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1. 发明授权

US08834780B2 Hydrodynamic spinning of polymer fiber in coaxial laminar flows 有权
标题翻译：聚合物纤维在同轴层流中的流体动力学纺丝
公开(公告)号：US08834780B2
公开(公告)日：2014-09-16
申请号：US12920066
申请日：2009-03-02
申请人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
发明人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
IPC分类号： B29C63/06 , D01D5/24 , A61L27/52 , D01D5/38 , D01D5/28
CPC分类号： D01D5/28 , A61L27/52 , D01D5/24 , D01D5/38
摘要： A polymer fiber is formed by hydrodynamic spinning. Fluids are forced to flow through a conduit to form a laminar flow comprising three or more layers of generally coaxial fluid flows, at respective flow rates selected to define a cross-section of a tubular middle layer of the fluid flows. The middle layer comprises a cross-linkable polymer precursor. Another layer of the fluid flows comprise a cross-linking agent. The polymer precursor, cross-linking agent and fluids are selected to prevent substantial diffusion of the polymer precursor away from the middle layer, and to allow a portion of the cross-linking agent to diffuse from the another layer into the middle layer to facilitate cross-linking of the polymer precursor in the middle layer to form a tubular polymer layer in a polymer fiber. The polymer layer thus has a cross-section generally corresponding to the cross-section of the middle layer.
摘要翻译：聚合物纤维通过流体动力纺丝形成。流体被迫流过导管以形成包含三层或更多层大体上同轴的流体流的层流，其各自的流速被选择为限定流体流的管状中间层的横截面。中间层包含可交联的聚合物前体。流体流的另一层包含交联剂。选择聚合物前体，交联剂和流体以防止聚合物前体远离中间层的实质性扩散，并且允许一部分交联剂从另一层扩散到中间层以促进交叉在中间层中连接聚合物前体以在聚合物纤维中形成管状聚合物层。聚合物层因此具有一般对应于中间层的横截面的横截面。

2. 发明申请

US20110006453A1 HYDRODYNAMIC SPINNING OF POLYMER FIBER IN COAXIAL LAMINAR FLOWS 有权
标题翻译：聚合纤维在同轴层流中的水动力纺丝
公开(公告)号：US20110006453A1
公开(公告)日：2011-01-13
申请号：US12920066
申请日：2009-03-02
申请人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
发明人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
IPC分类号： B29C63/06
CPC分类号： D01D5/28 , A61L27/52 , D01D5/24 , D01D5/38
摘要： A polymer fiber is formed by hydrodynamic spinning. Fluids are forced to flow through a conduit to form a laminar flow comprising three or more layers of generally coaxial fluid flows, at respective flow rates selected to define a cross-section of a tubular middle layer of the fluid flows. The middle layer comprises a cross-linkable polymer precursor. Another layer of the fluid flows comprise a cross-linking agent. The polymer precursor, cross-linking agent and fluids are selected to prevent substantial diffusion of the polymer precursor away from the middle layer, and to allow a portion of the cross-linking agent to diffuse from the another layer into the middle layer to facilitate cross-linking of the polymer precursor in the middle layer to form a tubular polymer layer in a polymer fiber. The polymer layer thus has a cross-section generally corresponding to the cross-section of the middle layer.
摘要翻译：聚合物纤维通过流体动力纺丝形成。流体被迫流过导管以形成包含三层或更多层大体上同轴的流体流的层流，其各自的流速被选择为限定流体流的管状中间层的横截面。中间层包含可交联的聚合物前体。流体流的另一层包含交联剂。选择聚合物前体，交联剂和流体以防止聚合物前体远离中间层的实质性扩散，并且允许一部分交联剂从另一层扩散到中间层以促进交叉在中间层中连接聚合物前体以在聚合物纤维中形成管状聚合物层。聚合物层因此具有一般对应于中间层的横截面的横截面。

