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1. 发明授权

US5527701A Aspergillus terreus blasticidin S deaminase, a blasticidin S deaminase gene, a vector incorporating said gene and a transformant containing said vector 失效
标题翻译：土曲霉杀稻瘟菌素S脱氨酶，杀稻瘟素S脱氨酶基因，结合所述基因的载体和含有所述载体的转化体
公开(公告)号：US5527701A
公开(公告)日：1996-06-18
申请号：US53006
申请日：1993-04-27
申请人： Isamu Yamaguchi , Makoto Kimura , Takashi Kamakura
发明人： Isamu Yamaguchi , Makoto Kimura , Takashi Kamakura
IPC分类号： C12N1/15 , C12N1/21 , C12N9/78 , C12N15/09 , C12N15/55 , C12N15/80 , C12N15/82 , C12R1/19 , C12R1/645 , C12R1/66 , C12N5/14 , C12N15/63
CPC分类号： C12N9/78 , C12N15/80 , C12N15/8209
摘要： According to the present invention, it is provided blasticidin S (hereinafter referred to as BcS) deaminase, a gene coding for the BcS deaminase, a vector incorporating the BcS deaminase gene and a transformant or a transductant transformed or transduced with the vector.It is an object of the present invention to provide BcS deaminase, a BcS deaminase gene, a vector incorporating the BcS deaminase gene and a transformant containing the vector by focusing on the fact that blasticidin S is an aminonucleoside antibiotic capable of inhibiting a protein synthesis in the wide range of organisms and is generally used as an agricultural antibiotic.It is another object of the present invention to establish expression vectors of above-mentioned BcS gene and to produce useful plants having drug resistance against specific agricultural chemicals.
摘要翻译：根据本发明，提供了杀稻瘟菌素S（以下称为BcS）脱氨酶，编码BcS脱氨酶的基因，结合有BcS脱氨酶基因的载体和转化体或与该载体转化或转导的转导体。本发明的目的是提供BcS脱氨酶，BcS脱氨酶基因，结合BcS脱氨酶基因的载体和含有该载体的转化体，其重点在于杀稻瘟素S是能够抑制蛋白质合成的氨基核苷抗体广泛的生物体，通常用作农业抗生素。本发明的另一个目的是建立上述BcS基因的表达载体并产生对特定农药具有耐药性的有用植物。

2. 发明授权

US06284286B1 Composition for prevention and extermination of plant disease 失效
标题翻译：用于预防和灭绝植物病害的组合物
公开(公告)号：US06284286B1
公开(公告)日：2001-09-04
申请号：US09115623
申请日：1998-07-14
申请人： Yutaka Arimoto , Isamu Yamaguchi , Yukio Sato , Shigeru Nomura
发明人： Yutaka Arimoto , Isamu Yamaguchi , Yukio Sato , Shigeru Nomura
IPC分类号： A01N5900
CPC分类号： A01N59/02 , A01N25/30 , A01N59/04 , A01N59/20 , Y02A50/358 , Y10S514/975 , A01N25/14 , A01N2300/00
摘要： A composition for prevention and extermination of plant disease which comprises a biocidal inorganic compound, an amphoteric surfactant, and at least one member selected from the group consisting of a nonionic surfactant and an anionic surfactant. The composition exhibits residual activity for a long period of time without phytotoxicity.
摘要翻译：一种用于预防和灭绝植物病害的组合物，其包含杀生物无机化合物，两性表面活性剂和选自非离子表面活性剂和阴离子表面活性剂中的至少一种。该组合物长时间显示残留活性而没有植物毒性。

