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1. 发明申请

US20050282819A1 Heterocyclic substituted indane derivatives and related compounds for the treatment of schizophrenia 审中-公开
标题翻译：杂环取代的茚满衍生物和相关化合物用于治疗精神分裂症
公开(公告)号：US20050282819A1
公开(公告)日：2005-12-22
申请号：US11007486
申请日：2004-12-08
申请人： James Graham , Brian Kornberg , Sham Nikam , Dejian Xie
发明人： James Graham , Brian Kornberg , Sham Nikam , Dejian Xie
IPC分类号： A61K31/42 , A61K31/425 , A61K31/496 , A61K31/497 , C07D261/20 , C07D275/04 , C07D417/02 , C07D417/12
CPC分类号： C07D261/20 , C07D275/04 , C07D417/12
摘要： This invention relates to compounds of the formula 1 wherein J, M, G, m, X, R1, R2, R4, R5, R6, R7, R8, R9, Y, n, z, and R11 are defined as in the specification, pharmaceutical compositions containing them and their use in the treatment of central nervous system and other disorders.
摘要翻译：本发明涉及式1化合物，其中J，M，G，m，X，R 1，R 2，R 4， R 5，R 6，R 7，R 8，R 9， Y，n，z和R 11如说明书中所定义，含有它们的药物组合物及其在治疗中枢神经系统和其它疾病中的用途。

2. 发明申请

US20120083504A1 Reverse Amide Compounds As Protein Deacetylase Inhibitors And Methods Of Use Thereof 有权
标题翻译：反酰胺化合物作为蛋白质脱乙酰酶抑制剂及其使用方法
公开(公告)号：US20120083504A1
公开(公告)日：2012-04-05
申请号：US13310168
申请日：2011-12-02
申请人： John H. van Duzer , Ralph Mazitschek , Walter Ogier , James E. Bradner , Guoxiang Huang , Dejian Xie , Nan Yu
发明人： John H. van Duzer , Ralph Mazitschek , Walter Ogier , James E. Bradner , Guoxiang Huang , Dejian Xie , Nan Yu
IPC分类号： A61K31/505 , A61P35/00 , A61P19/02 , A61P17/06 , A61P11/00 , A61P11/06 , A61P19/08 , A61P7/06 , A61P29/00 , A61P1/00 , A61P33/02 , A61P3/00 , A61P25/16 , A61P25/28 , C07D239/42
CPC分类号： A61K31/505 , A61K31/164 , A61K31/337 , A61K45/06 , C07C237/36 , C07C259/06 , C07D209/46 , C07D209/48 , C07D213/30 , C07D213/74 , C07D213/81 , C07D235/30 , C07D239/42 , C07D241/20 , C07D263/58 , C07D277/24 , C07D277/82 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D413/04 , C07D417/06
摘要： The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
摘要翻译：本发明涉及包含锌螯合剂基团的新型“逆酰胺”化合物，以及这些化合物在抑制HDAC6中的用途以及治疗与HDAC6有关的各种疾病，病症或病症。

3. 发明申请

US20110124633A1 Heterocyclic Compounds, Methods of Making Them and Their Use in Therapy 审中-公开
标题翻译：杂环化合物，其制备方法及其在治疗中的应用
公开(公告)号：US20110124633A1
公开(公告)日：2011-05-26
申请号：US12844403
申请日：2010-07-27
申请人： Judd Berman , Peter Sampson , Heinz W. Pauls , Jailall Ramnauth , David Douglas Manning , Matthew David Surman , Dejian Xie , Helene Yvonne Decornez
发明人： Judd Berman , Peter Sampson , Heinz W. Pauls , Jailall Ramnauth , David Douglas Manning , Matthew David Surman , Dejian Xie , Helene Yvonne Decornez
IPC分类号： A61K31/551 , A61K31/5517 , A61K31/5377 , A61K31/496 , A61K31/4375 , A61K31/4545 , A61K31/4439 , C07D471/04 , C07D413/12 , C07D401/06 , A61P31/04 , C07D413/06
CPC分类号： C07D213/73 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D495/04
摘要： In part, the present invention is directed to antibacterial compounds.
摘要翻译：部分地，本发明涉及抗菌化合物。