3. 发明授权

US08003380B2 High throughput cell-based assays fabricated with integrated silicon and cell culture technologies 有权
标题翻译：采用集成硅和细胞培养技术制造的高通量基于细胞的测定
公开(公告)号：US08003380B2
公开(公告)日：2011-08-23
申请号：US11325609
申请日：2006-01-04
申请人： Shyi Herng Kan , Jackie Y. Ying , Hanry Yu , Karl Schumacher , Susanne San San Ng , Wanxin Sun
发明人： Shyi Herng Kan , Jackie Y. Ying , Hanry Yu , Karl Schumacher , Susanne San San Ng , Wanxin Sun
IPC分类号： C12M1/12
CPC分类号： C12N5/0068 , B01L3/5085 , B01L2300/069 , B01L2300/0829 , B01L2300/0887 , C12M23/20 , C12M23/34 , C12M25/02 , C12N2533/10 , C12N2533/54 , C12N2535/10
摘要： The present invention relates to articles and methods involving porous materials (e.g., membranes) which may interact with species, such as biological molecules, cells, etc., whereby the species may adhere to or become immobilized with respect to a surface of the porous material or an adhesion layer coating the porous surface. The porous material may be capable of attaching species with control over the positioning and spatial distribution of the species across the surface of the material. Such articles and methods may be useful in, for example, biological assays, biological sensors, or in the culturing of biological cells.
摘要翻译：本发明涉及涉及可与物种如生物分子，细胞等相互作用的多孔材料（例如膜）的制品和方法，由此该物质可能相对于多孔材料的表面粘附或变得固定或涂覆多孔表面的粘附层。多孔材料可以能够附着物质以控制物质在材料表面上的定位和空间分布。这样的制品和方法可用于例如生物测定，生物传感器或生物细胞的培养。

4. 发明申请

US20110129924A1 Porous Polymeric Articles 审中-公开
标题翻译：多孔聚合物
公开(公告)号：US20110129924A1
公开(公告)日：2011-06-02
申请号：US12308960
申请日：2006-09-12
申请人： Jackie Y. Ying , Edwin Pei Yong Chow , Jeremy Ming Hock Loh , Karl Schumacher
发明人： Jackie Y. Ying , Edwin Pei Yong Chow , Jeremy Ming Hock Loh , Karl Schumacher
IPC分类号： C12N5/071
CPC分类号： A61L27/56 , B33Y80/00
摘要： Porous polymeric articles, and more specifically, porous polymeric articles for tissue engineering and organ replacement, are described. In some embodiments, methods described herein include use of a polymer-solvent system (e.g., phase inversion) to generate porosity in a structure. The process may include formation of a structure precursor material including a first crosslinkable component and a second component that can be precipitated in a precipitation medium. The structure precursor material may be shaped into a three-dimensional shape by a suitable technique such as three-dimensional printing. Upon shaping of the structure precursor material, at least a portion of the first component may be crosslinked. The structure may then be contacted with a precipitation medium to remove the precursor solvent from the structure, which can cause the second polymer component to precipitate and form a porous structure containing a network of uniform pores. In some embodiments, the porous structure is constructed and arranged for use as a template for ultrafiltration, cell growth, and/or for forming complex, biomimetic, porous biohybrid organs, where living cells can be immobilized and perform their normal physiological functions.
摘要翻译：描述了多孔聚合物制品，更具体地说，用于组织工程和器官置换的多孔聚合物制品。在一些实施方案中，本文所述的方法包括使用聚合物 - 溶剂体系（例如相转化）以在结构中产生孔隙。该方法可以包括形成包含可在沉淀介质中沉淀的第一可交联组分和第二组分的结构前体材料。结构前体材料可以通过诸如三维印刷之类的合适技术成形为三维形状。在结构前体材料成型时，第一组分的至少一部分可以是交联的。然后可以将结构与沉淀介质接触以从结构中除去前体溶剂，这可使第二聚合物组分沉淀并形成含有均匀孔网络的多孔结构。在一些实施方案中，多孔结构被构造和布置为用作超滤，细胞生长和/或形成复合物，仿生性，多孔生物杂交器官的模板，其中活细胞可被固定并执行其正常的生理功能。

