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1. 发明授权

US06210363B1 Methods and devices for occluding a vessel and performing differential perfusion 失效
公开(公告)号：US06210363B1
公开(公告)日：2001-04-03
申请号：US09256263
申请日：1999-02-23
申请人： Brady Esch , Janine Robinson , John Macoviak , Wilfred Samson , Eric Olsen
发明人： Brady Esch , Janine Robinson , John Macoviak , Wilfred Samson , Eric Olsen
IPC分类号： A61M2900
CPC分类号： A61B17/12136 , A61B17/12109 , A61B2017/00252 , A61M25/0052 , A61M25/10 , A61M2025/1052 , A61M2025/1097
摘要： The present invention includes an apparatus and methods for differentially perfusing a patient undergoing cardiopulmonary bypass. A cardiopulmonary bypass machine is configured to provide hypothermic oxygenated blood and normothermic oxygenated blood to an aortic balloon catheter. The catheter has arch perfusion ports and corporeal perfusion ports and is introduced into a patient's aorta and navigated transluminally until the occlusion balloon is located in the descending aorta. The occlusion balloon is inflated and hypothermic oxygenated blood is perfused to the arch vessels while normothermic oxygenated blood is perfused to the corporeal circulation. This procedure offers the benefit of cerebral protection from embolic events during cardiopulmonary bypass surgery.

2. 发明授权

US06702773B1 Methods and devices for performing differential perfusion 失效
标题翻译：用于进行差异灌注的方法和装置
公开(公告)号：US06702773B1
公开(公告)日：2004-03-09
申请号：US09495632
申请日：2000-02-01
申请人： John Macoviak , Brady Esch , Mike Lee , Wilfred J. Samson
发明人： John Macoviak , Brady Esch , Mike Lee , Wilfred J. Samson
IPC分类号： A61M3700
CPC分类号： A61M1/3653 , A61M1/1698 , A61M1/3613 , A61M1/3659 , A61M1/3666
摘要： A system for establishing differential perfusion without the use of an occlusion balloon or other flow separator devices. The flows through two lumens are controlled such that the blood flow issuing from one lumen terminating in the aortic arch supplies the entire demand of the cerebral subcirculation while the blood flow issuing from a second lumen terminating in the descending aorta supplies the entire demand of the corporeal subcirculation. When the two flows are properly balanced, an inversion layer forms therebetween and no intermixing of the two flows takes place.
摘要翻译：用于在不使用闭塞气囊或其它流动分离器装置的情况下建立差异灌注的系统。控制通过两个流明的流动，使得从终止于主动脉弓的一个腔中发出的血流提供了大脑亚循环的整个需求，而从下降的主动脉终止的第二个腔中发出的血流提供了整个体表的需求亚循环。当两个流动适当地平衡时，在其间形成反转层，并且不会发生两个流动的混合。

3. 发明授权

US06669680B1 Methods of maintaining selective flow within a vessel 失效
标题翻译：在容器内保持选择性流动的方法
公开(公告)号：US06669680B1
公开(公告)日：2003-12-30
申请号：US09564281
申请日：2000-05-04
申请人： John Macoviak , Wilfred Samson
发明人： John Macoviak , Wilfred Samson
IPC分类号： A61M3100
CPC分类号： A61M25/0067 , A61B17/12036 , A61B17/12045 , A61B17/12109 , A61B17/12131 , A61B17/12136 , A61B2017/1205 , A61M25/007 , A61M25/1002 , A61M2025/0037 , A61M2025/0073 , A61M2025/1072 , A61M2025/1095
摘要： The invention is a catheter with a fluid flow divider positioned near the distal end of the catheter for dividing a first lumen into two channels at a point where a second lumen branches from the first lumen, and for selectively perfusing the branch lumen. The invention is particularly suited for use in the aortic arch. The fluid flow divider may comprise one or more inflatable chambers or one or more deployable shrouds comprising a plurality of arms with a webbing extending between adjacent arms. The inflatable chambers may be relatively noncompliant or they may be compliant, exhibiting elastic behavior after initial inflation, to closely fit the aortic lumen size and curvature. The catheter may further include one or more additional or auxiliary flow control members located upstream or downstream from the fluid flow divider to further segment the patient's circulatory system for selective perfusion to different organ systems within the body or to assist in anchoring the catheter in a desired position.
摘要翻译：本发明是一种导管，其具有定位在导管远端附近的流体分流器，用于在第二腔从第一腔分支的点处将第一腔分成两个通道，并用于选择性地灌注分支腔。本发明特别适用于主动脉弓。流体分流器可以包括一个或多个可充气室或一个或多个可展开的护罩，其包括具有在相邻臂之间延伸的织带的多个臂。充气室可以是相对不符合的，或者它们可以是柔顺的，在初始充气之后表现出弹性，以紧密地适应主动脉腔的尺寸和曲率。导管还可以包括位于流体分流器的上游或下游的一个或多个附加或辅助流动控制构件，以进一步分割患者的循环系统，以选择性灌注到体内的不同器官系统，或帮助将导管锚定在期望的位置。

