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1. 发明申请

WO2012129576A3 SYSTEM AND METHOD FOR BIPHASIC TRANSDERMAL IONTOPHREOTIC DELIVERY OF THERAPEUTIC AGENTS 审中-公开
标题翻译：用于治疗药物的双向超声心动图输送的系统和方法
公开(公告)号：WO2012129576A3
公开(公告)日：2012-12-27
申请号：PCT/US2012030633
申请日：2012-03-26
申请人： INCUBE LABS LLC , IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
发明人： IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
IPC分类号： A61N1/30 , A61K9/70 , A61N1/04 , A61N1/36
CPC分类号： A61N1/325 , A61K9/0009 , A61K9/0014 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/303
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.
摘要翻译：各种实施方案提供了用于治疗剂的双相离子电渗透皮递送的方法和系统。用于这种传送的方法的实施例包括将至少一个电极组件定位成与患者的皮肤电连通。组合物包括包含被动地扩散入皮肤的治疗剂的溶液。使用具有例如极性和大小的特性的第一电流，在第一时段期间，将剂量的药剂从组合物输送到皮肤中，以将药剂排斥出组合体。在第二时段期间，使用具有吸引剂的特性的第二电流将试剂保持在组合中，使得药剂递送到皮肤中最小化。可以根据患者的输入要求递送剂量。实施方案可以用于递送由不希望的被动扩散引起不利影响的试剂。

2. 发明专利

AU2016277579A1 System and method for biphasic transdermal iontophoretic delivery of therapeutic agents 未知
公开(公告)号：AU2016277579A1
公开(公告)日：2017-01-12
申请号：AU2016277579
申请日：2016-12-20
申请人： INCUBE LABS LLC
发明人： IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
IPC分类号： A61N1/30 , A61K9/70 , A61N1/04 , A61N1/36
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical 5 communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is o used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

3. 发明专利

AU2012230701B2 System and method for biphasic transdermal iontophoretic delivery of therapeutic agents 未知
公开(公告)号：AU2012230701B2
公开(公告)日：2016-09-29
申请号：AU2012230701
申请日：2012-03-26
申请人： INCUBE LABS LLC
发明人： IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
IPC分类号： A61N1/30 , A61K9/70 , A61N1/04 , A61N1/36
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

4. 发明申请

WO2012092305A3 NANONIZED IRON COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
标题翻译：纳米铁组合物及其使用方法
公开(公告)号：WO2012092305A3
公开(公告)日：2012-11-01
申请号：PCT/US2011067445
申请日：2011-12-27
申请人： INCUBE LABS LLC
发明人： IMRAN MIR , HASHIM MIR , WANG LU , PATEL SANJAY , HARRIS JOEL , MORGAN PHIL
IPC分类号： A61K9/16 , A61K9/14 , A61K9/70 , A61K47/48 , A61P1/00 , A61P1/16
CPC分类号： A61K9/14 , A61K33/26
摘要： Embodiments of the invention provide nanonized iron compositions for treatment of iron deficiency such as iron deficiency anemia. Many embodiments provide nanonized iron compositions which are sized to minimize adverse reaction such as immune response, adverse GI reaction and allergic reaction to iron compound included in the composition. The nanonized iron compositions can be used in a variety of drug delivery forms, including an oral dosage form, a transdermal patch, in an intravenous solution or in a dialysate for treatment of a patient with chronic kidney disease (CKD). Embodiments of the invention also provide methods of using the nanonized iron compositions for the treatment of iron deficiency in a patient in need thereof including patients with iron deficiency anemia and CKD.
摘要翻译：本发明的实施方案提供用于治疗缺铁症如铁缺乏性贫血的纳米铁组合物。许多实施方案提供纳米尺寸的铁组合物，其尺寸被确定为最小化不利反应，例如免疫应答，不良GI反应和组合物中所含铁化合物的过敏反应。纳米铁组合物可以以多种药物递送形式使用，包括口服剂型，透皮贴剂，静脉内溶液或透析液中用于治疗患有慢性肾病（CKD）的患者。本发明的实施方案还提供了使用纳米铁组合物用于治疗有需要的患者包括缺铁性贫血和CKD患者的铁缺乏症的方法。

5. 发明专利

AU2012230701A1 System and method for biphasic transdermal iontophreotic delivery of therapeutic agents 未知
公开(公告)号：AU2012230701A1
公开(公告)日：2013-10-17
申请号：AU2012230701
申请日：2012-03-26
申请人： INCUBE LABS LLC
发明人： IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
IPC分类号： A61N1/30 , A61K9/70 , A61N1/04 , A61N1/36
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

6. 发明专利

AU2016277579B2 System and method for biphasic transdermal iontophoretic delivery of therapeutic agents 未知
公开(公告)号：AU2016277579B2
公开(公告)日：2018-04-05
申请号：AU2016277579
申请日：2016-12-20
申请人： INCUBE LABS LLC
发明人： IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
IPC分类号： A61N1/30 , A61K9/70 , A61N1/04 , A61N1/36
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical 5 communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is o used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

7. 发明专利

AU2012230701A2 System and method for biphasic transdermal iontophoretic delivery of therapeutic agents 未知
公开(公告)号：AU2012230701A2
公开(公告)日：2013-11-14
申请号：AU2012230701
申请日：2012-03-26
申请人： INCUBE LABS LLC
发明人： IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
IPC分类号： A61N1/30 , A61K9/70 , A61N1/04 , A61N1/36
摘要： Various embodiments provide methods and systems for the biphasic iontophoretic transdermal delivery of therapeutic agents. An embodiment of a method for such delivery comprises positioning at least one electrode assembly in electrical communication with a patient's skin. The assembly includes a solution comprising a therapeutic agent which passively diffuses into the skin. A dose of agent is delivered from the assembly into the skin during a first period using a first current having a characteristic e.g., polarity and magnitude, to repel the agent out of the assembly. During a second period, a second current having a characteristic to attract the agent is used to retain the agent in the assembly such that delivery of agent into skin is minimized. A dose of agent may be delivered on demand by an input from the patient. Embodiments may be used for delivery of agents which cause adverse effects from unwanted passive diffusion.

8. 发明公开

EP2688639A4 SYSTEM AND METHOD FOR BIPHASIC TRANSDERMAL IONTOPHORETIC DELIVERY OF THERAPEUTIC AGENTS 有权
标题翻译：系统和方法进行治疗的资金透皮相离子透入输送
公开(公告)号：EP2688639A4
公开(公告)日：2014-11-12
申请号：EP12760602
申请日：2012-03-26
申请人： INCUBE LABS LLC
发明人： IMRAN MIR , HASHIM MIR , MCLAUGHLIN GLEN , ARASTU HUMA , VAIDYANATHAN REKHA , HARRIS JOEL , KORUPOLU RADHIKA , MANGOGNA ANDREW , ONG CHANG , PATEL SANJAY , WANG LU , WILLIAMS TIMOTHY
IPC分类号： A61N1/30 , A61K9/00 , A61K9/70 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/04 , A61N1/32 , A61N1/36
CPC分类号： A61N1/325 , A61K9/0009 , A61K9/0014 , A61K31/4178 , A61K31/4468 , A61K31/454 , A61K31/5415 , A61N1/0436 , A61N1/044 , A61N1/0448 , A61N1/30 , A61N1/303

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