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1. 发明申请

WO2012129576A3 SYSTEM AND METHOD FOR BIPHASIC TRANSDERMAL IONTOPHREOTIC DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于治疗药物的双向超声心动图输送的系统和方法
公开(公告)号：WO2012129576A3
公开(公告)日：2012-12-27
申请号：PCT/US2012030633
申请日：2012-03-26
申请人： INCUBE LABS LLC , IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
发明人： IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
IPC分类号： A61N1/30 , A61K9/70 , A61N1/04 , A61N1/36
CPC分类号： A61N1/325 , A61K9/0009 , A61K9/0014 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/303
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.
摘要翻译：各种实施方案提供了用于治疗剂的双相离子电渗透皮递送的方法和系统。用于这种传送的方法的实施例包括将至少一个电极组件定位成与患者的皮肤电连通。组合物包括包含被动地扩散入皮肤的治疗剂的溶液。使用具有例如极性和大小的特性的第一电流，在第一时段期间，将剂量的药剂从组合物输送到皮肤中，以将药剂排斥出组合体。在第二时段期间，使用具有吸引剂的特性的第二电流将试剂保持在组合中，使得药剂递送到皮肤中最小化。可以根据患者的输入要求递送剂量。实施方案可以用于递送由不希望的被动扩散引起不利影响的试剂。

2. 发明申请

WO2012109394A2 APPARATUS, SYSTEM AND METHODS FOR PHOTOACOUSTIC DETECTION OF DEEP VEIN THROMBOSIS 审中-公开
标题翻译：用于深度检测深度血栓形成的装置，系统和方法
公开(公告)号：WO2012109394A2
公开(公告)日：2012-08-16
申请号：PCT/US2012024384
申请日：2012-02-08
申请人： INCUBE LABS LLC , IMRAN MIR , MCLAUGHLIN GLEN
发明人： IMRAN MIR , MCLAUGHLIN GLEN
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B8/00
CPC分类号： A61B5/0095 , A61B5/02028 , A61B8/0891
摘要： Embodiments of the invention provide apparatus, systems and methods for the detection of deep vein thrombosis (DVT) using photoacoustic measurement of hemoglobin in different states of oxygenation within tissue. One embodiment of a system for DVT detection comprises at least a first and second light source that emit light at first and second wavelengths, an acoustic transducer, a data converter and a processor. The first and second light sources are directed on the patient's skin to produce a photoacoustic signal (PS) correlated to an amount of absorbance of the first and second wavelengths by a target region of tissue beneath the patient's skin. The acoustic transducer detects the PS and transduces it into an electrical signal which is correlated to the PS. The data converter converts the electrical signal into a digital signal which is analyzed by the processor to detect the presence of DVT within the target region.
摘要翻译：本发明的实施例提供了使用组织内不同氧合状态的血红蛋白的光声测量来检测深静脉血栓形成（DVT）的装置，系统和方法。用于DVT检测的系统的一个实施例包括至少第一和第二光源，其发射第一和第二波长的光，声换能器，数据转换器和处理器。第一和第二光源被引导到患者的皮肤上，以产生与患者皮肤下面的组织的目标区域与第一和第二波长的吸光度相关的光声信号（PS）。声换能器检测PS并将其转换成与PS相关的电信号。数据转换器将电信号转换成由处理器分析的数字信号，以检测目标区域内DVT的存在。

3. 发明专利

AU2016277579A1 System and method for biphasic transdermal iontophoretic delivery of therapeutic agents 未知
公开(公告)号：AU2016277579A1
公开(公告)日：2017-01-12
申请号：AU2016277579
申请日：2016-12-20
申请人： INCUBE LABS LLC
发明人： IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
IPC分类号： A61N1/30 , A61K9/70 , A61N1/04 , A61N1/36
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical 5 communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is o used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

4. 发明专利

AU2012230701B2 System and method for biphasic transdermal iontophoretic delivery of therapeutic agents 未知
公开(公告)号：AU2012230701B2
公开(公告)日：2016-09-29
申请号：AU2012230701
申请日：2012-03-26
申请人： INCUBE LABS LLC
发明人： IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
IPC分类号： A61N1/30 , A61K9/70 , A61N1/04 , A61N1/36
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

5. 发明专利

AU2012230701A1 System and method for biphasic transdermal iontophreotic delivery of therapeutic agents 未知
公开(公告)号：AU2012230701A1
公开(公告)日：2013-10-17
申请号：AU2012230701
申请日：2012-03-26
申请人： INCUBE LABS LLC
发明人： IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
IPC分类号： A61N1/30 , A61K9/70 , A61N1/04 , A61N1/36
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

