专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US07232690B1 Method and device for detecting and isolating pharmacological compounds being contained in substance mixtures 失效
标题翻译：用于检测和分离物质混合物中所含的药理化合物的方法和装置
公开(公告)号：US07232690B1
公开(公告)日：2007-06-19
申请号：US10088868
申请日：2000-09-13
申请人： Jana Lenz , Rudolf Matusch , Hans Rainer Hoffmann
发明人： Jana Lenz , Rudolf Matusch , Hans Rainer Hoffmann
IPC分类号： G01N33/543
CPC分类号： G01N30/466 , G01N30/02 , G01N2030/625 , G01N2030/8813 , G01N2030/8831 , B01D15/3804
摘要： A process for isolating and/or identifying at least one active chemical substance from a mixture of active and inactive chemical substances, is characterized by the steps: a) adding a target to said mixture and forming a complex of target and at least one active chemical substance of the mixture, b) separating the complex from the inactive chemical substances of the mixture, and either c) liberating and isolating and/or identifying at least one active chemical substance from the separated complex or d) identifying at least one active chemical substance of the mixture by subtracting from a chromatogram of the mixture of active and inactive chemical substances a chromatogram of the mixture of inactive chemical substances which is obtained after separation of the complex, and possibly liberating and isolating the at least one active substance from the separated complex.
摘要翻译：用于从活性和非活性化学物质的混合物中分离和/或鉴定至少一种活性化学物质的方法的特征在于以下步骤：a）向所述混合物中加入靶并形成靶和至少一种活性化合物所述混合物的物质，b）将所述络合物与所述混合物的无活性化学物质分离，并且c）从分离的络合物中释放和分离和/或鉴定至少一种活性化学物质，或d）鉴定至少一种活性化学物质通过从活性和非活性化学物质的混合物的色谱图中减去在分离复合物之后获得的非活性化学物质的混合物的色谱图，并且可能从分离的复合物释放和分离至少一种活性物质。

2. 发明授权

US08481519B2 Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostatic hyperplasia, prostate carcinoma and spinobulbar muscular atrophy 失效
标题翻译：阿曲酸的分离，阿曲酸衍生物的合成，以及使用阿曲酸及其衍生物用于治疗良性前列腺增生，前列腺癌和旋转肌肉肌萎缩
公开(公告)号：US08481519B2
公开(公告)日：2013-07-09
申请号：US11883610
申请日：2006-01-28
申请人： Hans-Rainer Hoffmann , Rudolf Matusch , Aria Baniahmad
发明人： Hans-Rainer Hoffmann , Rudolf Matusch , Aria Baniahmad
IPC分类号： A01N43/00 , A61K31/33
CPC分类号： C07C311/17 , C07C67/56 , C07C69/84
摘要： A method for isolating atraric acid from biological material, atraric acid derivatives, the chemical synthesis thereof, and the use of atraric acid and the derivatives thereof for treating or producing a medicament for treating benign prostate hyperplasia, prostate carcinoma or spinobulbar muscular atrophy is provided. In addition, a basic substance for the development of other agents used for treating benign prostate hyperplasia, prostate carcinoma, or spinobulbar muscular atrophy is provided.
摘要翻译：提供了从生物材料中分离过酸的方法，过敏酸衍生物，其化学合成，以及使用阿曲酸及其衍生物来治疗或产生治疗良性前列腺增生，前列腺癌或旋涡状肌肉萎缩的药物。另外，提供了用于治疗良性前列腺增生，前列腺癌或旋涡状肌肉萎缩的其它药物的开发的基本物质。

3. 发明申请

US20110311593A1 N-HYDROXYLATED AMIDINE-, GUANIDINE- AND/OR AMINOHYDRAZONE-TYPE PRODRUGS FOR APPLICATION ON THE SKIN 审中-公开
标题翻译：用于皮肤应用的N-羟化的氨基酸，胍基和/或氨基酸衍生物类
公开(公告)号：US20110311593A1
公开(公告)日：2011-12-22
申请号：US13148422
申请日：2010-02-05
申请人： Rudolf Matusch , Hans-Rainer Hoffmann , Bodo Asmussen , Andreas Koch
发明人： Rudolf Matusch , Hans-Rainer Hoffmann , Bodo Asmussen , Andreas Koch
IPC分类号： A61K9/00 , C07D401/14 , C07D413/12 , C07D205/04 , A61P17/00 , C07H15/238 , A61K31/397 , A61K31/4439 , A61K31/7056 , A61K31/7052 , C07D413/14 , C07D403/12
CPC分类号： A61K9/0014
摘要： The invention relates to N-hydroxylated amidines, guanidines and aminohydrazones for application on the skin. In particular, the invention relates to transdermal therapeutic systems containing N-hydroxylated amidines, guanidines and aminohydrazones as a prodrug, and to methods for producing and using such systems.
摘要翻译：本发明涉及用于皮肤上的N-羟基化脒，胍和氨基腙。特别地，本发明涉及含有N-羟基化脒，胍和氨基腙作为前药的透皮治疗系统，以及制备和使用该系统的方法。

