61M2202/0413 , A61M2202/0427
摘要： A method and apparatus for collecting plasma reduced platelets potentially suspended in a synthetic solution from a donor. Whole blood is drawn from the donor and introduced into a separation chamber. Platelets are extracted from the separation chamber into a container, using, for example, surge (with anticoagulated plasma or a synthetic solution) or push methodologies. The remaining blood components in the separation chamber are returned back to the donor. The steps of drawing whole blood and introducing the whole blood into the separation chamber, extracting platelets from the separation chamber into the container, and returning the remaining components in the chamber back to the donor are repeated. The sequestered platelets in the container are reintroduced into the separation chamber, whereupon a plasma reduced platelet product is extracted.
摘要翻译：一种用于收集可能悬浮在来自供体的合成溶液中的血浆还原血小板的方法和装置。从供体抽出全血并引入分离室。使用例如喘振（具有抗凝血浆或合成溶液）或推进方法将血小板从分离室提取到容器中。分离室中的剩余血液成分返回给供体。将全血全血引入分离室，将分离室中的血小板从容器中取出并将其中的剩余组分重新送回供体的步骤。将容器中的隔离血小板重新引入分离室，从而提取血浆减少的血小板产物。

5. 发明申请

US20090259164A1 System and Method for Optimized Apheresis Draw and Return 有权
标题翻译：优化抽选和回报的系统和方法
公开(公告)号：US20090259164A1
公开(公告)日：2009-10-15
申请号：US12102427
申请日：2008-04-14
申请人： Etienne Pages , Michael Ragusa
发明人： Etienne Pages , Michael Ragusa
IPC分类号： A61M1/34
CPC分类号： A61M1/30 , A61M1/024 , A61M1/0245 , A61M1/14 , A61M1/1601 , A61M1/1603 , A61M1/1613 , A61M1/3472 , A61M1/36 , A61M1/3607 , A61M1/3621 , A61M1/3639 , A61M1/3663 , A61M1/3679 , A61M1/382 , A61M2205/3306 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3379 , A61M2205/3393
摘要： A blood processing device for collecting and exchanging blood components includes a venous-access device for drawing whole blood from a subject and returning unused blood components to the subject. The system may also include a blood component separation device that separates the drawn whole blood into a first blood component and a second blood component. The blood component separation device may also be configured to send the second blood component to a second blood component storage container. The system may use a return line that fluidly connects the venous-access device and the blood component separation device to return the first blood component to the subject. The system may also have a first and second pressure sensor located on the return line. The first pressure sensor may be located between the blood component separation device and the venous-access device and may determine a first pressure within the return line. The second pressure sensor may be located on the return line between the first pressure sensor and the venous-access device and may determine a second pressure within the return line. A pump connected to the return line may control the return flow rate within the return line based on a subject access pressure determined based on the first pressure and the second pressure.
摘要翻译：用于收集和交换血液成分的血液处理装置包括用于从对象抽取全血并将未使用的血液成分返回给对象的静脉通路装置。该系统还可以包括血液成分分离装置，其将抽取的全血分离成第一血液成分和第二血液成分。血液成分分离装置也可以构成为将第二血液成分送到第二血液成分储存容器。系统可以使用流体连接静脉通路装置和血液成分分离装置的返回管线，以将第一血液成分返回给对象。系统还可以具有位于返回管线上的第一和第二压力传感器。第一压力传感器可以位于血液成分分离装置和静脉通路装置之间，并且可以确定回流管线内的第一压力。第二压力传感器可以位于第一压力传感器和静脉通路装置之间的返回管线上，并且可以确定返回管线内的第二压力。连接到返回管路的泵可以基于基于第一压力和第二压力确定的对象进入压力来控制返回管线内的返回流量。

