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    • 6. 发明申请
    • Multi-Parameter X-Ray Computed Tomography
    • 多参数X射线计算机断层扫描
    • US20100310037A1
    • 2010-12-09
    • US12794160
    • 2010-06-04
    • Ge WANGWenxiang Cong
    • Ge WANGWenxiang Cong
    • G01N23/201A61B6/03
    • A61B6/06A61B6/032A61B6/4291A61B6/583
    • The present invention relates to the field of x-ray imaging. More particularly, embodiments of the invention relate to methods, systems, and apparatus for imaging, which can be used in a wide range of applications, including medical imaging, security screening, and industrial non-destructive testing to name a few. Specifically provided as embodiments of the invention are systems for x-ray imaging comprising: a) a first collimator-and-detector assembly having a first operable configuration to provide at least one first dataset comprising primary x-ray signals as a majority component of its data capable of being presented as a first image of an object subjected to x-ray imaging; b) a second collimator-and-detector assembly having a second operable configuration or wherein the first collimator-and-detector assembly is adjustable to a second configuration to provide at least one second dataset comprising primary and dark-field x-ray signals as a majority component of its data capable of being presented as a second image of the object; and c) a computer operably coupled with the collimator-and-detector assemblies comprising a computer readable medium embedded with processing means for combining the first dataset and the second dataset to extract the dark-field x-ray signals and produce a target image having higher contrast quality than the images based on the first or second dataset alone. Such systems can be configured to comprise at least two collimator-and-detector assemblies or configurations differing with respect to collimator height, collimator aperture, imaging geometry, or distance between an object subjected to the imaging and the collimator-and-detector assembly.
    • 本发明涉及X射线成像领域。 更具体地,本发明的实施例涉及用于成像的方法,系统和装置,其可以用于广泛的应用,包括医学成像,安全性筛选和工业非破坏性测试等等。 作为本发明的实施例具体提供的是用于x射线成像的系统,包括:a)第一准直仪和检测器组件,其具有第一可操作配置,以提供至少一个第一数据集,所述第一数据集包括主X射线信号作为其主要成分 能够被呈现为经受X射线成像的物体的第一图像的数据; b)具有第二可操作构型的第二准直器和检测器组件,或者其中第一准直器和检测器组件可调整到第二配置以提供包括主场和暗场x射线信号的至少一个第二数据集,作为 其数据的多数分量能够被呈现为对象的第二图像; 以及c)与所述准直仪和检测器组件可操作地耦合的计算机,包括嵌入有处理装置的计算机可读介质,所述处理装置用于组合所述第一数据集和所述第二数据集以提取所述暗场x射线信号并产生具有较高 对比质量比基于第一或第二数据集的图像单独。 这样的系统可以被配置为包括关于准直器高度,准直器孔径,成像几何形状或经受成像的物体与准直器和检测器组件之间的距离不同的至少两个准直器和检测器组件或构造。
    • 8. 发明授权
    • Multi-parameter X-ray computed tomography
    • 多参数X线计算机断层扫描
    • US08121249B2
    • 2012-02-21
    • US12794160
    • 2010-06-04
    • Ge WangWenxiang Cong
    • Ge WangWenxiang Cong
    • A61B6/00
    • A61B6/06A61B6/032A61B6/4291A61B6/583
    • The present invention relates to the field of x-ray imaging. More particularly, embodiments of the invention relate to methods, systems, and apparatus for imaging, which can be used in a wide range of applications, including medical imaging, security screening, and industrial non-destructive testing to name a few. Specifically provided as embodiments of the invention are systems for x-ray imaging comprising: a) a first collimator-and-detector assembly having a first operable configuration to provide at least one first dataset comprising primary x-ray signals as a majority component of its data capable of being presented as a first image of an object subjected to x-ray imaging; b) a second collimator-and-detector assembly having a second operable configuration or wherein the first collimator-and-detector assembly is adjustable to a second configuration to provide at least one second dataset comprising primary and dark-field x-ray signals as a majority component of its data capable of being presented as a second image of the object; and c) a computer operably coupled with the collimator-and-detector assemblies comprising a computer readable medium embedded with processing means for combining the first dataset and the second dataset to extract the dark-field x-ray signals and produce a target image having higher contrast quality than the images based on the first or second dataset alone. Such systems can be configured to comprise at least two collimator-and-detector assemblies or configurations differing with respect to collimator height, collimator aperture, imaging geometry, or distance between an object subjected to the imaging and the collimator-and-detector assembly.