4. 发明申请

US20050228495A1 Suspended heart valve devices, systems, and methods for supplementing, repairing, or replacing a native heart valve 审中-公开
标题翻译：悬吊心脏瓣膜装置，系统和补充，修复或更换天然心脏瓣膜的方法
公开(公告)号：US20050228495A1
公开(公告)日：2005-10-13
申请号：US11036745
申请日：2005-01-14
申请人： John Macoviak
发明人： John Macoviak
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61F2/2415 , A61F2/2418 , A61F2002/068 , A61F2220/0008 , A61F2220/0016 , A61F2220/005 , A61F2220/0058
摘要： A valve prosthesis is sized and configured to rest within a blood path subject to antegrade and retrograde blood flow. A trestle element on the prosthesis extends across the blood path. A leaflet assembly is suspended from the trestle element and extends into the blood path in alignment with blood flow. At least one mobile leaflet member on the leaflet assembly is sized and configured to assume orientations that change according to blood flow direction. The mobile leaflet member has a first orientation that permits antegrade blood flow and a second orientation that resists retrograde blood flow. The valve prosthesis, when implanted in a heart chamber or great vessel, serves to supplement and/or repair and/or replace native one-way heart valve function.
摘要翻译：瓣膜假体的尺寸和构造尺寸设置成静止在经过顺行和逆行血流的血液路径内。假肢上的一个支架元件延伸穿过血液路径。小叶组件从支架元件悬挂并延伸到与血流对准的血液路径中。小叶组件上的至少一个移动小叶构件的尺寸和构造被设计成呈现根据血液流动方向而变化的取向。移动小叶构件具有允许顺行血液流动的第一取向和抵抗逆行血流的第二取向。当瓣膜假体植入心脏腔或大容器中时，用于补充和/或修复和/或替代原位单向心脏瓣膜功能。

5. 发明申请

US20050228468A1 Devices, systems, and methods for treating atrial fibrillation 审中-公开
标题翻译：用于治疗房颤的装置，系统和方法
公开(公告)号：US20050228468A1
公开(公告)日：2005-10-13
申请号：US10815477
申请日：2004-04-01
申请人： John Macoviak , David Rahdert
发明人： John Macoviak , David Rahdert
IPC分类号： A61B18/14 , A61B19/00 , A61F2/00 , A61F2/02 , A61M35/00 , A61N1/00
CPC分类号： A61B18/1492 , A61B90/50 , A61B2018/00214 , A61B2018/00369 , A61B2018/00375 , A61B2218/002 , A61F2/2487
摘要： Devices, systems and methods establish scaffold-like structures within the heart or a body cavity. The scaffold-like structures establish a stable platform that makes it possible to accomplish a desired therapeutic and/or diagnostic objective in a targeted fashion in one or more tissue regions. The desired therapeutic and/or diagnostic objectives can include, e.g., (i) the delivery of various chemical, drug, and/or biological agents (in liquid, gel, or wafer form) into contact on or in the tissue regions, to accomplish, e.g., ablation or other therapeutic objectives in a controlled, precise fashion; and/or (ii) the delivery of mechanical, heat, cooling, or electrical energy to the tissue region—e.g., to promote the intake by tissue of a chemical, drug, or biological agent, or to pace heart tissue, or to form temporary or permanent conduction blocks, or to otherwise achieve localized effects in targeted tissue regions such as tissue shrinkage, or combinations thereof; and/or (iii) the positioning of physiologic sensors and/or monitors to analyze heart function for diagnostic purposes, e.g., to locate the origin of ectopic pacemakers or other regions where therapeutic intervention may be indicated.
摘要翻译：设备，系统和方法在心脏或体腔内建立支架样结构。脚手架结构建立了稳定的平台，使得可以在一个或多个组织区域中以目标方式实现期望的治疗和/或诊断目标。期望的治疗和/或诊断目标可以包括例如（i）将各种化学药物，药物和/或生物制剂（液体，凝胶或晶片形式）递送到组织区域上或组织区域中的接触以完成，例如，以可控制的精确方式消融或其他治疗目标; 和/或（ii）将机械，热，冷却或电能递送到组织区域 - 例如，促进化学，药物或生物制剂的组织的摄入，或者调节心脏组织，或形成临时或永久传导阻滞，或以其他方式实现靶组织区域如组织收缩或其组合的局部效应; 和/或（iii）生理传感器和/或监护仪的定位以分析用于诊断目的的心脏功能，例如定位异位心脏起搏器的起源或可指示治疗干预的其它区域。