5. 发明申请

US20100240117A1 THREE DIMENSIONAL FABRICATION OF BIOCOMPATIBLE STRUCTURES IN ANATOMICAL SHAPES AND DIMENSIONS FOR TISSUE ENGINEERING AND ORGAN REPLACEMENT 审中-公开
标题翻译：用于组织工程和组织替代的解剖形状和尺寸中生物化学结构的三维制造
公开(公告)号：US20100240117A1
公开(公告)日：2010-09-23
申请号：US12749831
申请日：2010-03-30
申请人： Jackie Y. Ying , Shyi Herng Kan , Jeremy Ming Hock Loh , Karl Schumacher , Tseng-Ming Hsieh
发明人： Jackie Y. Ying , Shyi Herng Kan , Jeremy Ming Hock Loh , Karl Schumacher , Tseng-Ming Hsieh
IPC分类号： C12M3/00 , C12M1/00
CPC分类号： A61L27/38 , A61L27/56 , B33Y80/00 , C12N5/0068 , C12N2533/30
摘要： Methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, biocompatible structures formed by three-dimensional fabrication, are described. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three-dimensional and can mimic the shapes and dimensions of tissues and/or organs, including the microarchitecture and porosities of the tissues and organs. Pores in the structure may allow delivery of molecules across the structure, and may facilitate cell migration and/or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal and/or may be used ex vivo as bioartificial assist devices.
摘要翻译：描述了涉及用于组织工程和器官置换的生物相容性结构的方法和装置，更具体地，涉及通过三维制造形成的生物相容性结构。在一些实施方案中，生物相容性结构是可用作组织工程模板和/或作为人造器官的细胞的支架。结构可以是三维的并且可以模拟组织和/或器官的形状和尺寸，包括组织和器官的微结构和孔隙率。结构中的孔可以允许跨结构传递分子，并且可以促进细胞迁移和/或结构与其宿主环境之间的结缔组织的产生。本发明的结构可以植入哺乳动物和/或作为生物人造辅助装置离体使用。

6. 发明申请

US20120184940A1 BIOARTIFICIAL KIDNEYS 审中-公开
标题翻译：生物科学家
公开(公告)号：US20120184940A1
公开(公告)日：2012-07-19
申请号：US13499490
申请日：2010-10-04
申请人： Jackie Y. Ying , Edwin Pei Yong Chow , Jeremy C.M. Teo , Karl Schumacher , Jeremy Ming Hock Loh , Rosa Yue Qi , Qunya Ong
发明人： Jackie Y. Ying , Edwin Pei Yong Chow , Jeremy C.M. Teo , Karl Schumacher , Jeremy Ming Hock Loh , Rosa Yue Qi , Qunya Ong
IPC分类号： A61M1/36 , A61M1/16
CPC分类号： B01D63/085 , A61F2/022 , A61M1/14 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M2205/3331 , A61M2209/088 , B01D61/145 , B01D69/141 , B01D2319/025 , B01D2319/06 , C12M23/54 , C12M25/02 , C12M29/04
摘要： The present invention generally relates to improved bioartificial kidneys (BAKs), and in certain embodiments to improved bioartificial kidneys that are portable and/or wearable by a user. In some embodiments, the BAKs may comprise an ultrafiltration unit and a reabsorption unit. The reabsorption unit may contain a reabsorption membrane having a layer of renal proximal tubule cells disposed thereon, where the renal proximal tubule cells selectively allow solutes to pass through the reabsorption membrane. In some embodiments, at least the reabsorption unit may be configured as a substantially flat-plate filtration device, which can impart advantageous properties such as improved maintenance of the renal proximal tubule cell layer, more facile monitoring of the renal proximal tubule cell layer as well as enhanced profile for wearability.
摘要翻译：本发明通常涉及改进的生物人造肾（BAK），并且在某些实施方案中涉及用户可携带和/或可穿戴的改进的生物人造肾。在一些实施方案中，BAK可以包括超滤单元和再吸收单元。再吸收单元可以包含其上设置有肾近端小管细胞层的再吸收膜，其中肾近端小管细胞选择性地允许溶质通过再吸收膜。在一些实施方案中，至少再吸收单元可以被配置为基本上平板的过滤装置，其可以赋予有利的性质，例如改善肾近端小管细胞层的维持性，更容易地监测肾近端小管细胞层作为耐磨性的增强型材。

