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1. 发明授权

US09687464B2 Anti-cancer agent delivery vehicles capable of improved loading 有权
公开(公告)号：US09687464B2
公开(公告)日：2017-06-27
申请号：US13634036
申请日：2011-03-11
申请人： Motoichi Kurisawa , Kun Liang , Susi Tan , Joo Eun Chung , Jackie Y. Ying
发明人： Motoichi Kurisawa , Kun Liang , Susi Tan , Joo Eun Chung , Jackie Y. Ying
IPC分类号： A61K31/33 , A61K31/282 , A61K9/00 , A61K9/107 , A61K31/337 , A61K31/353 , A61K31/704 , A61K31/7088 , A61K45/06 , A61K47/48
CPC分类号： A61K31/282 , A61K9/0019 , A61K9/1075 , A61K31/337 , A61K31/353 , A61K31/704 , A61K31/7088 , A61K45/06 , A61K47/48215 , A61K47/60 , A61K2300/00
摘要： There is provided a conjugate of a delivery agent containing a chemical moiety and at least one flavonoid. The flavonoid exists in a monomeric form or dimeric form before conjugation and remains in the monomeric form or dimeric form after conjugation. Preferably, the conjugate comprises two flavonoids. The delivery agent is conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. An anti-cancer agent delivery vehicle comprising an anti-cancer agent and the conjugate is also provided.

2. 发明授权

US08138163B2 Aldehyde conjugated flavonoid preparations 有权
标题翻译：醛共轭类黄酮制剂
公开(公告)号：US08138163B2
公开(公告)日：2012-03-20
申请号：US12952141
申请日：2010-11-22
申请人： Joo Eun Chung , Motoichi Kurisawa , Yi Yan Yang , Lang Zhuo
发明人： Joo Eun Chung , Motoichi Kurisawa , Yi Yan Yang , Lang Zhuo
IPC分类号： A61K31/787 , A61K9/50
CPC分类号： A61K31/787 , A61K47/60 , A61K47/61
摘要： There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8 position of the flavonoid A ring. The resulting conjugates may be used to form delivery vehicles to deliver high doses of flavonoids, and may also be used as delivery vehicles to deliver an additional bioactive agent.
摘要翻译：提供了在酸催化剂存在下将含有游离醛基的聚合物与类黄酮共轭的方法，使得聚合物与类黄酮A环的C6或C8位缀合。所得到的缀合物可以用于形成递送载体以递送高剂量的类黄酮，并且还可以用作递送载体以递送额外的生物活性剂。

3. 发明申请

US20110044992A1 METHOD OF DELIVERING AN ANTI-CANCER AGENT TO A CELL 有权
标题翻译：将抗癌剂递送至细胞的方法
公开(公告)号：US20110044992A1
公开(公告)日：2011-02-24
申请号：US12739668
申请日：2008-10-23
申请人： Jackie Y. Ying , Joo Eun Chung , Motoichi Kurisawa , Sean Pin Ng
发明人： Jackie Y. Ying , Joo Eun Chung , Motoichi Kurisawa , Sean Pin Ng
IPC分类号： A61K39/395 , A61P35/00 , C12N5/02
CPC分类号： A61K31/353 , A61K9/1075 , A61K39/39558 , A61K47/6919 , A61K2039/505 , B82Y5/00 , C08B37/0072 , C08G65/3317 , C08G65/3326 , C08L2203/02
摘要： There is provided a delivery vehicle comprising an anti-cancer agent together with a conjugate of a delivery agent containing a free aldehyde and a flavonoid, having the delivery agent conjugated at the C6 and/or the C8 position of the A ring of the flavonoid. The resulting delivery vehicles may be used to deliver an anti-cancer agent to a cell.
摘要翻译：提供了一种递送载体，其包含抗癌剂以及含有游离醛和类黄酮的递送剂的缀合物，其具有在类黄酮的A环的C 6和/或C 8位缀合的递送剂。所得到的递送载体可用于将抗癌剂递送至细胞。

4. 发明授权

US08834780B2 Hydrodynamic spinning of polymer fiber in coaxial laminar flows 有权
标题翻译：聚合物纤维在同轴层流中的流体动力学纺丝
公开(公告)号：US08834780B2
公开(公告)日：2014-09-16
申请号：US12920066
申请日：2009-03-02
申请人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
发明人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
IPC分类号： B29C63/06 , D01D5/24 , A61L27/52 , D01D5/38 , D01D5/28
CPC分类号： D01D5/28 , A61L27/52 , D01D5/24 , D01D5/38
摘要： A polymer fiber is formed by hydrodynamic spinning. Fluids are forced to flow through a conduit to form a laminar flow comprising three or more layers of generally coaxial fluid flows, at respective flow rates selected to define a cross-section of a tubular middle layer of the fluid flows. The middle layer comprises a cross-linkable polymer precursor. Another layer of the fluid flows comprise a cross-linking agent. The polymer precursor, cross-linking agent and fluids are selected to prevent substantial diffusion of the polymer precursor away from the middle layer, and to allow a portion of the cross-linking agent to diffuse from the another layer into the middle layer to facilitate cross-linking of the polymer precursor in the middle layer to form a tubular polymer layer in a polymer fiber. The polymer layer thus has a cross-section generally corresponding to the cross-section of the middle layer.
摘要翻译：聚合物纤维通过流体动力纺丝形成。流体被迫流过导管以形成包含三层或更多层大体上同轴的流体流的层流，其各自的流速被选择为限定流体流的管状中间层的横截面。中间层包含可交联的聚合物前体。流体流的另一层包含交联剂。选择聚合物前体，交联剂和流体以防止聚合物前体远离中间层的实质性扩散，并且允许一部分交联剂从另一层扩散到中间层以促进交叉在中间层中连接聚合物前体以在聚合物纤维中形成管状聚合物层。聚合物层因此具有一般对应于中间层的横截面的横截面。

