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1. 发明授权

US08862206B2 Extended interior methods and systems for spectral, optical, and photoacoustic imaging 有权
标题翻译：用于光谱，光学和光声成像的扩展内部方法和系统
公开(公告)号：US08862206B2
公开(公告)日：2014-10-14
申请号：US12945733
申请日：2010-11-12
申请人： Ge Wang , Yong Xu , Alexander Cong , Haiou Shen , Wenxiang Cong , Lin Yang , Yang Lu
发明人： Ge Wang , Yong Xu , Alexander Cong , Haiou Shen , Wenxiang Cong , Lin Yang , Yang Lu
IPC分类号： A61B5/05 , G01N23/04 , G06T11/00 , A61B6/00 , A61B6/03 , A61B5/00
CPC分类号： A61B6/032 , A61B5/0095 , A61B5/7232 , A61B6/4007 , A61B6/508 , G01N23/046 , G01N2223/419 , G01N2223/612 , G06T11/006 , G06T2211/424 , G06T2211/432 , G06T2211/436
摘要： The present invention relates to the field of medical imaging. More particularly, embodiments of the invention relate to methods, systems, and devices for imaging, including for tomography-based applications. Embodiments of the invention include, for example, a computed tomography based imaging system comprising: (a) at least one wide-beam gray-scale imaging chain capable of performing a global scan of an object and acquiring projection data relating to the object; (b) at least one narrow-beam true-color imaging chain capable of performing a spectral interior scan of a region of interest (ROI) of and acquiring projection data relating to the object; (c) a processing module operably configured for: (1) receiving the projection data; (2) reconstructing the ROI into an image by analyzing the data with a color interior tomography algorithm, aided by an individualized gray-scale reconstruction of an entire field of view (FOV), including the ROI; and (d) a processor for executing the processing module. The extended interior methods and systems for spectral, optical, and photoacoustic imaging presented in this application can lead to better medical diagnoses by providing images with higher resolution or quality, and can lead to safer procedures by providing systems capable of reducing a patient's exposure time to, and thus quantity of, potentially harmful x-rays. Embodiments of the invention also provide tools for real-time tomography-based analyses.
摘要翻译：本发明涉及医学成像领域。更具体地，本发明的实施例涉及用于成像的方法，系统和装置，包括用于基于层析摄影的应用。本发明的实施例包括例如基于计算机断层摄影的成像系统，包括：（a）至少一个能够执行对象的全局扫描并获取与该对象有关的投影数据的宽光束灰度级成像链; （b）至少一个能够执行感兴趣区域（ROI）的光谱内部扫描并获取与该对象有关的投影数据的窄束真彩色成像链; （c）可操作地配置用于：（1）接收投影数据的处理模块; （2）通过在包括ROI的整个视场（FOV）的个体化灰度重建的辅助下，利用颜色内部层析成像算法分析数据，将ROI重建成图像; 和（d）用于执行处理模块的处理器。本应用中提出的用于光谱，光学和光声成像的扩展内部方法和系统可以通过提供具有更高分辨率或质量的图像来导致更好的医学诊断，并且可以通过提供能够减少患者的暴露时间的系统来导致更安全的程序，因此可能有害x射线的数量。本发明的实施例还提供用于基于实时断层摄影的分析的工具。

