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1. 发明申请

US20070179435A1 Analyte detection system with periodic sample draw and body fluid analyzer 审中-公开
标题翻译：分析物检测系统，定期抽样和体液分析仪
公开(公告)号：US20070179435A1
公开(公告)日：2007-08-02
申请号：US11316212
申请日：2005-12-21
申请人： James Braig , Peter Rule
发明人： James Braig , Peter Rule
IPC分类号： A61M31/00 , G01N33/487 , A61B5/00
CPC分类号： A61B5/1486 , A61B5/145 , A61B5/14532 , A61B5/14539 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61B2562/0295 , A61M5/14232 , A61M2005/1726 , A61M2230/201 , G01N27/3271 , G01N33/49
摘要： An embodiment of a system for analyzing a body fluid of a patient comprises a fluid transport network having a patient end configured to provide fluid communication with the body fluid in the patient and a fluid delivery point spaced from the patient end. A pump system is coupled to the fluid transport network. The pump system has an infusion mode in which the pump system is operable to pump an infusion fluid toward the patient end of the fluid transport network and a draw mode in which the pump system is operable to draw the body fluid from the patient into the fluid transport network through the patient end. At least one electrochemical test element is located near the fluid delivery point of the fluid transport network. The electrochemical test element is positioned to receive a portion of the body fluid delivered to the delivery point by the fluid transport network. An analyte detection system is configured to receive the test element and to measure at least one analyte in the portion of the body fluid.
摘要翻译：用于分析患者体液的系统的实施例包括流体输送网络，其具有构造成提供与患者体液的流体连通的患者端和与患者端间隔开的流体输送点。泵系统耦合到流体输送网络。泵系统具有输液模式，其中泵系统可操作以将输液流体朝向流体输送网络的患者端泵送，并且抽吸模式，其中泵系统可操作以将体液从患者吸入流体运输网络通过病人端。至少一个电化学测试元件位于流体输送网络的流体输送点附近。电化学测试元件被定位成接收由流体输送网络输送到输送点的体液的一部分。分析物检测系统被配置为接收测试元件并测量体液部分中的至少一种分析物。

2. 发明申请

US20070083160A1 System and method for assessing measurements made by a body fluid analyzing device 审中-公开
标题翻译：用于评估由体液分析装置进行的测量的系统和方法
公开(公告)号：US20070083160A1
公开(公告)日：2007-04-12
申请号：US11316411
申请日：2005-12-21
申请人： W. Hall , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard King
发明人： W. Hall , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard King
IPC分类号： A61M37/00
CPC分类号： A61B5/157 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B2560/0271 , A61M5/14212 , A61M2230/20
摘要： In certain embodiments, a body fluid analyzing system includes a body fluid analyzer configured to be in fluid communication with a body fluid within a patient. The body fluid analyzing system further includes a communication interface configured to provide communication between the body fluid analyzer and a data system which includes at least one data file. The body fluid analyzer is configured to access the at least one data file via the communication interface.
摘要翻译：在某些实施例中，体液分析系统包括体液分析器，其构造成与患者体内的体液流体连通。体液分析系统还包括被配置为提供体液分析器与包括至少一个数据文件的数据系统之间的通信的通信接口。体液分析器被配置为经由通信接口访问至少一个数据文件。