3. 发明授权

US5750537A Use of 5HT.sub.3 antagonist to treat impotence 失效
标题翻译：使用5HT3拮抗剂治疗阳。
公开(公告)号：US5750537A
公开(公告)日：1998-05-12
申请号：US793798
申请日：1997-03-17
申请人： Kazuhiko Nomura , Isamu Yamaguchi
发明人： Kazuhiko Nomura , Isamu Yamaguchi
IPC分类号： A61K31/00 , A61K31/4178 , A61K31/4184 , A61K31/437 , A61K31/439 , A61K31/46 , A61K31/44 , A61K31/415
CPC分类号： A61K31/00 , A61K31/4178 , A61K31/4184 , A61K31/437 , A61K31/439 , A61K31/46
摘要： An impotence remedy containing a 5HT.sub.3 antagonist as the active ingredient.
摘要翻译： PCT No.PCT / JP95 / 01745 Sec。 371日期1997年3月17日 102（e）1997年3月17日PCT 1995年8月31日PCT PCT。出版物WO96 / 09069 日期1996年3月28日含有5HT3拮抗剂作为活性成分的阳ence药。

4. 发明授权

US06875461B2 Method for coating of biotissue substrates 失效
标题翻译：生物印迹底物涂层方法
公开(公告)号：US06875461B2
公开(公告)日：2005-04-05
申请号：US10474646
申请日：2002-06-17
申请人： Junzo Tanaka , Hironobu Fukuzaki , Yoichi Oka , Isamu Yamaguchi
发明人： Junzo Tanaka , Hironobu Fukuzaki , Yoichi Oka , Isamu Yamaguchi
IPC分类号： A61L27/00 , A61L27/32 , A61L27/36 , A61L21/00 , B05D3/00
CPC分类号： A61L27/3687 , A61L27/32
摘要： In a method for coating a calcium phosphate compound on a biotissue substrate or, particularly, in case the biotissue substrate is biotissue, there is provided a method for coating of biotissue substrate where the method causes no damage thereto, is very mild even to biotissues which are other than the biotissue to be coated and is able to form a uniform coat. A method for coating a calcium phosphate compound on a biotissue substrate by an alternate soaking method which is characterized in that, as the soaking solutions, there are used a solution containing a water-soluble calcium salt and borate and/or L-histidine and a phosphate solution.
摘要翻译：在生物印迹基质上涂覆磷酸钙化合物的方法中，特别是在生物印迹底物是生物组织的情况下，提供了一种涂覆生物印迹基质的方法，其中该方法不会对其造成损害，即使对于生物组织不同于待涂覆的生物组织，并且能够形成均匀的涂层。一种通过交替浸渍方法在生物组织底物上涂覆磷酸钙化合物的方法，其特征在于，作为浸泡溶液，使用含有水溶性钙盐和硼酸盐和/或L-组氨酸的溶液和磷酸盐溶液。

5. 发明申请

US20050053671A1 Alternate soaking apparatus and method for treatment of tissue materials 审中-公开
标题翻译：替代浸泡装置和组织材料处理方法
公开(公告)号：US20050053671A1
公开(公告)日：2005-03-10
申请号：US10927054
申请日：2004-08-27
申请人： Junzo Tanaka , Masataka Sakane , Hironobu Fukuzaki , Yoshikane Yokoyama , Kunihiro Ota , Masanori Kikuchi , Toshiyuki Ikoma , Isamu Yamaguchi
发明人： Junzo Tanaka , Masataka Sakane , Hironobu Fukuzaki , Yoshikane Yokoyama , Kunihiro Ota , Masanori Kikuchi , Toshiyuki Ikoma , Isamu Yamaguchi
IPC分类号： A61L27/32 , A61L27/36 , A61K33/42
CPC分类号： A61L27/3683 , A61L27/32 , A61L2430/40
摘要： The alternate soaking apparatus for treatment of tissue materials has a plurality of chemical liquid containers, a treatment container for soaking and treating a tissue material, a plurality of liquid feed tubes for providing fluid communication between the corresponding chemical liquid containers and the treatment container to introduce the respective chemical liquids into the treatment container, a liquid discharge tube for discharging the chemical liquids in the treatment container, and control means for controllably opening and closing the liquid feed tubes and the liquid discharge tube to allow the plurality of chemical liquids to be contained in the treatment container individually and alternately. A tissue material is treated using the above alternate soaking apparatus under the condition that one of chemical liquids is an aqueous solution containing calcium, and another one of chemical liquids is an aqueous solution containing phosphoric acid, so as to form a calcium phosphate compound on the surface of and in the inside of the treated tissue material. The present invention allows a ligament material and to be automatically synthesized with a calcium phosphate-based compound in a shorter time-period by a limited number of members during the operation while securing an aseptic condition.
摘要翻译：用于处理组织材料的替代浸泡装置具有多个化学液体容器，用于浸泡和处理组织材料的处理容器，用于在相应的化学液体容器和处理容器之间提供流体连通的多个液体进料管以引入进入处理容器的各化学液体，用于排出处理容器中的化学液体的液体排出管，以及用于可控地打开和关闭液体进料管和液体排出管以允许容纳多种化学液体的控制装置在处理容器中单独地和交替地。使用上述替代均热装置在化学液体是含有钙的水溶液的条件下处理组织材料，另一种化学液体是含有磷酸的水溶液，以便在其上形成磷酸钙化合物处理过的组织材料的表面和内部。本发明允许韧带材料，并且在确保无菌条件的同时在操作期间由有限数量的构件在较短的时间段内以磷酸钙基化合物自动合成。

