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1. 发明授权

US06726651B1 Method and apparatus for differentially perfusing a patient during cardiopulmonary bypass 失效
标题翻译：用于在体外循环期间差异灌注患者的方法和装置
公开(公告)号：US06726651B1
公开(公告)日：2004-04-27
申请号：US09368450
申请日：1999-08-04
申请人： Janine Robinson , Wilfred J. Samson , John A. Macoviak , Lisa M. Young , Brady Esch , Mike Lee , Eric Olsen
发明人： Janine Robinson , Wilfred J. Samson , John A. Macoviak , Lisa M. Young , Brady Esch , Mike Lee , Eric Olsen
IPC分类号： A61M2900
CPC分类号： A61B17/12109 , A61B17/12045 , A61B17/12136 , A61B2017/00243 , A61B2017/12127 , A61M1/3613 , A61M25/1011 , A61M2025/1015 , A61M2210/127
摘要： The present invention provides methods, systems and devices for performing cardipulmonary bypass (CPB), cardioplegic arrest, suction of fluid from the aorta to remove embolic or other fluid from the general circulation and the selective segmentation of the arterial system to perform differential perfusion eliminating hypoperfusion. An aortic catheter having an arch lumen which extends at least in part along the length of the catheter shaft has a proximal opening coupled to a CPB machine and a distal arch opening. A corporeal lumen extends at least in part along the length of the catheter shaft and has a proximal opening coupled to a CPB machine and a distal corporeal opening. A suction lumen extends at least in part along the length of the catheter shaft and has a proximal suction opening coupled to a suction source and a distal suction opening residing in the aortic lumen of a patient.
摘要翻译：本发明提供了用于执行心肺旁路（CPB），心脏停搏，从主动脉抽吸流体以从一般循环中除去栓塞或其他流体的方法，系统和装置，以及动脉系统的选择性分割以执行差异灌注以消除低灌注。具有弓形管腔的主动脉导管至少部分地沿着导管轴的长度延伸，具有联接到CPB机器和远侧弓形开口的近侧开口。体腔内沿着导管轴的长度至少部分地延伸，并具有连接到CPB机器和远端体孔的近端开口。抽吸腔沿着导管轴的长度至少部分地延伸，并且具有联接到吸入源的近侧吸入口和位于患者的主动脉腔内的远侧吸入口。

2. 发明授权

US06673042B1 Expandable venous cannula and method of use 失效
标题翻译：可扩展静脉插管及其使用方法
公开(公告)号：US06673042B1
公开(公告)日：2004-01-06
申请号：US09447457
申请日：1999-11-22
申请人： Wilfred J. Samson , Brady Esch , Michael J. Lee , Janine Robinson
发明人： Wilfred J. Samson , Brady Esch , Michael J. Lee , Janine Robinson
IPC分类号： A61M2900
CPC分类号： A61M29/02
摘要： The cannula of the present invention is useful for standard gravity drainage or vacuum assisted/suction drainage. The cannula of the present invention has a flexible shaft composed of a tubular body and an expandable scaffolding. The expandable scaffolding has a contracted position, facilitating insertion into a vessel and an expanded condition configured to allow optimal drainage in a vessel. The cannula is inserted into a vessel and navigated into an operative position within the patient's venous system. Once the cannula is in the proper position, the scaffolding is expanded either through passive, active, mechanic, hydraulic, pneumatic, thermal or electrical actuation. The cannula of the present invention is capable of expanding a collapsed vein to its normal diameter and/or capable of supporting the vein when suction is applied to the cannula to help increase fluid flow through the cannula.
摘要翻译：本发明的套管可用于标准重力排水或真空辅助/抽吸排水。本发明的插管具有由管状体和可扩展脚手架组成的柔性轴。可膨胀的脚手架具有收缩位置，便于插入容器中，并且膨胀状态被配置为允许容器中的最佳排水。将套管插入血管并导航到患者静脉系统内的操作位置。一旦插管处于适当的位置，脚手架就可以通过被动，主动，机械，液压，气动，热或电致动来扩展。本发明的插管能够将收缩的静脉膨胀至其正常直径和/或能够在将抽吸施加到套管上时支撑静脉，以帮助增加通过插管的流体流动。