3. 发明申请

US20060004267A1 Layered spectroscopic sample element with microporous membrane 审中-公开
标题翻译：具有微孔膜的分层光谱样品元件
公开(公告)号：US20060004267A1
公开(公告)日：2006-01-05
申请号：US11173768
申请日：2005-07-01
申请人： Peter Rule , James Braig , Philip Hartstein
发明人： Peter Rule , James Braig , Philip Hartstein
IPC分类号： A61B5/00
CPC分类号： B01L3/5023 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/1491 , B01L3/5027 , B01L3/508 , B01L2200/027 , B01L2300/0654 , B01L2300/069 , B01L2300/0825 , B01L2300/0887 , B01L2400/0406 , G01N21/03 , G01N21/8483 , G01N2021/0346
摘要： A spectroscopic sample holder comprises a microporous sheet. The microporous sheet has a top surface, a bottom surface substantially parallel to the top surface, and at least one side surface oriented substantially perpendicular to the top and bottom surfaces. The side surface forms an exposed transit opening configured to contact a material sample and distribute the contacted material sample into the microporous sheet. The spectroscopic sample holder further comprises a first planar support member positioned on, and substantially parallel to, the top surface of the microporous sheet. The spectroscopic sample holder further comprises a second planar support member positioned on the bottom surface of the microporous sheet, and oriented substantially parallel to the first planar support member.
摘要翻译：光谱样品架包括微孔片。微孔片具有基本平行于顶表面的顶表面，底表面以及基本上垂直于顶表面和底表面取向的至少一个侧表面。侧表面形成暴露的转移开口，其构造成接触材料样品并将接触的材料样品分配到微孔板中。光谱样品架还包括位于微孔板的顶表面上且基本上平行于微孔板的顶表面的第一平面支撑构件。光谱样品架还包括位于微孔板的底表面上并基本上平行于第一平面支撑构件定向的第二平面支撑构件。

4. 发明申请

US20070082342A1 Near-patient module for analyte detection system 审中-公开
标题翻译：用于分析物检测系统的近距离模块
公开(公告)号：US20070082342A1
公开(公告)日：2007-04-12
申请号：US11316681
申请日：2005-12-21
申请人： James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
发明人： James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N35/1095
摘要： In certain embodiments, an apparatus for analyzing the composition of bodily fluid includes a first fluid passageway having a patient end which is configured to provide fluid communication with a bodily fluid within a patient. The apparatus further includes at least one pump coupled to the first fluid passageway. The at least one pump has an infusion mode in which the pump is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further includes an analyte detection system accessible via the first fluid passageway such that the analyte detection system can receive at least one component of the drawn sample of bodily fluid and determine a concentration of at least one analyte. The analyte detection system is spaced from the patient end of the first fluid passageway. The apparatus further includes a fluid sensor located at or near the patient end of the first fluid passageway and spaced from the analyte detection system. The fluid sensor is configured to sense a property of a fluid within the first fluid passageway.
摘要翻译：在某些实施例中，用于分析体液组成的装置包括具有患者端的第一流体通道，该患者端构造成提供与患者体内的体液的流体连通。该装置还包括耦合到第一流体通道的至少一个泵。所述至少一个泵具有输注模式，其中所述泵可操作以通过患者端向患者输送输注流体，以及抽样模式，其中所述泵可操作以从患者抽取体液样本通过病人结束该装置还包括可经由第一流体通道接近的分析物检测系统，使得分析物检测系统可以接收抽取的体液样本的至少一个组分并确定至少一种分析物的浓度。分析物检测系统与第一流体通道的患者端隔开。该装置还包括位于第一流体通道的患者端处或附近的流体传感器，并与分析物检测系统间隔开。流体传感器构造成感测第一流体通道内的流体的性质。

5. 发明申请

US20060253097A1 Methods of treating diabetes 审中-公开
标题翻译：治疗糖尿病的方法
公开(公告)号：US20060253097A1
公开(公告)日：2006-11-09
申请号：US11256277
申请日：2005-10-21
申请人： James Braig , Kenneth Li , Peter Rule , Richard Keenan
发明人： James Braig , Kenneth Li , Peter Rule , Richard Keenan
IPC分类号： A61M31/00
CPC分类号： A61B5/14546 , A61B5/14532 , A61B5/1455
摘要： A method of treating a diabetic condition of a patient comprises providing a glucose detection system which is portable and usable by the patient, and which is configured to measure glucose levels with a standard error of less than about 30 mg/dL. The method further comprises making a plurality of measurements of the patient's glucose level with the portable, patient-usable glucose detection system. The method further comprises administering a diabetes treatment to the patient based on one or more of the measurements of the patient's glucose level.
摘要翻译：一种治疗患者糖尿病状况的方法包括提供可由患者携带和使用的葡萄糖检测系统，其被配置为以小于约30mg / dL的标准误差测量葡萄糖水平。该方法还包括利用便携式，病人可用的葡萄糖检测系统对患者的葡萄糖水平进行多次测量。该方法还包括基于对患者血糖水平的一个或多个测量值向患者施用糖尿病治疗。

