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1. 发明授权

US06702773B1 Methods and devices for performing differential perfusion 失效
标题翻译：用于进行差异灌注的方法和装置
公开(公告)号：US06702773B1
公开(公告)日：2004-03-09
申请号：US09495632
申请日：2000-02-01
申请人： John Macoviak , Brady Esch , Mike Lee , Wilfred J. Samson
发明人： John Macoviak , Brady Esch , Mike Lee , Wilfred J. Samson
IPC分类号： A61M3700
CPC分类号： A61M1/3653 , A61M1/1698 , A61M1/3613 , A61M1/3659 , A61M1/3666
摘要： A system for establishing differential perfusion without the use of an occlusion balloon or other flow separator devices. The flows through two lumens are controlled such that the blood flow issuing from one lumen terminating in the aortic arch supplies the entire demand of the cerebral subcirculation while the blood flow issuing from a second lumen terminating in the descending aorta supplies the entire demand of the corporeal subcirculation. When the two flows are properly balanced, an inversion layer forms therebetween and no intermixing of the two flows takes place.
摘要翻译：用于在不使用闭塞气囊或其它流动分离器装置的情况下建立差异灌注的系统。控制通过两个流明的流动，使得从终止于主动脉弓的一个腔中发出的血流提供了大脑亚循环的整个需求，而从下降的主动脉终止的第二个腔中发出的血流提供了整个体表的需求亚循环。当两个流动适当地平衡时，在其间形成反转层，并且不会发生两个流动的混合。

2. 发明授权

US06726651B1 Method and apparatus for differentially perfusing a patient during cardiopulmonary bypass 失效
标题翻译：用于在体外循环期间差异灌注患者的方法和装置
公开(公告)号：US06726651B1
公开(公告)日：2004-04-27
申请号：US09368450
申请日：1999-08-04
申请人： Janine Robinson , Wilfred J. Samson , John A. Macoviak , Lisa M. Young , Brady Esch , Mike Lee , Eric Olsen
发明人： Janine Robinson , Wilfred J. Samson , John A. Macoviak , Lisa M. Young , Brady Esch , Mike Lee , Eric Olsen
IPC分类号： A61M2900
CPC分类号： A61B17/12109 , A61B17/12045 , A61B17/12136 , A61B2017/00243 , A61B2017/12127 , A61M1/3613 , A61M25/1011 , A61M2025/1015 , A61M2210/127
摘要： The present invention provides methods, systems and devices for performing cardipulmonary bypass (CPB), cardioplegic arrest, suction of fluid from the aorta to remove embolic or other fluid from the general circulation and the selective segmentation of the arterial system to perform differential perfusion eliminating hypoperfusion. An aortic catheter having an arch lumen which extends at least in part along the length of the catheter shaft has a proximal opening coupled to a CPB machine and a distal arch opening. A corporeal lumen extends at least in part along the length of the catheter shaft and has a proximal opening coupled to a CPB machine and a distal corporeal opening. A suction lumen extends at least in part along the length of the catheter shaft and has a proximal suction opening coupled to a suction source and a distal suction opening residing in the aortic lumen of a patient.
摘要翻译：本发明提供了用于执行心肺旁路（CPB），心脏停搏，从主动脉抽吸流体以从一般循环中除去栓塞或其他流体的方法，系统和装置，以及动脉系统的选择性分割以执行差异灌注以消除低灌注。具有弓形管腔的主动脉导管至少部分地沿着导管轴的长度延伸，具有联接到CPB机器和远侧弓形开口的近侧开口。体腔内沿着导管轴的长度至少部分地延伸，并具有连接到CPB机器和远端体孔的近端开口。抽吸腔沿着导管轴的长度至少部分地延伸，并且具有联接到吸入源的近侧吸入口和位于患者的主动脉腔内的远侧吸入口。