3. 发明授权

US06702773B1 Methods and devices for performing differential perfusion 失效
标题翻译：用于进行差异灌注的方法和装置
公开(公告)号：US06702773B1
公开(公告)日：2004-03-09
申请号：US09495632
申请日：2000-02-01
申请人： John Macoviak , Brady Esch , Mike Lee , Wilfred J. Samson
发明人： John Macoviak , Brady Esch , Mike Lee , Wilfred J. Samson
IPC分类号： A61M3700
CPC分类号： A61M1/3653 , A61M1/1698 , A61M1/3613 , A61M1/3659 , A61M1/3666
摘要： A system for establishing differential perfusion without the use of an occlusion balloon or other flow separator devices. The flows through two lumens are controlled such that the blood flow issuing from one lumen terminating in the aortic arch supplies the entire demand of the cerebral subcirculation while the blood flow issuing from a second lumen terminating in the descending aorta supplies the entire demand of the corporeal subcirculation. When the two flows are properly balanced, an inversion layer forms therebetween and no intermixing of the two flows takes place.
摘要翻译：用于在不使用闭塞气囊或其它流动分离器装置的情况下建立差异灌注的系统。控制通过两个流明的流动，使得从终止于主动脉弓的一个腔中发出的血流提供了大脑亚循环的整个需求，而从下降的主动脉终止的第二个腔中发出的血流提供了整个体表的需求亚循环。当两个流动适当地平衡时，在其间形成反转层，并且不会发生两个流动的混合。

4. 发明授权

US06210363B1 Methods and devices for occluding a vessel and performing differential perfusion 失效
公开(公告)号：US06210363B1
公开(公告)日：2001-04-03
申请号：US09256263
申请日：1999-02-23
申请人： Brady Esch , Janine Robinson , John Macoviak , Wilfred Samson , Eric Olsen
发明人： Brady Esch , Janine Robinson , John Macoviak , Wilfred Samson , Eric Olsen
IPC分类号： A61M2900
CPC分类号： A61B17/12136 , A61B17/12109 , A61B2017/00252 , A61M25/0052 , A61M25/10 , A61M2025/1052 , A61M2025/1097
摘要： The present invention includes an apparatus and methods for differentially perfusing a patient undergoing cardiopulmonary bypass. A cardiopulmonary bypass machine is configured to provide hypothermic oxygenated blood and normothermic oxygenated blood to an aortic balloon catheter. The catheter has arch perfusion ports and corporeal perfusion ports and is introduced into a patient's aorta and navigated transluminally until the occlusion balloon is located in the descending aorta. The occlusion balloon is inflated and hypothermic oxygenated blood is perfused to the arch vessels while normothermic oxygenated blood is perfused to the corporeal circulation. This procedure offers the benefit of cerebral protection from embolic events during cardiopulmonary bypass surgery.

5. 发明授权

US06592612B1 Method and apparatus for providing heat exchange within a catheter body 失效
标题翻译：用于在导管体内提供热交换的方法和装置
公开(公告)号：US06592612B1
公开(公告)日：2003-07-15
申请号：US09564958
申请日：2000-05-04
申请人： Wilfred Samson , Hoa Nguyen , Mike Lee , Brady Esch , Eric Olsen , Jeff Valko
发明人： Wilfred Samson , Hoa Nguyen , Mike Lee , Brady Esch , Eric Olsen , Jeff Valko
IPC分类号： A61F700
CPC分类号： A61F7/12 , A61F2007/126
摘要： The present invention relates to catheters for selectively cooling or warming tissue within a patient's vasculature. The present invention utilizes novel heat exchanging devices, which reside inside the catheter body for selectively altering the temperature of fluid that flows through the catheter shaft. In addition, the present invention utilizes novel pumping devices, which reside within a patient's vasculature for withdrawing oxygenated blood into the catheter body where heat exchange occurs across a heat transfer interface for selective cooling or warming of the blood occurs. The present invention can be used in a multiplicity of medical disciplines where it is advantageous to selectively alter the temperature of tissue, including beating heart applications, as well as stopped heart medical interventions.
摘要翻译：本发明涉及用于选择性地冷却或加热病人脉管系统内的组织的导管。本发明利用新的热交换装置，它们位于导管主体内部，用于选择性地改变流过导管轴的流体的温度。此外，本发明利用新的泵送装置，其驻留在患者的脉管系统内，用于将含氧血液抽出到导管体中，导管主体的热交换发生在热传递界面上，用于血液的选择性冷却或升温。本发明可以用于多种医学学科，其中有选择地改变组织的温度，包括心脏跳动的应用以及停止的心脏医学干预。