6. 发明申请

US20060216209A1 Analyte detection system with distributed sensing 审中-公开
标题翻译：分析检测系统
公开(公告)号：US20060216209A1
公开(公告)日：2006-09-28
申请号：US11316205
申请日：2005-12-21
申请人： James Braig , Peter Rule
发明人： James Braig , Peter Rule
IPC分类号： B01L3/00
CPC分类号： A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N35/1095
摘要： In certain embodiments, a sampling assembly is for use with a main analyzer. The main analyzer is configured to sense an analyte in a body fluid obtained from a patient through a first fluid passageway extending from the main analyzer. The sampling assembly includes an instrument portion separate from the main analyzer and including at least one sensor. The instrument portion is removably engaged with the first fluid passageway. The at least one sensor is in sensing engagement with the first fluid passageway such that the at least one sensor can sense a property of a fluid within the first fluid passageway.
摘要翻译：在某些实施例中，采样组件用于主分析器。主分析器构造成通过从主分析器延伸的第一流体通道感测从患者获得的体液中的分析物。采样组件包括与主分析器分离并且包括至少一个传感器的仪器部分。仪器部分可移除地与第一流体通道接合。所述至少一个传感器与第一流体通道感应接合，使得至少一个传感器可感测第一流体通道内的流体的特性。

7. 发明申请

US20060030790A1 Sample element with barrier material and vacuum 审中-公开
标题翻译：具有阻隔材料和真空的样品元件
公开(公告)号：US20060030790A1
公开(公告)日：2006-02-09
申请号：US10913666
申请日：2004-08-06
申请人： James Braig , Peter Rule , Philip Hartstein , Heidi Smith
发明人： James Braig , Peter Rule , Philip Hartstein , Heidi Smith
IPC分类号： A61B5/00
CPC分类号： A61B5/14546 , A61B5/14532 , A61B5/150022 , A61B5/150099 , A61B5/150213 , A61B5/150221 , A61B5/150274 , A61B5/150358 , A61B5/150412 , A61B5/150503 , A61B5/15117 , A61B5/15125 , A61B5/15136 , A61B5/1514 , A61B2562/0295
摘要： Disclosed is a sample element for holding a volume of bodily fluid drawn from the skin of a patient at a withdrawal site. The sample element comprises a housing defining a sample chamber therein, and a barrier. The sample element also comprises a vacuum source. The barrier has a first side configured to contact the skin of the patient at the withdrawal site, and a second side in fluid communication with the sample chamber. The barrier is configured to be pierced by a lance to permit the bodily fluid to pass from the first side to the second side. Additionally, the vacuum source can be actuated to draw the bodily fluid through the barrier and into the sample chamber. Also disclosed is a method of drawing a bodily fluid form the skin of a patient at a withdrawal site. The method comprises placing a first side of a barrier against the skin of the patient at the withdrawal site. The method further comprises forming a first opening through the barrier and a second opening in the skin of the patient at the withdrawal site. The first and second openings are in fluid communication. The method further comprises applying suction at the first opening of the barrier to draw a bodily fluid from the patient.
摘要翻译：公开了一种用于在取出部位保持从患者皮肤抽取的体液体积的样本元件。样品元件包括在其中限定样品室的壳体和屏障。样品元件还包括真空源。屏障具有被配置成在抽出部位接触患者皮肤的第一侧和与样品室流体连通的第二侧。障碍物被构造成被喷枪刺穿以允许体液从第一侧通过到第二侧。此外，可以致动真空源以将体液通过屏障并进入样品室。还公开了一种在抽出部位从患者的皮肤上吸取体液的方法。该方法包括将屏障的第一侧放置在患者的皮肤处于撤出部位。所述方法还包括在所述抽出部位形成穿过所述屏障的第一开口和所述患者皮肤中的第二开口。第一和第二开口处于流体连通状态。该方法还包括在屏障的第一开口处施加抽吸以从患者抽取体液。

