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1. 发明申请

US20060235348A1 Method of extracting and analyzing the composition of bodily fluids 审中-公开
标题翻译：提取和分析体液组成的方法
公开(公告)号：US20060235348A1
公开(公告)日：2006-10-19
申请号：US11314964
申请日：2005-12-21
申请人： David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peng Zheng , Peter Rule , Richard Keenan , Richard King
发明人： David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peng Zheng , Peter Rule , Richard Keenan , Richard King
IPC分类号： A61M31/00 , A61M37/00 , A61B5/00
CPC分类号： A61B5/157 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/1411 , A61B5/1427 , A61B5/1451 , A61B5/14517 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B10/0064 , A61B2560/0443 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M5/1723 , A61M5/365 , A61M5/38 , A61M2205/12 , A61M2205/3306 , A61M2230/20 , A61M2230/201 , G01N21/03 , G01N21/3577 , G01N2021/3595 , G01N2201/02 , G01N2201/061 , Y10T137/4478 , Y10T137/7722 , Y10T137/86485 , Y10T436/111666 , Y10T436/2575
摘要： A method of extracting and analyzing bodily fluids from a patient at the point of care for the patient is provided. The method comprises establishing fluid communication between an analyte detection system and a bodily fluid in the patient. A portion of the bodily fluid is drawn from the patient. The drawn portion is separated into a first component of the bodily fluid, while the analyte detection system remains in fluid communication with the patient. The analyte detection system analyzes the first component to measure a concentration of an analyte.
摘要翻译：提供了在患者护理点从患者提取和分析体液的方法。该方法包括在患者体内建立分析物检测系统和体液之间的流体连通。体液的一部分从患者身上抽出。被抽取的部分被分离成体液的第一组分，而分析物检测系统保持与患者的流体连通。分析物检测系统分析第一组分以测量分析物的浓度。

2. 发明申请

US20070082342A1 Near-patient module for analyte detection system 审中-公开
标题翻译：用于分析物检测系统的近距离模块
公开(公告)号：US20070082342A1
公开(公告)日：2007-04-12
申请号：US11316681
申请日：2005-12-21
申请人： James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
发明人： James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N35/1095
摘要： In certain embodiments, an apparatus for analyzing the composition of bodily fluid includes a first fluid passageway having a patient end which is configured to provide fluid communication with a bodily fluid within a patient. The apparatus further includes at least one pump coupled to the first fluid passageway. The at least one pump has an infusion mode in which the pump is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further includes an analyte detection system accessible via the first fluid passageway such that the analyte detection system can receive at least one component of the drawn sample of bodily fluid and determine a concentration of at least one analyte. The analyte detection system is spaced from the patient end of the first fluid passageway. The apparatus further includes a fluid sensor located at or near the patient end of the first fluid passageway and spaced from the analyte detection system. The fluid sensor is configured to sense a property of a fluid within the first fluid passageway.
摘要翻译：在某些实施例中，用于分析体液组成的装置包括具有患者端的第一流体通道，该患者端构造成提供与患者体内的体液的流体连通。该装置还包括耦合到第一流体通道的至少一个泵。所述至少一个泵具有输注模式，其中所述泵可操作以通过患者端向患者输送输注流体，以及抽样模式，其中所述泵可操作以从患者抽取体液样本通过病人结束该装置还包括可经由第一流体通道接近的分析物检测系统，使得分析物检测系统可以接收抽取的体液样本的至少一个组分并确定至少一种分析物的浓度。分析物检测系统与第一流体通道的患者端隔开。该装置还包括位于第一流体通道的患者端处或附近的流体传感器，并与分析物检测系统间隔开。流体传感器构造成感测第一流体通道内的流体的性质。

3. 发明申请

US20070060872A1 Apparatus and methods for analyzing body fluid samples 审中-公开
公开(公告)号：US20070060872A1
公开(公告)日：2007-03-15
申请号：US11352956
申请日：2006-02-13
申请人： W. Hall , David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
发明人： W. Hall , David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
IPC分类号： A61M31/00 , A61B5/00 , A61D5/00
CPC分类号： A61B5/14546 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M2230/20
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength λ. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

