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1. 发明专利

IL245290D0 Transdermal therapeutic system for administering the active substance buprenorphine 未知
公开(公告)号：IL245290D0
公开(公告)日：2016-06-30
申请号：IL24529016
申请日：2016-04-21
申请人： LOHMANN THERAPIE SYST LTS , MICHAEL HORSTMANN , WALTER MULLER , THOMAS HILLE
发明人： MICHAEL HORSTMANN , WALTER MULLER , THOMAS HILLE
IPC分类号： A61K20060101
摘要： The therapeutic system has an active substance impermeable rear layer (1), a detention adhesive, and a matrix layer (2) containing an active substance buprenorphine and carboxylic acid i.e. levulinic acid, and a detachable protection layer (3). The matrix layer is formed on the basis of amine-resistant dimethyl polysiloxane or polyisobutylene, where the matrix layer dissolves the buprenorphine in the carboxylic acid. A solution in a form of droplets is dispersed in the matrix layer, which stays in diffusible contact with a polyacrylate layer.

2. 发明专利

IL198743A Transdermal therapeutic system for administering the active substance buprenorphine 未知
公开(公告)号：IL198743A
公开(公告)日：2016-05-31
申请号：IL19874309
申请日：2009-05-14
申请人： LTS LOHMANN THERAPIE-SYSTEME AG , MICHAEL HORSTMANN , WALTER MULLER , THOMAS HILLE
发明人： MICHAEL HORSTMANN , WALTER MULLER , THOMAS HILLE
IPC分类号： A61K20060101 , A61L20060101 , A61P20060101
摘要： The therapeutic system has an active substance impermeable rear layer (1), a detention adhesive, and a matrix layer (2) containing an active substance buprenorphine and carboxylic acid i.e. levulinic acid, and a detachable protection layer (3). The matrix layer is formed on the basis of amine-resistant dimethyl polysiloxane or polyisobutylene, where the matrix layer dissolves the buprenorphine in the carboxylic acid. A solution in a form of droplets is dispersed in the matrix layer, which stays in diffusible contact with a polyacrylate layer.

3. 发明专利

IL217731D0 DESTRUCTIVE DISPOSAL OF MEDICAL ACTIVE INGREDIENTS IN TRANSDERMAL THERAPEUTIC SYSTEMS 未知
公开(公告)号：IL217731D0
公开(公告)日：2012-03-29
申请号：IL21773112
申请日：2012-01-25
申请人： LOHMANN THERAPIE SYST LTS , MARGIT WIRZ , THOMAS HILLE
IPC分类号： B09B20060101
摘要： The invention relates to a multilayered structure used in the destructive disposal of medical active ingredients contained in transdermal therapeutic systems (=TTS). The structure has a multi-layer design and contains at least one layer having agents embedded therein and at least one fiber layer. It may additionally include a protective layer. The structure according to the invention is stored separately from the TTS. The separately stored structure is brought into contact with the TTS after use of the TTS.

4. 发明授权

US10568845B2 Transdermal therapeutic system with fentanyl or related substances 有权
公开(公告)号：US10568845B2
公开(公告)日：2020-02-25
申请号：US10487393
申请日：2002-07-10
申请人： Walter Müller , Thomas Hille
发明人： Walter Müller , Thomas Hille
IPC分类号： A61K9/70 , A61K31/4468
摘要： The invention relates to a transdermal therapeutic system (TTS), comprising a backing layer, which is permeable to the active ingredient, at least one matrix layer, comprising fentanyl or an active agent analogous to fentanyl, based on polyacrylate and a protective layer to be removed before usage, characterized in that the polyacrylate polymer is self-adhesive, free of carboxyl groups, has a saturation solubility for fentanyl of 3 to 20 wt. %, preferably of 4 to 12 and particularly of 5 to 10 wt. % and the layers contain at least 80% of the included active ingredient in a molecularly-dispersed, dissolved form.

5. 发明授权

US09200529B2 Method for adjusting the radial gaps which exist between blade airfoil tips or rotor blades and a passage wall 有权
标题翻译：用于调节叶片翼型尖端或转子叶片之间存在的径向间隙的通道壁的方法
公开(公告)号：US09200529B2
公开(公告)日：2015-12-01
申请号：US13703956
申请日：2011-06-09
申请人： Tobias Buchal , Björn Buchholz , Thomas Hille , Anna Kapustina , Mirko Milazar , Eric Schwerin
发明人： Tobias Buchal , Björn Buchholz , Thomas Hille , Anna Kapustina , Mirko Milazar , Eric Schwerin
IPC分类号： G01R31/28 , H02K15/00 , F04D27/02 , F01D21/04 , F01D21/14 , F01D11/14 , F01D21/00 , G01B7/14
CPC分类号： F01D11/14 , F01D21/003 , F01D21/04 , F05D2260/80 , G01B7/14 , G01B2210/58 , Y10T29/49004
摘要： A method for measuring and adjusting gaps between a rotor and a stator of a machine using a sensor is provided. The measuring is conducted when the rotor is operated at a rotational speed below a nominal rotational speed of the machine and without the machine being in operation. The adjusting of the gap is carried out as a function of at least one gap dimension of the gap. The sensor is not resistant to an operating temperature of the machine occurring in a region where the sensor is located. After completion of the measuring the machine is operated with the sensor.
摘要翻译：提供了使用传感器来测量和调整机器的转子和定子之间的间隙的方法。当转子以低于机器额定转速的转速操作且没有机器运行时进行测量。间隙的调整作为间隙的至少一个间隙尺寸的函数进行。传感器不能抵抗传感器所在区域发生的机器的工作温度。测量完成后，机器用传感器操作。