6. 发明授权

US06660372B1 Resin composition for a non-woven fabric-like design and process for producing a molded article of a resin having a non-woven fabric like design 有权
标题翻译：用于无纺织物设计的树脂组合物和用于生产具有无纺织物设计的树脂的模塑制品的方法
公开(公告)号：US06660372B1
公开(公告)日：2003-12-09
申请号：US09535228
申请日：2000-03-24
申请人： Masaki Kondou , Isamu Yamaguchi , Masaki Mizuno , Nobuhiko Todaka
发明人： Masaki Kondou , Isamu Yamaguchi , Masaki Mizuno , Nobuhiko Todaka
IPC分类号： B32B2704
CPC分类号： C08L23/10 , C08J5/06 , C08K7/06 , C08L23/04 , C08L23/16 , C08L51/06 , C08L2203/12 , Y10T428/23986 , Y10T428/23993 , Y10T428/24994 , Y10T428/249943 , Y10T428/249945 , Y10T428/25 , Y10T428/254 , C08L2666/04 , C08L2666/24
摘要： A resin composition for producing a molded article having a surface which has an appearance of a non-woven fabric, which comprises fiber piles of carbonized polyacrylonitrile having a nitrogen content of 10% by weight or more or fiber piles of viscose rayon mass-colored with a pigment; a process for producing a molded article of a resin having a surface which has an appearance of a non-woven fabric which comprises mixing the resin composition with an uncolored resin and molding the prepared mixture; and a molded article produced by using the resin composition. The resin composition can be pelletized with stability and, when the resin composition is mixed with pellets of an uncolored resin and molded, the molded article shows excellent mechanical properties and durability for a long time, exhibits a non-woven fabric appearance with warmth and depth and has an excellent recycling property.
摘要翻译：一种用于制造具有无纺织物外观的表面的模制品的树脂组合物，其包含氮含量为10重量％以上的碳化聚丙烯腈纤维束或者具有颜料; 制造具有无纺布外观的表面的树脂成型体的制造方法，其包括将树脂组合物与未着色树脂混合并成型所制备的混合物; 和通过使用该树脂组合物制造的模制品。树脂组合物可以稳定地造粒，并且当将树脂组合物与未着色树脂的颗粒混合并模制时，模塑制品长时间显示出优异的机械性能和耐久性，表现出具有温暖和深度的无纺布外观并具有优良的回收性能。

