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1. 发明授权

US06680284B1 Method for producing powdery particle-reduced formulations with the aid of compressed gases 失效
标题翻译：借助于压缩气体生产粉末颗粒减少配方的方法
公开(公告)号：US06680284B1
公开(公告)日：2004-01-20
申请号：US10030035
申请日：2002-01-03
申请人： Jürgen Heidlas , Martin Ober , Johann Wiesmüller
发明人： Jürgen Heidlas , Martin Ober , Johann Wiesmüller
IPC分类号： A01N2512
CPC分类号： A61K9/14 , A61K9/1617 , Y10S514/959 , Y10S516/922 , Y10S516/928
摘要： For the preparation of pulverulent particle-reduced formulations with the aid of compressed gases, the solid compound to be formulated, a poorly soluble and usually bioactive active compound, is homogeneously ground together with 10-99% by weight (based on the formulation) of a carrier material which is essentially soluble in the compressed gas mixture, in the presence of compressed gas or mixtures thereof in a stirred autoclave having a mechanical grinding device at process temperatures between 10 and 200° C. and at process pressures between 5 and 500 bar, and in a second process stage the compressed gas mixture, usually dimethyl ether, pure propane and/or carbon dioxide, is expanded by lowering the pressure and separated off from the homogenate, which can also be present as a melt. Finally, the pulverulent particle-reduced formulation is recovered from the homogenate obtained, with which significant improvements in the solubility properties and in particular in the bioavailability of originally poorly soluble and nonsoluble compounds are to be achieved.
摘要翻译：为了在压缩气体的帮助下制备粉末颗粒减少的制剂，将待配制的固体化合物，难溶性和通常为生物活性的活性化合物与10-99重量％（基于制剂）均匀地研磨在压缩气体或其混合物的存在下，基本上可溶于压缩气体混合物的载体材料在具有机械研磨装置的搅拌高压釜中，处理温度为10-200℃，过程压力为5至500巴，并且在第二工艺阶段，压缩气体混合物，通常是二甲醚，纯丙烷和/或二氧化碳，通过降低压力而膨胀，并从匀浆中分离，其也可以熔体形式存在。最后，从获得的匀浆中回收粉末颗粒减少的制剂，其中可以实现溶解性能，特别是原始难溶性和不溶性化合物的生物利用度的显着改善。

2. 发明授权

US07713581B2 Method of impregnating a carrier a matrix with solid and/or liquid compounds using compressed gases, and materials thus impregnated 有权
标题翻译：用固体和/或液体化合物使用压缩气体浸渍载体载体的方法以及如此浸渍的材料
公开(公告)号：US07713581B2
公开(公告)日：2010-05-11
申请号：US11598484
申请日：2006-11-09
申请人： Jürgen Heidlas , Zhengfeng Zhang , Kurt Stork , Johann Wiesmüller , Martin Ober , Johann Obersteiner
发明人： Jürgen Heidlas , Zhengfeng Zhang , Kurt Stork , Johann Wiesmüller , Martin Ober , Johann Obersteiner
IPC分类号： B05D7/00 , B05D3/04 , B01J13/02 , A61J3/07
CPC分类号： C08J9/122 , A01C1/06 , A01N25/00 , A23K40/00 , A23L5/00 , A23L5/30 , A23V2002/00 , C08J2201/032 , C08J2203/06 , C08J2203/08 , Y02P20/544 , A23V2300/44
摘要： The invention relates to a method for impregnating a support matrix with solid and/or liquid compounds using a compressed gas or a compressed mixture of gases at densities ranging from 0.15 to 1.3 kg/l and at least two unsymmetrical pressure changes (pulsations). The method is further characterized in that both a multitude of impregnating substances such as biologically active compounds, technical materials or metal-organic compounds, as well as support matrices of biological origin and organic or inorganic substances can be used that have large inner surfaces and/or inner surfaces that are difficult to access.
摘要翻译：本发明涉及一种使用压缩气体或压缩的浓度为0.15-1.3kg / l和至少两个不对称压力变化（脉动）的气体的固体和/或液体化合物浸渍载体基质的方法。该方法的特征还在于，可以使用诸如生物活性化合物，工业材料或金属有机化合物的许多浸渍物质，以及生物来源的支持基质和有机或无机物质，其具有大的内表面和/ 或难以进入的内表面。

