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1. 发明申请

US20080213196A1 ENZYME CONTAINING COMPOSITION, PROCESS OF PRODUCING SAID COMPOSITION AND ITS USE 有权
标题翻译：含酶组合物，生产组合物的方法及其用途
公开(公告)号：US20080213196A1
公开(公告)日：2008-09-04
申请号：US12122027
申请日：2008-05-16
申请人： Ingo Haberlein , Rainer Guggenberger , Wolfgang Weinmann , Oliver Kappler
发明人： Ingo Haberlein , Rainer Guggenberger , Wolfgang Weinmann , Oliver Kappler
IPC分类号： A61K8/96 , A61K38/47 , A61Q11/00
CPC分类号： A61K38/47 , A61K38/482 , A61K38/488 , A61K38/4886 , A61K2300/00
摘要： The present invention relates to a composition comprising at least one biologically active protease and at least one biologically active glycosidase wherein the proteases and the glycosidases are present in an activity ratio of from 1,000,000:1 to 1:1,000,000 and wherein the composition has a total enzyme activity of at least 2 U/ml. Furthermore, the present invention relates to a process of producing such enzyme comprising composition and to processes of removing caries. Moreover, the invention relates to the use of one or more enzyme comprising compositions for producing a treatment agent for removing caries.
摘要翻译：本发明涉及包含至少一种生物活性蛋白酶和至少一种生物活性糖苷酶的组合物，其中所述蛋白酶和所述糖苷酶以1,000,000:1-1,000,000,000的活性比存在，并且其中所述组合物具有总酶至少2 U / ml的活性。此外，本发明涉及生产这种酶的方法，其包含组合物和去除龋齿的方法。此外，本发明涉及一种或多种含酶组合物用于制备用于去除龋齿的治疗剂的用途。

2. 发明申请

US20060115436A1 Enzyme containing composition, process of producing said composition and its use 审中-公开
标题翻译：含酶组合物，所述组合物的制备方法及其用途
公开(公告)号：US20060115436A1
公开(公告)日：2006-06-01
申请号：US10525294
申请日：2003-05-16
申请人： Ingo Haberlein , Rainer Guggenberger , Wolfgang Weinmann , Oliver Kappler
发明人： Ingo Haberlein , Rainer Guggenberger , Wolfgang Weinmann , Oliver Kappler
IPC分类号： A61K8/96
CPC分类号： A61K38/47 , A61K38/482 , A61K38/488 , A61K38/4886 , A61K2300/00
摘要： The present invention relates to a composition comprising at least one biologically active protease and at least one biologically active glycosidase wherein the proteases and the glycosidases are present in an activity ratio of from 1,000,000:1 to 1:1,000,000 and wherein the composition has a total enzyme activity of at least 2 U/ml. Furthermore, the present invention relates to a process of producing such an enzyme comprising composition and to processes of removing caries. Moreover, the invention relates to the use of one or more enzyme comprising compositions for producing a treatment agent for removing caries.
摘要翻译：本发明涉及包含至少一种生物活性蛋白酶和至少一种生物活性糖苷酶的组合物，其中所述蛋白酶和所述糖苷酶以1,000,000:1-1,000,000,000的活性比存在，并且其中所述组合物具有总酶至少2 U / ml的活性。此外，本发明涉及生产包含组合物的酶的方法和去除龋齿的方法。此外，本发明涉及一种或多种含酶组合物用于制备用于去除龋齿的治疗剂的用途。