6. 发明申请

US20050004503A1 Method and apparatus for treating acute myocardial infarction with hypothermic perfusion 审中-公开
标题翻译：用低温灌注治疗急性心肌梗死的方法和装置
公开(公告)号：US20050004503A1
公开(公告)日：2005-01-06
申请号：US10897491
申请日：2004-07-23
申请人： Wilfred Samson , Janine Robinson , Brady Esch
发明人： Wilfred Samson , Janine Robinson , Brady Esch
IPC分类号： A61B17/00 , A61B17/12 , A61F2/958 , A61F7/12 , A61M1/36 , A61M5/44 , A61M25/00 , A61M29/02 , A61M37/00
CPC分类号： A61M25/1011 , A61B17/12022 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B2017/00243 , A61B2017/12127 , A61F7/12 , A61F2007/126 , A61M1/3613 , A61M1/369 , A61M5/44 , A61M25/00 , A61M2025/1015 , A61M2025/1095 , A61M2205/366 , A61M2210/125 , A61M2210/127
摘要： An apparatus and method are described for quickly inducing therapeutic hypothermia of the heart by perfusing the myocardium with hypothermic fluid in alternatingly antegrade and retrograde directions. The apparatus and method provide rapid cooling of the affected myocardium to achieve optimal myocardial salvage in a patient experiencing acute myocardial infarction. The therapeutic hypothermia system includes one or more coronary artery perfusion catheters, a coronary sinus perfusion catheter and a fluid source for delivering a hypothermically-cooled physiologically-acceptable fluid, such as saline solution, oxygenated venous blood, autologously-oxygenated arterial blood and/or an oxygenated blood substitute. The system may also include one or more guidewires, subselective catheters and/or interventional catheters introduced through a lumen in one or more of the perfusion catheters.
摘要翻译：描述了一种装置和方法，用于通过在交替顺行和逆行方向上用低温流体灌注心肌来快速诱导心脏的治疗低温。该装置和方法提供受影响的心肌的快速冷却，以在经历急性心肌梗塞的患者中实现最佳的心肌救助。治疗低温系统包括一个或多个冠状动脉灌注导管，冠状窦灌注导管和用于递送低温生理学上可接受的流体的流体源，例如盐水溶液，含氧静脉血，自体氧合的动脉血和/或氧合血液替代品。该系统还可以包括通过一个或多个灌注导管中的内腔引入的一个或多个导线，子选择性导管和/或介入导管。

7. 发明申请

US20050080374A1 Method and apparatus for treating acute myocardial infarction with selective hypothermic perfusion 审中-公开
标题翻译：用选择性低温灌注治疗急性心肌梗死的方法和装置
公开(公告)号：US20050080374A1
公开(公告)日：2005-04-14
申请号：US10897498
申请日：2004-07-23
申请人： Brady Esch , Hoa Nguyen , Huu Nguyen , Janine Robinson , Manny Javier
发明人： Brady Esch , Hoa Nguyen , Huu Nguyen , Janine Robinson , Manny Javier
IPC分类号： A61F7/12 , A61M1/36 , A61M5/44 , A61M25/00 , A61M37/00
CPC分类号： A61M1/369 , A61F7/12 , A61F2007/126 , A61M1/3613 , A61M5/44 , A61M25/00 , A61M2205/366 , A61M2210/125
摘要： The present invention provides an apparatus and method for induction of therapeutic hypothermia of the heart by selective hypothermic perfusion of the myocardium through the patient's coronary arteries. The apparatus consists of a guiding catheter into which blood is drawn from the aorta, directed over a heat exchanger and expelled directly into a coronary artery.
摘要翻译：本发明提供一种用于通过患者冠状动脉选择性低温灌注心肌来诱导心脏治疗性低温的装置和方法。该装置由引导导管组成，血液从主动脉中抽出，引导导管穿过热交换器并直接排入冠状动脉。

8. 发明申请

US20070050000A1 Apparatus and method for ensuring thermal treatment of a hollow anatomical structure 有权
标题翻译：用于确保中空解剖结构的热处理的装置和方法
公开(公告)号：US20070050000A1
公开(公告)日：2007-03-01
申请号：US11491067
申请日：2006-07-21
申请人： Brady Esch , Radit Tantisira , Russell Thompson , Brian Farley
发明人： Brady Esch , Radit Tantisira , Russell Thompson , Brian Farley
IPC分类号： A61F7/00 , A61F7/12
CPC分类号： A61B18/082 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B18/24 , A61B90/39 , A61B2017/00026 , A61B2017/00084 , A61B2017/00119 , A61B2017/00123 , A61B2017/00132 , A61B2018/00636 , A61B2018/00666 , A61B2018/00779 , A61B2018/00791 , A61B2018/00827 , A61B2018/046 , A61B2090/0811 , A61B2090/3925 , A61B2090/3937 , A61B2090/3945
摘要： A working end of a catheter includes at least one therapeutic element, such as a resistive heating element, usable to deliver energy for ligating, or reducing the diameter of, a hollow anatomical structure. In certain examples, the catheter includes a lumen to accommodate a guide wire or to allow fluid delivery. In certain embodiments, a balloon is inflated to place resistive element(s) into apposition with a hollow anatomical structure and to occlude the structure. Indexing devices and methods are also disclosed for successively treating portions of the hollow anatomical structure. In certain examples, marks along the catheter shaft provide visual verification to the physician of the relative position of the therapeutic element of the catheter. Embodiments of indexing devices may include pairs of rings and/or hinged arms that move a catheter a desired indexed position between successive treatments.
摘要翻译：导管的工作端包括至少一个治疗元件，例如电阻加热元件，其可用于递送用于结扎或减小中空解剖结构的直径的能量。在某些实例中，导管包括用于容纳引导线或允许流体输送的内腔。在某些实施例中，气囊被充气以将电阻元件放置成与中空解剖结构并置并阻塞结构。还公开了分级装置和方法，用于连续处理中空解剖结构的部分。在某些实例中，沿着导管轴的标记为医师提供导管治疗元件的相对位置的视觉验证。分度装置的实施例可以包括成对的环和/或铰链臂，其使导管在连续的处理之间移动期望的分度位置。

