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1. 发明授权

US10136635B2 Irradiation of red blood cells and anaerobic storage 有权
公开(公告)号：US10136635B2
公开(公告)日：2018-11-27
申请号：US13289722
申请日：2011-11-04
申请人： Tatsuro Yoshida , Paul J. Vernucci
发明人： Tatsuro Yoshida , Paul J. Vernucci
IPC分类号： A61B19/00 , A01N1/02 , A61J1/10 , A61L2/08
摘要： A blood storage system comprising: a collection vessel for red blood cells; an oxygen or oxygen and carbon dioxide depletion device; a storage vessel for red blood cells; tubing connecting the collection vessel to the oxygen or oxygen and carbon dioxide depletion device and the oxygen or oxygen and carbon dioxide depletion device to the storage vessel; and a gamma or X-ray irradiating device is used to irradiate red blood cells stored in the vessel, storing red blood cells under anaerobic conditions.

2. 发明授权

US08569052B2 Oxygen depletion devices and methods for removing oxygen from red blood cells 有权
标题翻译：氧消耗装置和从红细胞中去除氧的方法
公开(公告)号：US08569052B2
公开(公告)日：2013-10-29
申请号：US13115532
申请日：2011-05-25
申请人： William J. Federspiel , Brian J. Frankowski , Tatsuro Yoshida , Paul J. Vernucci
发明人： William J. Federspiel , Brian J. Frankowski , Tatsuro Yoshida , Paul J. Vernucci
IPC分类号： C12N5/00
CPC分类号： C12N5/0641 , A01N1/0236 , A61M1/0272 , A61M2202/0208 , A61M2202/0429
摘要： An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are adapted to receiving and conveying red blood cells. There is another embodiment of an oxygen depletion device and method for removing oxygen from red blood cells.
摘要翻译：氧耗尽装置。设备有一个墨盒; 多个中空纤维，其在所述药筒内从入口到出口延伸; 一定量的氧清除剂，其被包装在筒内并与多个中空纤维相邻并在其间。中空纤维适于接收和输送红细胞。还有一种氧还原装置和从红细胞中除氧的方法。

3. 发明申请

US20120129149A1 REMOVAL OF OXYGEN FROM BIOLOGICAL FLUIDS 审中-公开
标题翻译：从生物流体中去除氧气
公开(公告)号：US20120129149A1
公开(公告)日：2012-05-24
申请号：US13387528
申请日：2010-07-31
申请人： William J. Federspiel , Tatsuro Yoshida , Paul J. Vernucci , Brian Joseph Frankowski , Laura Wheeler Lund
发明人： William J. Federspiel , Tatsuro Yoshida , Paul J. Vernucci , Brian Joseph Frankowski , Laura Wheeler Lund
IPC分类号： A61M1/36
CPC分类号： B01D63/02 , A61M1/0209 , A61M1/0272 , A61M1/0281 , A61M1/3472 , A61M2202/0208 , B01D63/04 , B01D2311/13 , B01D2311/2626 , B01D2313/40 , A61M2202/0014
摘要： A system for reducing the concentration of oxygen in a fluid including red blood cells includes a housing, a plurality of hollow tubes extending within the housing and adapted for flow of the fluid therethrough, wherein each tube includes an inlet and an outlet, and a carrier system that reduces the concentration of oxygen at an exterior surface of the tubes to facilitate transport of oxygen from the fluid flowing through the tubes to an exterior of the tubes.
摘要翻译：用于减少包括红细胞的流体中的氧浓度的系统包括壳体，在壳体内延伸并适于使流体流过其中的多个中空管，其中每个管包括入口和出口，以及载体系统，其减少管的外表面处的氧浓度，以便于将氧从流过管的流体输送到管的外部。