6. 发明授权

US08628489B2 Three-line apheresis system and method 有权
标题翻译：三线血液分离系统及方法
公开(公告)号：US08628489B2
公开(公告)日：2014-01-14
申请号：US12102407
申请日：2008-04-14
申请人： Etienne Pagès , Michael Ragusa
发明人： Etienne Pagès , Michael Ragusa
IPC分类号： A61M37/00 , A61M1/00 , A61M1/14 , A61M1/36
CPC分类号： A61M1/367 , A61M1/0209 , A61M1/0218 , A61M1/30 , A61M1/303 , A61M1/304 , A61M1/3601 , A61M1/3603 , A61M1/3604 , A61M1/3621 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M1/387 , A61M2202/0071
摘要： A blood processing system for collecting and exchanging blood components includes a venous-access device for drawing whole blood from a subject and returning blood components to the subject. The system may also include three lines connecting the venous access device to a blood component separation device and an anticoagulant source. A blood draw line fluidly connects to the venous-access device to the blood component separation device. An anticoagulant line introduces anticoagulant into the drawn whole blood. A return line, fluidly connected to the venous-access device and the blood component separation device, and returns uncollected blood component to the subject. Each line may have a pump that controls flow through the line. The blood component separation device separates the drawn blood into a first blood component and a second blood component, and may be configured to send the first blood component to a first blood component bag.
摘要翻译：用于收集和交换血液成分的血液处理系统包括用于从对象抽取全血并将血液成分返回到受试者的静脉通路装置。该系统还可以包括将静脉进入装置连接到血液成分分离装置和抗凝血剂源的三条线。血液抽吸管线与静脉通路装置流体连接到血液成分分离装置。抗凝血剂线将抗凝血剂引入全血中。流体地连接到静脉通路装置和血液成分分离装置的返回管线，并将未收集的血液成分返回给受试者。每条线路可能都有一个泵来控制通过管路的流量。血液成分分离装置将抽取的血液分离成第一血液成分和第二血液成分，并且可以将第一血液成分发送到第一血液成分袋。

7. 发明授权

US08702637B2 System and method for optimized apheresis draw and return 有权
标题翻译：优化采集和回收的系统和方法
公开(公告)号：US08702637B2
公开(公告)日：2014-04-22
申请号：US12102427
申请日：2008-04-14
申请人： Etienne Pagès , Michael Ragusa
发明人： Etienne Pagès , Michael Ragusa
IPC分类号： A61M1/30 , A61M1/34 , A61M1/36 , A61M1/38 , A61M1/14
CPC分类号： A61M1/30 , A61M1/024 , A61M1/0245 , A61M1/14 , A61M1/1601 , A61M1/1603 , A61M1/1613 , A61M1/3472 , A61M1/36 , A61M1/3607 , A61M1/3621 , A61M1/3639 , A61M1/3663 , A61M1/3679 , A61M1/382 , A61M2205/3306 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3379 , A61M2205/3393
摘要： A blood processing device includes a venous-access device, a blood component separation device, a return line, a draw line, a first pressure sensor, a second pressure sensor, and a first pump. The first pressure sensor is located on the return line between the blood component separation device and the venous-access device, and determines a first pressure. The second pressure sensor is located on the draw line between the blood component separation device and the venous-access device, and determines a second pressure. The first pump is connected to at least one of the return line and the draw line and controls a flow rate within the connected line based on a subject access pressure determined based upon the first and second pressures.
摘要翻译：血液处理装置包括静脉通路装置，血液成分分离装置，返回线，牵引线，第一压力传感器，第二压力传感器和第一泵。第一压力传感器位于血液成分分离装置与静脉输入装置之间的返回管路上，确定第一压力。第二压力传感器位于血液成分分离装置与静脉通路装置之间的牵引线上，并确定第二压力。第一泵连接到返回线和牵引线中的至少一个，并且基于基于第一和第二压力确定的受试者进入压力来控制连接管线内的流量。

8. 发明授权

US08834402B2 System and method for the re-anticoagulation of platelet rich plasma 有权
标题翻译：血小板富集血浆重新抗凝的系统和方法
公开(公告)号：US08834402B2
公开(公告)日：2014-09-16
申请号：US12402565
申请日：2009-03-12
申请人： Etienne Pagès , Michael Ragusa
发明人： Etienne Pagès , Michael Ragusa
IPC分类号： A61M37/00 , A61M1/36 , A61M1/28 , A61M1/02 , A61M5/14
CPC分类号： A61M1/3672 , A61M1/0209 , A61M1/0218 , A61M1/288 , A61M1/3603 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3693 , A61M1/38 , A61M1/382 , A61M2005/1402 , A61M2005/1403 , A61M2202/0071 , A61M2202/0413 , A61M2202/0415 , A61M2202/0427 , A61M2205/3379 , A61M2205/75 , B01D2221/10
摘要： A method for the re-anticoagulation of platelet rich plasma in a blood apheresis system includes priming the blood apheresis system with anticoagulant, such that a volume of anticoagulant is transferred to a PRP container. The method may then transfer the anticoagulant within the PRP container to a red blood cell container, and collect a volume of platelet rich plasma within the PRP container. The platelet rich plasma may be collected in a plurality of cycles. Between collection cycles, the method may transfer a portion of the volume of anticoagulant from the red blood cell container to the PRP container.
摘要翻译：用于在血液分离系统中重新抗凝血小板血浆的方法包括用抗凝血剂引发血液分离系统，使得一定量的抗凝血剂转移到PRP容器中。然后，该方法可以将PRP容器内的抗凝血剂转移到红细胞容器中，并在PRP容器内收集一定体积的富含血小板的血浆。可以以多个周期收集富血小板血浆。在收集周期之间，该方法可以将抗凝血剂的一部分从红细胞容器转移到PRP容器。