7. 发明授权

US08207085B2 Photocatalytic titanium oxide sol, and coating composition and member using the same 有权
标题翻译：光催化氧化钛溶胶，以及涂料组合物和使用其的成分
公开(公告)号：US08207085B2
公开(公告)日：2012-06-26
申请号：US12973531
申请日：2010-12-20
申请人： Taketoshi Kuroda , Hiroyuki Izutsu , Isamu Yamaguchi , Yoshiyuki Nakanishi
发明人： Taketoshi Kuroda , Hiroyuki Izutsu , Isamu Yamaguchi , Yoshiyuki Nakanishi
IPC分类号： B01J23/02 , B01J23/04 , B01J23/70 , B01J23/72 , B01J23/48 , B01J23/50 , B01F3/04 , B01F3/06 , B01F3/12 , C09K3/30 , C01B13/00 , C01C1/00 , C01D1/02 , C01G3/02 , C01G5/00 , C01G7/00 , C01G23/047
CPC分类号： B01J35/004 , B01J23/8926 , B01J37/0219 , B01J37/10 , C01G23/047 , C01P2002/52 , C01P2006/60 , C01P2006/63 , C01P2006/80 , Y10S502/501
摘要： A photocatalytic coating composition comprising photocatalytic titanium oxide, silver, copper and a quaternary ammonium hydroxide. The photocatalytic coating composition may include a photocatalytic titanium oxide sol dispersed in a binder. Furthermore, a photocatalytic member includes a substrate having a surface coated with the photocatalytic coating composition. The photocatalyst coating composition can contain highly antibacterial silver by skillfully utilizing copper and a quaternary ammonium hydroxide, and accordingly can show an antibacterial effect not only in a dark place simply due to silver, but also a higher antibacterial effect in a conventional application of employing ultraviolet sterilization by concomitantly using the photocatalyst titanium oxide sol according to the present invention and an ultraviolet sterilizer.
摘要翻译：包含光催化氧化钛，银，铜和季铵氢氧化物的光催化涂料组合物。光催化涂料组合物可以包括分散在粘合剂中的光催化氧化钛溶胶。此外，光催化剂构件包括具有涂覆有光催化涂料组合物的表面的基材。光催化剂涂料组合物通过巧妙地利用铜和氢氧化季铵可以含有高度抗菌的银，因此，不仅在黑暗的地方仅仅由于银而具有抗菌作用，而且在常规应用紫外线中也具有较高的抗菌作用通过同时使用根据本发明的光催化剂氧化钛溶胶和紫外线灭菌器灭菌。

8. 发明授权

US07553887B2 Resin composition for automotive parts 失效
标题翻译：汽车部件用树脂组合物
公开(公告)号：US07553887B2
公开(公告)日：2009-06-30
申请号：US10645608
申请日：2003-08-22
申请人： Yoshio Sugimoto , Ikunori Sakai , Yusuke Umetani , Naoki Shoji , Keita Nagano , Takao Mizoshita , Isamu Yamaguchi
发明人： Yoshio Sugimoto , Ikunori Sakai , Yusuke Umetani , Naoki Shoji , Keita Nagano , Takao Mizoshita , Isamu Yamaguchi
IPC分类号： C08J3/00 , C08K3/08 , C08K9/00 , C08K9/04 , C08L53/00 , C08L83/00 , C09B67/00 , C09D5/38 , C09J7/02
CPC分类号： C08K9/08 , C08K3/01 , C08L53/00 , C08L23/14 , C08L2666/02 , C08L2666/04
摘要： To provide a resin composition comprising a polypropylene resin composition and an aluminum flake pigment for use as an automotive resin composition, which is excellent in mechanical strength, physical properties and flowability, and enables to produce molded products showing good metallic appearance.A composition comprising a crystalline propylene/ethylene block copolymer, an elastomeric polymer and an inorganic filler is a preferred example of the polypropylene resin composition, and aluminum flakes surface-coated with a polymer containing as constituent units acrylic acid, an acrylic acid ester, epoxylated polybutadiene and divinylbenzene are preferred examples of the aluminum flake pigment.
摘要翻译：提供一种树脂组合物，其包含聚丙烯树脂组合物和用作汽车树脂组合物的铝薄片颜料，其机械强度，物理性能和流动性优异，并且能够生产显示出良好金属外观的模制品。包含结晶丙烯/乙烯嵌段共聚物，弹性体聚合物和无机填料的组合物是聚丙烯树脂组合物的优选实例，并且表面涂覆有含有作为构成单元的丙烯酸的聚合物的铝薄片，丙烯酸酯，环氧化聚丁二烯和二乙烯基苯是铝片状颜料的优选实例。