4. 发明申请

US20060189926A1 Apparatus and methods for analyzing body fluid samples 审中-公开
公开(公告)号：US20060189926A1
公开(公告)日：2006-08-24
申请号：US11316407
申请日：2005-12-21
申请人： W. Hall , David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
发明人： W. Hall , David Callicoat , Jennifer Gable , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard Keenan
IPC分类号： A61M31/00 , A61B5/00
CPC分类号： A61B5/14546 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150358 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M2230/20
摘要： An apparatus is provided for monitoring a predetermined parameter of a patient's body fluid while infusing an infusion fluid into the patient. The apparatus comprises an infusion line and a catheter configured for insertion into a blood vessel of the patient, and a reversible infusion pump connected between a source of an infusion fluid and the infusion line and catheter. The apparatus further comprises a body fluid sensor assembly mounted in fluid communication with the infusion line and which includes a first sensor and a sample cell. The first sensor provides a signal indicative of a predetermined parameter of any fluid present in the infusion line. The sample cell is substantially transmissive to light comprising a wavelength B. The apparatus further comprises a controller that is configured to operate the infusion pump in a forward direction so as to pump the infusion fluid through the infusion line and catheter for infusion into the patient. The controller is configured to intermittently interrupt its operating of the infusion pump in the forward direction to operate the infusion pump in a rearward direction so as to draw a body fluid sample from the patient through the catheter and infusion line. The body fluid sample drawn from the patient is disposed such that a first portion of the body fluid sample is in sensing contact with the first sensor of the body fluid sensor assembly, and a second portion of the body fluid sample is disposed within the sample cell of the body fluid sensor assembly. The controller further is configured to monitor the signal provided by the first sensor of the body fluid sensor assembly and to detect a change in the signal indicative of the arrival of the body fluid sample at the first sensor. The controller, in response to detecting the arrival of the body fluid sample at the first sensor, is configured to cease its operating of the infusion pump in the rearward direction. The signal produced by the first sensor provides an indication of a predetermined parameter of the patient's body fluid when the body fluid sample is in sensing contact with the first sensor.

5. 发明申请

US20070083160A1 System and method for assessing measurements made by a body fluid analyzing device 审中-公开
标题翻译：用于评估由体液分析装置进行的测量的系统和方法
公开(公告)号：US20070083160A1
公开(公告)日：2007-04-12
申请号：US11316411
申请日：2005-12-21
申请人： W. Hall , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard King
发明人： W. Hall , James Braig , Kenneth Witte , Mark Wechsler , Peter Rule , Richard King
IPC分类号： A61M37/00
CPC分类号： A61B5/157 , A61B5/0002 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/4839 , A61B2560/0271 , A61M5/14212 , A61M2230/20
摘要： In certain embodiments, a body fluid analyzing system includes a body fluid analyzer configured to be in fluid communication with a body fluid within a patient. The body fluid analyzing system further includes a communication interface configured to provide communication between the body fluid analyzer and a data system which includes at least one data file. The body fluid analyzer is configured to access the at least one data file via the communication interface.
摘要翻译：在某些实施例中，体液分析系统包括体液分析器，其构造成与患者体内的体液流体连通。体液分析系统还包括被配置为提供体液分析器与包括至少一个数据文件的数据系统之间的通信的通信接口。体液分析器被配置为经由通信接口访问至少一个数据文件。

6. 发明申请

US20060195046A1 Analyte detection system with reduced sample volume 有权
标题翻译：分析物检测系统，样品量减少
公开(公告)号：US20060195046A1
公开(公告)日：2006-08-31
申请号：US11316686
申请日：2005-12-21
申请人： Bernhard Sterling , Jennifer Gable , James Braig , Mark Wechsler , Peng Zheng , Peter Rule , Richard Keenan
发明人： Bernhard Sterling , Jennifer Gable , James Braig , Mark Wechsler , Peng Zheng , Peter Rule , Richard Keenan
IPC分类号： A61B5/155
CPC分类号： A61B5/14546 , A61B5/145 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/4839 , A61M5/14212 , A61M2230/20 , G01N35/1095
摘要： In certain embodiments, a method samples a body fluid of a patient. The method includes providing a fluid handling system having one or more fluid passageways. The method further includes infusing an infusion fluid by way of a fluid handling system into a patient through one or more fluid passageways. The method further includes obtaining a sample of body fluid by way of a fluid handling system from a patient through one or more fluid passageways. The obtained sample is no more than 400 microliters in volume. The method further includes analyzing at least an analyzed portion of the obtained sample by way of an analyte detection system operatively associated with the fluid handling system to determine a concentration of at least one analyte.
摘要翻译：在某些实施方案中，方法对患者的体液进行取样。该方法包括提供具有一个或多个流体通道的流体处理系统。该方法还包括通过流体处理系统通过一个或多个流体通道将输注液输入患者体内。该方法还包括通过来自患者的流体处理系统通过一个或多个流体通道获得体液样品。所得样品的体积不超过400微升。该方法还包括通过可操作地与流体处理系统相关联的分析物检测系统分析所获得的样品的至少一部分分析物，以确定至少一种分析物的浓度。