7. 发明授权

US07718351B2 Three-dimensional fabrication of biocompatible structures in anatomical shapes and dimensions for tissue engineering and organ replacement 失效
标题翻译：用于组织工程和器官置换的解剖学形状和尺寸的生物相容性结构的三维制造
公开(公告)号：US07718351B2
公开(公告)日：2010-05-18
申请号：US11375375
申请日：2006-03-14
申请人： Jackie Y. Ying , Shyi-Herng Kan , Jeremy Loh Ming Hock , Karl Schumacher , James Tseng-Ming Hsieh
发明人： Jackie Y. Ying , Shyi-Herng Kan , Jeremy Loh Ming Hock , Karl Schumacher , James Tseng-Ming Hsieh
IPC分类号： G03F1/00
CPC分类号： A61L27/38 , A61L27/56 , B33Y80/00 , C12N5/0068 , C12N2533/30
摘要： Methods and apparatuses involving biocompatible structures for tissue engineering and organ replacement and, more specifically, biocompatible structures formed by three-dimensional fabrication, are described. In some embodiments, the biocompatible structures are scaffolds for cells that can be used as tissue engineering templates and/or as artificial organs. The structures may be three-dimensional and can mimic the shapes and dimensions of tissues and/or organs, including the microarchitecture and porosities of the tissues and organs. Pores in the structure may allow delivery of molecules across the structure, and may facilitate cell migration and/or generation of connective tissue between the structure and its host environment. Structures of the invention can be implanted into a mammal and/or may be used ex vivo as bioartificial assist devices.
摘要翻译：描述了涉及用于组织工程和器官置换的生物相容性结构的方法和装置，更具体地，涉及通过三维制造形成的生物相容性结构。在一些实施方案中，生物相容性结构是可用作组织工程模板和/或作为人造器官的细胞的支架。结构可以是三维的并且可以模拟组织和/或器官的形状和尺寸，包括组织和器官的微结构和孔隙率。结构中的孔可以允许跨结构传递分子，并且可以促进细胞迁移和/或结构与其宿主环境之间的结缔组织的产生。本发明的结构可以植入哺乳动物和/或作为生物人造辅助装置离体使用。

8. 发明申请

US20080079920A1 Wafer exposure device and method 审中-公开
标题翻译：晶圆曝光装置及方法
公开(公告)号：US20080079920A1
公开(公告)日：2008-04-03
申请号：US11541400
申请日：2006-09-29
申请人： Heiko Hommen , Norman Birnstein , Karl Schumacher , Jens Staecker
发明人： Heiko Hommen , Norman Birnstein , Karl Schumacher , Jens Staecker
IPC分类号： G03B27/52
CPC分类号： G03F7/7085 , G03F9/7026 , G03F9/7088 , H01L21/681
摘要： A wafer exposure device includes a wafer stage. An optical exposure system exposes a wafer on the wafer stage. A sensor block measures a distance to a wafer provided on the wafer stage. The sensor block includes a plurality of height level sensors. Each height level sensor measures and outputs height level values. The wafer exposure device compares with one another the measured height level values outputted by respective height level sensors. The wafer exposure device calculates individual sensor position offset values to be attributed to the individual height level sensors. The wafer exposure device corrects the measured height level values output by the respective height level sensors using the calculated sensor position offset values of the respective height level sensor.
摘要翻译：晶片曝光装置包括晶片台。光学曝光系统在晶片台上露出晶片。传感器块测量到设置在晶片台上的晶片的距离。传感器块包括多个高度水平传感器。每个高度传感器测量并输出高度值。晶片曝光装置将相应的高度电平传感器输出的测量高度电平值彼此进行比较。晶片曝光装置计算归因于各个高度传感器的各个传感器位置偏移值。晶片曝光装置使用计算出的相应高度传感器的传感器位置偏移值来校正由各个高度传感器输出的测量高度值。

