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1. 发明申请

WO1993014754A1 HISTAMINE DERIVATIVES AND METHODS FOR THEIR USE AS IMMUNOMODULATORS 审中-公开
标题翻译：组胺衍生物及其作为免疫调节剂使用的方法
公开(公告)号：WO1993014754A1
公开(公告)日：1993-08-05
申请号：PCT/US1993000659
申请日：1993-01-25
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. ...
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. ... , MELMON, Kenneth, L. , GREENSTEIN, Julia, L. , KHOSROPOUR, Parisa
IPC分类号： A61K31/415
CPC分类号： A61K38/17 , A61K31/415 , A61K39/35 , A61K39/39 , A61K2039/55511 , A61K2300/00
摘要： The present invention provides methods for using histamine derivatives as immunomodulators and in immunotherapeutics. More specifically the present invention provides methods for inhibiting at least a portion of an antigen specific antibody response and/or a portion of a T cell proliferative response by the immune system of a mammal comprising administering to said mammal an effective amount of a composition comprising at least one histamine derivative having binding specificity for at least one histamine receptor. The invention also pertains to methods of treating sensitivity to a particular antigen and methods of treating T cell mediated disease in a person by administering to the person a therapeutically effective amount of a composition comprising at least one histamine derivative having binding specificity for at least one histamine receptor, optionally administering to the person the antigen or an immunogenic portion thereof and further optionally administering to the person a peptide comprising at least one T cell epitope of said antigen.
摘要翻译：本发明提供使用组胺衍生物作为免疫调节剂和免疫治疗剂的方法。更具体地，本发明提供了通过哺乳动物的免疫系统抑制至少一部分抗原特异性抗体应答和/或一部分T细胞增殖应答的方法，所述方法包括向所述哺乳动物施用有效量的组合物，其包含至少一种对至少一种组胺受体具有结合特异性的组胺衍生物。本发明还涉及治疗对特定抗原的敏感性的方法和通过向该人施用治疗有效量的包含至少一种对至少一种组胺具有结合特异性的组胺衍生物的组合物来治疗人的T细胞介导的疾病的方法受体，任选地向该人施用抗原或其免疫原性部分，并进一步任选地向该人施用包含所述抗原的至少一个T细胞表位的肽。

2. 发明申请

WO1993013772A1 METHODS FOR USING HISTAMINE DERIVATIVES AS IMMUNOMODULATORS AND IN IMMUNOTHERAPEUTICS 审中-公开
标题翻译：使用组胺衍生物作为免疫调节剂和免疫组织化学的方法
公开(公告)号：WO1993013772A1
公开(公告)日：1993-07-22
申请号：PCT/US1993000664
申请日：1993-01-19
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , GREENSTEIN, Julia, L. , MELMON, Kenneth, L.
IPC分类号： A61K31/415
CPC分类号： A61K39/35 , A61K31/415 , C07K14/415 , C07K16/16
摘要： The present invention provides methods using histamine derivatives as immunomodulators and in immunotherapeutics. More specifically the present invention provides methods for inhibiting at least a portion of an antigen specific antibody response by the immune system of a mammal comprising administering to said mammal an effective amount of a composition comprising at least one histamine derivative having binding specificity for at least one histamine receptor. The invention also pertains to methods of treating sensitivity to a particular antigen in an individual by administering to the individual a therapeutically effective amount of a composition comprising at least one histamine derivative having binding specificity for at least one histamine receptor, and in conjunction therewith, optionally administering to the individual the antigen or the immunogenic or T-cell stimulating portion thereof to which the individual may be sensitive.
摘要翻译：本发明提供使用组胺衍生物作为免疫调节剂和免疫治疗剂的方法。更具体地，本发明提供了通过哺乳动物的免疫系统抑制至少一部分抗原特异性抗体应答的方法，所述方法包括向所述哺乳动物施用有效量的包含至少一种对至少一种具有结合特异性的组胺衍生物的组合物组胺受体。本发明还涉及通过向个体施用治疗有效量的包含至少一种对至少一种组胺受体具有结合特异性的组胺衍生物的组合物，并且与其组合，任选地治疗对个体中特定抗原的敏感性的方法向个体施用个体可能敏感的抗原或其免疫原性或T细胞刺激部分。