7. 发明申请

US20060189858A1 Analyte detection system for multiple analytes 有权
标题翻译：多种分析物的分析物检测系统
公开(公告)号：US20060189858A1
公开(公告)日：2006-08-24
申请号：US11314176
申请日：2005-12-21
申请人： Bernhard Sterling , James Braig , Kenneth Witte , Peter Rule , Richard Keenan , W. Hall
发明人： Bernhard Sterling , James Braig , Kenneth Witte , Peter Rule , Richard Keenan , W. Hall
IPC分类号： A61B5/00 , A61M31/00
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient; and a pump unit in operative engagement with the fluid handling network. The pump unit has an infusion mode in which the pump unit is operable to deliver infusion fluid to the patient through the patient end, and a sample draw mode in which the pump unit is operable to draw a sample of the bodily fluid from the patient through the patient end. The apparatus further comprises a spectroscopic analyzer positioned to analyze at least a portion of the sample; a processor in communication with or incorporated into the spectroscopic analyzer; and stored program instructions executable by the processor to obtain measurements of two or more properties of the sample. In one implementation, the pump unit comprises a first pump operable in the infusion mode but not in the sample draw mode, and a second pump operable in the sample draw mode but not in the infusion mode.
摘要翻译：一种用于分析体液组成的装置。该装置包括流体处理网络，其包括被配置为保持患者体内与体液的流体连通的患者端; 以及与所述流体处理网络操作地接合的泵单元。泵单元具有输注模式，其中泵单元可操作以通过患者端向患者输送输注流体，以及抽样模式，其中泵单元可操作以从患者抽取体液样本，通过病人结束所述设备还包括定位成分析样品的至少一部分的光谱分析仪; 与光谱分析仪通信或并入其中的处理器; 以及可由处理器执行的存储的程序指令，以获得样本的两个或多个属性的测量。在一个实施方案中，泵单元包括可在输液模式中操作但不在样品抽取模式中的第一泵，以及可在样品抽取模式中操作但不在输注模式中的第二泵。

8. 发明申请

US20060200071A1 Method and apparatus for detection of multiple analytes 有权
标题翻译：检测多种分析物的方法和装置
公开(公告)号：US20060200071A1
公开(公告)日：2006-09-07
申请号：US11314173
申请日：2005-12-21
申请人： Bernhard Sterling , James Braig , Peter Rule , W. Hall , Mark Wechsler , Jennifer Gable
发明人： Bernhard Sterling , James Braig , Peter Rule , W. Hall , Mark Wechsler , Jennifer Gable
IPC分类号： A61M31/00 , A61B5/00
CPC分类号： A61M5/1723 , A61B5/14532 , A61B5/14546 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150755 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M5/14212 , A61M5/14232 , A61M5/16854 , A61M2205/12 , A61M2230/20 , A61M2230/201 , G01N1/14 , G01N21/05 , G01N21/274 , G01N21/35 , G01N2021/0346
摘要： An apparatus for analyzing the composition of bodily fluid. The apparatus comprises a fluid handling network including a patient end configured to maintain fluid communication with a bodily fluid in a patient and at least one pump intermittently operable to draw a sample of bodily fluid from the patient. The apparatus further comprises a fluid analyzer positioned to analyze at least a portion of the sample and measure the presence of two or more analytes. Also disclosed is a method for analyzing the composition of a bodily fluid in a patient. The method comprises drawing a sample of the bodily fluid of the patient through a fluid handling network configured to maintain fluid communication with a bodily fluid in a patient. The method further comprises analyzing the at least a portion of the sample in a fluid analyzer to estimate the concentration of two or more analytes in the sample.
摘要翻译：一种用于分析体液组成的装置。该装置包括流体处理网络，其包括被配置为保持与患者体内的体液的流体连通的患者端以及间歇地可操作以从患者抽取体液样本的至少一个泵。该装置还包括流体分析器，定位成分析样品的至少一部分并测量两种或多种分析物的存在。还公开了一种用于分析患者体液组成的方法。该方法包括通过流体处理网络来绘制患者的体液样本，流体处理网络被配置为保持患者体内与体液的流体连通。该方法还包括在流体分析仪中分析样品的至少一部分以估计样品中两种或多种分析物的浓度。