3. 发明授权

US06673042B1 Expandable venous cannula and method of use 失效
标题翻译：可扩展静脉插管及其使用方法
公开(公告)号：US06673042B1
公开(公告)日：2004-01-06
申请号：US09447457
申请日：1999-11-22
申请人： Wilfred J. Samson , Brady Esch , Michael J. Lee , Janine Robinson
发明人： Wilfred J. Samson , Brady Esch , Michael J. Lee , Janine Robinson
IPC分类号： A61M2900
CPC分类号： A61M29/02
摘要： The cannula of the present invention is useful for standard gravity drainage or vacuum assisted/suction drainage. The cannula of the present invention has a flexible shaft composed of a tubular body and an expandable scaffolding. The expandable scaffolding has a contracted position, facilitating insertion into a vessel and an expanded condition configured to allow optimal drainage in a vessel. The cannula is inserted into a vessel and navigated into an operative position within the patient's venous system. Once the cannula is in the proper position, the scaffolding is expanded either through passive, active, mechanic, hydraulic, pneumatic, thermal or electrical actuation. The cannula of the present invention is capable of expanding a collapsed vein to its normal diameter and/or capable of supporting the vein when suction is applied to the cannula to help increase fluid flow through the cannula.
摘要翻译：本发明的套管可用于标准重力排水或真空辅助/抽吸排水。本发明的插管具有由管状体和可扩展脚手架组成的柔性轴。可膨胀的脚手架具有收缩位置，便于插入容器中，并且膨胀状态被配置为允许容器中的最佳排水。将套管插入血管并导航到患者静脉系统内的操作位置。一旦插管处于适当的位置，脚手架就可以通过被动，主动，机械，液压，气动，热或电致动来扩展。本发明的插管能够将收缩的静脉膨胀至其正常直径和/或能够在将抽吸施加到套管上时支撑静脉，以帮助增加通过插管的流体流动。

4. 发明授权

US06508777B1 Circulatory support system and method of use for isolated segmental perfusion 失效
标题翻译：循环支持系统和孤立性分段灌注使用方法
公开(公告)号：US06508777B1
公开(公告)日：2003-01-21
申请号：US09306555
申请日：1999-05-06
申请人： John Macoviak , Wilfred J. Samson , Steve Baker , James J. Leary
发明人： John Macoviak , Wilfred J. Samson , Steve Baker , James J. Leary
IPC分类号： A61M3700
CPC分类号： A61M25/1011 , A61M1/3653 , A61M1/3659 , A61M25/0032 , A61M2025/0034 , A61M2025/0036
摘要： A circulatory support system and method for circulatory support are described for performing cardiopulmonary bypass using differential perfusion and/or isolated segmental perfusion of the circulatory system. The circulatory support system includes one or more venous cannulae for draining blood from the venous side of the patient's circulatory system, one or more arterial cannulae for perfusing the arterial side of the patient's circulatory system, and one or more blood circulation pumps connected between the venous cannulae and the arterial cannulae. The arterial cannulae and the venous cannulae of the circulatory support system may take one of several possible configurations. The circulatory support system is configured to segment a patient's circulatory system into one or more isolated circulatory loops. The circulatory loops may be isolated from one another and/or from the remainder of the patient's circulatory system on the venous side, as well as on the arterial side, for isolated closed loop circulatory support of separate organ systems. The circulatory support system is suitable for use in minimally-invasive cardiac surgery, using thoracoscopic, port-access or minithoracotomy techniques, or for standard open-chest cardiac surgery.
摘要翻译：描述了用于循环支持的循环支持系统和方法，用于使用循环系统的差分灌注和/或分离的分段灌注进行心肺分流术。循环支持系统包括用于从患者循环系统的静脉侧排出血液的一个或多个静脉插管，用于灌注患者循环系统的动脉侧的一个或多个动脉插管和连接在患者循环系统的动脉侧的一个或多个血液循环泵插管和动脉插管。循环支持系统的动脉插管和静脉插管可以采取几种可能的构型之一。循环支持系统被配置为将患者的循环系统分成一个或多个隔离的循环循环。循环循环可以彼此隔离和/或从静脉侧以及动脉侧的患者循环系统的其余部分分离，用于分离的器官系统的闭环循环支持。循环支持系统适用于微创心脏手术，使用胸腔镜，门禁或小切开术技术或标准胸腔心脏手术。