6. 发明专利

AU2016277579B2 System and method for biphasic transdermal iontophoretic delivery of therapeutic agents 未知
公开(公告)号：AU2016277579B2
公开(公告)日：2018-04-05
申请号：AU2016277579
申请日：2016-12-20
申请人： INCUBE LABS LLC
发明人： IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
IPC分类号： A61N1/30 , A61K9/70 , A61N1/04 , A61N1/36
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical 5 communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is o used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

7. 发明专利

AU2012230701A2 System and method for biphasic transdermal iontophoretic delivery of therapeutic agents 未知
公开(公告)号：AU2012230701A2
公开(公告)日：2013-11-14
申请号：AU2012230701
申请日：2012-03-26
申请人： INCUBE LABS LLC
发明人： IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
IPC分类号： A61N1/30 , A61K9/70 , A61N1/04 , A61N1/36
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

8. 发明公开

EP2688639A4 SYSTEM AND METHOD FOR BIPHASIC TRANSDERMAL IONTOPHORETIC DELIVERY OF THERAPEUTIC AGENTS 有权
标题翻译：系统和方法进行治疗的资金透皮相离子透入输送
公开(公告)号：EP2688639A4
公开(公告)日：2014-11-12
申请号：EP12760602
申请日：2012-03-26
申请人： INCUBE LABS LLC
发明人： IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
IPC分类号： A61N1/30 , A61K9/00 , A61K9/70 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/04 , A61N1/32 , A61N1/36
CPC分类号： A61N1/325 , A61K9/0009 , A61K9/0014 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/303

9. 发明申请

WO2004080364A3 PORTABLE ULTRASOUND UNIT AND DOCKING STATION 审中-公开
标题翻译：便携式超声波单元和对接站
公开(公告)号：WO2004080364A3
公开(公告)日：2004-12-23
申请号：PCT/US2004006959
申请日：2004-03-03
申请人： ZONARE MEDICAL SYSTEMS INC , SMITH SCOTT F , HAYDEN MICHAEL E , FELIX IAN , DEBUSSCHERE DEREK , MCLAUGHLIN GLEN
发明人： SMITH SCOTT F , HAYDEN MICHAEL E , FELIX IAN , DEBUSSCHERE DEREK , MCLAUGHLIN GLEN
IPC分类号： A61B17/22 , A61B19/00 , A61B19/02 , G06F1/16
CPC分类号： G01S15/899 , A61B5/024 , A61B5/08 , A61B5/145 , A61B5/7275 , A61B8/00 , A61B8/4209 , A61B8/4405 , A61B8/4427 , A61B8/4433 , A61B8/462 , A61B8/467 , A61B8/468 , A61B8/546 , A61B8/56 , A61B17/2251 , A61B50/10 , A61B50/13 , A61B90/36 , A61B2017/00017 , A61B2017/00199 , A61B2017/00225 , A61B2090/378 , A61B2560/0456 , G01S7/52082 , G06F1/1632
摘要： A portable ultrasound unit and docking cart for the unit are provided. When the portable unit is mounted to the docking cart, the docking cart transforms the portable unit into a cart-based system with enhanced features and functionality such as improved ergonomics, ease of use, a larger display format, external communications connectivity, multiple transducer connections, and increased data processing capabilities. A clinician display and patient display may be provided on the cart. Communications circuitry in the docking cart may be used to support communications between the docking cart's processor and external networks and devices. The docking cart may receive physiological signals such as cardiac signals and may use this information to synchronize ultrasound imaging operations with a patient's physiological condition. Adjustable user interface controls, data handling features, security features, power control functions, and thermal management capabilities may be provided in the docking cart.
摘要翻译：提供便携式超声波单元和对接单元。当便携式单元安装到对接小车上时，对接小车将便携式单元转变成基于购物车的系统，其具有增强的特征和功能，例如改进的人体工程学，易用性，更大的显示格式，外部通信连接性，多个换能器连接并增加了数据处理能力。可以在购物车上提供临床医生显示器和患者显示器。对接小车中的通信电路可用于支持对接小车的处理器与外部网络和设备之间的通信。对接小车可以接收诸如心脏信号的生理信号并且可以使用该信息来使超声成像操作与患者的生理状况同步。对接车中可以提供可调节的用户界面控件，数据处理功能，安全功能，电源控制功能和散热管理功能。

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