9. 发明申请

US20050036146A1 Sample element qualification 审中-公开
标题翻译：样品单元鉴定
公开(公告)号：US20050036146A1
公开(公告)日：2005-02-17
申请号：US10824933
申请日：2004-04-15
申请人： James Braig , Kenneth Witte , Philip Hartstein , Ken Li , Peter Rule
发明人： James Braig , Kenneth Witte , Philip Hartstein , Ken Li , Peter Rule
IPC分类号： G01N21/03 , G01N21/59 , G01N21/86 , G01N35/00 , G01N21/00
CPC分类号： G01N35/00732 , G01N21/03 , G01N21/5907 , G01N21/8483 , G01N2035/00752 , G01N2035/00762 , G01N2035/00772 , G01N2035/00782
摘要： A sample element includes first and second substantially parallel faces separated by an intermediate member. The parallel faces and the intermediate member at least partially define a sample chamber configured to hold a volume of fluid. The sample element further includes an optical path extending through the parallel faces and the intermediate member, such that electromagnetic radiation can propagate through the sample chamber. The sample element further includes an identifying compound disposed within or on at least one of the parallel faces. The identifying compound has at least one indexed optical absorbance feature, such that spectral analysis of electromagnetic radiation propagated through the sample chamber yields the indexed optical absorbance feature. Detection of the indexed optical absorbance feature in electromagnetic radiation propagated through the sample chamber indicates to an analyte detection system whether the sample element is configured for use with the analyte detection system.
摘要翻译：样品元件包括由中间构件分隔开的第一和第二基本上平行的面。平行面和中间构件至少部分地限定了构造成保持一定体积的流体的样品室。样本元件还包括延伸穿过平行面和中间构件的光路，使得电磁辐射可以传播通过样品室。样本元件还包括设置在至少一个平行面内或之中的识别化合物。识别化合物具有至少一个索引的光吸收特征，使得通过样品室传播的电磁辐射的光谱分析产生索引的光吸收特征。通过样品室传播的电磁辐射中的指示光吸收特征的检测表明分析物检测系统是否将样品元件配置为与分析物检测系统一起使用。

10. 发明申请

US20050037482A1 Dual measurement analyte detection system 审中-公开
标题翻译：双测量分析物检测系统
公开(公告)号：US20050037482A1
公开(公告)日：2005-02-17
申请号：US10826006
申请日：2004-04-15
申请人： James Braig , Peter Rule , Kenneth Witte , Philip Hartstein , Bernhard Sterling
发明人： James Braig , Peter Rule , Kenneth Witte , Philip Hartstein , Bernhard Sterling
IPC分类号： A61B5/00 , C12M1/34
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546
摘要： An analyte detection system is configured to measure concentrations of at least first and second analytes in a single material sample supported by a sample element. The measurement of a second analyte can be conditioned on a quantitative or qualitative result of the first measurement. In one embodiment, the first analyte is glucose and the second analyte is a ketone. According to such an embodiment the ketone is measured if the result of the glucose measurement exceeds a previously-specified value or falls outside of a previously-specified range.
摘要翻译：分析物检测系统被配置为测量由样品元素支持的单个材料样品中的至少第一和第二分析物的浓度。第二分析物的测量可以对第一次测量的定量或定性结果进行调节。在一个实施方案中，第一分析物是葡萄糖，第二分析物是酮。根据这样的实施方案，如果葡萄糖测量结果超过预先规定的值或者超出预先规定的范围，则测量酮。

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