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1. 发明授权

US08664247B2 Acyclic organonitro compounds for use in treating cancer 有权
标题翻译：用于治疗癌症的无环有机硝基化合物
公开(公告)号：US08664247B2
公开(公告)日：2014-03-04
申请号：US13593737
申请日：2012-08-24
申请人： Jan Scicinski , Bryan T. Oronsky , Robert Wardle , Louis Cannizzo , Nicholas A. Straessler
发明人： Jan Scicinski , Bryan T. Oronsky , Robert Wardle , Louis Cannizzo , Nicholas A. Straessler
IPC分类号： A61K31/08 , A61K31/27 , A61K31/17 , A61K31/16 , A61K31/18 , C07D401/12 , A61K31/225 , A61K31/444 , A61K31/265 , A61K31/22 , A61P35/00 , C07C205/29
CPC分类号： C07D213/79 , A61K31/047 , A61K31/08 , A61K31/16 , A61K31/225 , C07C205/15 , C07C205/29 , C07C205/40 , C07C233/36 , C07C2601/02 , C07D307/68
摘要： The present invention provides acyclic, geminal-dinitro organic compounds, methods of synthesizing the compounds, pharmaceutical compositions, therapeutic methods, and medical kits for treating various conditions using such compounds and pharmaceutical compositions. The compounds and compositions are useful in the treatment of cancer.
摘要翻译：本发明提供无环，偕二硝基有机化合物，合成化合物的方法，药物组合物，治疗方法和用于使用这些化合物和药物组合物治疗各种病症的医疗试剂盒。化合物和组合物可用于治疗癌症。

2. 发明申请

US20130053418A1 ACYCLIC ORGANONITRO COMPOUNDS FOR USE IN TREATING CANCER 有权
标题翻译： ACYCLIC ORGANONITRO化合物用于治疗癌症
公开(公告)号：US20130053418A1
公开(公告)日：2013-02-28
申请号：US13593737
申请日：2012-08-24
申请人： Jan Scicinski , Bryan T. Oronsky , Robert Wardle , Louis Cannizzo , Nicholas A. Straessler
发明人： Jan Scicinski , Bryan T. Oronsky , Robert Wardle , Louis Cannizzo , Nicholas A. Straessler
IPC分类号： A61K31/08 , A61K31/27 , A61K31/17 , A61K31/16 , A61K31/18 , C07D401/12 , A61K31/225 , A61K31/444 , A61P35/00 , C07C205/29 , C07C205/49 , A61K31/265 , A61K31/22
CPC分类号： C07D213/79 , A61K31/047 , A61K31/08 , A61K31/16 , A61K31/225 , C07C205/15 , C07C205/29 , C07C205/40 , C07C233/36 , C07C2601/02 , C07D307/68
摘要： The present invention provides acyclic, geminal-dinitro organic compounds, methods of synthesizing the compounds, pharmaceutical compositions, therapeutic methods, and medical kits for treating various conditions using such compounds and pharmaceutical compositions. The compounds and compositions are useful in the treatment of cancer.
摘要翻译：本发明提供无环，偕二硝基有机化合物，合成化合物的方法，药物组合物，治疗方法和用于使用这些化合物和药物组合物治疗各种病症的医疗试剂盒。化合物和组合物可用于治疗癌症。

