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1. 发明申请

WO1992004462A1 PATHOGEN-SPECIFIC CTL THERAPY 审中-公开
标题翻译：病因特异性CTL治疗
公开(公告)号：WO1992004462A1
公开(公告)日：1992-03-19
申请号：PCT/US1991006441
申请日：1991-09-06
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION , NEW ENGLAND MEDICAL CENTER HOSPITALS, INC.
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , NEW ENGLAND MEDICAL CENTER HOSPITALS, INC. , LIEBERMAN, Judy , GEFTER, Malcolm
IPC分类号： C12P21/02
CPC分类号： A61K35/17
摘要： Disclosed is a method for the treatment of a patient infected with an intracellular pathogen, involving administering to the patient an intracellular pathogen-specific, cytotoxic T lymphocyte-stimulatory antigen, or a preparation of the patient's lymphocytes enriched for intracellular pathogen-specific cytotoxic T lymphocytes.
摘要翻译：公开了一种用于治疗感染细胞内病原体的患者的方法，包括向患者施用细胞内病原体特异性细胞毒性T淋巴细胞刺激性抗原或富含细胞内病原体特异性细胞毒性T淋巴细胞的患者淋巴细胞的制剂。

2. 发明申请

WO1993016725A1 EARLY ANTIGEN FOR AUTOIMMUNE DIABETES 审中-公开
标题翻译：早产儿自发性糖尿病
公开(公告)号：WO1993016725A1
公开(公告)日：1993-09-02
申请号：PCT/US1993001716
申请日：1993-02-25
申请人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD ... , IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： THE BOARD OF TRUSTEES OF THE LELAND STANFORD ... , IMMULOGIC PHARMACEUTICAL CORPORATION , FATHMAN, C., Garrison , PABORSKY, Lisa , GELBER, Cohava
IPC分类号： A61K39/00
CPC分类号： C07K14/705 , A61K38/00 , G01N33/5091
摘要： Antigens associated with the beta islet cells that activate T-cell populations in inducing type I diabetes are disclosed. These antigens are useful in diagnosis and therapy of type I diabetes.
摘要翻译：公开了与诱导I型糖尿病激活T细胞群体的β岛细胞相关的抗原。这些抗原可用于I型糖尿病的诊断和治疗。

3. 发明申请

WO1993014754A1 HISTAMINE DERIVATIVES AND METHODS FOR THEIR USE AS IMMUNOMODULATORS 审中-公开
标题翻译：组胺衍生物及其作为免疫调节剂使用的方法
公开(公告)号：WO1993014754A1
公开(公告)日：1993-08-05
申请号：PCT/US1993000659
申请日：1993-01-25
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. ...
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. ... , MELMON, Kenneth, L. , GREENSTEIN, Julia, L. , KHOSROPOUR, Parisa
IPC分类号： A61K31/415
CPC分类号： A61K38/17 , A61K31/415 , A61K39/35 , A61K39/39 , A61K2039/55511 , A61K2300/00
摘要： The present invention provides methods for using histamine derivatives as immunomodulators and in immunotherapeutics. More specifically the present invention provides methods for inhibiting at least a portion of an antigen specific antibody response and/or a portion of a T cell proliferative response by the immune system of a mammal comprising administering to said mammal an effective amount of a composition comprising at least one histamine derivative having binding specificity for at least one histamine receptor. The invention also pertains to methods of treating sensitivity to a particular antigen and methods of treating T cell mediated disease in a person by administering to the person a therapeutically effective amount of a composition comprising at least one histamine derivative having binding specificity for at least one histamine receptor, optionally administering to the person the antigen or an immunogenic portion thereof and further optionally administering to the person a peptide comprising at least one T cell epitope of said antigen.
摘要翻译：本发明提供使用组胺衍生物作为免疫调节剂和免疫治疗剂的方法。更具体地，本发明提供了通过哺乳动物的免疫系统抑制至少一部分抗原特异性抗体应答和/或一部分T细胞增殖应答的方法，所述方法包括向所述哺乳动物施用有效量的组合物，其包含至少一种对至少一种组胺受体具有结合特异性的组胺衍生物。本发明还涉及治疗对特定抗原的敏感性的方法和通过向该人施用治疗有效量的包含至少一种对至少一种组胺具有结合特异性的组胺衍生物的组合物来治疗人的T细胞介导的疾病的方法受体，任选地向该人施用抗原或其免疫原性部分，并进一步任选地向该人施用包含所述抗原的至少一个T细胞表位的肽。

