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1. 发明授权

US08710092B2 Substituted indolo 4,3 FG quinolines useful for treating migraine 有权
标题翻译：取代吲哚4,3吡啶喹啉可用于治疗偏头痛
公开(公告)号：US08710092B2
公开(公告)日：2014-04-29
申请号：US12978314
申请日：2010-12-23
申请人： Jian Zhang , Robert O. Cook , Thomas A. Armer , Sergey Alexandrovich Kosarev , Dejian Xie
发明人： Jian Zhang , Robert O. Cook , Thomas A. Armer , Sergey Alexandrovich Kosarev , Dejian Xie
IPC分类号： A61K31/40
CPC分类号： C07D519/02 , C07D457/04
摘要： Provided herein are substituted indolo[4,3-fg]quinolines of Formula (I) and (II) where R1-R6 and R13 are as defined in the specification and pharmaceutical compositions thereof which are useful in treating, preventing, or ameliorating a variety of medical disorders such as, for example, migraine. In other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and or 5-HT1B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of regulating serotonin transport using the compounds and compositions disclosed herein.
摘要翻译：本文提供了式（I）和（II）的取代的吲哚并[4,3-f]喹啉，其中R 1 -R 6和R 13如说明书及其药物组合物中所定义，其可用于治疗，预防或改善品种的医学病症，例如偏头痛。在其它实施方案中，本文提供了使用本文公开的化合物和组合物来激发受体例如5-HT1D和/或5-HT1B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物拮抗或抑制受体例如5-HT 2B受体的活性的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物调节5-羟色胺转运的方法。

2. 发明授权

US08604035B2 Fluoroergoline analogs 有权
公开(公告)号：US08604035B2
公开(公告)日：2013-12-10
申请号：US13531371
申请日：2012-06-22
申请人： Robert O. Cook , Jian Zhang , Thomas A. Armer
发明人： Robert O. Cook , Jian Zhang , Thomas A. Armer
IPC分类号： A01N43/58 , A01N43/60 , A61K31/50 , A61K31/495
CPC分类号： C07D519/02 , A61K9/0075 , A61K9/0078 , A61K31/495 , A61K31/4985 , C07D457/04 , C07D498/04 , C07D498/14 , C07D519/00
摘要： Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.

3. 发明申请

US20120329806A1 NOVEL FLUOROERGOLINE ANALOGS 有权
标题翻译：新型荧光素类似物
公开(公告)号：US20120329806A1
公开(公告)日：2012-12-27
申请号：US13531371
申请日：2012-06-22
申请人： Robert O. Cook , Jian Zhang , Thomas A. Armer
发明人： Robert O. Cook , Jian Zhang , Thomas A. Armer
IPC分类号： C07D519/02 , A61P25/06 , A61K31/4985
CPC分类号： C07D519/02 , A61K9/0075 , A61K9/0078 , A61K31/495 , A61K31/4985 , C07D457/04 , C07D498/04 , C07D498/14 , C07D519/00
摘要： Provided herein are novel fluoroergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein.
摘要翻译：本文提供新的氟麦角灵衍生物及其组合物。在其它实施方案中，本文提供了使用本文公开的化合物和组合物治疗，预防或改善各种医学病症例如偏头痛的方法。在其它实施方案中，本文提供的是使用本文公开的化合物和组合物来激发受体例如5-HT1D和/或5-HT1B受体而不激发5-HT 2B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物来拮抗或抑制受体例如肾上腺素α2A和/或α2B受体的活性的方法。

4. 发明授权

US08946420B2 Neuromodulatory compounds 有权
标题翻译：神经调节化合物
公开(公告)号：US08946420B2
公开(公告)日：2015-02-03
申请号：US13531427
申请日：2012-06-22
申请人： Robert O. Cook , Jian Zhang , Thomas A. Armer
发明人： Robert O. Cook , Jian Zhang , Thomas A. Armer
IPC分类号： A61K31/48 , C07D457/12
CPC分类号： C07D457/12 , A61K31/48
摘要： Provided herein are novel neuromodulatory compounds and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine and Parkinson's disease, using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein. In other embodiments, provided herein are methods of agonizing dopaminergic D2 receptors and/or antagonizing or inhibiting activity of receptors such as the 5-HT2 receptors using the compounds and compositions disclosed herein.
摘要翻译：本文提供了新型神经调节化合物及其组合物。在其它实施方案中，本文提供了使用本文公开的化合物和组合物治疗，预防或改善各种医学病症例如偏头痛和帕金森病的方法。在其它实施方案中，本文提供的是使用本文公开的化合物和组合物来激发受体例如5-HT1D和/或5-HT1B受体而不激发5-HT 2B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物来拮抗或抑制受体例如肾上腺素α2A和/或α2B受体的活性的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物来激发多巴胺能D2受体和/或拮抗或抑制受体（例如5-HT 2受体）的活性的方法。

5. 发明申请

US20130165469A1 NOVEL NEUROMODULATORY COMPOUNDS 有权
公开(公告)号：US20130165469A1
公开(公告)日：2013-06-27
申请号：US13531427
申请日：2012-06-22
申请人： Robert O. Cook , Jian Zhang , Thomas A. Armer
发明人： Robert O. Cook , Jian Zhang , Thomas A. Armer
IPC分类号： C07D457/12 , A61P25/06 , A61P25/16 , A61K31/48
CPC分类号： C07D457/12 , A61K31/48
摘要： Provided herein are novel neuromodulatory compounds and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine and Parkinson's disease, using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1B receptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2B receptors using the compounds and compositions disclosed herein. In other embodiments, provided herein are methods of agonizing dopaminergic D2 receptors and/or antagonizing or inhibiting activity of receptors such as the 5-HT2 receptors using the compounds and compositions disclosed herein.