3. 发明授权

US09139519B2 Organonitro thioether compounds and medical uses thereof 有权
标题翻译：有机硝基硫醚化合物及其医疗用途
公开(公告)号：US09139519B2
公开(公告)日：2015-09-22
申请号：US14349004
申请日：2012-05-18
申请人： Jan Scicinski , Bryan T. Oronsky
发明人： Jan Scicinski , Bryan T. Oronsky
IPC分类号： A61K31/397 , C07D205/04 , A61K31/19 , A61K31/198 , A61K31/215 , A61K31/337 , A61K45/06 , A61N5/10
CPC分类号： A61K31/397 , A61K31/19 , A61K31/198 , A61K31/215 , A61K31/337 , A61K38/05 , A61K45/06 , A61N5/10 , C07D205/04
摘要： The invention provides organonitro thioether compounds, compositions containing such compounds, isolated organonitro thioether compounds and methods for using such compounds and compositions to treat cancer in a patient. Exemplary organonitro thioether compounds described herein include 2-(3,3-dinitroazetidin-1-yl)-2-oxoethyl thioethers and variants thereof. Another aspect of the invention provides a pharmaceutical composition, comprising a pharmaceutically acceptable carrier and an organonitro thioether compound described herein, such as a compound of Formula I or II. Another aspect of the invention provides a method of treating cancer in a patient. The method comprises administering to a patient in need thereof a therapeutically effective amount of an organonitro thioether compound described herein, such as a compound of Formula I or II, to treat the cancer.
摘要翻译：本发明提供有机硫醚化合物，含有这些化合物的组合物，分离的有机硫醚化合物和使用这些化合物和组合物治疗患者癌症的方法。本文所述的示例性有机亚硫醚化合物包括2-（3,3-二硝基吖丁啶-1-基）-2-氧代乙基硫醚及其变体。本发明的另一方面提供了药物组合物，其包含本文所述的药学上可接受的载体和有机硫醚化合物，例如式I或II的化合物。本发明的另一方面提供了一种治疗患者癌症的方法。该方法包括向有需要的患者施用治疗有效量的本文所述的有机硝基硫醚化合物，例如式I或II的化合物，以治疗癌症。

4. 发明申请

US20120149678A1 Organonitro Compounds for Use in Treating Non-Hodgkin's Lymphoma and Leukemia, and Methods Relating Thereto 审中-公开
标题翻译：用于治疗非霍奇金淋巴瘤和白血病的有机硝基化合物及其相关方法
公开(公告)号：US20120149678A1
公开(公告)日：2012-06-14
申请号：US13315888
申请日：2011-12-09
申请人： Bryan T. Oronsky , Susan Knox , Jan Scicinski , Shoucheng Ning
发明人： Bryan T. Oronsky , Susan Knox , Jan Scicinski , Shoucheng Ning
IPC分类号： A61K31/397 , A61K31/4468 , A61K31/12 , A61K31/16 , A61K31/04 , A61P35/02 , A61K31/445 , A61K31/255 , A61K31/22 , A61K31/40 , A61P35/00
CPC分类号： A61K31/04 , A61K31/12 , A61K31/16 , A61K31/22 , A61K31/255 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/4468
摘要： The invention provides organonitro compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat non-Hodgkin's lymphoma and certain leukemias in a patient. The compounds, compositions, kits, and methods are contemplated to provide a therapeutic benefit in treating non-Hodgkin's lymphoma, chronic lymphocytic leukemia, acute myelogenous leukemia, chronic myelogenous leukemia, and acute lymphoblastic leukemia. Exemplary organonitro compounds described herein include alkyl-substituted and acyl-substituted di-nitroheterocycles.
摘要翻译：本发明提供了有机腈化合物，含有这些化合物的组合物，医疗试剂盒，以及使用这些化合物和组合物治疗患者中非霍奇金淋巴瘤和某些白血病的方法。预期化合物，组合物，试剂盒和方法可用于治疗非霍奇金淋巴瘤，慢性淋巴细胞白血病，急性骨髓性白血病，慢性骨髓性白血病和急性成淋巴细胞性白血病的治疗益处。本文所述的示例性有机亚硝基化合物包括烷基取代的和酰基取代的二 - 氮杂环。