5. 发明授权

US08410165B2 Aldehyde conjugated flavonoid preparations 有权
标题翻译：醛共轭类黄酮制剂
公开(公告)号：US08410165B2
公开(公告)日：2013-04-02
申请号：US13243929
申请日：2011-09-23
申请人： Joo Eun Chung , Motoichi Kurisawa , Yi Yan Yang , Lang Zhuo
发明人： Joo Eun Chung , Motoichi Kurisawa , Yi Yan Yang , Lang Zhuo
IPC分类号： A61K31/35 , A61K31/715
CPC分类号： A61K31/787 , A61K47/60 , A61K47/61
摘要： There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8 position of the flavonoid A ring. The resulting conjugates may be used to form delivery vehicles to deliver high doses of flavonoids, and may also be used as delivery vehicles to deliver an additional bioactive agent.
摘要翻译：提供了在酸催化剂存在下将含有游离醛基的聚合物与类黄酮共轭的方法，使得聚合物与类黄酮A环的C6或C8位缀合。所得到的缀合物可以用于形成递送载体以递送高剂量的类黄酮，并且还可以用作递送载体以递送额外的生物活性剂。

6. 发明申请

US20120288564A1 Interpenetrating polymer network comprising fibrin 有权
标题翻译：包含纤维蛋白的互穿聚合物网络
公开(公告)号：US20120288564A1
公开(公告)日：2012-11-15
申请号：US13068481
申请日：2011-05-11
申请人： Motoichi Kurisawa , Fan Lee
发明人： Motoichi Kurisawa , Fan Lee
IPC分类号： A61K9/00 , A61K38/36 , C12N5/02 , C12P21/06
CPC分类号： A61K9/00 , A61K38/363 , A61K38/4833 , A61L27/225 , A61L27/3808 , A61L27/52 , C12N5/0068 , C12N5/069 , C12N2533/56 , C12N2533/80 , C12N2537/10 , C12P21/00 , C12P21/06 , C12Y111/01007
摘要： There is provided a method of forming a hydrogel, the method comprising: providing a mixture of a polymer comprising a cross-linkable pendant phenolic group, peroxidase, H2O2, fibrinogen, and thrombin, at concentration sufficient to enzymatically cross-link the polymer and to cleave the fibrinogen to yield fibrin; and allowing the mixture to form a hydrogel. There is also provided a hydrogel comprising a cross-linked network of a polymer interpenetrated by fibrin fibers, the polymer cross-linked by oxidative coupling between phenolic groups pendant on the polymer.
摘要翻译：提供了形成水凝胶的方法，该方法包括：提供包含可交联的侧基酚基，过氧化物酶，H 2 O 2，纤维蛋白原和凝血酶的聚合物的混合物，其浓度足以使聚合物酶促交联，并且切断纤维蛋白原产生纤维蛋白; 并使混合物形成水凝胶。还提供了包含由纤维蛋白纤维互穿的聚合物的交联网络的水凝胶，该聚合物通过在聚合物上悬挂的酚基之间的氧化偶联而交联。

7. 发明申请

US20120070433A1 FLAVONOID HYDROGEL 有权
公开(公告)号：US20120070433A1
公开(公告)日：2012-03-22
申请号：US13375097
申请日：2010-05-17
申请人： Motoichi Kurisawa , Fan Lee , Joo Eun Chung , Pui Yik Chan
发明人： Motoichi Kurisawa , Fan Lee , Joo Eun Chung , Pui Yik Chan
IPC分类号： A61K39/395 , C12N5/09 , C12P19/26 , A61K31/738 , C12N11/10
CPC分类号： A61K31/353 , A61K9/0024 , A61K31/015 , A61K31/05 , A61K31/738 , A61K47/61 , A61K47/6903 , A61L27/54 , C08J3/075 , C08J2397/00 , C12P17/06 , C12P19/26
摘要： There is provided methods for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid including a method for producing a hydrogel that is capable of adhesion of cells and which comprises enzymatically cross-linked conjugates of a hydrogel forming agent and a flavonoid. There is also provided a method for producing a hydrogel comprising conjugates of a hydrogel forming agent and a flavonoid without the addition of an exogenous peroxide or peroxidase or without the addition of an exogenous peroxide. Hydrogels produced by such methods and methods of using the hydrogels are also described herein.
摘要翻译：提供了包含水凝胶形成剂和类黄酮的缀合物的水凝胶的方法，包括能够粘附细胞的水凝胶的制造方法，其包含水凝胶形成剂和类黄酮的酶交联的缀合物。还提供了一种制备水凝胶的方法，其包括水凝胶形成剂和类黄酮的缀合物，而不加入外源性过氧化物酶或过氧化物酶或不加入外源过氧化物。本文还描述了通过这些使用水凝胶的方法和方法生产的水凝胶。