3. 发明授权

US06288130B1 Oil-free glycerophospholipid formulations and method for the production thereof 失效
标题翻译：无油甘油磷脂制剂及其制备方法
公开(公告)号：US06288130B1
公开(公告)日：2001-09-11
申请号：US09381527
申请日：1999-09-20
申请人： Jürgen Heidlas , Karl-Heinz Zirzow , Johann Wiesmüller , Martin Ober , Franz Michlbauer , Jürgen Graefe
发明人： Jürgen Heidlas , Karl-Heinz Zirzow , Johann Wiesmüller , Martin Ober , Franz Michlbauer , Jürgen Graefe
IPC分类号： B01F1714
CPC分类号： A61K8/062 , A23J7/00 , A61K8/06 , A61K8/345 , A61K8/553 , A61K2800/52 , A61Q19/00 , C07F9/103
摘要： The invention relates to oil-free glycerophospholipid formulations which contain a homogeneous mixture of glycerophospholipids and an anhydrous, liquid polyol compound such as glycerol in a molar ratio of 1:0.1 to 1. These formulations are produced, eg, by extracting a starting material consisting of an oil-containing glycerophospholipid (mixture) and the polyol component with a compressed hydrocarbon (mixture) in a rectifying column. The oil-free formulation can be obtained from the melt at the bottom of the column in the form of free-flowing powder, which is ideally suited for stabilising oil-in-water emulsions.
摘要翻译：本发明涉及无油甘油磷脂制剂，其含有摩尔比为1:0.1至1的甘油磷脂和无水液体多元醇化合物如甘油的均匀混合物。这些制剂例如通过提取包含的含油甘油磷脂（混合物）和多元醇组分与精馏塔中的压缩烃（混合物）混合。无油配方可以从柱底部的熔体以自由流动的粉末形式获得，其理想地适用于稳定水包油乳液。

4. 发明授权

US07186768B2 Silane-modified oxidic or siliceous filler, process for its production and its use 有权
标题翻译：硅烷改性的氧化或硅质填料，其生产和使用的过程
公开(公告)号：US07186768B2
公开(公告)日：2007-03-06
申请号：US10423901
申请日：2003-04-25
申请人： Karsten Korth , Kurt Eichenauer , Reimund Pieter , Oliver Klockmann , Jürgen Heidlas , Martin Ober , Rudolf Zobel
发明人： Karsten Korth , Kurt Eichenauer , Reimund Pieter , Oliver Klockmann , Jürgen Heidlas , Martin Ober , Rudolf Zobel
IPC分类号： C08K3/18
CPC分类号： C08K9/06 , A61K8/25 , A61K8/585 , A61K2800/412 , A61K2800/612 , A61Q11/00 , A61Q19/00 , C01P2004/54 , C01P2004/61 , C01P2006/12 , C01P2006/14 , C01P2006/16 , C08K3/013 , C08K3/22 , C08K3/34 , C09C1/3036 , C09C1/3081 , C09C1/3684 , C09C3/12 , C09D7/62 , C09D7/69 , C09D11/03 , C08L21/00
摘要： Silane-modified oxidic or siliceous filler with a bead fraction below 75 μm of less than 15 wt. % and a median particle size distribution between of 150 to 500 μm, which is produced by the reaction of at least one microbeaded or microgranular, oxidic or siliceous filler in a compressed gas with at least one silane. The silane-modified oxidic or siliceous fillers are used in rubber compounds.
摘要翻译：硅烷改性的氧化或硅质填料，珠粒分数低于75μm，小于15wt。％和通过至少一种微珠或微粒，氧化或硅质填料在压缩气体中与至少一种硅烷反应而产生的150至500μm之间的中值粒度分布。硅烷改性的氧化或硅质填料用于橡胶混合物中。