5. 发明申请

US20140349988A1 ORGANONITRO THIOETHER COMPOUNDS AND MEDICAL USES THEREOF 有权
标题翻译： ORGANONITRO THIOETHER化合物及其医疗用途
公开(公告)号：US20140349988A1
公开(公告)日：2014-11-27
申请号：US14349004
申请日：2012-05-18
申请人： Jan Scicinski , Bryan T. Oronsky
发明人： Jan Scicinski , Bryan T. Oronsky
IPC分类号： C07D205/04 , A61K45/06 , A61N5/10 , A61K31/397
CPC分类号： A61K31/397 , A61K31/19 , A61K31/198 , A61K31/215 , A61K31/337 , A61K38/05 , A61K45/06 , A61N5/10 , C07D205/04
摘要： The invention provides organonitro thioether compounds, compositions containing such compounds, isolated organonitro thioether compounds and methods for using such compounds and compositions to treat cancer in a patient. Exemplary organonitro thioether compounds described herein include 2-(3,3-dinitroazetidin-1-yl)-2-oxoethyl thioethers and variants thereof. Another aspect of the invention provides a pharmaceutical composition, comprising a pharmaceutically acceptable carrier and an organonitro thioether compound described herein, such as a compound of Formula I or II. Another aspect of the invention provides a method of treating cancer in a patient. The method comprises administering to a patient in need thereof a therapeutically effective amount of an organonitro thioether compound described herein, such as a compound of Formula I or II, to treat the cancer.
摘要翻译：本发明提供有机硫醚化合物，含有这些化合物的组合物，分离的有机硫醚化合物和使用这些化合物和组合物治疗患者癌症的方法。本文所述的示例性有机亚硫醚化合物包括2-（3,3-二硝基吖丁啶-1-基）-2-氧代乙基硫醚及其变体。本发明的另一方面提供了药物组合物，其包含本文所述的药学上可接受的载体和有机硫醚化合物，例如式I或II的化合物。本发明的另一方面提供了一种治疗患者癌症的方法。该方法包括向有需要的患者施用治疗有效量的本文所述的有机硝基硫醚化合物，例如式I或II的化合物，以治疗癌症。

6. 发明授权

US08784872B2 Formulation for decreasing tobacco, alcohol, drug or food consumption 失效
标题翻译：减少烟草，酒精，药物或食物消费的配方
公开(公告)号：US08784872B2
公开(公告)日：2014-07-22
申请号：US11942414
申请日：2007-11-19
申请人： Bryan T. Oronsky , Neil C. Oronsky , Arnold L. Oronsky
发明人： Bryan T. Oronsky , Neil C. Oronsky , Arnold L. Oronsky
IPC分类号： A61K9/00 , A61K47/00 , A61K9/68 , A61K36/00 , A61K31/4168 , A61K9/12 , A61K9/70
CPC分类号： A61K47/34 , A24B15/16 , A61K9/0056 , A61K9/08 , A61K47/02 , A61K47/32 , A61K47/36
摘要： Formulations have been developed which assist individuals having an addiction such as smoking to reduce or quit engaging in the addictive behavior. Representative behaviors include smoking, excessive alcohol or food ingestion, drug addiction, and ingestion of caffeine or junk food providing quick “highs”. The formulations assist the smoker to become dissatisfied with smoking, until he or she willingly gives up the habit or at least cuts down on the number of cigarettes smoked per day as an initial step towards quitting in the future. The formulations can also be used in conjunction with other known formulations, such as nicotine gum or patch. The formulations contain hydrophilic polymers, for example, polyethylene glycol (PEG) alone or in combination or polyvinyl pyrrolidone (PVP) (also known as povidone or polyvidone alone or in combination.), sweeteners and/or flavorings, viscosity modifiers/binders, and pH or buffering agents.
摘要翻译：已经开发了帮助患有吸烟等成瘾的个体减少或戒除上瘾行为的制剂。代表性的行为包括吸烟，过度酒精或食物摄入，吸毒成瘾，以及摄取咖啡因或垃圾食品，提供快速“高”。这些配方有助于吸烟者对吸烟不满意，直到他或她愿意放弃习惯，或者至少减少每天吸烟的香烟数量，作为今后戒烟的最初步骤。制剂也可以与其它已知的制剂结合使用，例如尼古丁胶或贴剂。制剂含有亲水性聚合物，例如单独使用或组合使用的聚乙二醇（PEG）或聚乙烯吡咯烷酮（PVP）（也称为聚维酮或聚维酮，单独或组合使用），甜味剂和/或调味剂，粘度调节剂/粘合剂和 pH或缓冲剂。