5. 发明授权

US06585689B1 Aortic catheter and methods for inducing cardioplegic arrest and for selective aortic perfusion 失效
标题翻译：主动脉导管和诱导心脏停跳和选择性主动脉灌注的方法
公开(公告)号：US06585689B1
公开(公告)日：2003-07-01
申请号：US09658741
申请日：2000-09-11
申请人： John A. Macoviak , Wilfred J. Samson , Steve G. Baker , Karl Van Dyk
发明人： John A. Macoviak , Wilfred J. Samson , Steve G. Baker , Karl Van Dyk
IPC分类号： A61M500
CPC分类号： A61B17/12109 , A61B17/12045 , A61B17/12136 , A61M25/1011 , A61M2210/127
摘要： The present invention provides an aortic catheter having an upstream occlusion member positioned in the ascending aorta between the coronary arteries and the brachiocephalic artery and a downstream anchoring member positioned in the descending aorta, downstream of the aortic arch. The upstream occlusion member is in the form of a narrow, disk-shaped inflatable balloon. The downstream anchoring member may be a larger inflatable balloon or other anchoring structure that provides sufficient friction to prevent migration of the balloon catheter in the upstream or downstream direction. In addition, an arch perfusion lumen, a corporeal perfusion lumen and a cardioplegia lumen are provided for performing selective perfusion and cardioplegic arrest.
摘要翻译：本发明提供了一种主动脉导管，其具有定位在冠状动脉和头臂动脉之间的升主动脉中的上游阻塞构件和位于主动脉弓下游的降主动脉中的下游锚固构件。上游阻塞构件是窄的盘形可充气气囊的形式。下游锚固构件可以是较大的可膨胀球囊或其它锚定结构，其提供足够的摩擦力以防止气囊导管在上游或下游方向上的移动。此外，提供了一个拱灌注腔，一个体液灌注腔和一个心麻痹腔，用于进行选择性灌注和心脏停搏。

6. 发明授权

US06267747B1 Aortic catheter with porous aortic root balloon and methods for inducing cardioplegic arrest 失效
公开(公告)号：US06267747B1
公开(公告)日：2001-07-31
申请号：US09306696
申请日：1999-05-06
申请人： Wilfred J. Samson , Janine Robinson , Steve Baker , James J. Leary
发明人： Wilfred J. Samson , Janine Robinson , Steve Baker , James J. Leary
IPC分类号： A61M2900
CPC分类号： A61M25/10 , A61M1/3613 , A61M5/16881 , A61M25/0075 , A61M25/1002 , A61M39/22 , A61M2025/0073 , A61M2025/0076 , A61M2025/1052 , A61M2025/1072 , A61M2025/1086 , A61M2025/1097 , A61M2202/047 , A61M2210/127
摘要： The present invention relates to a catheter or cannula system that facilitates cardiopulmonary bypass surgeries and enables prolonged circulatory support of the heart. More specifically, the present invention provides an aortic catheter system including a porous aortic root balloon capable of occluding the aorta, delivering cardioplegia and providing tactile feedback and helping to maintain the competency of regurgitant aortic valves.

7. 发明授权

US5334154A Perfusion type dilatation catheter having perfusion ports with depressed proximal edges 失效
标题翻译：灌注型扩张导管具有凹陷近端的灌注口
公开(公告)号：US5334154A
公开(公告)日：1994-08-02
申请号：US925568
申请日：1992-08-04
申请人： Wilfred J. Samson , Motasim M. Sirhan , Jovito L. Fernando
发明人： Wilfred J. Samson , Motasim M. Sirhan , Jovito L. Fernando
IPC分类号： A61M25/00 , A61M29/02 , A61M29/00
CPC分类号： A61M25/104 , A61M25/0023 , A61M2025/0183 , A61M25/007
摘要： A perfusion-type dilatation catheter with perfusion ports in the wall of the catheter shaft wherein the proximal edges of the perfusion ports have depressions extending into a guidewire receiving inner lumen which passes through the catheter shaft. The depressed proximal edges prevent excursions of guidewires through the perfusion ports as the guidewire is passed through the guidewire receiving inner lumen. The perfusion ports may be conveniently made by forming holes into the wall of the catheter shaft, inserting shaping pins into the holes, heating the wall of the catheter shaft to make it readily deformable and then rotating the shaping pins proximally along the longitudinal axis of the catheter shaft so that the rotated shaping pins form depressions along the proximal edges of the perfusion ports which extend into the guidewire receiving inner lumen within the catheter shaft.
摘要翻译：一种灌注型扩张导管，其在导管轴的壁中具有灌注端口，其中灌注端口的近侧边缘具有延伸进入穿过导管轴的内腔的导丝的凹陷。当导丝穿过导丝接收内腔时，凹陷的近侧边缘防止导线穿过灌注端口的偏移。可以通过在导管轴的壁中形成孔，将成形销插入孔中，加热导管轴的壁使其易于变形，然后使成形销沿着纵向轴线向近侧旋转来方便地制造灌注端口导管轴，使得旋转的成形销沿着灌注端口的近侧边缘形成凹陷，其延伸到导管内的内导管内的内导管中。