4. 发明授权

US06337026B1 Leukocyte reduction filtration media 有权
标题翻译：白细胞还原过滤介质
公开(公告)号：US06337026B1
公开(公告)日：2002-01-08
申请号：US09264276
申请日：1999-03-08
申请人： Eric K. Lee , Paul J. Vernucci , Samuel C. Williams
发明人： Eric K. Lee , Paul J. Vernucci , Samuel C. Williams
IPC分类号： B01D3700
CPC分类号： B01D39/2024 , B01D39/163 , B01D39/1661 , B01D2239/0216 , B01D2239/064 , Y10T428/25 , Y10T428/254
摘要： A high capacity leukocyte depletion filtration media incorporates a high specific surface area components with a matrix of fibers, yielding a filtration medium that removes leukocytes by at least 99.99%. The filtration medium uses a significantly low weight ratio of high specific surface area components to the matrix of fibers. The high specific area creates a multitude of adhesion sites for leukocytes while the low weight ratios allow good filtration flow rates. The filtration medium is incorporated into a filter device for removing leukocytes from biological fluids.
摘要翻译：高容量白细胞消耗过滤介质将高比表面积组分与纤维基质结合，产生过滤介质，其将白细胞除去至少99.99％。过滤介质使用显着低重量比的高比表面积组分与纤维基质。高比例区域为白细胞产生大量的粘附位点，而低重量比允许良好的过滤流速。将过滤介质结合到用于从生物流体中除去白细胞的过滤装置中。

5. 发明授权

US09005343B2 Integrated leukocyte, oxygen and/or CO2 depletion, and plasma separation filter device 有权
标题翻译：综合白细胞，氧气和/或二氧化碳耗竭以及血浆分离过滤装置
公开(公告)号：US09005343B2
公开(公告)日：2015-04-14
申请号：US13572412
申请日：2012-08-10
申请人： Tatsuro Yoshida , Paul J. Vernucci
发明人： Tatsuro Yoshida , Paul J. Vernucci
IPC分类号： B01D53/22 , B01D19/00 , B01D61/00 , A61M1/36 , A61M1/02
CPC分类号： B01D19/0031 , A61M1/0209 , A61M1/0213 , A61M1/0218 , A61M1/0272 , A61M1/0281 , A61M1/262 , A61M1/34 , A61M1/3403 , A61M1/3633 , A61M1/3679 , A61M1/38 , A61M2202/0208 , A61M2202/0225 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , B01D61/147
摘要： A blood filter device comprising: a housing comprising an outer wall and a first inlet, a first outlet and a second outlet; a membrane which is capable of separating plasma from the blood, wherein the membrane forms an inner chamber; a leukocyte and oxygen and/or carbon dioxide depletion media disposed wherein the inner chamber, the leukocyte and oxygen and/or carbon dioxide depletion media is capable of depleting leukocytes and oxygen and/or carbon dioxide from the blood; an outer chamber disposed between the outer wall and the membrane, wherein the plasma which permeates through the membrane enters the outer chamber and exits the filter device via the first outlet; whereby the blood which has been depleted of oxygen and/or carbon dioxide, leukocytes and plasma exists and filter device via the second outlet.
摘要翻译：一种血液过滤装置，包括：壳体，包括外壁和第一入口，第一出口和第二出口; 能够从血液中分离血浆的膜，其中所述膜形成内腔; 设置有白细胞和氧和/或二氧化碳耗尽介质，其中所述内室，所述白细胞和氧和/或二氧化碳消耗介质能够从血液中消耗白细胞和氧和/或二氧化碳; 设置在外壁和膜之间的外室，其中渗透通过膜的等离子体进入外室并经由第一出口离开过滤器装置; 由此已经耗尽氧气和/或二氧化碳，白细胞和等离子体的血液经由第二出口存在并过滤装置。