4. 发明申请

US20120190693A1 Reverse Amide Compounds As Protein Deacetylase Inhibitors And Methods Of Use Thereof 有权
公开(公告)号：US20120190693A1
公开(公告)日：2012-07-26
申请号：US13437672
申请日：2012-04-02
申请人： John H. van Duzer , Ralph Mazitschek , Walter Ogier , James E. Bradner , Guoxiang Huang , Dejian Xie , Nan Yu
发明人： John H. van Duzer , Ralph Mazitschek , Walter Ogier , James E. Bradner , Guoxiang Huang , Dejian Xie , Nan Yu
IPC分类号： A61K31/4965 , C07D403/12 , C07D239/42 , C07D213/74 , A61P35/02 , A61K31/166 , A61K31/506 , A61K31/505 , A61K31/4402 , A61P35/00 , C07C259/06 , C07D241/20
CPC分类号： A61K31/505 , A61K31/164 , A61K31/337 , A61K45/06 , C07C237/36 , C07C259/06 , C07D209/46 , C07D209/48 , C07D213/30 , C07D213/74 , C07D213/81 , C07D235/30 , C07D239/42 , C07D241/20 , C07D263/58 , C07D277/24 , C07D277/82 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D413/04 , C07D417/06
摘要： The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.

5. 发明授权

US08609678B2 Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof 有权
标题翻译：作为蛋白质脱乙酰酶抑制剂的反酰胺化合物及其使用方法
公开(公告)号：US08609678B2
公开(公告)日：2013-12-17
申请号：US13437672
申请日：2012-04-02
申请人： John H. Van Duzer , Ralph Mazitschek , Walter Ogier , James E. Bradner , Guoxiang Huang , Dejian Xie , Nan Yu
发明人： John H. Van Duzer , Ralph Mazitschek , Walter Ogier , James E. Bradner , Guoxiang Huang , Dejian Xie , Nan Yu
IPC分类号： A01N43/54 , A61K31/505 , C07D239/42 , C07D401/04 , C07D239/02
CPC分类号： A61K31/505 , A61K31/164 , A61K31/337 , A61K45/06 , C07C237/36 , C07C259/06 , C07D209/46 , C07D209/48 , C07D213/30 , C07D213/74 , C07D213/81 , C07D235/30 , C07D239/42 , C07D241/20 , C07D263/58 , C07D277/24 , C07D277/82 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D413/04 , C07D417/06
摘要： The present invention relates to “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
摘要翻译：本发明涉及包含锌螯合剂基团的“逆酰胺”化合物，以及这些化合物在抑制HDAC6中的用途以及治疗与HDAC6有关的各种疾病，病症或病症。

6. 发明授权

US08394810B2 Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof 有权
标题翻译：作为蛋白质脱乙酰酶抑制剂的反酰胺化合物及其使用方法
公开(公告)号：US08394810B2
公开(公告)日：2013-03-12
申请号：US13010974
申请日：2011-01-21
申请人： John H. van Duzer , Ralph Mazitschek , Walter Ogier , James E. Bradner , Guoxiang Huang , Dejian Xie , Nan Yu
发明人： John H. van Duzer , Ralph Mazitschek , Walter Ogier , James E. Bradner , Guoxiang Huang , Dejian Xie , Nan Yu
IPC分类号： A61K31/505
CPC分类号： A61K31/505 , A61K31/164 , A61K31/337 , A61K45/06 , C07C237/36 , C07C259/06 , C07D209/46 , C07D209/48 , C07D213/30 , C07D213/74 , C07D213/81 , C07D235/30 , C07D239/42 , C07D241/20 , C07D263/58 , C07D277/24 , C07D277/82 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D413/04 , C07D417/06
摘要： The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
摘要翻译：本发明涉及包含锌螯合剂基团的新型逆酰胺化合物，以及这些化合物在抑制HDAC6中的用途以及治疗与HDAC6相关的各种疾病，病症或病症。

7. 发明申请

US20110152280A1 NOVEL ERGOLINE ANALOGS 有权
标题翻译：新的胆固醇类似物
公开(公告)号：US20110152280A1
公开(公告)日：2011-06-23
申请号：US12978314
申请日：2010-12-23
申请人： ROBERT O. COOK , Thomas A. Armer , Sergey Alexandrovich Kosarev , Dejian Xie
发明人： ROBERT O. COOK , Thomas A. Armer , Sergey Alexandrovich Kosarev , Dejian Xie
IPC分类号： A61K31/4985 , C07D519/02 , A61P25/06 , A61P25/16 , A61P25/24 , A61P25/00 , A61P1/08 , A61P3/00
CPC分类号： C07D519/02 , C07D457/04
摘要： Provided herein are novel ergoline derivatives and pharmaceutical compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and or 5-HT1B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of regulating serotonin transport using the compounds and compositions disclosed herein.
摘要翻译：本文提供了新的麦角灵衍生物及其药物组合物。在其它实施方案中，本文提供的是使用本文公开的化合物和组合物治疗，预防或改善各种医学病症例如偏头痛的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物来激发受体例如5-HT1D和/或5-HT1B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物拮抗或抑制受体例如5-HT 2B受体的活性的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物调节5-羟色胺转运的方法。