2. 发明申请

US20110282181A1 EXTENDED INTERIOR METHODS AND SYSTEMS FOR SPECTRAL, OPTICAL, AND PHOTOACOUSTIC IMAGING 有权
标题翻译：用于光谱，光学和光电成像的扩展内部方法和系统
公开(公告)号：US20110282181A1
公开(公告)日：2011-11-17
申请号：US12945733
申请日：2010-11-12
申请人： Ge WANG , Yong Xu , Alexander Cong , Haiou Shen , Wenxiang Cong , Lin Yang , Yang Lu
发明人： Ge WANG , Yong Xu , Alexander Cong , Haiou Shen , Wenxiang Cong , Lin Yang , Yang Lu
IPC分类号： A61B6/00 , A61B6/03 , G06K9/00 , G01N23/04
CPC分类号： A61B6/032 , A61B5/0095 , A61B5/7232 , A61B6/4007 , A61B6/508 , G01N23/046 , G01N2223/419 , G01N2223/612 , G06T11/006 , G06T2211/424 , G06T2211/432 , G06T2211/436
摘要： The present invention relates to the field of medical imaging. More particularly, embodiments of the invention relate to methods, systems, and devices for imaging, including for tomography-based applications. Embodiments of the invention include, for example, a computed tomography based imaging system comprising: (a) at least one wide-beam gray-scale imaging chain capable of performing a global scan of an object and acquiring projection data relating to the object; (b) at least one narrow-beam true-color imaging chain capable of performing a spectral interior scan of a region of interest (ROI) of and acquiring projection data relating to the object; (c) a processing module operably configured for: (1) receiving the projection data; (2) reconstructing the ROI into an image by analyzing the data with a color interior tomography algorithm, aided by an individualized gray-scale reconstruction of an entire field of view (FOV), including the ROI; and (d) a processor for executing the processing module. The extended interior methods and systems for spectral, optical, and photoacoustic imaging presented in this application can lead to better medical diagnoses by providing images with higher resolution or quality, and can lead to safer procedures by providing systems capable of reducing a patient's exposure time to, and thus quantity of, potentially harmful x-rays. Embodiments of the invention also provide tools for real-time tomography-based analyses.
摘要翻译：本发明涉及医学成像领域。更具体地，本发明的实施例涉及用于成像的方法，系统和装置，包括用于基于层析摄影的应用。本发明的实施例包括例如基于计算机断层摄影的成像系统，包括：（a）至少一个能够执行对象的全局扫描并获取与该对象有关的投影数据的宽光束灰度级成像链; （b）至少一个能够执行感兴趣区域（ROI）的光谱内部扫描并获取与该对象有关的投影数据的窄束真彩色成像链; （c）可操作地配置用于：（1）接收投影数据的处理模块; （2）通过在包括ROI的整个视场（FOV）的个体化灰度重建的辅助下，利用颜色内部层析成像算法分析数据，将ROI重建成图像; 和（d）用于执行处理模块的处理器。本应用中提出的用于光谱，光学和光声成像的扩展内部方法和系统可以通过提供具有更高分辨率或质量的图像来导致更好的医学诊断，并且可以通过提供能够减少患者的暴露时间的系统来导致更安全的程序，因此可能有害x射线的数量。本发明的实施例还提供用于基于实时断层摄影的分析的工具。

3. 发明授权

US08798722B2 Fiber array for optical imaging and therapeutics 有权
标题翻译：用于光学成像和治疗的光纤阵列
公开(公告)号：US08798722B2
公开(公告)日：2014-08-05
申请号：US13203800
申请日：2010-03-01
申请人： Christopher Rylander , Thomas A. Campbell , Ge Wang , Yong Xu , Mehmet Alpaslan Kosoglu
发明人： Christopher Rylander , Thomas A. Campbell , Ge Wang , Yong Xu , Mehmet Alpaslan Kosoglu
IPC分类号： A61B5/00
CPC分类号： A61B18/203 , A61B5/0059 , A61B5/0066 , A61B5/0084 , A61B5/411 , A61B5/442 , A61B5/444 , A61B5/685 , A61B2018/00452 , A61N5/0616 , A61N2005/0631 , A61N2005/067 , G02B6/032 , G02B6/06 , G02B6/262
摘要： The present invention relates to the field of optical imaging and therapeutics. More particularly, embodiments of the present invention provide minimally-invasive Fiberoptic Microneedle Devices (FMDs) for light-based therapeutics, which physically penetrate tissue and deliver light directly into the target area below the skin surface (FIG. 1). A preferred embodiment of the invention is a fiberoptic microneedle device comprising: (a) one or more silica-based needles capable of guiding light and comprising a length of about 0.5-6 mm, a base having an outer diameter in the range of about 100-150 micron, and a tip having an outer diameter in the range of about 5-20 micron; (b) a support member to which the needles are secured; (c) a ferrule comprising one or more holes for each of the needles, wherein the ferrule is operably configured to provide mechanical support to each needle at all or some portion of the length of the needle. Embodiments of the invention enable depth-selective and deep photothermal therapeutics and can be adapted for use with any laser-based treatment or diagnostic in which light is used to detect or treat targets under or on the skin surface.
摘要翻译：本发明涉及光学成像和治疗学领域。更具体地说，本发明的实施例提供了用于基于光的治疗剂的微创光纤微针装置（FMD），其物理地穿透组织并将光直接传送到皮肤表面下方的目标区域（图1）。本发明的优选实施例是一种光纤微针装置，包括：（a）一个或多个能够引导光并且包括约0.5-6mm的长度的基于二氧化硅的针，具有约100的外径的基部 -150微米，以及外径在约5-20微米范围内的尖端; （b）固定针的支撑构件; （c）套圈，其包括用于每个针的一个或多个孔，其中所述套圈可操作地构造成在所述针的所述长度的全部或某一部分处为每个针提供机械支撑。本发明的实施方案可实现深度选择性和深度光热治疗剂，并且可适用于任何基于激光的治疗或诊断，其中光用于检测或治疗皮肤表面下或皮肤表面上的靶标。