3. 发明申请

WO1993008279A1 T CELL EPITOPES OF THE MAJOR ALLERGENS FROM DERMATOPHAGOIDES (HOUSE DUST MITE) 审中-公开
标题翻译：主要来源于erm O ID）））））））））））））））））））））
公开(公告)号：WO1993008279A1
公开(公告)日：1993-04-29
申请号：PCT/US1992008637
申请日：1992-10-15
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , Garman, Richard, D. , GREENSTEIN, Julia, L. , KUO, Mei-Chang , ROGERS, Bruce, L.
IPC分类号： C12N15/12
CPC分类号： C07K14/43531 , A61K38/00 , C07K2319/02 , C07K2319/40
摘要： The present invention provides isolated peptides of the major protein allergens of the genus Dermatophagoides. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der f I, or Der f II. The invention also pertains to modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided.
摘要翻译：本发明提供了Dermatophagoides属的主要蛋白质过敏原的分离的肽。本发明范围内的肽包含至少一种T细胞表位，或优选至少两种选自变应原Der p I，Der p II，Der f I或Der f II的蛋白质变应原的T细胞表位。本发明还涉及与相应的天然存在的变应原或其部分具有相似或增强的治疗性质但具有减少的副作用的修饰肽。本发明还提供了编码本发明的肽的核酸序列。还提供了治疗或诊断对个体中的尘螨的敏感性的方法和包含本发明的一种或多种肽的治疗组合物。

4. 发明申请

WO1991006571A1 A HUMAN T CELL REACTIVE FELINE PROTEIN (TRFP) ISOLATED FROM HOUSE DUST AND USES THEREFOR 审中-公开
标题翻译：从家庭尘埃中分离的人体细胞反应性蛋白质（TRFP）及其用途
公开(公告)号：WO1991006571A1
公开(公告)日：1991-05-16
申请号：PCT/US1990006548
申请日：1990-11-02
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , GEFTER, Malcolm, L. , GARMAN, Richard, D. , GREENSTEIN, Julia, L. , KUO, Mei-chang , ROGERS, Bruce, L. , BRAUER, Andrew, W.
IPC分类号： C07K15/06
CPC分类号： G01N33/5091 , A61K38/00 , A61K39/35 , C07K14/47 , C07K14/4705 , C07K16/18 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/40 , C12N15/62
摘要： A substantially pure, covalently linked human T cell reactive feline protein (TRFP) of approximately 40,000 MW has been isolated from vacuum bag extract obtained by affinity purification of house dust collected from several homes with cats; DNA encoding all or a portion of the TRFP or peptide; compositions containing such a protein or peptide or portions thereof; and antibodies reactive with the TRFP or peptide are disclosed. Also disclosed are recombinant TRFP or peptide; modified or mutated TRFP peptides; their use for diagnostic or therapeutic purposes.
摘要翻译：从真空袋提取物中分离出大约40,000MW的基本上纯的，共价连接的人T细胞反应性猫科动物蛋白（TRFP），该真空袋提取物是通过亲和纯化从几个家庭用猫收集的房屋粉尘获得的; 编码全部或部分TRFP或肽的DNA; 含有这种蛋白质或肽或其部分的组合物; 并且公开了与TRFP或肽反应的抗体。还公开了重组TRFP或肽; 修饰或突变的TRFP肽; 它们用于诊断或治疗目的。