8. 发明申请

US20060183908A1 Heterocyclic compounds, methods of making them and their use in therapy 有权
标题翻译：杂环化合物，其制备方法及其在治疗中的应用
公开(公告)号：US20060183908A1
公开(公告)日：2006-08-17
申请号：US10537747
申请日：2003-12-05
申请人： Judd Berman , Peter Sampson , Heinz Pauls , Jailall Ramnauth , David Douglas , Matthew Surman , Dejian Xie , Helene Decornez
发明人： Judd Berman , Peter Sampson , Heinz Pauls , Jailall Ramnauth , David Douglas , Matthew Surman , Dejian Xie , Helene Decornez
IPC分类号： C07D491/00 , C07D471/02
CPC分类号： C07D213/73 , C07D401/12 , C07D405/12 , C07D409/12 , C07D471/04 , C07D495/04
摘要： In part, the present invention is directed to antibacterial compounds of formula (I) wherein A is a bicyclic heteroaryl ring or a tricyclic ring and R2 is an heterocyclic residue; L is a bond, or L is alkyl, alkenyl or cycloalkyl.
摘要翻译：部分地，本发明涉及式（I）的抗细菌化合物，其中A是双环杂芳基环或三环，R 2是杂环残基; L是键，或L是烷基，烯基或环烷基。

9. 发明授权

US08710092B2 Substituted indolo 4,3 FG quinolines useful for treating migraine 有权
标题翻译：取代吲哚4,3吡啶喹啉可用于治疗偏头痛
公开(公告)号：US08710092B2
公开(公告)日：2014-04-29
申请号：US12978314
申请日：2010-12-23
申请人： Jian Zhang , Robert O. Cook , Thomas A. Armer , Sergey Alexandrovich Kosarev , Dejian Xie
发明人： Jian Zhang , Robert O. Cook , Thomas A. Armer , Sergey Alexandrovich Kosarev , Dejian Xie
IPC分类号： A61K31/40
CPC分类号： C07D519/02 , C07D457/04
摘要： Provided herein are substituted indolo[4,3-fg]quinolines of Formula (I) and (II) where R1-R6 and R13 are as defined in the specification and pharmaceutical compositions thereof which are useful in treating, preventing, or ameliorating a variety of medical disorders such as, for example, migraine. In other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and or 5-HT1B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of regulating serotonin transport using the compounds and compositions disclosed herein.
摘要翻译：本文提供了式（I）和（II）的取代的吲哚并[4,3-f]喹啉，其中R 1 -R 6和R 13如说明书及其药物组合物中所定义，其可用于治疗，预防或改善品种的医学病症，例如偏头痛。在其它实施方案中，本文提供了使用本文公开的化合物和组合物来激发受体例如5-HT1D和/或5-HT1B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物拮抗或抑制受体例如5-HT 2B受体的活性的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物调节5-羟色胺转运的方法。

10. 发明授权

US08148526B1 Reverse amide compounds as protein deacetylase inhibitors and methods of use thereof 有权
标题翻译：作为蛋白质脱乙酰酶抑制剂的反酰胺化合物及其使用方法
公开(公告)号：US08148526B1
公开(公告)日：2012-04-03
申请号：US13310168
申请日：2011-12-02
申请人： John H. van Duzer , Ralph Mazitschek , Walter Ogier , James E. Bradner , Guoxiang Huang , Dejian Xie , Nan Yu
发明人： John H. van Duzer , Ralph Mazitschek , Walter Ogier , James E. Bradner , Guoxiang Huang , Dejian Xie , Nan Yu
IPC分类号： C07D239/42 , A61K31/505
CPC分类号： A61K31/505 , A61K31/164 , A61K31/337 , A61K45/06 , C07C237/36 , C07C259/06 , C07D209/46 , C07D209/48 , C07D213/30 , C07D213/74 , C07D213/81 , C07D235/30 , C07D239/42 , C07D241/20 , C07D263/58 , C07D277/24 , C07D277/82 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/04 , C07D413/04 , C07D417/06
摘要： The present invention relates to novel “reverse amide” compounds comprising a zinc chelator group, and the use of such compounds in the inhibition of HDAC6 and in the treatment of various diseases, disorders or conditions related to HDAC6.
摘要翻译：本发明涉及包含锌螯合剂基团的新型“逆酰胺”化合物，以及这些化合物在抑制HDAC6中的用途以及治疗与HDAC6有关的各种疾病，病症或病症。

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