6. 发明申请

US20050222489A1 Devices, systems, and methods for reshaping a heart valve annulus, including the use of a bridge implant 审中-公开
标题翻译：用于重塑心脏瓣膜环的装置，系统和方法，包括使用桥接植入物
公开(公告)号：US20050222489A1
公开(公告)日：2005-10-06
申请号：US11089949
申请日：2005-03-25
申请人： David Rahdert , Timothy Machold , Robert Chang , John Macoviak
发明人： David Rahdert , Timothy Machold , Robert Chang , John Macoviak
IPC分类号： A61B5/04 , A61B17/00 , A61B17/04 , A61B17/08 , A61F2/00 , A61F2/02 , A61F2/24 , A61F13/00
CPC分类号： A61F2/2487 , A61B17/00234 , A61B17/0401 , A61B17/0469 , A61B17/0487 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/00876 , A61B2017/0417 , A61B2017/0453 , A61B2017/0454 , A61B2017/0458 , A61B2017/0464 , A61B2017/0496 , A61F2/2445 , A61F2/2451 , A61F2/2454 , A61F2/2466 , A61F2210/009 , A61F2230/0093 , A61F2250/0012
摘要： Implants or systems of implants and methods apply a selected force vector or a selected combination of force vectors within or across the left atrium, which allow mitral valve leaflets to better coapt. The implants or systems of implants and methods make possible rapid deployment, facile endovascular delivery, and full intra-atrial retrievability. The implants or systems of implants and methods also make use of strong fluoroscopic landmarks. The implants or systems of implants and methods make use of an adjustable implant and a fixed length implant. The implants or systems of implants and methods may also utilize a bridge stop to secure the implant, and the methods of implantation employ various tools.
摘要翻译：植入物或植入物和方法的系统在左心房内或横过左心房施加选定的力向量或力向量的选择组合，这允许二尖瓣小叶更好地适应。植入物和植入物和方法的植入物或系统使得可以快速部署，容易的血管内递送和完全的房内可检索性。植入物或植入物和方法的植入物或系统也利用强荧光检查标志。植入物和植入物和植入物的系统利用可调植入物和固定长度植入物。植入物和植入物的方式的植入物或系统还可以利用桥接止动件来固定植入物，并且植入方法使用各种工具。

7. 发明申请

US20050055089A1 Devices, systems, and methods for reshaping a heart valve annulus 有权
标题翻译：用于重塑心脏瓣膜环的装置，系统和方法
公开(公告)号：US20050055089A1
公开(公告)日：2005-03-10
申请号：US10894433
申请日：2004-07-19
申请人： John Macoviak , Robert Chang , David Rahdert , Timothy Machold
发明人： John Macoviak , Robert Chang , David Rahdert , Timothy Machold
IPC分类号： A61F2/24
CPC分类号： A61F2/2442 , A61B17/0469 , A61B2017/00876 , A61F2/2445 , A61F2/2451 , A61F2/2466 , A61F2/2487 , A61F2210/009 , A61F2250/0012 , A61F2250/0098 , Y10S623/904
摘要： Implants or systems of implants apply a selected force vector or a selected combination of force vectors within or across the left atrium, which allow mitral valve leaflets to better coapt. The implants or systems of implants make possible rapid deployment, facile endovascular delivery, and full intra-atrial retrievability. The implants or systems of implants also make use of strong fluoroscopic landmarks.
摘要翻译：植入物或植入物系统在左心房内或穿过左心房施加选定的力矢量或力矢量的选择组合，这允许二尖瓣小叶更好地适应。植入物或植入物系统使得可以快速部署，容易的血管内递送和完全的心房内可追溯性。植入物或植入物系统还利用强荧光检查标志。

8. 发明申请

US20060252984A1 Devices, systems, and methods for reshaping a heart valve annulus 审中-公开
公开(公告)号：US20060252984A1
公开(公告)日：2006-11-09
申请号：US11389819
申请日：2006-03-27
申请人： David Rahdert , Timothy Machold , Robert Chang , John Macoviak
发明人： David Rahdert , Timothy Machold , Robert Chang , John Macoviak
IPC分类号： A61F2/02 , A61F2/24
CPC分类号： A61B17/3478 , A61B17/0401 , A61B17/0482 , A61B17/0485 , A61B17/0487 , A61B17/320016 , A61B17/32053 , A61B17/3207 , A61B17/320725 , A61B2017/00252 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00619 , A61B2017/00867 , A61B2017/00876 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0451 , A61B2017/0458 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0496 , A61B2017/06176 , A61B2017/22044 , A61B2090/062 , A61B2090/0811 , A61F2/2451 , A61F2/2487 , A61F2002/30079 , A61F2210/009
摘要： Implants or systems of implants and methods apply a selected force vector or a selected combination of force vectors within or across the left atrium, which allow mitral valve leaflets to better coapt. The implants or systems of implants and methods make possible rapid deployment, facile endovascular delivery, and full intra-atrial retrievability. The implants or systems of implants and methods also make use of strong fluoroscopic landmarks. The implants or systems of implants and methods make use of an adjustable implant and a fixed length implant. The implants or systems of implants and methods may also utilize a bridge stop to secure the implant, and the methods of implantation employ various tools.