7. 发明授权

US09511016B2 Topical composition for treating pain 有权
标题翻译：用于治疗疼痛的局部组合物
公开(公告)号：US09511016B2
公开(公告)日：2016-12-06
申请号：US11851241
申请日：2007-09-06
申请人： Bryan T. Oronsky , Neil C. Oronsky , Arnold L. Oronsky
发明人： Bryan T. Oronsky , Neil C. Oronsky , Arnold L. Oronsky
IPC分类号： A61K31/23 , A61K31/56 , A61L15/16 , A61P1/14 , A61P11/08 , A61P25/00 , A61K9/00 , A61K31/685 , A61K31/215 , A61K31/01 , A61K31/045 , A61K31/19
CPC分类号： A61K9/0014 , A61K9/0009 , A61K31/01 , A61K31/045 , A61K31/19 , A61K31/215 , A61K31/23 , A61K31/56 , A61K31/685
摘要： Topical compositions having as the active ingredient a lipid, fatty acid ester, natural wax, sterol, or combinations thereof referred to herein as “lipophilic vehicle” or “LV” and methods of use, have been developed for the amelioration or prevention of pain or the sequelae of pain. The composition may be in the form of an ointment, cream, gel, lotion, spray, foam, paste, patch, suspension or dispersion. The composition is variably effective to treat visceral, somatic and neuropathic pain both acute and chronic as well as muscle pain and stiffness and joint pain and stiffness.
摘要翻译：已经开发了具有作为活性成分的脂质，脂肪酸酯，天然蜡，甾醇或其组合的称为“亲脂性载体”或“LV”的使用方法的局部组合物，用于改善或预防疼痛或疼痛的后遗症。组合物可以是软膏剂，霜剂，凝胶剂，洗剂，喷雾剂，泡沫剂，糊剂，贴剂，悬浮液或分散体的形式。该组合物可有效治疗急性和慢性的内脏，躯体和神经性疼痛，以及肌肉疼痛和僵硬以及关节疼痛和僵硬。

8. 发明申请

US20080213904A1 Monitoring drug compliance, food-intake or toxin-intake using non-invasively-read labels 审中-公开
标题翻译：使用非侵入式阅读标签监测药物依从性，食物摄入量或毒素摄入量
公开(公告)号：US20080213904A1
公开(公告)日：2008-09-04
申请号：US11895400
申请日：2007-08-23
申请人： John W. Sliwa , Herbert L. Berman , Bryan T. Oronsky , Carol A. Tosaya
发明人： John W. Sliwa , Herbert L. Berman , Bryan T. Oronsky , Carol A. Tosaya
IPC分类号： G01N33/00 , G01N37/00 , G01N21/64 , F21K2/00
CPC分类号： G01N21/6428 , A61B5/0059 , A61B5/117 , A61B5/1171 , A61B5/411 , G01N21/71 , Y10T436/13
摘要： A system is disclosed for monitoring a property of an ingested or in-taken drug, food, drink or toxic substance, non-invasively or minimally invasively, which can also identify the subject person being monitored, if desired. The system comprises: a means of labeling the substance with a labeling media to have a useful signature indicative of, or bearing a relation to the property; a means to allow the signature to be read non-invasively or minimally invasively; and a means to identify, in any manner, who is being monitored.
摘要翻译：公开了一种系统，用于非侵入式或最低侵入性地监测摄入或摄入的药物，食物，饮料或有毒物质的性质，如果需要，还可以识别被监测的受试者。该系统包括：用标签介质标记物质的手段，以便具有指示或与该财产有关系的有用签名; 允许非侵入性或最小程度地侵入签名的手段; 并且以任何方式识别谁正在被监视的手段。