4. 发明申请

US20080177107A1 Isolation of N-Butylbenzenesulfonamide, Synthesis of Benzenesulfonamide Derivatives, and Use of N-Butylbenzenesulfonamide and Benzenesulfonamide Derivatives for Treating Benign Prostatic Hyperplasia and/or Prostate Carcinoma 失效
标题翻译： N-丁基苯磺酰胺的分离，苯磺酰胺衍生物的合成以及N-丁基苯磺酰胺和苯磺酰胺衍生物用于治疗良性前列腺增生和/或前列腺癌的用途
公开(公告)号：US20080177107A1
公开(公告)日：2008-07-24
申请号：US11883415
申请日：2006-01-28
申请人： Rudolf Matusch , Aria Baniahmad , Hans-Rainer Hoffmann
发明人： Rudolf Matusch , Aria Baniahmad , Hans-Rainer Hoffmann
IPC分类号： C07C311/16 , C07C303/00
CPC分类号： A61K36/736 , A61K31/18
摘要： A process for isolating N-butylbenzenesulfonamide (NBBS) from biological material, the chemical synthesis of benzenesulfonamide derivatives, the use of NBBS and benzenesulfonamide derivatives for treating benign prostatic hyperplasia and/or prostate carcinomas the production of medicaments for the treatment thereof, and the use of NBBS and benzenesulfonamide derivatives as a lead substance in the development of active substances for treating benign prostatic hyperplasia and/or prostate carcinoma are provided.
摘要翻译：从生物材料中分离出N-丁基苯磺酰胺（NBBS）的方法，苯磺酰胺衍生物的化学合成，使用NBBS和苯磺酰胺衍生物治疗良性前列腺增生和/或前列腺癌，用于治疗药物的生产和使用的NBBS和苯磺酰胺衍生物作为铅物质在开发用于治疗良性前列腺增生和/或前列腺癌的活性物质中的用途。

5. 发明授权

US5895660A Deuterated active substances in transdermal application 失效
标题翻译：经皮应用中的氘代活性物质
公开(公告)号：US5895660A
公开(公告)日：1999-04-20
申请号：US666269
申请日：1996-08-15
申请人： Hans-Rainer Hoffmann , Thomas Hille , Andreas Koch , Rudolf Matusch
发明人： Hans-Rainer Hoffmann , Thomas Hille , Andreas Koch , Rudolf Matusch
IPC分类号： A61K9/00 , A61K9/06 , A61K31/05 , A61K31/135 , A61K31/19 , A61K31/20 , A61K31/485 , A61K45/08 , A61P17/00 , A61F13/00
CPC分类号： A61K31/135 , A61K31/05 , A61K31/19 , A61K31/20 , A61K31/485 , Y10S514/946 , Y10S514/947 , Y10S514/969
摘要： A drug for the release of active substances to the skin, which has an increased deuterium portion as compared to the natural isotope distribution.
摘要翻译： PCT No.PCT / EP94 / 04047 Sec。 371日期：1996年8月15日 102（e）日期1996年8月15日PCT 1994年12月6日PCT PCT。 WO95 / 17188 PCT公开号日期：1995年6月29日一种用于向皮肤释放活性物质的药物，其与天然同位素分布相比具有增加的氘部分。

6. 发明申请

US20120273491A1 CLOSURE SYSTEM FOR CONTAINERS 有权
标题翻译：集装箱封闭系统
公开(公告)号：US20120273491A1
公开(公告)日：2012-11-01
申请号：US13546034
申请日：2012-07-11
申请人： Hans-Rainer Hoffmann , Rudolf Matusch
发明人： Hans-Rainer Hoffmann , Rudolf Matusch
IPC分类号： B65D41/16 , B65D41/50
CPC分类号： A61J1/065 , A61J1/062 , A61J1/1468 , B65D2251/0093
摘要： A closure system for containers used for storing or administering substances in the form of liquids, pastes or powders that allows the container to be securely closed permanently and in a virus-proof, bacteria-proof and spore-proof manner. The container having an opening that is to be closed, a cap provided with a through-hole, the cap including a substantially cylindrical securing area, and a closure element for sealing the opening. The container includes an end face which surrounds the opening and on which the closure element bears. The closure element comprises a virus-proof, bacteria-proof and spore-proof film, and the cap comprises at least one closed, elastic sealing lip bearing resiliently in a direction towards the closure element in the operative position.
摘要翻译：用于储存或管理液体，糊剂或粉末形式的容器的容器封闭系统，其允许容器永久地牢固地封闭并且以防病毒，防细菌和防孢子的方式。具有要封闭的开口的容器，设置有通孔的盖，所述盖包括基本上圆柱形的固定区域和用于密封开口的封闭元件。容器包括围绕开口的端面，封闭元件承载在该端面上。闭合元件包括防病毒，防细菌和防孢子的膜，并且帽包括在操作位置沿朝向闭合元件的方向弹性地弹性地延伸的至少一个封闭的弹性密封唇。