6. 发明申请

US20130312249A1 METHOD FOR ADJUSTING THE RADIAL GAPS WHICH EXIST BETWEEN BLADE AIRFOIL TIPS OR ROTOR BLADES AND A PASSAGE WALL 有权
标题翻译：调整叶片飞行器叶片或转子叶片和通风壁之间存在的径向叶片的方法
公开(公告)号：US20130312249A1
公开(公告)日：2013-11-28
申请号：US13703956
申请日：2011-06-09
申请人： Tobias Buchal , Björn Buchholz , Thomas Hille , Anna Kapustina , Mirko Milazar , Eric Schwerin
发明人： Tobias Buchal , Björn Buchholz , Thomas Hille , Anna Kapustina , Mirko Milazar , Eric Schwerin
IPC分类号： F01D11/14
CPC分类号： F01D11/14 , F01D21/003 , F01D21/04 , F05D2260/80 , G01B7/14 , G01B2210/58 , Y10T29/49004
摘要： A method for measuring and adjusting gaps between a rotor and a stator of a machine using a sensor is provided. The measuring is conducted when the rotor is operated at a rotational speed below a nominal rotational speed of the machine and without the machine being in operation. The adjusting of the gap is carried out as a function of at least one gap dimension of the gap. The sensor is not resistant to an operating temperature of the machine occurring in a region where the sensor is located. After completion of the measuring the machine is operated with the sensor.
摘要翻译：提供了使用传感器来测量和调整机器的转子和定子之间的间隙的方法。当转子以低于机器额定转速的转速操作且没有机器运行时进行测量。间隙的调整作为间隙的至少一个间隙尺寸的函数进行。传感器不能抵抗传感器所在区域发生的机器的工作温度。测量完成后，机器用传感器操作。

7. 发明授权

US08258939B2 System and method for controlling one or more vehicle features based on driver status 有权
标题翻译：基于驾驶员状态来控制一个或多个车辆特征的系统和方法
公开(公告)号：US08258939B2
公开(公告)日：2012-09-04
申请号：US12966520
申请日：2010-12-13
申请人： Thomas Lee Miller , Brian Bennie , Andrew D. Sarkisian , Matthew J. Dalebout , Lawrence Daniel Cepuran , Anthony Dwayne Cooprider , Ronald Patrick Brombach , Kevin Thomas Hille , Karl William Wojcik , John Robert Van Wiemeersch , Terry Thomas Cwik , Scott Alan Watkins , Shimul Bhuva , Aaron Lewis Mills
发明人： Thomas Lee Miller , Brian Bennie , Andrew D. Sarkisian , Matthew J. Dalebout , Lawrence Daniel Cepuran , Anthony Dwayne Cooprider , Ronald Patrick Brombach , Kevin Thomas Hille , Karl William Wojcik , John Robert Van Wiemeersch , Terry Thomas Cwik , Scott Alan Watkins , Shimul Bhuva , Aaron Lewis Mills
IPC分类号： B60Q1/00
CPC分类号： B60R25/00 , B60R21/01546 , B60R25/241
摘要： In at least one embodiment, a device for controlling one or more vehicle features for a primary driver and a secondary driver is provided. The device comprises at least one controller that is configured to receive at least one driver status signal indicative of the driver being one of the primary driver and the secondary driver and to determine whether the driver of the vehicle is the one of the primary driver and the secondary driver based on the at least one driver status signal. The controller is further configured to control one or more vehicle features and to prevent the one or more vehicle features from being disabled in response to determining that the at least one driver status signal indicates that the driver of the vehicle is the secondary driver.
摘要翻译：在至少一个实施例中，提供了用于控制主驱动器和辅助驱动器的一个或多个车辆特征的装置。该设备包括至少一个控制器，其被配置为接收指示驾驶员是主要驾驶员和次要驾驶员中的一个的至少一个驾驶员状态信号，并且确定车辆的驾驶员是否是主要驾驶员和基于所述至少一个驾驶员状态信号的次驾驶员。响应于确定所述至少一个驾驶员状态信号指示所述车辆的驾驶员是次要驾驶员，所述控制器还被配置成控制一个或多个车辆特征并且防止所述一个或多个车辆特征被禁用。