5. 发明授权

US09191881B2 Wireless network for automation, realtime and/or industrial applications 有权
标题翻译：用于自动化，实时和/或工业应用的无线网络
公开(公告)号：US09191881B2
公开(公告)日：2015-11-17
申请号：US13046499
申请日：2011-03-11
申请人： Kai Benjamins , Stefan Keller , Jörg Müller , Martin Ober , Stephan Wolf
发明人： Kai Benjamins , Stefan Keller , Jörg Müller , Martin Ober , Stephan Wolf
IPC分类号： H04W48/12 , H04W36/30 , H04W36/00 , H04W52/02 , H04W48/20 , H04W88/02 , H04W36/08 , H04W88/08 , H04W92/20
CPC分类号： H04W48/12 , H04W36/00 , H04W36/08 , H04W36/30 , H04W48/20 , H04W52/0216 , H04W88/02 , H04W88/08 , H04W92/20 , Y02D70/1222 , Y02D70/1224 , Y02D70/1242 , Y02D70/142 , Y02D70/146 , Y02D70/22
摘要： The present invention describes a wireless network, in particular for automation, realtime and/or industrial applications, having at least two access network nodes and at least one radio station for wireless communication with at least one of the at least two access network nodes, wherein each of the at least two access network nodes uses a data channel selected from a set of available selectable data channels for wireless communication with a radio station assigned to it in each case, wherein a control communication channel which is distinct from the selectable data channels is provided in addition, and each of the at least two access network nodes is embodied for wirelessly sending information messages over the control communication channel and the at least one radio station is embodied for receiving the control communication channel.
摘要翻译：本发明描述了一种无线网络，特别是对于自动化，实时和/或工业应用，具有至少两个接入网络节点和至少一个用于与所述至少两个接入网络节点中的至少一个进行无线通信的无线电台站，其中所述至少两个接入网络节点中的每一个使用从一组可用的可选数据信道中选择的数据信道，用于在每种情况下与分配给它的无线电台进行无线通信，其中与所述可选数据信道不同的控制通信信道是并且所述至少两个接入网络节点中的每一个被实现为在所述控制通信信道上无线地发送信息消息，并且所述至少一个无线电台被实现为用于接收所述控制通信信道。

6. 发明申请

US20110222510A1 Wireless Network for Automation, Realtime and/or Industrial Applications 有权
标题翻译：用于自动化，实时和/或工业应用的无线网络
公开(公告)号：US20110222510A1
公开(公告)日：2011-09-15
申请号：US13046499
申请日：2011-03-11
申请人： Kai Benjamins , Stefan Keller , Jörg Müller , Martin Ober , Stephan Wolf
发明人： Kai Benjamins , Stefan Keller , Jörg Müller , Martin Ober , Stephan Wolf
IPC分类号： H04W4/00 , H04W36/00
CPC分类号： H04W48/12 , H04W36/00 , H04W36/08 , H04W36/30 , H04W48/20 , H04W52/0216 , H04W88/02 , H04W88/08 , H04W92/20 , Y02D70/1222 , Y02D70/1224 , Y02D70/1242 , Y02D70/142 , Y02D70/146 , Y02D70/22
摘要： The present invention describes a wireless network, in particular for automation, realtime and/or industrial applications, having at least two access network nodes and at least one radio station for wireless communication with at least one of the at least two access network nodes, wherein each of the at least two access network nodes uses a data channel selected from a set of available selectable data channels for wireless communication with a radio station assigned to it in each case, wherein a control communication channel which is distinct from the selectable data channels is provided in addition, and each of the at least two access network nodes is embodied for wirelessly sending information messages over the control communication channel and the at least one radio station is embodied for receiving the control communication channel.
摘要翻译：本发明描述了一种无线网络，特别是对于自动化，实时和/或工业应用，具有至少两个接入网络节点和至少一个用于与所述至少两个接入网络节点中的至少一个进行无线通信的无线电台站，其中所述至少两个接入网络节点中的每一个使用从一组可用的可选择数据信道中选择的数据信道，用于在每种情况下与分配给它的无线电台进行无线通信，其中与所述可选数据信道不同的控制通信信道是并且所述至少两个接入网络节点中的每一个被实现为在所述控制通信信道上无线地发送信息消息，并且所述至少一个无线电台被实现为用于接收所述控制通信信道。