8. 发明授权

US06695811B2 Aortic catheter with porous aortic arch balloon 失效
标题翻译：主动脉导管多孔主动脉弓气球
公开(公告)号：US06695811B2
公开(公告)日：2004-02-24
申请号：US10267254
申请日：2002-10-08
申请人： Wilfred J. Samson , John A. Macoviak
发明人： Wilfred J. Samson , John A. Macoviak
IPC分类号： A61M3100
CPC分类号： A61M25/104 , A61B17/12045 , A61B17/12109 , A61B17/12136 , A61B2017/00243 , A61B2017/12127 , A61M25/10 , A61M2025/0057 , A61M2025/1052 , A61M2025/1072 , A61M2025/1086 , A61M2210/127
摘要： A method and device for perfusing an organ system is provided. The device may be further described as a catheter or cannula with an expandable flow control member positioned of the distal portion of the catheter shaft. The flow control member has a porous portion, and at least one impermeable portion, which prevent fluid from flowing out the ends of the flow control member. The flow control member is further characterized as having an interior chamber that is in fluid communication with a perfusion lumen that extends along the length of the catheter shaft and is in fluid communication with an external perfusion pump. The perfusion lumen is configured for providing flow to the interior of the flow control member, to create radial expansion thereof and to provide adequate flow to the arch vessels through said porous portion to sustain the metabolic demands of the brain.
摘要翻译：提供了一种用于灌注器官系统的方法和装置。该装置可以被进一步描述为导管或套管，其具有定位在导管轴的远端部分的可扩张流量控制构件。流量控制构件具有多孔部分和至少一个防渗部分，其防止流体从流动控制构件的端部流出。流量控制构件的特征还在于具有与沿着导管轴的长度延伸并且与外部灌注泵流体连通的灌注腔流体连通的内部腔室。灌注腔构造成用于向流动控制构件的内部提供流动，以产生其径向膨胀，并且通过所述多孔部分向拱形血管提供足够的流动以维持大脑的代谢需求。