5. 发明申请

WO1998014216A2 HAPTEN-CARRIER CONJUGATES FOR USE IN DRUG-ABUSE THERAPY AND METHODS FOR PREPARATION OF SAME 审中-公开
标题翻译：用于药物滥用治疗的HAPTEN-CARRIER缀合物及其制备方法
公开(公告)号：WO1998014216A2
公开(公告)日：1998-04-09
申请号：PCT/US1997017506
申请日：1997-09-30
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , SWAIN, Philip, A , GREENSTEIN, Julia, L. , EXLEY, Mark, A. , FOX, Barbara, S. , POWERS, Stephen, P. , GEFTER, Malcolm, L.
IPC分类号： A61K47/48
CPC分类号： A61K39/0013 , A61K47/6415 , A61K47/6425 , A61K47/646 , A61K2039/6037 , Y02A50/412
摘要： Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo are described. Methods of preparing said conjugates and therapeutic compositions are also described. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of a drug addiction. The therapeutic composition is suitable for co-therapy with other conventional drugs. Passive immunization using antibodies raised against the hapten-carrier conjugates of the invention are also described.
摘要翻译：本发明涉及能够引发抗半抗原抗体的体内反应的半抗原 - 载体缀合物。还描述了制备所述缀合物和治疗组合物的方法。当半抗原是使用的药物时，含有半抗原 - 载体缀合物的治疗组合物特别适用于治疗药物成瘾。该治疗组合物可以与其他常规药物联合使用。还描述了本发明中使用针对半抗原 - 载体缀合物的抗体的被动免疫。

6. 发明申请

WO1996030049A2 HAPTEN-CARRIER CONJUGATES FOR USE IN DRUG-ABUSE THERAPY 审中-公开
标题翻译：用于药物滥用治疗的HAPTEN-CARRIER结合物
公开(公告)号：WO1996030049A2
公开(公告)日：1996-10-03
申请号：PCT/US1996004189
申请日：1996-03-27
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , SWAIN, Philip, A. , SCHAD, Victoria, C. , GREENSTEIN, Julia, L. , EXLEY, Mark, A. , FOX, Barbara, S. , POWERS, Stephen, P. , GEFTER, Malcolm, L. , BRINER, Thomas, J.
IPC分类号： A61K47/48
CPC分类号： A61K39/0013 , A61K47/646 , A61K2039/6037
摘要： Hapten-carrier conjugates capable of eliciting anti-hapten antibodies in vivo by administering, in a therapeutic composition, are disclosed. Methods of preparing said conjugates and therapeutic compositions are also disclosed. Where the hapten is a drug of abuse, a therapeutic composition containing the hapten-carrier conjugate is particularly useful in the treatment of drug addiction, more particularly, cocaine addiction. Passive immunization using antibodies raised against conjugates of the instant invention is also disclosed. The therapeutic composition is suitable for co-therapy with other conventional drugs.
摘要翻译：公开了通过在治疗组合物中施用能够在体内引发抗半抗原抗体的穿孔载体缀合物。还公开了制备所述缀合物和治疗组合物的方法。当半抗原是滥用药物时，含有半抗原 - 载体结合物的治疗组合物特别可用于治疗药物成瘾，特别是可卡因成瘾。还公开了使用针对本发明的缀合物产生的抗体的被动免疫。该治疗组合物适用于与其它常规药物共同治疗。

7. 发明申请

WO1995026980A2 HAPTENATED PEPTIDES AND USES THEREOF 审中-公开
标题翻译：成熟的肽及其用途
公开(公告)号：WO1995026980A2
公开(公告)日：1995-10-12
申请号：PCT/US1995004121
申请日：1995-03-30
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , HACKETT, Charles, J. , GREENSTEIN, Julia, L. , GEFTER, Malcolm, L. , WILSON, Kurt, Jeff , GELBER, Cohava
IPC分类号： C07K07/01
CPC分类号： C07K7/06 , A61K39/385 , A61K2039/605 , C07K7/08 , C07K14/005 , C07K14/47 , C12N2740/16022
摘要： MHC-binding carrier peptides linked to catechol derivatives are provided which are recognized by urushiol-specific T lymphocytes. The compounds are useful in therapeutic compositions and methods for desensitizing individuals against contact sensitivity to haptens, such as urushiol of poison ivy/poison oak.
摘要翻译：提供与儿茶酚衍生物连接的MHC结合载体肽，其被漆酚特异性T淋巴细胞识别。这些化合物可用于治疗组合物和使抗个体抵抗对半抗原的接触敏感性的方法，例如毒藤/毒橡胶的漆酚。