8. 发明申请

US20120129415A1 Destructive Disposal of Medical Active Ingredients in Transdermal Therapeutic Systems 审中-公开
标题翻译：医疗活性成分在经皮治疗系统中的破坏性处置
公开(公告)号：US20120129415A1
公开(公告)日：2012-05-24
申请号：US13388829
申请日：2010-07-29
申请人： Margit Wirz , Thomas Hille
发明人： Margit Wirz , Thomas Hille
IPC分类号： B32B5/16
CPC分类号： B09B3/0075 , A61K9/7038 , A61K31/485 , A61K45/06 , B09B2220/14 , Y10T428/249921 , Y10T442/30 , Y10T442/40 , Y10T442/60 , A61K2300/00
摘要： The invention relates to a multilayered structure used in the destructive disposal of medical active ingredients contained in transdermal therapeutic systems (=TTS). The structure has a multi-layer design and contains at least one layer having agents embedded therein and at least one fiber layer. It may additionally include a protective layer. The structure according to the invention is stored separately from the TTS. The separately stored structure is brought into contact with the TTS after use of the TTS.
摘要翻译：本发明涉及用于破坏性处置透皮治疗系统（= TTS）中所含医疗活性成分的多层结构。该结构具有多层设计并且包含至少一层具有嵌入其中的试剂和至少一个纤维层的层。它还可以包括保护层。根据本发明的结构与TTS分开存储。在使用TTS之后，单独存储的结构与TTS接触。

9. 发明授权

US08142594B2 Method for the multi-track tailoring of transdermal therapeutic patches 失效
标题翻译：透皮治疗贴片多轨裁剪方法
公开(公告)号：US08142594B2
公开(公告)日：2012-03-27
申请号：US12657317
申请日：2010-01-19
申请人： Thomas Hille , Peter Steinborn
发明人： Thomas Hille , Peter Steinborn
IPC分类号： B29C65/48 , B29C65/52 , B32B37/02 , B32B37/26 , B32B38/04 , B32B38/10
CPC分类号： A61F13/0276 , Y10T156/10 , Y10T156/1072 , Y10T156/1074
摘要： A method for the multi-track tailoring of transdermal therapeutic patches having at least a one-layer, adhesive reservoir foil containing an active ingredient, which is disposed between an adhesive back foil and a removable protective foil. The reservoir foils are applied per track with their adhesive layers on a transport element moving discontinuously in the longitudinal direction of the reservoir foils. After separating sections of the size of a patch or band aid the same are transferred to a further transport element that is moved continuously for depositing the same thereon in spaced relationship. The present invention provides a method for multi-track tailoring, wherein web-shaped reservoir foils, which can be unwound from rolls, may be utilized without producing any waste containing the active ingredient.
摘要翻译：一种用于多皮肤定制经皮治疗斑块的方法，其具有至少一层含有活性成分的粘合剂储存器箔，其设置在粘合剂背箔和可移除的保护箔之间。储存器箔每个轨道施加，其粘合剂层在沿储存器箔的纵向不连续移动的输送元件上。在将贴片或带状辅助材料的尺寸分隔开之后，相同的部分被转移到连续移动以便以间隔开的方式沉积在其上的另外的输送元件。本发明提供了一种用于多轨裁剪的方法，其中可以使用可以从卷展开的网状储存器箔，而不产生含有活性成分的任何废物。

10. 发明授权

US08019545B2 System and method for controlling object detection based on driver status 有权
公开(公告)号：US08019545B2
公开(公告)日：2011-09-13
申请号：US12026872
申请日：2008-02-06
申请人： Thomas Lee Miller , Anthony Dwayne Cooprider , Ronald Patrick Brombach , Kevin Thomas Hille , John Robert Van Wiemeersch , Karl William Wojcik , Shimul Bhuva , Aaron Lewis Mills
发明人： Thomas Lee Miller , Anthony Dwayne Cooprider , Ronald Patrick Brombach , Kevin Thomas Hille , John Robert Van Wiemeersch , Karl William Wojcik , Shimul Bhuva , Aaron Lewis Mills
IPC分类号： G08G1/16
摘要： Primary and secondary keys are adapted to be associated to primary and secondary drivers. A key ignition device is positioned on each of the primary and secondary keys and is configured to generate a driver status signal indicative of whether the driver the primary driver or the secondary driver. A controller is operably coupled to the key ignition device. The controller is adapted to determine whether the driver is the primary driver or the secondary driver. The controller is adapted to generate a position notification signal indicative of the position of the object with respect to the vehicle. The controller is adapted to notify the primary and secondary drivers of the position of the object. The controller is adapted to selectively control the operation of generating the position notification signals based on whether the driver is the primary driver or the secondary driver.

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