9. 发明申请

US20060106456A9 Devices, systems, and methods for reshaping a heart valve annulus 审中-公开
标题翻译：用于重塑心脏瓣膜环的装置，系统和方法
公开(公告)号：US20060106456A9
公开(公告)日：2006-05-18
申请号：US10677104
申请日：2003-10-01
申请人： Timothy Machold , David Rahdert , John Macoviak , Robert Chang , Rick Soss
发明人： Timothy Machold , David Rahdert , John Macoviak , Robert Chang , Rick Soss
IPC分类号： A61F2/24
CPC分类号： A61F2/2412 , A61B17/22012 , A61B18/1492 , A61B90/00 , A61B90/50 , A61B2017/00243 , A61B2017/00247 , A61B2017/22097 , A61B2017/320052 , A61B2018/00392 , A61F2/2445 , A61F2/2454 , A61F2/2466 , Y10S623/904
摘要： Devices, systems, and methods employ an implant that is sized and configured to attach to the annulus of a dysfunctional heart valve annulus. In use, the implant extends across the major axis of the annulus above and/or along the valve annulus. The implant reshapes the major axis dimension and/or other surrounding anatomic structures. The implant restores to the heart valve annulus and leaflets a more functional anatomic shape and tension. The more functional anatomic shape and tension are conducive to coaptation of the leaflets, which, in turn, reduces retrograde flow or regurgitation. The implant improves function to the valve, without surgically cinching, resecting, and/or fixing in position large portions of a dilated annulus, or without the surgical fixation of ring-like structures.
摘要翻译：装置，系统和方法采用尺寸和构造成附着到功能障碍性心脏瓣膜环的环的植入物。在使用中，植入物跨过瓣膜环上方和/或沿着瓣膜环的环的长轴延伸。植入物重塑长轴尺寸和/或其他周围的解剖结构。植入物恢复到心脏瓣膜环，并具有更多功能的解剖形状和张力。功能更多的解剖形状和张力有利于小叶的接合，这又降低逆行流动或反流。植入物可以改善瓣膜的功能，而无需外科手术收紧，切除和/或固定在扩张的环的大部分位置，或无环状结构的手术固定。

10. 发明申请

US20060106278A1 Devices, systems, and methods for reshaping a heart valve annulus, including the use of an adjustable bridge implant system 审中-公开
公开(公告)号：US20060106278A1
公开(公告)日：2006-05-18
申请号：US11255529
申请日：2005-10-21
申请人： Timothy Machold , David Scott , David Rahdert , David Tholfsen , Robert Chang , John Macoviak
发明人： Timothy Machold , David Scott , David Rahdert , David Tholfsen , Robert Chang , John Macoviak
IPC分类号： A61B17/12 , A61F2/24
CPC分类号： A61B17/00234 , A61B17/0401 , A61B17/0469 , A61B17/0482 , A61B17/0485 , A61B17/0487 , A61B17/3478 , A61B2017/00243 , A61B2017/00252 , A61B2017/00575 , A61B2017/00592 , A61B2017/00606 , A61B2017/00867 , A61B2017/00876 , A61B2017/0417 , A61B2017/0419 , A61B2017/0445 , A61B2017/0451 , A61B2017/0453 , A61B2017/0454 , A61B2017/0458 , A61B2017/0461 , A61B2017/0462 , A61B2017/0464 , A61B2017/0496 , A61B2017/06176 , A61F2/2445 , A61F2/2451 , A61F2/2466 , A61F2/2487 , A61F2210/009 , A61F2250/0012
摘要： Implants or systems of implants and methods apply a selected force vector or a selected combination of force vectors within or across the left atrium, which allow mitral valve leaflets to better coapt. The implants or systems of implants and methods make possible rapid deployment, facile endovascular delivery, and full intra-atrial adjustability and retrievability years after implant. The implants or systems of implants and methods also make use of strong fluoroscopic landmarks. The implants or systems of implants and methods make use of an adjustable implant and a fixed length implant. The implants or systems of implants and methods may also utilize an adjustable bridge stop to secure the implant, and the methods of implantation employ various tools.

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