4. 发明申请

US20110313298A1 FIBER ARRAY FOR OPTICAL IMAGING AND THERAPEUTICS 有权
标题翻译：用于光学成像和治疗的光纤阵列
公开(公告)号：US20110313298A1
公开(公告)日：2011-12-22
申请号：US13203800
申请日：2010-03-01
申请人： Christopher Rylander , Thomas A. Campbell , Ge Wang , Yong Xu , Mehmet Alpaslan Kosoglu
发明人： Christopher Rylander , Thomas A. Campbell , Ge Wang , Yong Xu , Mehmet Alpaslan Kosoglu
IPC分类号： A61B6/00 , A61M37/00
CPC分类号： A61B18/203 , A61B5/0059 , A61B5/0066 , A61B5/0084 , A61B5/411 , A61B5/442 , A61B5/444 , A61B5/685 , A61B2018/00452 , A61N5/0616 , A61N2005/0631 , A61N2005/067 , G02B6/032 , G02B6/06 , G02B6/262
摘要： The present invention relates to the field of optical imaging and therapeutics. More particularly, embodiments of the present invention provide minimally-invasive Fiberoptic Microneedle Devices (FMDs) for light-based therapeutics, which physically penetrate tissue and deliver light directly into the target area below the skin surface (FIG. 1). A preferred embodiment of the invention is a fiberoptic microneedle device comprising: (a) one or more silica-based needles capable of guiding light and comprising a length of about 0.5-6 mm, a base having an outer diameter in the range of about 100-150 micron, and a tip having an outer diameter in the range of about 5-20 micron; (b) a support member to which the needles are secured; (c) a ferrule comprising one or more holes for each of the needles, wherein the ferrule is operably configured to provide mechanical support to each needle at all or some portion of the length of the needle. Embodiments of the invention enable depth-selective and deep photothermal therapeutics and can be adapted for use with any laser-based treatment or diagnostic in which light is used to detect or treat targets under or on the skin surface.
摘要翻译：本发明涉及光学成像和治疗领域。更具体地说，本发明的实施例提供了用于基于光的治疗剂的微创光纤微针装置（FMD），其物理地穿透组织并将光直接传送到皮肤表面下方的目标区域（图1）。本发明的优选实施例是一种光纤微针装置，包括：（a）一个或多个能够引导光并且包括约0.5-6mm的长度的基于二氧化硅的针，具有约100的外径的基部 -150微米，以及外径在约5-20微米范围内的尖端; （b）固定针的支撑构件; （c）套圈，其包括用于每个针的一个或多个孔，其中所述套圈可操作地构造成在所述针的所述长度的全部或某一部分处为每个针提供机械支撑。本发明的实施方案可实现深度选择性和深度光热治疗剂，并且可适用于任何基于激光的治疗或诊断，其中光用于检测或治疗皮肤表面下或皮肤表面上的靶标。