9. 发明申请

US20060293647A1 Methods and apparatus for introducing tumescent fluid to body tissue 有权
公开(公告)号：US20060293647A1
公开(公告)日：2006-12-28
申请号：US11472793
申请日：2006-06-22
申请人： Robert McRae , Michael Mirizzi , Brady Esch , Anna Prestezog , Todd Schoenberger , Halil Karabey , Jeff Zalewski
发明人： Robert McRae , Michael Mirizzi , Brady Esch , Anna Prestezog , Todd Schoenberger , Halil Karabey , Jeff Zalewski
IPC分类号： A61B18/04 , A61M31/00
CPC分类号： A61B18/18 , A61B18/1477 , A61B18/1492 , A61B2018/0016 , A61B2018/00214 , A61B2018/00404 , A61B2018/1425 , A61B2018/1475 , A61B2218/002 , A61M25/0068 , A61M25/0074 , A61M25/0082 , A61M25/0084 , A61M2025/0087 , A61M2202/0007 , A61M2210/12
摘要： A catheter is usable to treat a hollow anatomical structure (HAS). The catheter comprises one or more shafts which extend away from a proximal end of the catheter toward a distal end thereof. The catheter further comprises an HAS constriction energy source located at or near the distal end of the catheter. The catheter further comprises at least one radially expandable transmural fluid delivery channel located in the catheter near the HAS constriction energy source.

10. 发明申请

US20070100405A1 Systems and methods for treating a hollow anatomical structure 审中-公开
标题翻译：用于治疗中空解剖结构的系统和方法
公开(公告)号：US20070100405A1
公开(公告)日：2007-05-03
申请号：US11491348
申请日：2006-07-21
申请人： Russell Thompson , Brady Esch , Robert McRae , Michael Abelmann , Brian Farley , Vijay Dhaka , Fiona Sander
发明人： Russell Thompson , Brady Esch , Robert McRae , Michael Abelmann , Brian Farley , Vijay Dhaka , Fiona Sander
IPC分类号： A61F7/12
CPC分类号： A61B18/082 , A61B18/08 , A61B18/1492 , A61B18/20 , A61B18/24 , A61B90/39 , A61B2017/00026 , A61B2017/00084 , A61B2017/00119 , A61B2017/00123 , A61B2017/00132 , A61B2018/00636 , A61B2018/00666 , A61B2018/00779 , A61B2018/00791 , A61B2018/00827 , A61B2018/046 , A61B2090/0811 , A61B2090/3925 , A61B2090/3937 , A61B2090/3945
摘要： A working end of a catheter includes at least one therapeutic element, such as a resistive heating element, usable to deliver energy for ligating, or reducing the diameter of, a hollow anatomical structure. In certain examples, the catheter includes a lumen to accommodate a guide wire or to allow fluid delivery. In certain embodiments, a balloon is inflated to place resistive element(s) into apposition with a hollow anatomical structure and to occlude the structure. Indexing devices and methods are also disclosed for successively treating portions of the hollow anatomical structure. In certain examples, marks along the catheter shaft provide visual verification to the physician of the relative position of the therapeutic element of the catheter. Embodiments of indexing devices may include pairs of rings and/or hinged arms that move a catheter a desired indexed position between successive treatments.
摘要翻译：导管的工作端包括至少一个治疗元件，例如电阻加热元件，其可用于递送用于结扎或减小中空解剖结构的直径的能量。在某些实例中，导管包括用于容纳引导线或允许流体输送的内腔。在某些实施例中，气囊被充气以将电阻元件放置成与中空解剖结构并置并阻塞结构。还公开了分级装置和方法，用于连续处理中空解剖结构的部分。在某些实例中，沿着导管轴的标记为医师提供导管治疗元件的相对位置的视觉验证。分度装置的实施例可以包括成对的环和/或铰链臂，其使导管在连续的处理之间移动期望的分度位置。

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