6. 发明申请

US20130047861A1 INTEGRATED LEUKOCYTE, OXYGEN AND/OR CO2 DEPLETION, AND PLASMA SEPARATION FILTER DEVICE 有权
公开(公告)号：US20130047861A1
公开(公告)日：2013-02-28
申请号：US13572412
申请日：2012-08-10
申请人： Tatsuro YOSHIDA , Paul J. VERNUCCI
发明人： Tatsuro YOSHIDA , Paul J. VERNUCCI
IPC分类号： A61M1/36 , B01D61/00 , B01D19/00
CPC分类号： B01D19/0031 , A61M1/0209 , A61M1/0213 , A61M1/0218 , A61M1/0272 , A61M1/0281 , A61M1/262 , A61M1/34 , A61M1/3403 , A61M1/3633 , A61M1/3679 , A61M1/38 , A61M2202/0208 , A61M2202/0225 , A61M2202/0415 , A61M2202/0427 , A61M2202/0429 , A61M2202/0439 , B01D61/147
摘要： A blood filter device comprising: a housing comprising an outer wall and a first inlet, a first outlet and a second outlet; a membrane which is capable of separating plasma from the blood, wherein the membrane forms an inner chamber; a leukocyte and oxygen and/or carbon dioxide depletion media disposed wherein the inner chamber, the leukocyte and oxygen and/or carbon dioxide depletion media is capable of depleting leukocytes and oxygen and/or carbon dioxide from the blood; an outer chamber disposed between the outer wall and the membrane, wherein the plasma which permeates through the membrane enters the outer chamber and exits the filter device via the first outlet; whereby the blood which has been depleted of oxygen and/or carbon dioxide, leukocytes and plasma exists and filter device via the second outlet.

7. 发明授权

US08535421B2 Blood storage bag system and depletion devices with oxygen and carbon dioxide depletion capabilities 有权
公开(公告)号：US08535421B2
公开(公告)日：2013-09-17
申请号：US12901350
申请日：2010-10-08
申请人： Tatsuro Yoshida , Paul J. Vernucci
发明人： Tatsuro Yoshida , Paul J. Vernucci
IPC分类号： B01D53/22 , B01D19/00 , A61J1/10 , A61J1/14
CPC分类号： C12N5/0641 , A01N1/0221 , A01N1/0226 , A61K35/18 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/0272 , A61M1/342 , A61M2202/0208 , A61M2202/0225 , B01D19/0031 , B01D53/22
摘要： A blood storage system. The system has a collection bag for red blood cells; an oxygen/carbon dioxide depletion device; a storage bag for red blood cells; and tubing connecting the collection bag to the depletion device and the depletion device to the storage bag. The depletion device includes a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; a plurality of hollow fibers or gas-permeable films extending within the receptacle from an entrance to an exit thereof. The hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells.

8. 发明申请

US20120100523A1 OXYGEN DEPLETION DEVICES AND METHODS FOR REMOVING OXYGEN FROM RED BLOOD CELLS 有权
标题翻译：氧气去除装置和从红细胞中除去氧气的方法
公开(公告)号：US20120100523A1
公开(公告)日：2012-04-26
申请号：US13115532
申请日：2011-05-25
申请人： William J. Federspiel , Brian J. Frankowski , Tatsuro Yoshida , Paul J. Vernucci
发明人： William J. Federspiel , Brian J. Frankowski , Tatsuro Yoshida , Paul J. Vernucci
IPC分类号： A61M1/34
CPC分类号： C12N5/0641 , A01N1/0236 , A61M1/0272 , A61M2202/0208 , A61M2202/0429
摘要： An oxygen depletion device. The device has a cartridge; a plurality of hollow fibers extending within the cartridge from an entrance to an exit thereof; an amount of an oxygen scavenger packed within the cartridge and contiguous to and in between the plurality of hollow fibers. The hollow fibers are adapted to receiving and conveying red blood cells. There is another embodiment of an oxygen depletion device and method for removing oxygen from red blood cells.
摘要翻译：氧耗尽装置。设备有一个墨盒; 多个中空纤维，其在所述药筒内从入口到出口延伸; 一定量的氧清除剂，其被包装在筒内并与多个中空纤维相邻并在其间。中空纤维适于接收和输送红细胞。还有一种氧还原装置和从红细胞中除氧的方法。