3. 发明授权

US09050332B2 Enzyme containing composition, process of producing said composition and its use 有权
标题翻译：含酶组合物，所述组合物的制备方法及其用途
公开(公告)号：US09050332B2
公开(公告)日：2015-06-09
申请号：US12122027
申请日：2008-05-16
申请人： Ingo Häberlein , Rainer Guggenberger , Wolfgang Weinmann , Oliver Kappler
发明人： Ingo Häberlein , Rainer Guggenberger , Wolfgang Weinmann , Oliver Kappler
IPC分类号： A61K38/47 , A61K38/48
CPC分类号： A61K38/47 , A61K38/482 , A61K38/488 , A61K38/4886 , A61K2300/00
摘要： The present invention relates to a composition comprising at least one biologically active protease and at least one biologically active glycosidase wherein the proteases and the glycosidases are present in an activity ratio of from 1,000,000:1 to 1:1,000,000 and wherein the composition has a total enzyme activity of at least 2 U/ml. Furthermore, the present invention relates to a process of producing such enzyme comprising composition and to processes of removing caries. Moreover, the invention relates to the use of one or more enzyme comprising compositions for producing a treatment agent for removing caries.
摘要翻译：本发明涉及包含至少一种生物活性蛋白酶和至少一种生物活性糖苷酶的组合物，其中所述蛋白酶和所述糖苷酶以1,000,000:1-1,000,000,000的活性比存在，并且其中所述组合物具有总酶至少2 U / ml的活性。此外，本发明涉及生产这种酶的方法，其包含组合物和去除龋齿的方法。此外，本发明涉及一种或多种含酶组合物用于制备用于去除龋齿的治疗剂的用途。

4. 发明授权

US07097456B1 Amalgam substitute 失效
标题翻译：汞合金替代品
公开(公告)号：US07097456B1
公开(公告)日：2006-08-29
申请号：US10110941
申请日：2000-10-20
申请人： Karsten Dede , Oliver Frey , Oswald Gasser , Rainer Guggenberger , Thomas Luchterhandt , Wolfgang Weinmann , Thomas Klettke
发明人： Karsten Dede , Oliver Frey , Oswald Gasser , Rainer Guggenberger , Thomas Luchterhandt , Wolfgang Weinmann , Thomas Klettke
IPC分类号： A61C5/00
CPC分类号： A61K6/0017 , A61K6/0023 , A61K6/083 , C08L33/00
摘要： The invention relates to filling systems containing as component i) a sealing system which is capable of bonding to the tooth hard substance, as component ii) a filling material suitable for restorative dentistry, the filling system containing in addition a component iii) in component i) and/or component ii) which reduces the curing of the respective other component by disturbance of the curing mechanism only in the boundary layer between sealant and filling material such that the bonding between components i) and ii) is less than the bonding of component i) to the tooth hard substance.
摘要翻译：本发明涉及包含作为组分的密封系统的填充系统，i）能够粘合到牙齿硬质物质上的密封系统，作为组分ii）适于修复牙科的填充材料，填充系统另外还包含组分i中的组分iii））和/或组分ii），其仅通过在密封剂和填充材料之间的边界层中的固化机理的干扰来减少相应的其它组分的固化，使得组分i）和ii）之间的键合小于组分我）到牙齿硬物质。