5. 发明授权

US09481665B2 Process for preparing PI3K inhibitor buparsilib 有权
标题翻译：制备PI3K抑制剂布比西利的方法
公开(公告)号：US09481665B2
公开(公告)日：2016-11-01
申请号：US14656774
申请日：2015-03-13
申请人： Yong Xu
发明人： Yong Xu
IPC分类号： C07D401/04 , C07D239/48
CPC分类号： C07D401/04 , C07D239/48
摘要： The present disclosure provides a new process for preparing PI3K inhibitor buparsilib. The whole reaction route of the present invention is simple and easy to control for the industrial production.
摘要翻译：本公开提供了制备PI3K抑制剂布比塞利的新方法。本发明的整个反应路线对于工业生产来说是简单且易于控制的。

6. 发明授权

US09296721B1 Method for preparing ALK inhibitor ceritinib 有权
标题翻译：制备ALK抑制剂塞立替尼的方法
公开(公告)号：US09296721B1
公开(公告)日：2016-03-29
申请号：US14622640
申请日：2015-02-13
申请人： Yong Xu
发明人： Yong Xu
IPC分类号： C07D239/48 , C07D401/12 , C07D211/26
CPC分类号： C07D401/12 , C07D211/26 , Y02P20/55
摘要： Embodiment of present disclosure provides a method for preparing ceritinib of formula I, comprising: (1) contacting a compound of formula 12b with an amino protective group to obtain a compound of formula 3; (2) contacting the compound of formula 3 with a compound of formula 9a to obtain a compound of formula 5; and (3) subjecting the compound of formula 5 to a deprotection reaction to obtain the ceritinib of formula I. Then ceritinib may be effectively prepared.
摘要翻译：本公开的实施方案提供了制备式I的硫可替尼的方法，包括：（1）使式12b化合物与氨基保护基接触，得到式3的化合物; （2）使式3化合物与式9a化合物接触，得到式5化合物; 和（3）使式5的化合物进行脱保护反应，得到式I的硫可替尼他。然后，可以有效地制备硫尼替尼。

7. 发明申请

US20140329807A1 HETEROCYCLIC PROTEIN KINASE INHIBITORS 有权
标题翻译：杂环蛋白激酶抑制剂
公开(公告)号：US20140329807A1
公开(公告)日：2014-11-06
申请号：US14234109
申请日：2012-07-20
申请人： Yong Xu , Benjamin Gary Brenning , Steven G. Kultgen , Xiaohui Liu , Michael Saunders , Koc-Kan Ho
发明人： Yong Xu , Benjamin Gary Brenning , Steven G. Kultgen , Xiaohui Liu , Michael Saunders , Koc-Kan Ho
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention provides protein kinase having one of the following structures (I), (II) or (III): or a stereoisomer, prodrug, tautomer or pharmaceutically acceptable salt thereof, wherein R, R1, R2 and X are as defined herein. Compositions and methods for using the same in the treatment of cancer, autoimmune, inflammatory and other Pim kinase-associated conditions are also disclosed.
摘要翻译：本发明提供具有以下结构（I），（II）或（III）之一的蛋白激酶：或其立体异构体，前药，互变异构体或其药学上可接受的盐，其中R，R 1，R 2和X如本文所定义。还公开了用于治疗癌症，自身免疫性，炎性和其它Pim激酶相关病症的组合物和方法。

8. 发明申请

US20140079750A1 TOOTH REMINERALIZING ORAL CARE COMPOSITIONS 审中-公开
标题翻译：牙齿保养口腔护理组合物
公开(公告)号：US20140079750A1
公开(公告)日：2014-03-20
申请号：US14110933
申请日：2012-03-29
申请人： Xiaoke Li , Yan Deng , Guan-Jun Ding , Yong Xu
发明人： Xiaoke Li , Yan Deng , Guan-Jun Ding , Yong Xu
IPC分类号： A61K6/00 , A61Q11/00
CPC分类号： A61K6/0023 , A61K6/0008 , A61K8/0241 , A61K8/19 , A61K8/24 , A61K2800/412 , A61Q11/00
摘要： Oral care compositions suitable for whitening and remineralizing teeth are described. The oral care compositions comprise a phosphate source and regeneration-source calcium salt having a particle size of five (5) microns or less so that in-situ hydroxyapatite may be generated upon use.
摘要翻译：描述了适用于美白和再矿化牙齿的口腔护理组合物。口腔护理组合物包含粒径为五（5）微米或更小的磷酸盐源和再生源钙盐，使得在使用时可能产生原位羟基磷灰石。