9. 发明申请

US20120024156A1 BLOOD STORAGE BAG SYSTEM AND DEPLETION DEVICES WITH OXYGEN AND CARBON DIOXIDE DEPLETION CAPABILITIES 有权
标题翻译：血液储存袋系统和具有氧气和二氧化碳排泄能力的装置
公开(公告)号：US20120024156A1
公开(公告)日：2012-02-02
申请号：US12901350
申请日：2010-10-08
申请人： Tatsura Yoshida , Paul J. Vernucci
发明人： Tatsura Yoshida , Paul J. Vernucci
IPC分类号： A61J1/14 , A61J1/10 , B65D85/00 , B01D19/00
CPC分类号： C12N5/0641 , A01N1/0221 , A01N1/0226 , A61K35/18 , A61M1/0209 , A61M1/0218 , A61M1/0231 , A61M1/0272 , A61M1/342 , A61M2202/0208 , A61M2202/0225 , B01D19/0031 , B01D53/22
摘要： A blood storage system. The system has a collection bag for red blood cells; an oxygen/carbon dioxide depletion device; a storage bag for red blood cells; and tubing connecting the collection bag to the depletion device and the depletion device to the storage bag. The depletion device includes a receptacle of a solid material having an inlet and an outlet adapted to receiving and expelling a flushing gas; a plurality of hollow fibers or gas-permeable films extending within the receptacle from an entrance to an exit thereof. The hollow fibers or gas-permeable films are adapted to receiving and conveying red blood cells.
摘要翻译：血液储存系统。该系统具有红细胞收集袋; 氧/二氧化碳消耗装置; 红血球储存袋; 以及将收集袋连接到耗尽装置和将耗尽装置连接到存储袋的管道。耗尽装置包括固体材料的容器，其具有适于接收和排出冲洗气体的入口和出口; 多个中空纤维或气体可渗透膜，在容器内从入口到出口延伸。中空纤维或透气膜适于接收和输送红细胞。

10. 发明授权

US06629919B2 Core for blood processing apparatus 有权
标题翻译：核心为血液处理设备
公开(公告)号：US06629919B2
公开(公告)日：2003-10-07
申请号：US09764702
申请日：2001-01-18
申请人： Yáir Egozy , Paul J. Vernucci , Lelie E. Rose , Etienne Pages
发明人： Yáir Egozy , Paul J. Vernucci , Lelie E. Rose , Etienne Pages
IPC分类号： B04B104
CPC分类号： B04B7/08 , B04B5/0442 , B04B2005/0464 , B04B2005/0478
摘要： The invention is directed to a centrifugation bowl with a rotating core. The centrifugation bowl includes a rotating bowl body which defines a primary separation chamber. The core, which is generally cylindrically shaped and is disposed within the bowl body, defines a secondary separation chamber. A stationary header assembly may be mounted on top of the bowl body through a rotating seal. The stationary header assembly includes an inlet port for receiving whole blood and an outlet port from which one or more blood components are withdrawn. The inlet port is in fluid communication with a feed tube that extends into the primary separation chamber. The outlet port is in fluid communication with an effluent tube that extends into the bowl body. The effluent tube includes an entryway at a first radial position relative to a central, rotating axis of the bowl. The core is arranged at a second radial position that is outboard from the entryway to the effluent tube and includes one or more core passageways for providing fluid communication between the primary and secondary separation chambers. A sealed region is formed at the upper edge of the core relative to its attachment point to the bowl body. Also provided is a method for recovering a whole blood fraction from a donor using the core of the present invention.
摘要翻译：本发明涉及具有旋转芯的离心碗。离心碗包括限定一次分离室的旋转碗体。通常为圆柱形且设置在碗体内的芯部限定了二次分离室。固定的头部组件可以通过旋转的密封件安装在碗体的顶部上。固定头部组件包括用于接收全血的入口和一个或多个血液成分被从其中排出的出口。入口与进入主分离室的进料管流体连通。出口端口与延伸到碗体内的流出物管道流体连通。流出管包括相对于碗的中心旋转轴线的第一径向位置处的入口。芯部布置在第二径向位置，该第二径向位置从出入口管的入口处外侧，并且包括一个或多个用于在初级分离室和第二分离室之间提供流体连通的芯通道。在芯的上边缘处相对于其与碗体的附接点形成密封区域。还提供了使用本发明的核心从供体中回收全血部分的方法。

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