8. 发明申请

WO1994024281A1 T CELL EPITOPES OF THE MAJOR ALLERGENS FROM DERMATOPHAGOIDES (HOUSE DUST MITE) 审中-公开
标题翻译：主要来源于erm O ID）））））））））））））））））））））
公开(公告)号：WO1994024281A1
公开(公告)日：1994-10-27
申请号：PCT/US1993003471
申请日：1993-04-14
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , GARMAN, Richard, D. , KUO, Mei-chang , GREENSTEIN, Julia, L. , ROGERS, Bruce, L.
IPC分类号： C12N15/12
CPC分类号： C07K14/43531 , A61K38/00 , C07K2319/00
摘要： The present invention provides isolated peptides and/or modified peptides of the major protein allergens of the genus Dermatophagoides. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Der p I, Der p II, Der f I, or Der f II. The invention also pertains to peptides which have been further modified having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects. The invention further provides nucleic acid sequences coding for peptides of the invention. Methods of treatment or of diagnosis of sensitivity to house dust mites in an individual and therapeutic composition comprising one or more peptides of the invention are also provided.
摘要翻译：本发明提供了皮肤癣菌属的主要蛋白质过敏原的分离的肽和/或修饰的肽。本发明范围内的肽包含至少一种T细胞表位，或优选至少两种选自变应原Der p I，Der p II，Der f I或Der f II的蛋白质变应原的T细胞表位。本发明还涉及已被进一步修饰的肽，其具有与相应的天然存在的变应原或其部分相似或增强的治疗性质，但具有减少的副作用。本发明还提供了编码本发明的肽的核酸序列。还提供了处理或诊断个体中对尘螨的敏感性的方法和包含本发明的一种或多种肽的治疗组合物。

9. 发明申请

WO1993021321A3 T CELL EPITOPES OF THE MAJOR ALLERGENS FROM AMBROSIA ARTEMISIIFOLIA 审中-公开
公开(公告)号：WO1993021321A3
公开(公告)日：1993-10-28
申请号：PCT/US1993003156
申请日：1993-04-06
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： IMMULOGIC PHARMACEUTICAL CORPORATION , KUO, Mei-chang , GARMAN, Richard, D. , GREENSTEIN, Julia, L.
IPC分类号： C12N15/29

10. 发明公开

EP0636180A1 T CELL EPITOPES OF THE MAJOR ALLERGENS FROM $i(AMBROSIA ARTEMISIIFOLIA) 失效
标题翻译： T细胞与主表位的变应原AMBROSIA ARTEMSIIFOLIA的。
公开(公告)号：EP0636180A1
公开(公告)日：1995-02-01
申请号：EP93911584.0
申请日：1993-04-06
申请人： IMMULOGIC PHARMACEUTICAL CORPORATION
发明人： KUO, Mei-chang , GARMAN, Richard, D. , GREENSTEIN, Julia, L.
IPC分类号： C12N15 , A61K38 , A61K39 , A61P37 , C07K14 , C12N1 , C12P21 , G01N33 , C12R1
CPC分类号： C07K14/415 , A61K39/00 , G01N33/68
摘要： The present invention provides isolated peptides of the major protein allergens of Ambrosia artemisiifolia, or short ragweed pollen. Peptides within the scope of the invention comprise at least one T cell epitope, or preferably at least two T cell epitopes of a protein allergen selected from the allergens Amb a I.1, Amb a I.2, Amb a I.3, Amb a I.4 and Amb a II. Modified peptides having similar or enhanced therapeutic properties as the corresponding, naturally-occurring allergen or portion thereof, but having reduced side effects are disclosed. The invention also provides nucleic acids having sequences encoding peptides of the invention. Methods of treatment or of diagnosis of sensitivity to ragweed pollen allergens in an individual and therapeutic compositions comprising one or more peptides of the invention are also provided.

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