7. 发明授权

US08262604B2 Single-use injector with at least one draw hook 有权
标题翻译：一次性注射器至少有一个拉钩
公开(公告)号：US08262604B2
公开(公告)日：2012-09-11
申请号：US12455964
申请日：2009-06-10
申请人： Bodo Asmussen , Hans-Rainer Hoffmann , Rudolf Matusch , Uwe Wortmann
发明人： Bodo Asmussen , Hans-Rainer Hoffmann , Rudolf Matusch , Uwe Wortmann
IPC分类号： A61M5/30
CPC分类号： A61M5/30 , A61M5/2033 , A61M5/24 , A61M5/3007 , A61M5/31515 , A61M2005/2073 , A61M2005/2488 , A61M2005/2492 , A61M2005/312
摘要： A single-use injector is disclosed comprising a housing (10), arranged in which are at least one mechanical spring energy store (50), at least one piston-cylinder unit (100), which can be effectively filled at least for a certain time, at least one piston-actuating ram (60) and at least one triggering unit (80). The spring energy store comprises at least one pre-tensioned spring element. The spring-loaded piston-actuating ram (60) has at least one retaining rod or hook (62), which can be moved transversely, at least in certain regions, and by means of a supporting portion supports the tensioned spring energy store on at least one resting surface of the housing. When actuation occurs, the triggering unit (80) releases the supporting portion to allow it to move away from the resting surface.
摘要翻译：公开了一种一次性注射器，其包括壳体（10），其布置有至少一个机械弹簧能量存储器（50），至少一个活塞 - 气缸单元（100），其至少可以有效地填充至少一定的至少一个活塞致动柱塞（60）和至少一个触发单元（80）。弹簧能量储存器包括至少一个预张紧弹簧元件。弹簧加载的活塞致动冲头（60）具有至少一个保持杆或钩（62），其可以至少在某些区域中横向移动，并且借助于支撑部分支撑张紧的弹簧能量储存在壳体的至少一个搁置表面。当致动发生时，触发单元（80）释放支撑部分以允许其移动远离静止表面。

8. 发明申请

US20050053647A1 Pharmaceutical product comprising the active substance diamorphine, and its use in a process for treating opiate addiction 审中-公开
标题翻译：包含活性物质二氢吗啡的药物产品及其用于治疗阿片成瘾的方法
公开(公告)号：US20050053647A1
公开(公告)日：2005-03-10
申请号：US10942297
申请日：2004-09-16
申请人： Rudolf Matusch , Bernd Adam , Andreas Koch , Hans-Rainer Hoffmann , Bodo Asmussen
发明人： Rudolf Matusch , Bernd Adam , Andreas Koch , Hans-Rainer Hoffmann , Bodo Asmussen
IPC分类号： A61K9/70 , A61K31/485 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/22 , A61K47/32 , A61K47/34 , A61P25/04 , A61P25/36
CPC分类号： A61K9/7053 , A61K9/7061 , A61K31/485
摘要： The invention relates to pharmaceutical preparations that are used in a method for treating opiate addiction or opiate dependence, especially heroin dependence. The active substance used is preferably diamorphine and/or one of the pharmaceutically acceptable acid addition salts thereof. The invention also relates to a method for treating opiate dependence.
摘要翻译：本发明涉及用于治疗阿片成瘾或阿片依赖性，特别是海洛因依赖性的方法中的药物制剂。所使用的活性物质优选为二氢吗啡和/或其药学上可接受的酸加成盐之一。本发明还涉及一种治疗阿片依赖性的方法。

9. 发明授权

US06617452B2 Process for the isolation of galanthamine 有权
公开(公告)号：US06617452B2
公开(公告)日：2003-09-09
申请号：US10241585
申请日：2002-09-12
申请人： Thomas Hille , Hans-Rainer Hoffmann , Mirko Kreh , Rudolf Matusch
发明人： Thomas Hille , Hans-Rainer Hoffmann , Mirko Kreh , Rudolf Matusch
IPC分类号： A61K3155
CPC分类号： C07D491/04
摘要： The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of the galanthamine thus produced in galenic preparations; and the galanthamine thus produced for treating narrow-angle glaucoma, Alzheimer's disease, as well as alcohol and nicotine dependence.

10. 发明授权

US06573376B2 Process for the isolation of galanthamine 有权
公开(公告)号：US06573376B2
公开(公告)日：2003-06-03
申请号：US09986792
申请日：2001-11-09
申请人： Thomas Hille , Hans-Rainer Hoffmann , Mirko Kreh , Rudolf Matusch
发明人： Thomas Hille , Hans-Rainer Hoffmann , Mirko Kreh , Rudolf Matusch
IPC分类号： C07D49108
CPC分类号： C07D491/04
摘要： The subject matter of the present invention concerns a process for the isolation of the alkaloid galanthamine; the galanthamine itself which has been produced according to this process; the use of the galanthamine thus produced in galenic preparations; and the galanthamine thus produced for treating narrow-angle glaucoma, Alzheimer's disease, as well as alcohol and nicotine dependence.

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式