4. 发明申请

WO1993013772A1 METHODS FOR USING HISTAMINE DERIVATIVES AS IMMUNOMODULATORS AND IN IMMUNOTHERAPEUTICS 审中-公开
标题翻译：使用组胺衍生物作为免疫调节剂和免疫组织化学的方法
公开(公告)号：WO1993013772A1
公开(公告)日：1993-07-22
申请号：PCT/US1993000664
申请日：1993-01-19
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , GREENSTEIN, Julia, L. , MELMON, Kenneth, L.
IPC分类号： A61K31/415
CPC分类号： A61K39/35 , A61K31/415 , C07K14/415 , C07K16/16
摘要： The present invention provides methods using histamine derivatives as immunomodulators and in immunotherapeutics. More specifically the present invention provides methods for inhibiting at least a portion of an antigen specific antibody response by the immune system of a mammal comprising administering to said mammal an effective amount of a composition comprising at least one histamine derivative having binding specificity for at least one histamine receptor. The invention also pertains to methods of treating sensitivity to a particular antigen in an individual by administering to the individual a therapeutically effective amount of a composition comprising at least one histamine derivative having binding specificity for at least one histamine receptor, and in conjunction therewith, optionally administering to the individual the antigen or the immunogenic or T-cell stimulating portion thereof to which the individual may be sensitive.
摘要翻译：本发明提供使用组胺衍生物作为免疫调节剂和免疫治疗剂的方法。更具体地，本发明提供了通过哺乳动物的免疫系统抑制至少一部分抗原特异性抗体应答的方法，所述方法包括向所述哺乳动物施用有效量的包含至少一种对至少一种具有结合特异性的组胺衍生物的组合物组胺受体。本发明还涉及通过向个体施用治疗有效量的包含至少一种对至少一种组胺受体具有结合特异性的组胺衍生物的组合物，并且与其组合，任选地治疗对个体中特定抗原的敏感性的方法向个体施用个体可能敏感的抗原或其免疫原性或T细胞刺激部分。

5. 发明申请

WO1993008279A1 T CELL EPITOPES OF THE MAJOR ALLERGENS FROM DERMATOPHAGOIDES (HOUSE DUST MITE) 审中-公开
标题翻译：主要来源于erm O ID）））））））））））））））））））））
公开(公告)号：WO1993008279A1
公开(公告)日：1993-04-29
申请号：PCT/US1992008637
申请日：1992-10-15
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , Garman, Richard, D. , GREENSTEIN, Julia, L. , KUO, Mei-Chang , ROGERS, Bruce, L.
IPC分类号： C12N15/12
CPC分类号： C07K14/43531 , A61K38/00 , C07K2319/02 , C07K2319/40
摘要： The present invention provides isolated peptides of the major protein allergens of the genus Dermatophagoides. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der f I, or Der f II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided.
摘要翻译：本发明提供了Dermatophagoides属的主要蛋白质过敏原的分离的肽。本发明范围内的肽包含至少一种T细胞表位，或优选至少两种选自变应原Der p I，Der p II，Der f I或Der f II的蛋白质变应原的T细胞表位。本发明还涉及与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的修饰肽。本发明还提供了编码本发明的肽的核酸序列。还提供了治疗或诊断对个体中的尘螨的敏感性的方法和包含本发明的一种或多种肽的治疗组合物。