9. 发明申请

US20090177124A1 Sleep apnea prevention and relief device 审中-公开
标题翻译：睡眠呼吸暂停防治装置
公开(公告)号：US20090177124A1
公开(公告)日：2009-07-09
申请号：US12291631
申请日：2008-11-10
申请人： John W. Silwa , Bryan T. Oronsky
发明人： John W. Silwa , Bryan T. Oronsky
IPC分类号： A61H7/00
CPC分类号： A61F5/56
摘要： A sleep apnea prevention and relief device is provided that is useful for a patient diagnosed with obstructive sleep apnea. For example, a form-fitting neck device is provided with a suction generation or creation means to create continuous or lasting negative pressure upon or around the neck in order to urge substantially outward expansion of the soft tissues that are compressing the pharynx and creating the obstruction.
摘要翻译：提供了一种对诊断为阻塞性睡眠呼吸暂停的患者有用的睡眠呼吸暂停预防和救济装置。例如，形状适配的颈部装置设置有抽吸产生或创建装置，以在颈部上或周围产生连续或持续的负压，以便促进正在压缩咽部的软组织的基本向外膨胀并产生阻塞。

10. 发明申请

US20090093761A1 Medical-procedure assistance device and method with improved optical contrast, and new practitioner-safety, device-fixation, electrode and magnetic treatment and lumen-dilation capabilities 审中-公开
标题翻译：具有改善的光学对比度的医疗手术辅助装置和方法，以及新的从业者 - 安全性，装置固定，电极和磁疗以及管腔扩张能力
公开(公告)号：US20090093761A1
公开(公告)日：2009-04-09
申请号：US11973052
申请日：2007-10-05
申请人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky , Carol A Tosaya , George W. Keilman
发明人： John W. Sliwa , Bryan T. Oronsky , Herbert L. Berman , Neil C. Oronsky , Carol A Tosaya , George W. Keilman
IPC分类号： A61M5/32
CPC分类号： A61M5/427 , A61B17/3403 , A61B90/30 , A61B2090/309 , A61B2090/373 , A61N1/0452 , A61N1/0456 , A61N1/325 , A61N1/36021
摘要： Many medical procedures, such as needle-sticking, could benefit from an assistive device that improves the optical contrast of externally targeted features and lumens of interest residing in and underneath the skin and/or exposed organ tissues. The inventive inexpensive device and method are useable on such externally targeted features and lumens while also protecting the practitioner and freeing up both of his/her hands, if necessary, to thereby eliminate practitioner self-sticking problems. The present device provides good optical contrast and also provides splash-protection against HIV, hepatitis and other blood-borne diseases. The inventive device method and apparatus may also include vibratory subcutaneous electrical nerve stimulation (TENS), drug-based or heating treatment capabilities for reducing pain, both perceived and real pain, associated with a device guided procedure. Finally, the pain reduction mechanisms have also been found useful for lumen dilation.
摘要翻译：许多医疗程序，例如针刺，可以从辅助装置中获益，该辅助装置改善外部目标特征和驻留在皮肤和/或暴露的器官组织下方的感兴趣的流明的光学对比度。本发明的廉价的装置和方法可用于这样的外部目标特征和流明，同时还保护从业者并且如果需要释放他/她的双手，从而消除从业者自身的问题。本装置提供良好的光学对比度，并且还提供针对艾滋病毒，肝炎和其他血源性疾病的飞溅防护。本发明的装置方法和装置还可以包括振动皮下电神经刺激（TENS），基于药物的或加热处理能力，用于减少与装置引导的过程相关的疼痛，感觉和真实疼痛。最后，还发现减轻疼痛的机制可用于管腔扩张。

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