8. 发明申请

US20120016015A1 ALDEHYDE CONJUGATED FLAVONOID PREPARATIONS 有权
标题翻译： ALDEHYDE CONJUGATED FLAVONOID制剂
公开(公告)号：US20120016015A1
公开(公告)日：2012-01-19
申请号：US13243929
申请日：2011-09-23
申请人： Joo Eun Chung , Motoichi Kurisawa , Yi Yan Yang , Lang Zhuo
发明人： Joo Eun Chung , Motoichi Kurisawa , Yi Yan Yang , Lang Zhuo
IPC分类号： A61K31/352 , A61P43/00
CPC分类号： A61K31/787 , A61K47/60 , A61K47/61
摘要： There is provided a method of conjugating a polymer containing a free aldehyde group with a flavonoid in the presence of an acid catalyst, such that the polymer is conjugated to the C6 or C8 position of the flavonoid A ring. The resulting conjugates may be used to form delivery vehicles to deliver high doses of flavonoids, and may also be used as delivery vehicles to deliver an additional bioactive agent.
摘要翻译：提供了在酸催化剂存在下将含有游离醛基的聚合物与类黄酮共轭的方法，使得聚合物与类黄酮A环的C6或C8位缀合。所得到的缀合物可以用于形成递送载体以递送高剂量的类黄酮，并且还可以用作递送载体以递送额外的生物活性剂。

9. 发明申请

US20110006453A1 HYDRODYNAMIC SPINNING OF POLYMER FIBER IN COAXIAL LAMINAR FLOWS 有权
标题翻译：聚合纤维在同轴层流中的水动力纺丝
公开(公告)号：US20110006453A1
公开(公告)日：2011-01-13
申请号：US12920066
申请日：2009-03-02
申请人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
发明人： Jackie Y. Ying , Min Hu , Rensheng Deng , Karl Schumacher , Motoichi Kurisawa
IPC分类号： B29C63/06
CPC分类号： D01D5/28 , A61L27/52 , D01D5/24 , D01D5/38
摘要： A polymer fiber is formed by hydrodynamic spinning. Fluids are forced to flow through a conduit to form a laminar flow comprising three or more layers of generally coaxial fluid flows, at respective flow rates selected to define a cross-section of a tubular middle layer of the fluid flows. The middle layer comprises a cross-linkable polymer precursor. Another layer of the fluid flows comprise a cross-linking agent. The polymer precursor, cross-linking agent and fluids are selected to prevent substantial diffusion of the polymer precursor away from the middle layer, and to allow a portion of the cross-linking agent to diffuse from the another layer into the middle layer to facilitate cross-linking of the polymer precursor in the middle layer to form a tubular polymer layer in a polymer fiber. The polymer layer thus has a cross-section generally corresponding to the cross-section of the middle layer.
摘要翻译：聚合物纤维通过流体动力纺丝形成。流体被迫流过导管以形成包含三层或更多层大体上同轴的流体流的层流，其各自的流速被选择为限定流体流的管状中间层的横截面。中间层包含可交联的聚合物前体。流体流的另一层包含交联剂。选择聚合物前体，交联剂和流体以防止聚合物前体远离中间层的实质性扩散，并且允许一部分交联剂从另一层扩散到中间层以促进交叉在中间层中连接聚合物前体以在聚合物纤维中形成管状聚合物层。聚合物层因此具有一般对应于中间层的横截面的横截面。

10. 发明申请

US20090169532A1 CURABLE BONE CEMENT 审中-公开
标题翻译：可固化骨水泥
公开(公告)号：US20090169532A1
公开(公告)日：2009-07-02
申请号：US12280777
申请日：2006-02-27
申请人： Jackie Y. Ying , Shona Pek , Motoichi Kurisawa , Joo Eun Chung
发明人： Jackie Y. Ying , Shona Pek , Motoichi Kurisawa , Joo Eun Chung
IPC分类号： A61K35/14 , A61K47/42 , A61K47/36 , A61K47/34
CPC分类号： A61L24/001 , A61L24/0094 , A61L27/48 , A61L27/50 , A61L2430/02
摘要： The present invention describes a curable bone cement. The cement comprises a curable polymeric binder and a filler, and is capable of curing without substantial evolution of heat on exposure to a curing agent. The binder comprises phenol groups which are capable of reacting in order to cure the cement.
摘要翻译：本发明描述了可固化骨粘固剂。水泥包含可固化的聚合物粘合剂和填料，并且能够在暴露于固化剂时固化而没有显着的热释放。粘合剂包括能够反应以便固化水泥的苯酚基团。

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