5. 发明授权

US06908953B2 Polymerizable compositions based on epoxides 失效
标题翻译：基于环氧化物的可聚合组合物
公开(公告)号：US06908953B2
公开(公告)日：2005-06-21
申请号：US10389814
申请日：2003-03-18
申请人： Wolfgang Weinmann , Oswald Gasser , Rainer Guggenberger , Gunther Lechner , Wolfgang Soglowek , Joachim Zech
发明人： Wolfgang Weinmann , Oswald Gasser , Rainer Guggenberger , Gunther Lechner , Wolfgang Soglowek , Joachim Zech
IPC分类号： A61K6/087 , C07F7/08 , C07F7/21 , C08G59/20 , C08G59/22 , C08G59/24 , C08G59/30 , C08G59/32 , C08K3/00 , C08L63/00 , G03F7/038 , A61K6/093
CPC分类号： A61K6/0023 , A61K6/0017 , A61K6/087 , A61K6/09 , A61K6/093 , C07F7/0838 , C07F7/21 , C08G59/22 , C08G59/24 , C08G59/306 , C08G59/3218 , C08G59/3254 , C08L63/00 , G03F7/038 , C08L83/10 , C08L83/12
摘要： The present invention is directed to polymerizable dental compositions containing (a) 3 to 80 wt. % of cycloaliphatic epoxides; b) 0 to 80 wt. % of an epoxide or a mixture of epoxides which are different from a); c) 3 to 85 wt. % of a filler material; d) 0.01 to 25 wt. % of initiators, inhibitors and/or accelerators; e) 0 to 25 wt. % of auxiliary agents, the individual percentages of which are in relation to the total weight. The new polymerizable agents are particularly suited as dental material.
摘要翻译：本发明涉及可聚合牙科用组合物，其含有（a）3-80重量％％脂环族环氧化物; b）0至80wt。％的不同于a）的环氧化物或环氧化物的混合物; c）3-85重量％％的填料; d）0.01〜25重量％％的引发剂，抑制剂和/或促进剂; e）0-25重量％辅助剂的百分比，其各自的百分比与总重量有关。新的可聚合剂特别适用于牙科材料。

6. 发明授权

US06566413B1 Polymerisable materials which are based on hardenable siloxane compounds 有权
公开(公告)号：US06566413B1
公开(公告)日：2003-05-20
申请号：US09868525
申请日：2001-09-19
申请人： Wolfgang Weinmann , Joachim Zech , Oswald Gasser , Rainer Guggenberger , Gunther Eckhardt , Peter Bissinger , Wolfgang Soglowek
发明人： Wolfgang Weinmann , Joachim Zech , Oswald Gasser , Rainer Guggenberger , Gunther Eckhardt , Peter Bissinger , Wolfgang Soglowek
IPC分类号： C08F246
CPC分类号： A61K6/083 , C07F7/21 , C08L51/085
摘要： The invention relates to novel cyclic siloxane compounds of the following general formula (I): in which: n=0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 preferably 1, 2, 3, 4, 5; A=H or C1-C15 alk(en)yl, C3-C15 cycloalk(en)yl, C6-C12 aryl, C8-C18 alkaryl, where, in the said radicals, in each case one or more C atoms can be replaced by O, C═O, O(C═O), SiR2 and/or NR, R being an aliphatic radical with 1 to 7 C atoms, in which one or more C atoms can be replaced by O, C═O, and/or O(C═O); B=E or a linear, branched or polycyclic aliphatic- or aromatic-groups-containing hydrocarbon radical which links 2 to 10 of the cyclosiloxane radicals defined above, less B, to one another and contains 2 to 50 C atoms and additionally 0 to 30 other atoms from the group O, N, S, P, Si, Cl, F, Br, I and from which correspondingly 1 to 9, preferably 1 to 4 of the above defined cyclosiloxane radicals, less B, are pending; E=A or a polymerizable group G—Q—L, where on average up to 50% or less of the groups E correspond to representatives of A; G=C1-10 alk(en)ylene; Q=O, N—A or a di- or polyvalent linear, branched or cyclic alcohol, amine or aminoalcohol radical with 2 to 10 C atoms; L=an organic radical, containing a C═C double bond, with 2 to 10 C atoms; and with the proviso that no annelated siloxane ring systems can occur in (I), and also dental compositions which contain the compounds of formula (I) and/or compounds of formula (II): in which: T=independently of each other H or C1-C10 alk(en)yl, C3-C10 cycloalk(en)yl, C6-C12 aryl or C8-C8 alkaryl; N=a polymerizable group R1—R2—R3; b=0 to 500, where the proportion b may be at most 50% of the repeat units (b+c); c=1 to 1000; R1=C1-C10 alk(en)ylene; R2=O, N—T or a di- or polyvalent linear, branched or cyclic alcohol, amine or aminoalcohol radical with 2 to 10 C atoms; R3=an organic radical, containing a C═C double bond, with 3 to 10 C atoms; V=SiMe2T, SiEt2T, SiMePhT, SiPh2T.