9. 发明申请

US20060192943A1 Optimizing focal plane fitting functions for an image field on a substrate 审中-公开
标题翻译：优化基板上图像场的焦平面拟合功能
公开(公告)号：US20060192943A1
公开(公告)日：2006-08-31
申请号：US11066913
申请日：2005-02-25
申请人： William Roberts , Gerhard Kunkel , Patrick Lomtscher , Karl Schumacher
发明人： William Roberts , Gerhard Kunkel , Patrick Lomtscher , Karl Schumacher
IPC分类号： G01B9/00
CPC分类号： G03F7/70641
摘要： An exposure tool includes an illumination source, a blazed phase grating reticle, a lens system, a focus sensor configured for maintaining a focus of the lens system, a stage holding a sample, and a controller. The controller is configured to control the illumination source and a position of the blazed phase grating reticle and the lens system relative to the stage to expose the sample according to a product shot map to generate a blazed phase grating sample. The controller is configured to adjust a focus offset of the exposure tool by product shot to improve focal plane fitting based on feedback generated from an analysis of images of the blazed phase grating sample.
摘要翻译：曝光工具包括照明源，闪耀相位光栅掩模版，透镜系统，被配置为保持透镜系统的焦点的焦点传感器，保持样本的台阶和控制器。控制器被配置为控制照明源和闪耀的相位光栅掩模版和透镜系统相对于台的位置，以根据产品镜头图曝光样品以产生闪耀的相位光栅样本。控制器被配置为通过产品镜头来调整曝光工具的聚焦偏移，以根据从闪耀相位光栅样本的图像分析产生的反馈改善焦平面拟合。

10. 发明申请

US20060194130A1 Run to run control for lens aberrations 审中-公开
标题翻译：运行以运行镜头像差控制
公开(公告)号：US20060194130A1
公开(公告)日：2006-08-31
申请号：US11065931
申请日：2005-02-25
申请人： William Roberts , Gerhard Kunkel , Patrick Lomtscher , Karl Schumacher
发明人： William Roberts , Gerhard Kunkel , Patrick Lomtscher , Karl Schumacher
IPC分类号： G03B27/00 , G03C5/00 , G03B27/42
CPC分类号： G03F7/70258 , G03F7/70283 , G03F7/706
摘要： An exposure tool includes an illumination source, a blazed phase grating reticle, a reticle stage holding the blazed phase grating reticle, a lens system including at least one adjustable lens element, a wafer stage holding a sample, and a controller. The controller is configured to control the illumination source and the position of the blazed phase grating reticle and the lens system relative to the wafer stage to expose the sample to generate a blazed phase grating sample. The controller is configured to adjust the at least one adjustable lens element to compensate for aberrations of the lens system based on feedback generated from analyzing images of the blazed phase grating sample.
摘要翻译：曝光工具包括照明源，闪耀相位光栅掩模版，保持闪耀相位光栅掩模版的掩模版台，包括至少一个可调透镜元件的透镜系统，保持样品的晶片台和控制器。控制器被配置为控制照明源和闪耀相位光栅掩模版和透镜系统相对于晶片台的位置以暴露样品以产生闪耀的相位光栅样本。控制器被配置为基于从分析闪耀相位光栅样本的图像产生的反馈来调整至少一个可调透镜元件以补偿透镜系统的像差。

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