9. 发明授权

US08454548B2 System and method for plasma reduced platelet collection 有权
标题翻译：血浆减少血小板收集的系统和方法
公开(公告)号：US08454548B2
公开(公告)日：2013-06-04
申请号：US12102486
申请日：2008-04-14
申请人： Toshiyasu Ohashi , Etienne Pagès , Dominique Uhlmann , Pascal Maillard , Michael Ragusa
发明人： Toshiyasu Ohashi , Etienne Pagès , Dominique Uhlmann , Pascal Maillard , Michael Ragusa
IPC分类号： A61M37/00 , A61M1/36 , A61M1/38 , B01D36/00
CPC分类号： A61M1/0263 , A61M1/0209 , A61M1/0218 , A61M1/0259 , A61M1/0272 , A61M1/029 , A61M1/3693 , A61M1/3696 , A61M1/38 , A61M1/382 , A61M2202/0413 , A61M2202/0427
摘要： A method and apparatus for collecting plasma reduced platelets potentially suspended in a synthetic solution from a donor. Whole blood is drawn from the donor and introduced into a separation chamber. Platelets are extracted from the separation chamber into a container, using, for example, surge (with anticoagulated plasma or a synthetic solution) or push methodologies. The remaining blood components in the separation chamber are returned back to the donor. The steps of drawing whole blood and introducing the whole blood into the separation chamber, extracting platelets from the separation chamber into the container, and returning the remaining components in the chamber back to the donor are repeated. The sequestered platelets in the container are reintroduced into the separation chamber, whereupon a plasma reduced platelet product is extracted.
摘要翻译：一种用于收集可能悬浮在来自供体的合成溶液中的血浆还原血小板的方法和装置。从供体抽出全血并引入分离室。使用例如喘振（具有抗凝血浆或合成溶液）或推进方法将血小板从分离室提取到容器中。分离室中的剩余血液成分返回给供体。将全血全血引入分离室，将分离室中的血小板从容器中取出并将其中的剩余组分重新送回供体的步骤。将容器中的隔离血小板重新引入分离室，从而提取血浆减少的血小板产物。

10. 发明授权

US08647289B2 System and method for optimized apheresis draw and return 有权
公开(公告)号：US08647289B2
公开(公告)日：2014-02-11
申请号：US13076882
申请日：2011-03-31
申请人： Etienne Pagès , Michael Ragusa
发明人： Etienne Pagès , Michael Ragusa
IPC分类号： A61M1/00 , A61M1/14 , A61M1/30 , A61M1/36 , A61M37/00
CPC分类号： A61M1/30 , A61M1/024 , A61M1/0245 , A61M1/14 , A61M1/1601 , A61M1/1603 , A61M1/1613 , A61M1/3472 , A61M1/36 , A61M1/3607 , A61M1/3621 , A61M1/3639 , A61M1/3663 , A61M1/3679 , A61M1/382 , A61M2205/3306 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/3351 , A61M2205/3355 , A61M2205/3379 , A61M2205/3393
摘要： A blood processing device includes a venous-access device, a blood component separation device, a return line, a draw line, a first pressure sensor, a second pressure sensor, and a first pump. The first pressure sensor is located on the return line between the blood component separation device and the venous-access device, and determines a first pressure. The second pressure sensor is located on the draw line between the blood component separation device and the venous-access device, and determines a second pressure. The first pump is connected to at least one of the return line and the draw line and controls a flow rate within the connected line based on a subject access pressure determined based upon the first and second pressures.

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