9. 发明授权

US06673040B1 System and methods for catheter procedures with circulatory support in high risk patients 失效
标题翻译：高风险患者循环支持导管手术的系统和方法
公开(公告)号：US06673040B1
公开(公告)日：2004-01-06
申请号：US09384467
申请日：1999-08-27
申请人： Wilfred J. Samson , John A. Macoviak
发明人： Wilfred J. Samson , John A. Macoviak
IPC分类号： A61M2900
CPC分类号： A61M25/1011 , A61B17/12022 , A61B17/12109 , A61B17/12136 , A61B2017/00243 , A61B2017/22072 , A61M25/0032 , A61M25/007 , A61M25/0075 , A61M25/0082 , A61M2025/0036 , A61M2025/1095 , A61M2210/125 , A61M2210/127
摘要： A system and methods are described for performing catheter based procedures on high risk patients that mitigate the risk to the patient and extend the acceptable time window for response when emergencies or complications arise. The system is useful for stopped heart catheter procedures or as a safety backup in beating heart catheter procedures and is compatible with concurrent or sequential surgical interventions. The system combines a therapeutic or diagnostic catheter subsystem with a selective aortic perfusion and cardiopulmonary bypass subsystem. The catheter subsystem may include catheters for angioplasty, stent delivery, atherectomy, valvuloplasty or other diagnostic or therapeutic procedures. The selective aortic perfusion and cardiopulmonary bypass subsystem generally includes catheters and/or cannulas for draining blood from the patient's venous or arterial system, a perfusion pump, a blood oxygenator, at least one blood heat exchanger and catheters and/or cannulas for perfusing oxygenated blood into the patient's arterial system. The arterial perfusion catheters and/or cannulas are constructed with an upstream flow control member located in the patient's ascending aorta and a downstream flow control member located in the patient's descending aorta. The external flow control members may take the form of inflatable occlusion balloons and/or selectively deployable external catheter flow control valves. The external flow control members may be mounted on a single elongated catheter or cannula shaft or they may be mounted on separate catheter or cannula shafts for independent placement and deployment.
摘要翻译：描述了一种系统和方法，用于对高风险患者执行基于导管的程序，以减轻患者的风险，并在出现紧急情况或并发症时延长可接受的响应时间窗口。该系统对于停止的心脏导管程序或作为心脏导管手术中的安全备份是有用的，并且与并发或顺序的外科手术兼容。该系统将治疗或诊断导管子系统与选择性主动脉灌注和体外循环子系统相结合。导管子系统可以包括用于血管成形术，支架递送，粥样斑块切除术，瓣膜成形术或其它诊断或治疗程序的导管。选择性主动脉灌注和心肺旁路子系统通常包括用于从患者的静脉或动脉系统排出血液的导管和/或插管，灌注泵，血液充氧器，至少一个血液热交换器以及用于灌注含氧血液的导管和/或插管进入病人的动脉系统。动脉灌注导管和/或插管由位于患者升主动脉中的上游流量控制构件和位于患者降主动脉中的下游流量控制构件构成。外部流量控制构件可采取充气闭塞气球和/或可选择性地展开的外部导管流量控制阀的形式。外部流量控制构件可以安装在单个细长的导管或套管轴上，或者它们可以安装在单独的导管或套管轴上以用于独立的放置和展开。

10. 发明授权

US06669674B1 Introducer and perfusion cannula 失效
标题翻译：引导器和灌注插管
公开(公告)号：US06669674B1
公开(公告)日：2003-12-30
申请号：US09566859
申请日：2000-05-08
申请人： John A. Macoviak , Wilfred J. Samson , Lynn M. Thompson , James J. Leary
发明人： John A. Macoviak , Wilfred J. Samson , Lynn M. Thompson , James J. Leary
IPC分类号： A61M2500
CPC分类号： A61M25/06 , A61B17/221 , A61B17/3417 , A61B17/3421 , A61B17/3423 , A61B2017/3447 , A61M25/04 , A61M2025/0233
摘要： The present invention discloses a multi-access cannula for use in a variety of surgical procedures, particularly for use in the course of performing conventional open-chest and peripheral access cardiopulmonary bypass (CPB). The multi-access cannula is capable of being inserted through a single puncture site with a percutaneous tip. At the appropriate depth of insertion, a closure seal may be engaged at the point of entry to secure the positioning of the cannula and prevent leakage of blood from the incision. Once the cannula is at the appropriate position the cannula provides a multiplicity of procedural options for the surgeon. For example, when approaching through the ascending aorta, the multi-access cannula enables the simultaneous passage of various fluids and multiple catheters or instruments in opposing directions within the lumen of the aortic arch through a single insertion site.
摘要翻译：本发明公开了一种用于各种外科手术的多通道插管，特别用于执行传统胸腔和外周进入体外循环（CPB）的过程中。多通路插管能够通过具有经皮尖端的单个穿刺部位插入。在适当的插入深度处，封闭密封件可以在入口处接合以固定套管的定位并防止血液从切口泄漏。一旦插管位于适当的位置，套管为外科医生提供了多种程序选择。例如，当通过升主动脉接近时，多通路套管能够通过单个插入位点同时通过主动脉弓内腔内的相反方向的各种流体和多个导管或器械。

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