7. 发明授权

US06245828B1 Polymerizable compositions based on epoxides 有权
标题翻译：基于环氧化物的可聚合组合物
公开(公告)号：US06245828B1
公开(公告)日：2001-06-12
申请号：US09101867
申请日：1998-09-21
申请人： Wolfgang Weinmann , Oswald Gasser , Rainer Guggenberger , Gunther Lechner , Wolfgang Soglowek , Joachim Zech
发明人： Wolfgang Weinmann , Oswald Gasser , Rainer Guggenberger , Gunther Lechner , Wolfgang Soglowek , Joachim Zech
IPC分类号： A61K6087
CPC分类号： A61K6/0023 , A61K6/0017 , A61K6/087 , A61K6/09 , A61K6/093 , C07F7/0838 , C07F7/21 , C08G59/22 , C08G59/24 , C08G59/306 , C08G59/3218 , C08G59/3254 , C08L63/00 , G03F7/038 , C08L83/10 , C08L83/12
摘要： The present invention is directed to polymerizable dental compositions containing a) 3 to 80 wt. % of cycloaliphatic epoxides; b) 0 to 80 wt. % of an epoxide or a mixture of epoxides which are different from a); c) 3 to 85 wt. % of a filer material; d) 0.01 to 25 wt. % of initiators, inhibitors and/or accelerators; e) 0 to 25 wt. % of auxiliary agents, the individual percentages of which are in relation to the total weight. The new polymerizable agents are particularly suited as dental material.
摘要翻译：本发明涉及可聚合牙科组合物，其含有a）3-80wt。％脂环族环氧化物; b）0至80wt。％的不同于a）的环氧化物或环氧化物的混合物; c）3-85重量％％的档案资料; d）0.01〜25重量％％的引发剂，抑制剂和/或促进剂; e）0-25重量％辅助剂的百分比，其各自的百分比与总重量有关。新的可聚合剂特别适用于牙科材料。

8. 发明申请

US20130030076A1 RADIATION CURABLE COMPOSITION, PROCESS OF PRODUCTION AND USE THEREOF 有权
标题翻译：辐射可固化组合物，生产工艺及其应用
公开(公告)号：US20130030076A1
公开(公告)日：2013-01-31
申请号：US13640342
申请日：2011-04-19
申请人： Wolfgang Weinmann , Joachim W. Zech , Wolf Steiger , Arne Thaler
发明人： Wolfgang Weinmann , Joachim W. Zech , Wolf Steiger , Arne Thaler
IPC分类号： C08G73/06 , C08J3/28
CPC分类号： C08K5/0025 , A61K6/10 , C08L101/025 , C08L71/02
摘要： The invention relates to a radiation curable composition for taking a dental impression comprising (A) a cationically hardenable compound comprising at least one aziridine moiety, and (B) a radiation sensitive starter, the radiation sensitive starter comprising an onium salt, a ferrocenium salt, a combination or mixture thereof.
摘要翻译：本发明涉及一种用于摄取牙印的可辐射固化组合物，其包含（A）包含至少一个氮丙啶部分的阳离子可硬化化合物和（B）辐射敏感起始剂，所述辐射敏感起始物包含鎓盐，二茂铁盐，其组合或混合物。