6. 发明授权

US09012640B2 Cabergoline derivatives 有权
标题翻译：卡麦角灵衍生物
公开(公告)号：US09012640B2
公开(公告)日：2015-04-21
申请号：US13531432
申请日：2012-06-22
申请人： Jian Zhang , Thomas A. Armer
发明人： Jian Zhang , Thomas A. Armer
IPC分类号： C07D457/06 , A61K31/48
CPC分类号： A61K31/48 , C07D457/06
摘要： Provided herein are novel cabergoline analogs and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, Parkinson's disease using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing the 5-HT2B receptor and 5-HT2C receptors the using the compounds and compositions disclosed herein.
摘要翻译：本文提供新颖的卡麦角林类似物及其组合物。在其它实施方案中，本文提供了使用本文公开的化合物和组合物治疗，预防或改善各种医学病症例如帕金森病的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物拮抗5-HT 2B受体和5-HT 2C受体的方法。

7. 发明申请

US20130345253A1 NOVEL CABERGOLINE DERIVATIVES 有权
标题翻译：新型CABGGOLINE衍生物
公开(公告)号：US20130345253A1
公开(公告)日：2013-12-26
申请号：US13531432
申请日：2012-06-22
申请人： Jian Zhang , Thomas A. Armer
发明人： Jian Zhang , Thomas A. Armer
IPC分类号： C07D457/06 , A61P25/16 , A61P25/06 , A61K31/48 , A61P25/00
CPC分类号： A61K31/48 , C07D457/06
摘要： Provided herein are novel cabergoline analogs and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, Parkinson's disease using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing the 5-HT2B receptor and 5-HT2C receptors the using the compounds and compositions disclosed herein.
摘要翻译：本文提供新颖的卡麦角林类似物及其组合物。在其它实施方案中，本文提供了使用本文公开的化合物和组合物治疗，预防或改善各种医学病症例如帕金森病的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物拮抗5-HT 2B受体和5-HT 2C受体的方法。

8. 发明授权

US08592445B2 Iso-ergoline derivatives 失效
标题翻译：异麦角灵衍生物
公开(公告)号：US08592445B2
公开(公告)日：2013-11-26
申请号：US13531416
申请日：2012-06-22
申请人： Jian Zhang , Robert O. Cook
发明人： Jian Zhang , Robert O. Cook
IPC分类号： A01N43/42 , A61K31/44
CPC分类号： C07D457/12 , C07D519/00 , C07D519/02
摘要： Provided herein are novel iso-ergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1Breceptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2Breceptors using the compounds and compositions disclosed herein.
摘要翻译：本文提供新颖的异麦角灵衍生物及其组合物。在其它实施方案中，本文提供了使用本文公开的化合物和组合物治疗，预防或改善各种医学病症例如偏头痛的方法。在其它实施方案中，本文提供的是使用本文公开的化合物和组合物来激发受体例如5-HT1D和/或5-HT1B受体而不激发5-HT 2B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物拮抗或抑制受体例如肾上腺素α2A和/或α2B受体的活性的方法。

9. 发明申请

US20130158064A1 NOVEL ISO-ERGOLINE DERIVATIVES 失效
标题翻译：新型的ISO-ERGOLINE衍生物
公开(公告)号：US20130158064A1
公开(公告)日：2013-06-20
申请号：US13531416
申请日：2012-06-22
申请人： Jian Zhang , Robert O. Cook
发明人： Jian Zhang , Robert O. Cook
IPC分类号： C07D457/12 , A61P25/06 , A61P25/16 , A61K31/48
CPC分类号： C07D457/12 , C07D519/00 , C07D519/02
摘要： Provided herein are novel iso-ergoline derivatives and compositions thereof. In other embodiments, provided herein are methods of treatment, prevention, or amelioration of a variety of medical disorders such as, for example, migraine using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of agonizing receptors such as, for example, the 5-HT1D and/or the 5-HT1Breceptor, without agonizing the 5-HT2B receptor using the compounds and compositions disclosed herein. In still other embodiments, provided herein are methods of antagonizing or inhibiting activity at receptors such as, for example, the adrenergic alpha2A and/or the alpha2Breceptors using the compounds and compositions disclosed herein.
摘要翻译：本文提供新颖的异麦角灵衍生物及其组合物。在其它实施方案中，本文提供了使用本文公开的化合物和组合物治疗，预防或改善各种医学病症例如偏头痛的方法。在其它实施方案中，本文提供的是使用本文公开的化合物和组合物来激发受体例如5-HT1D和/或5-HT1B受体而不激发5-HT 2B受体的方法。在其它实施方案中，本文提供了使用本文公开的化合物和组合物拮抗或抑制受体例如肾上腺素α2A和/或α2B受体的活性的方法。

10. 外观设计

USD980356S1 Automatic ball launcher 有权
公开(公告)号：USD980356S1
公开(公告)日：2023-03-07
申请号：US29844017
申请日：2022-06-25
申请人： Jian Zhang
设计人： Jian Zhang

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