7. 发明申请

US20070054032A1 Method of impregnating a carrier a matrix with solid and/or liquid compounds using compressed gases, and materials thus impregnated 有权
标题翻译：用固体和/或液体化合物使用压缩气体浸渍载体载体的方法以及如此浸渍的材料
公开(公告)号：US20070054032A1
公开(公告)日：2007-03-08
申请号：US11598484
申请日：2006-11-09
申请人： Jurgen Heidlas , Zhengfeng Zhang , Kurt Stork , Johann Wiesmuller , Martin Ober , Johann Obersteiner
发明人： Jurgen Heidlas , Zhengfeng Zhang , Kurt Stork , Johann Wiesmuller , Martin Ober , Johann Obersteiner
IPC分类号： A61L33/00 , B05D1/18 , B05D3/00
CPC分类号： C08J9/122 , A01C1/06 , A01N25/00 , A23K40/00 , A23L5/00 , A23L5/30 , A23V2002/00 , C08J2201/032 , C08J2203/06 , C08J2203/08 , Y02P20/544 , A23V2300/44
摘要： The invention relates to a method for impregnating a support matrix with solid and/or liquid compounds using a compressed gas or a compressed mixture of gases at densities ranging from 0.15 to 1.3 kg/l and at least two unsymmetrical pressure changes (pulsations). The method is further characterized in that both a multitude of impregnating substances such as biologically active compounds, technical materials or metal-organic compounds, as well as support matrices of biological origin and organic or inorganic substances can be used that have large inner surfaces and/or inner surfaces that are difficult to access.
摘要翻译：本发明涉及一种使用压缩气体或压缩的浓度为0.15-1.3kg / l和至少两个不对称压力变化（脉动）的气体的固体和/或液体化合物浸渍载体基质的方法。该方法的特征还在于，可以使用诸如生物活性化合物，工业材料或金属有机化合物的许多浸渍物质，以及生物来源的支持基质和有机或无机物质，其具有大的内表面和/ 或难以进入的内表面。

8. 发明授权

US5811563A Process for the fractionation of wool wax acid mixtures 失效
$Process for the fractionation of wool wax acid mixtures$
标题翻译：羊毛蜡酸混合物分馏方法
公开(公告)号：US5811563A
公开(公告)日：1998-09-22
申请号：US614131
申请日：1996-03-12
申请人： Jurgen Heidlas , Martin Ober , Jan Cully
发明人： Jurgen Heidlas , Martin Ober , Jan Cully
IPC分类号： C07C51/43 , C11B11/00 , C11C1/00 , C07C1/00
CPC分类号： C11C1/005 , C07C51/43 , C11B11/005 , Y02W30/74
摘要： Disclosed is a process for the fractionation of wool wax acid mixtures by dissolving the starting material in a polar organic solvent (mixture). The dissolved wool wax acid mixture is treated at a temperature between -5 and 30.degree. C. and at a pressure between 10 and 70 bar with gaseous carbon dioxide and the hydroxy-fatty acids that accumulate as a solid are separated from the solution.
摘要翻译：公开了通过将原料溶解在极性有机溶剂（混合物）中来分级羊毛蜡酸混合物的方法。将溶解的羊毛蜡酸混合物在-5至30℃的温度和10至70巴之间的压力下用气态二氧化碳处理，并将作为固体积聚的羟基脂肪酸与溶液分离。

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