9. 发明授权

US07098259B2 Cationically curable dental materials 有权
标题翻译：阳离子固化牙科材料
公开(公告)号：US07098259B2
公开(公告)日：2006-08-29
申请号：US10250812
申请日：2002-01-08
申请人： Stefan Hoescheler , Wolfgang Weinmann , Andrea Stippschild , Susanne Wegner
发明人： Stefan Hoescheler , Wolfgang Weinmann , Andrea Stippschild , Susanne Wegner
IPC分类号： A61K6/08 , A61K5/00 , C08K3/22
CPC分类号： A61K6/005 , A61K6/09 , C08L83/12
摘要： The invention relates to a polymerizable dental material containing: (a) 3 to 80 wt. % of one or more cationically curable monomers; (b) 3 to 90 wt. % of one or more radio-opaque fillers; (c) 0.01 to 25 wt. % of initiators, retarders and/or accelerators, and; (d) 0 to 25 wt. % of auxiliary agents, whereby the cited percentages each refer to the total weight of the material. Filler (b) is produced by means of a melting method and is selected so that it has a refractive index of nD=1.49–1.54, so that the viscosity of the polymerizable dental material, after a period of at least 9 months during which it was stored at a temperature ranging from 20 to 25° C., has a value of +/−50 % of the initial value measured 24 hours after the polymerizable dental material was produced, and so that the polymerizable dental material has a reactivity of the type that, once polymerization is initiated, the amount of the maximum heat flux generated by the dental material equals at least 0.8 mW/mg, and this maximum heat flux is attained within a period of no longer than 60s.
摘要翻译：本发明涉及一种可聚合牙科材料，其包含：（a）3-80wt。％的一种或多种阳离子可固化的单体; （b）3-90wt。％的一种或多种不透射线填料; （c）0.01〜25wt。％的引发剂，缓凝剂和/或促进剂，以及; （d）0〜25wt。％的辅助剂，其中引用的百分比各自指材料的总重量。填料（b）通过熔融法生产，选择为具有n D D = 1.49-1.54的折射率，使得可聚合牙科材料的粘度在一段时间之后在20〜25℃的温度范围内保存至少9个月，在可聚合牙科材料生产后24小时测量的初始值的+/- 50％的值，可聚合牙科材料具有这样的反应性，其一旦聚合开始，由牙科材料产生的最大热通量的量等于至少0.8mW / mg，并且该最大热通量在不超过 60年代。

10. 发明授权

US06779656B2 Polymerizable preparations based on epoxides that contain silicon 有权
标题翻译：基于含有硅的环氧化物的可聚合制剂
公开(公告)号：US06779656B2
公开(公告)日：2004-08-24
申请号：US10169911
申请日：2002-07-11
申请人： Thomas Klettke , Wolfgang Weinmann
发明人： Thomas Klettke , Wolfgang Weinmann
IPC分类号： B65D2508
CPC分类号： B65D25/08 , A61K6/0017 , A61K6/0023 , A61K6/087 , C08G59/306 , C08G59/3254 , C08L63/00
摘要： The invention relates to polymerizable preparations which contain: (a) 3 to 80 wt. % of an epoxy or of a mixture of epoxies of general formula (I), whereby n and m, independent of one another, represent 0, 1, 2 or 3, and n+m ranges from 2 to 6, and whereby the molar mass of the epoxy or the average molar mass of the mixture of epoxies ranges from 250 to 1000 g/mol; (b) 0 to 80 wt. % of an epoxy or of a mixture of epoxies that differ from (a); (c) 3 to 85 wt. % of fillers; (d) 0.001 to 25 wt. % of initiators, retarders and/or accelerators, and; (e) 0 to 25 wt. % of auxiliary agents, whereby the specified percentages refer to the total weight of the preparation.
摘要翻译：本发明涉及可聚合制剂，其含有：（a）3-80wt。环氧基或通式（I）的环氧化合物的混合物的％，其中n和m彼此独立地表示0,1,2或3，n + m的范围为2至6，并且其中摩尔环氧树脂的质量或环氧化物混合物的平均摩尔质量为250至1000g / mol; （b）0〜80wt。％的环氧树脂或不同于（a）的环氧树脂混合物; （c）3-85重量％填料％（d）0.001〜25重量％％的引发剂，缓凝剂和/或促进剂，以及; （e）0〜25wt。％的辅助剂，其中指定的百分比是指制剂的总重量。

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