    • 本发明涉及X射线成像领域。 更具体地,本发明的实施例涉及用于成像的方法,系统和装置,其可以用于广泛的应用,包括医学成像,安全性筛选和工业非破坏性测试等等。 作为本发明的实施例具体提供的是用于x射线成像的系统,包括:a)第一准直仪和检测器组件,其具有第一可操作配置,以提供至少一个第一数据集,所述第一数据集包括主X射线信号作为其主要成分 能够被呈现为经受x射线成像的物体的第一图像的数据; b)具有第二可操作构型的第二准直器和检测器组件,或者其中第一准直器和检测器组件可调整到第二配置以提供包括主场和暗场x射线信号的至少一个第二数据集,作为 其数据的多数分量能够被呈现为对象的第二图像; 以及c)与所述准直仪和检测器组件可操作地耦合的计算机,包括嵌入有处理装置的计算机可读介质,所述处理装置用于组合所述第一数据集和所述第二数据集以提取所述暗场x射线信号并产生具有较高 对比质量比基于第一或第二数据集的图像单独。 这样的系统可以被配置为包括关于准直器高度,准直器孔径,成像几何形状或经受成像的物体与准直器和检测器组件之间的距离不同的至少两个准直器和检测器组件或构造。
    • 9. 发明申请
    • EXTENDED INTERIOR METHODS AND SYSTEMS FOR SPECTRAL, OPTICAL, AND PHOTOACOUSTIC IMAGING
    • 用于光谱,光学和光电成像的扩展内部方法和系统
    • US20110282181A1
    • 2011-11-17
    • US12945733
    • 2010-11-12
    • Ge WANGYong XuAlexander CongHaiou ShenWenxiang CongLin YangYang Lu
    • Ge WANGYong XuAlexander CongHaiou ShenWenxiang CongLin YangYang Lu
    • A61B6/00A61B6/03G06K9/00G01N23/04
    • A61B6/032A61B5/0095A61B5/7232A61B6/4007A61B6/508G01N23/046G01N2223/419G01N2223/612G06T11/006G06T2211/424G06T2211/432G06T2211/436
    • The present invention relates to the field of medical imaging. More particularly, embodiments of the invention relate to methods, systems, and devices for imaging, including for tomography-based applications. Embodiments of the invention include, for example, a computed tomography based imaging system comprising: (a) at least one wide-beam gray-scale imaging chain capable of performing a global scan of an object and acquiring projection data relating to the object; (b) at least one narrow-beam true-color imaging chain capable of performing a spectral interior scan of a region of interest (ROI) of and acquiring projection data relating to the object; (c) a processing module operably configured for: (1) receiving the projection data; (2) reconstructing the ROI into an image by analyzing the data with a color interior tomography algorithm, aided by an individualized gray-scale reconstruction of an entire field of view (FOV), including the ROI; and (d) a processor for executing the processing module. The extended interior methods and systems for spectral, optical, and photoacoustic imaging presented in this application can lead to better medical diagnoses by providing images with higher resolution or quality, and can lead to safer procedures by providing systems capable of reducing a patient's exposure time to, and thus quantity of, potentially harmful x-rays. Embodiments of the invention also provide tools for real-time tomography-based analyses.
    • 本发明涉及医学成像领域。 更具体地,本发明的实施例涉及用于成像的方法,系统和装置,包括用于基于层析摄影的应用。 本发明的实施例包括例如基于计算机断层摄影的成像系统,包括:(a)至少一个能够执行对象的全局扫描并获取与该对象有关的投影数据的宽光束灰度级成像链; (b)至少一个能够执行感兴趣区域(ROI)的光谱内部扫描并获取与该对象有关的投影数据的窄束真彩色成像链; (c)可操作地配置用于:(1)接收投影数据的处理模块; (2)通过在包括ROI的整个视场(FOV)的个体化灰度重建的辅助下,利用颜色内部层析成像算法分析数据,将ROI重建成图像; 和(d)用于执行处理模块的处理器。 本应用中提出的用于光谱,光学和光声成像的扩展内部方法和系统可以通过提供具有更高分辨率或质量的图像来导致更好的医学诊断,并且可以通过提供能够减少患者的暴露时间的系统来导致更安全的程序 ,因此可能有害x射线的数量。 本发明的实施例还提供用于基于实时断层摄影的分析的工具。
    • 10. 发明申请
    • SYSTEMS AND METHODS FOR MULTI-SPECTRAL BIOLUMINESCENCE TOMOGRAPHY
    • 多光谱生物荧光光谱的系统与方法
    • US20070244395A1
    • 2007-10-18
    • US11619495
    • 2007-01-03
    • Ge WangAlexander CongWeimin HanMing JiangHaiou ShenWenxiang Cong
    • Ge WangAlexander CongWeimin HanMing JiangHaiou ShenWenxiang Cong
    • A61B5/00
    • A61B5/0059A61B5/0077A61B6/03A61B6/4488A61B6/482A61B6/508A61B6/5247A61B2503/40
    • Bioluminescent imaging has proven to be a valuable tool for monitoring physiological and pathological activities at cellular and molecular levels in living small animals. Using biological techniques, target cells can be tagged with reporters which generate characteristic photons in a wide spectrum covering the infra-red range. Part of the diffused light can reach the body surface of a subject/specimen (e.g., a small animal), be separated into several spectral bands using optical means, and collected by a sensitive camera. Systems and methods are disclosed herein for multi-spectral bioluminescence tomography (MBLT), in which an image of an underlying 3D bioluminescent source distribution is synergistically reconstructed from spectrally resolved datasets externally measured. This MBLT process involves two or multiple imaging modalities that produce structural information of the object and optical properties of the object as well to enable and improve the quality of MBLT.
    • 已经证明生物发光成像是监测活的小动物细胞和分子水平的生理和病理活动的有价值的工具。 使用生物学技术,靶细胞可以用记录器进行标记,记者在覆盖红外范围的广谱中产生特征光子。 扩散光的一部分可以到达对象/标本(例如,小动物)的身体表面,使用光学装置分离成若干光谱带,并由敏感摄像机收集。 本文公开了用于多光谱生物发光断层摄影(MBLT)的系统和方法,其中底层3D生物发光源分布的图像从外部测量的光谱解析数据集协同地重建。 该MBLT过程涉及产生物体的结构信息和对象的光学性质的两个或多个成像模态,以及实现和提高MBLT的质量。