9. 发明申请

US20090075974A1 AGENT FOR PROPHYLAXIS AND TREATMENT OF PANCREATITIS 审中-公开
标题翻译：预防和治疗胰腺炎的药物
公开(公告)号：US20090075974A1
公开(公告)日：2009-03-19
申请号：US11912737
申请日：2006-04-27
申请人： Isamu Yamaguchi , Kentaro Hamada , Yasunari Kashihara
发明人： Isamu Yamaguchi , Kentaro Hamada , Yasunari Kashihara
IPC分类号： A61K31/496 , G01N33/53 , A61K31/554 , A61K31/407 , A61K31/495 , A61K31/451 , A61K31/5415 , A61K31/438 , A61K31/55 , A61K31/519
CPC分类号： G01N33/942 , A61K31/517 , C07D401/06 , C07D471/04 , C07D471/10 , G01N33/6893 , G01N2500/04 , G01N2800/067
摘要： Disclosed is a pharmaceutical composition for prophylaxis and treatment of pancreatitis comprising a 5-HT2A receptor antagonist as an effective component, wherein the binding activity (pKi) of the 5-HT2A receptor antagonist to a 5-HT2A receptor is higher at least by 1.0 than the binding activities to a 5-HT2B receptor and a 5-HT2C receptor. Preferably the binding activity (pKi) of the 5-HT2A receptor antagonist to the 5-HT2A receptor is at least 7.0, and more preferably at least 8.0. The present invention also provides a method of identifying a candidate substance for prophylactic and therapeutic agent for pancreatitis, comprising determining whether a test substance has a 5-HT2A receptor antagonistic activity.
摘要翻译：公开了一种用于预防和治疗胰腺炎的药物组合物，其包含5-HT 2A受体拮抗剂作为有效成分，其中5-HT 2A受体拮抗剂对5-HT 2A受体的结合活性（pKi）高至少比1.0 对5-HT2B受体和5-HT2C受体的结合活性。优选地，5-HT 2A受体拮抗剂对5-HT 2A受体的结合活性（pKi）至少为7.0，更优选至少为8.0。本发明还提供了鉴定胰腺炎预防和治疗剂候选物质的方法，其包括测定检测物质是否具有5-HT 2A受体拮抗活性。

10. 发明授权

US06554606B1 Mold clamping apparatus of injection molding machine 失效
标题翻译：注塑机模具夹紧装置
公开(公告)号：US06554606B1
公开(公告)日：2003-04-29
申请号：US09667762
申请日：2000-09-22
申请人： Atsushi Koide , Hiroo Okubo , Junichi Yamashita , Isamu Yamaguchi
发明人： Atsushi Koide , Hiroo Okubo , Junichi Yamashita , Isamu Yamaguchi
IPC分类号： B29C4564
CPC分类号： B29C45/66 , B29C2045/1792
摘要： A mold clamping apparatus of an injection molding machine includes a drive mechanism. The drive mechanism includes a first drive mechanism for opening/closing a mold at high speed through advancement/retreat of a movable platen effected by means of a first drive motor unit and a first ball screw mechanism; a second drive mechanism for clamping the mold at high pressure through application of pressure to a pressing member effected by means of a second drive motor unit and a second ball screw mechanism; an engagement mechanism for engaging the movable platen with the pressing member in the course of advancement of the movable platen; and a clutch mechanism which is operated after establishment of the engagement effected by the engagement mechanism, in order to interlock the pressing member with the movable platen to thereby enable the pressing member to apply pressure to the movable platen.
摘要翻译：注塑机的模具夹紧装置包括驱动机构。驱动机构包括用于通过第一驱动马达单元和第一滚珠丝杠机构进行的可动压板的前进/后退而高速打开/关闭模具的第一驱动机构; 第二驱动机构，用于通过对通过第二驱动马达单元和第二滚珠丝杠机构进行加压的构件施加压力来在高压下夹紧模具; 接合机构，用于在可动压板的前进过程中将可动压板与压紧构件接合; 以及离合器机构，其在由接合机构实现的接合之后被操作，以便使按压构件与可动压板互锁，从而使得按压构件能够对可动压板施加压力。

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