9. 发明申请

US20110256092A1 QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION 审中-公开
标题翻译：用于调制DNA甲基化的喹啉衍生物
公开(公告)号：US20110256092A1
公开(公告)日：2011-10-20
申请号：US13047635
申请日：2011-03-14
申请人： Pasit Phiasivongsa , Sanjeev G. Redkar , Swarna Gamage , Darby Brooke , William Denny , David J. Bearss , Hariprasad Vankayalapati , Yong Xu , Krzysztof Swierczek
发明人： Pasit Phiasivongsa , Sanjeev G. Redkar , Swarna Gamage , Darby Brooke , William Denny , David J. Bearss , Hariprasad Vankayalapati , Yong Xu , Krzysztof Swierczek
IPC分类号： A61K31/4709 , C12N5/071 , C12N9/99 , A61K31/706 , A61K38/20 , A61P7/06 , A61K39/395 , A61K38/12 , A61K38/15 , A61P35/00 , A61P35/02 , C07D401/12 , A61K38/21
CPC分类号： C07D401/12
摘要： Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.
摘要翻译：喹啉衍生物，特别是4-苯胺基喹啉衍生物。这样的喹啉衍生物可用于DNA甲基化的调节，例如通过选择性抑制DNA甲基转移酶DNMT1有效抑制C-5位上胞嘧啶的甲基化。提供了合成大量4-苯胺基喹啉衍生物和调节DNA甲基化的方法。还提供了用于配制和施用这些化合物或组合物以治疗诸如癌症和血液学疾病的病症的方法。

10. 发明申请

US20090285772A1 QUINOLINE DERIVATIVES FOR MODULATING DNA METHYLATION 失效
标题翻译：用于调制DNA甲基化的喹啉衍生物
公开(公告)号：US20090285772A1
公开(公告)日：2009-11-19
申请号：US12422067
申请日：2009-04-10
申请人： Pasit Phiasivongsa , Sanjeev G. Redkar , Swarna Gamage , Darby Brooke , William Denny , David J. Bearss , Hariprasad Vankayalapati , Yong Xu , Krzysztof Swierczek
发明人： Pasit Phiasivongsa , Sanjeev G. Redkar , Swarna Gamage , Darby Brooke , William Denny , David J. Bearss , Hariprasad Vankayalapati , Yong Xu , Krzysztof Swierczek
IPC分类号： A61K31/47 , C07D215/38 , C07D401/12 , A61K31/506 , A61K31/7064 , A61K38/20 , A61K38/21 , A61K39/395 , A61P35/00
CPC分类号： C07D401/12
摘要： Quinoline derivatives, particularly 4-anilinoquinoline derivatives, are provided. Such quinoline derivatives can be used for modulation of DNA methylation, such as effective inhibition of methylation of cytosine at the C-5 position, for example via selective inhibition of DNA methyltransferase DNMT1. Methods for synthesizing numerous 4-anilinoquinoline derivatives and for modulating DNA methylation are provided. Also provided are methods for formulating and administering these compounds or compositions to treat conditions such as cancer and hematological disorders.
摘要翻译：喹啉衍生物，特别是4-苯胺基喹啉衍生物。这样的喹啉衍生物可用于DNA甲基化的调节，例如通过选择性抑制DNA甲基转移酶DNMT1有效抑制C-5位上胞嘧啶的甲基化。提供了合成大量4-苯胺基喹啉衍生物和调节DNA甲基化的方法。还提供了用于配制和施用这些化合物或组合物以治疗诸如癌症和血液学疾病的病症的方法。

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