6. 发明申请

WO1992022579A1 MIMIC PEPTIDES OF gp120 审中-公开
标题翻译： gp120的MIMIC肽
公开(公告)号：WO1992022579A1
公开(公告)日：1992-12-23
申请号：PCT/US1992004972
申请日：1992-03-19
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , GEFTER, Malcolm, L. , MELMON, Kenneth, L.
IPC分类号： C07K13/00
CPC分类号： C40B40/02 , A61K39/00 , C07K14/005 , C12N15/1037 , C12N2740/16122 , G01N33/54393 , G01N33/56988
摘要： Disclosed are peptides having a primary amino acid sequence which is unrelated to gp120. The peptides are characterized by the ability to stimulate the production of anti-gp120, particularly anti-V3-loop, antibodies when administered to a mammal. The peptides are also characterized by the ability to interfere with viral function. The peptides can be formulated as a vaccine composition and administered as a method for stimulating an HIV-1 neutralizing immune response.
摘要翻译：公开了具有与gp120无关的一级氨基酸序列的肽。肽的特征在于当施用于哺乳动物时刺激抗gp120，特别是抗V3环的抗体的产生的能力。肽的特征还在于干扰病毒功能的能力。肽可以配制成疫苗组合物并作为刺激HIV-1中和免疫应答的方法施用。

7. 发明申请

WO1996020950A2 COMPOSITIONS AND METHODS FOR TREATING RHEUMATOID ARTHRITIS 审中-公开
标题翻译：用于治疗炎症性脑膜炎的组合物和方法
公开(公告)号：WO1996020950A2
公开(公告)日：1996-07-11
申请号：PCT/US1996000206
申请日：1996-01-04
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , ROTHBARD, Jonathan , FUGGER, Lars, Henrik , SONDERSTRUP-MCDEVITT, Grete
IPC分类号： C07K07/08
CPC分类号： C07K14/78 , A61K38/00
摘要： The present invention provides peptides, therapeutic compositions, and methods for treatment of rheumatoid arthritis in mammals, specifically in humans. The peptides of the invention comprise fragments of type II collagen which bind specifically with human major histocompatibility complex proteins known to be genetically linked to susceptibility to rheumatoid arthritis. The therapeutic compositions of the invention comprise the peptides, alone or in combination with other collagen peptides. In one method of the invention, therapeutic compositions of the peptides are administered by injection, transdermally, by inhalation, or orally to a patient in need of treatment.
摘要翻译：本发明提供了在哺乳动物，特别是人类中治疗类风湿性关节炎的肽，治疗组合物和方法。本发明的肽包含II型胶原的片段，其与已知与类风湿性关节炎易感性基因相关的人类主要组织相容性复合蛋白特异性结合。本发明的治疗组合物单独或与其它胶原肽组合包含肽。在本发明的一种方法中，肽的治疗组合物通过注射，经皮，吸入或口服施用于需要治疗的患者。

8. 发明申请

WO1995015976A1 NUCLEIC ACIDS ENCODING A HOUSE DUST MITE ALLERGEN, DER P III, AND USES THEREFOR 审中-公开
标题翻译：核酸编码一个房屋尘埃冥王星过敏原，第三阶段及其用途
公开(公告)号：WO1995015976A1
公开(公告)日：1995-06-15
申请号：PCT/US1994014073
申请日：1994-12-07
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION , INSTITUTE FOR CHILD HEALTH RESEARCH
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , INSTITUTE FOR CHILD HEALTH RESEARCH , THOMAS, Wayne, R. , CHUA, Kaw-Yan , ROGERS, Bruce, L. , KUO, Mei-chang
IPC分类号： C07K14/435
CPC分类号： C07K14/43531 , A61K38/00
摘要： Isolated nucleic acids encoding an allergen of Dermatophagoides pteronyssinus, Der p III, are disclosed. A cDNA encoding a peptide having a Der p III activity and a predicted molecular weight of about 24,985 daltons is also described. The nucleic acids can be used as probes to detect the presence of Der p III nucleic acid in a sample or for the recombinant production of peptides having an activity of Der p III. Peptides having an activity of Der p III can be used in compositions suitable for pharmaceutical administration or methods of diagnosing sensitivity to house dust mites.
摘要翻译：公开了编码Dermatophagoides pteronyssinus，Der p III的变应原的分离的核酸。还描述了编码具有Der p III活性和约24,985道尔顿的预测分子量的肽的cDNA。核酸可以用作探针，以检测样品中Der p III核酸的存在或重组产生具有Der p III活性的肽。具有Der p III活性的肽可用于适用于药物施用的组合物或诊断对尘螨敏感性的方法。