8. 发明申请

US20050106749A1 Sample element for use in material analysis 审中-公开
标题翻译：用于材料分析的样品元素
公开(公告)号：US20050106749A1
公开(公告)日：2005-05-19
申请号：US10877965
申请日：2004-06-25
申请人： James Braig , Bernhard Sterling , Peter Rule , Philip Hartstein , Kenneth Li
发明人： James Braig , Bernhard Sterling , Peter Rule , Philip Hartstein , Kenneth Li
IPC分类号： G01N21/03 , G01N21/35 , G01N21/86 , G01N31/22
CPC分类号： G01N21/8483 , G01N21/0303 , G01N21/3577
摘要： A system and method are provided for determining a concentration of an analyte in a material sample. The method includes providing a sample element with a sample chamber at least partially defined by at least one window formed from a material having greater than about 1% wavelength-domain variation in absorbtivity of electromagnetic radiation incident thereon. The method further includes employing the sample element with an analyte detection system which determines the concentration of the analyte with clinically acceptable accuracy.
摘要翻译：提供了用于确定材料样品中分析物浓度的系统和方法。所述方法包括提供样品室，所述样品室至少部分地由至少一个窗口形成，所述至少一个窗口由从其入射的电磁辐射的吸收率具有大于约1％波长域的变化的材料形成。该方法还包括使用样品元件分析物检测系统，其以临床可接受的精度确定分析物的浓度。

9. 发明申请

US20050038674A1 System and method for managing a chronic medical condition 审中-公开
标题翻译：用于管理慢性医疗状况的系统和方法
公开(公告)号：US20050038674A1
公开(公告)日：2005-02-17
申请号：US10826004
申请日：2004-04-15
申请人： James Braig , Peter Rule , Michael Munrow , Philip Hartstein
发明人： James Braig , Peter Rule , Michael Munrow , Philip Hartstein
IPC分类号： G06F19/00 , G06Q50/00 , G06F17/60
CPC分类号： G06F19/3418 , G06F19/3456 , G06Q50/22 , G16H10/60 , G16H40/40
摘要： A system for management of a chronic medical condition generally comprises a plurality of networked physical and/or virtual elements configured to cooperate to aid in management of a chronic medical condition of a patient. The system is configured to provide a primary caregiver with current data relating to the patient's medical condition, and to allow the caregiver to provide appropriate changes to the patient's treatment via an analyte detection meter. The meter is generally configured to calculate a treatment dosage by combining a plurality of patient-affected and caregiver-affected variables. One embodiment relates to a system for management of a diabetic condition in which the primary caregiver is provided with glucose concentration data as well as other information relating to a diabetic condition. The primary caregiver can then make appropriate changes to correction factors to be implemented in an analyte detection meter which is configured to calculate an insulin dosage.
摘要翻译：用于管理慢性医疗状况的系统通常包括多个联网物理和/或虚拟元件，其被配置为协作以帮助管理患者的慢性医疗状况。该系统被配置为向主要照顾者提供与患者的医疗状况相关的当前数据，并且允许护理人员通过分析物检测仪器对患者的治疗提供适当的改变。仪器通常被配置为通过组合多个患者受影响和受照顾者影响的变量来计算治疗剂量。一个实施方案涉及一种用于管理糖尿病状态的系统，其中主要护理者具有葡萄糖浓度数据以及与糖尿病状况有关的其它信息。然后，主要护理者可以对被配置为计算胰岛素剂量的分析物检测计进行校正因子的适当改变。

10. 发明申请

US20050037482A1 Dual measurement analyte detection system 审中-公开
标题翻译：双测量分析物检测系统
公开(公告)号：US20050037482A1
公开(公告)日：2005-02-17
申请号：US10826006
申请日：2004-04-15
申请人： James Braig , Peter Rule , Kenneth Witte , Philip Hartstein , Bernhard Sterling
发明人： James Braig , Peter Rule , Kenneth Witte , Philip Hartstein , Bernhard Sterling
IPC分类号： A61B5/00 , C12M1/34
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546
摘要： An analyte detection system is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element. The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.
摘要翻译：分析物检测系统被配置为测量由样品元素支持的单个材料样品中的至少第一和第二分析物的浓度。第二分析物的测量可以对第一次测量的定量或定性结果进行调节。在一个实施方案中，第一分析物是葡萄糖，第二分析物是酮。根据这样的实施方案，如果葡萄糖测量结果超过预先规定的值或者超出预先规定的范围，则测量酮。

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