9. 发明申请

WO1994005790A1 CLONING AND SEQUENCING OF ALLERGENS OF DERMATOPHAGOIDES (HOUSE DUST MITE) 审中-公开
标题翻译： D OF OF OF））））））））））））））））））））
公开(公告)号：WO1994005790A1
公开(公告)日：1994-03-17
申请号：PCT/US1993008518
申请日：1993-09-10
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION , THOMAS, Wayne, R. , CHUA, Kaw-Yan
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION
IPC分类号： C12N15/12
CPC分类号： C07K14/43531 , A61K38/00 , C07K14/5403 , Y10S436/826
摘要： The present invention features isolated DNA encoding allergens of Dermatophagoides (house dust mites) particularly of the species Dermatophagoides farinae and Dermatophagoides pteronyssinus, which are protein allergens or peptides which include at least one epitope of the protein allergen. In particular, the invention provides DNA encoding the major D. farinae allergens, Der f I and Der f II and DNA encoding the major D. pteronyssinus allergens, Der p I and Der p II. The present invention further relates to proteins and peptides encoded by the isolated D. farinae and D. pteronyssinus DNA, including proteins containing sequence polymorphisms. In addition, the proteins or peptides encoded by the isolated DNA, their use as diagnostic and therapeutic reagents and methods of diagnosing and treating sensitivity to house dust mite allergens, are disclosed.
摘要翻译：本发明的特征在于编码Dermatophagoides（房尘螨）变应原的分离的DNA，特别是Dermatophagoides farinae和Dermatophagoides pteronyssinus，它们是包括蛋白质变应原的至少一个表位的蛋白质过敏原或肽。特别地，本发明提供编码主要D. farinae过敏原Der f I和Der f II的DNA和编码主要D.pteronyssinus变应原Der P I和Der p II的DNA。本发明还涉及由分离的D. farinae和D.pteronyssinus DNA编码的蛋白质和肽，包括含有序列多态性的蛋白质。此外，公开了由分离的DNA编码的蛋白质或肽，它们作为诊断和治疗试剂的用途以及诊断和治疗房屋尘螨过敏原敏感性的方法。

10. 发明申请

WO1993001213A1 ALLERGENIC PROTEINS AND PEPTIDES FROM JAPANESE CEDAR POLLEN 审中-公开
标题翻译：来自日本CEDAR POLLEN的过敏蛋白和肽
公开(公告)号：WO1993001213A1
公开(公告)日：1993-01-21
申请号：PCT/US1992005661
申请日：1992-07-10
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , GRIFFITH, Irwin, J. , POLLOCK, Joanne , BOND, Julian, F.
IPC分类号： C07K15/10
CPC分类号： C07K14/415 , A61K38/00 , A61K39/00 , C07K16/16
摘要： The present invention provides nucleic acid sequences coding for the Cryptomeria japonica major pollen allergen Cry j I and fragments thereof. The present invention also provides purified Cry j I and at least one fragment thereof produced in a host cell transformed with a nucleic acid sequence coding for Cry j I or at least one fragment thereof and fragments of Cry j prepared synthetically. Cry j I and fragments thereof are useful for diagnosing, treating, and preventing Japanese cedar pollinosis.
摘要翻译：本发明提供了编码粳稻主要花粉过敏原Cryj I及其片段的核酸序列。本发明还提供了在宿主细胞中产生的纯化的Cry I和至少一个片段，该宿主细胞用编码Cryj I或其至少一个片段的核酸序列和合成制备的Cryj片段转化。 Cry j I及其片段可用于诊断，治疗和预防日本雪松花粉病。

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