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1. 发明授权

US08862206B2 Extended interior methods and systems for spectral, optical, and photoacoustic imaging 有权
标题翻译：用于光谱，光学和光声成像的扩展内部方法和系统
公开(公告)号：US08862206B2
公开(公告)日：2014-10-14
申请号：US12945733
申请日：2010-11-12
申请人： Ge Wang , Yong Xu , Alexander Cong , Haiou Shen , Wenxiang Cong , Lin Yang , Yang Lu
发明人： Ge Wang , Yong Xu , Alexander Cong , Haiou Shen , Wenxiang Cong , Lin Yang , Yang Lu
IPC分类号： A61B5/05 , G01N23/04 , G06T11/00 , A61B6/00 , A61B6/03 , A61B5/00
CPC分类号： A61B6/032 , A61B5/0095 , A61B5/7232 , A61B6/4007 , A61B6/508 , G01N23/046 , G01N2223/419 , G01N2223/612 , G06T11/006 , G06T2211/424 , G06T2211/432 , G06T2211/436
摘要： The present invention relates to the field of medical imaging. More particularly, embodiments of the invention relate to methods, systems, and devices for imaging, including for tomography-based applications. Embodiments of the invention include, for example, a computed tomography based imaging system comprising: (a) at least one wide-beam gray-scale imaging chain capable of performing a global scan of an object and acquiring projection data relating to the object; (b) at least one narrow-beam true-color imaging chain capable of performing a spectral interior scan of a region of interest (ROI) of and acquiring projection data relating to the object; (c) a processing module operably configured for: (1) receiving the projection data; (2) reconstructing the ROI into an image by analyzing the data with a color interior tomography algorithm, aided by an individualized gray-scale reconstruction of an entire field of view (FOV), including the ROI; and (d) a processor for executing the processing module. The extended interior methods and systems for spectral, optical, and photoacoustic imaging presented in this application can lead to better medical diagnoses by providing images with higher resolution or quality, and can lead to safer procedures by providing systems capable of reducing a patient's exposure time to, and thus quantity of, potentially harmful x-rays. Embodiments of the invention also provide tools for real-time tomography-based analyses.
摘要翻译：本发明涉及医学成像领域。更具体地，本发明的实施例涉及用于成像的方法，系统和装置，包括用于基于层析摄影的应用。本发明的实施例包括例如基于计算机断层摄影的成像系统，包括：（a）至少一个能够执行对象的全局扫描并获取与该对象有关的投影数据的宽光束灰度级成像链; （b）至少一个能够执行感兴趣区域（ROI）的光谱内部扫描并获取与该对象有关的投影数据的窄束真彩色成像链; （c）可操作地配置用于：（1）接收投影数据的处理模块; （2）通过在包括ROI的整个视场（FOV）的个体化灰度重建的辅助下，利用颜色内部层析成像算法分析数据，将ROI重建成图像; 和（d）用于执行处理模块的处理器。本应用中提出的用于光谱，光学和光声成像的扩展内部方法和系统可以通过提供具有更高分辨率或质量的图像来导致更好的医学诊断，并且可以通过提供能够减少患者的暴露时间的系统来导致更安全的程序，因此可能有害x射线的数量。本发明的实施例还提供用于基于实时断层摄影的分析的工具。

2. 发明申请

US20110282181A1 EXTENDED INTERIOR METHODS AND SYSTEMS FOR SPECTRAL, OPTICAL, AND PHOTOACOUSTIC IMAGING 有权
标题翻译：用于光谱，光学和光电成像的扩展内部方法和系统
公开(公告)号：US20110282181A1
公开(公告)日：2011-11-17
申请号：US12945733
申请日：2010-11-12
申请人： Ge WANG , Yong Xu , Alexander Cong , Haiou Shen , Wenxiang Cong , Lin Yang , Yang Lu
发明人： Ge WANG , Yong Xu , Alexander Cong , Haiou Shen , Wenxiang Cong , Lin Yang , Yang Lu
IPC分类号： A61B6/00 , A61B6/03 , G06K9/00 , G01N23/04
CPC分类号： A61B6/032 , A61B5/0095 , A61B5/7232 , A61B6/4007 , A61B6/508 , G01N23/046 , G01N2223/419 , G01N2223/612 , G06T11/006 , G06T2211/424 , G06T2211/432 , G06T2211/436
摘要： The present invention relates to the field of medical imaging. More particularly, embodiments of the invention relate to methods, systems, and devices for imaging, including for tomography-based applications. Embodiments of the invention include, for example, a computed tomography based imaging system comprising: (a) at least one wide-beam gray-scale imaging chain capable of performing a global scan of an object and acquiring projection data relating to the object; (b) at least one narrow-beam true-color imaging chain capable of performing a spectral interior scan of a region of interest (ROI) of and acquiring projection data relating to the object; (c) a processing module operably configured for: (1) receiving the projection data; (2) reconstructing the ROI into an image by analyzing the data with a color interior tomography algorithm, aided by an individualized gray-scale reconstruction of an entire field of view (FOV), including the ROI; and (d) a processor for executing the processing module. The extended interior methods and systems for spectral, optical, and photoacoustic imaging presented in this application can lead to better medical diagnoses by providing images with higher resolution or quality, and can lead to safer procedures by providing systems capable of reducing a patient's exposure time to, and thus quantity of, potentially harmful x-rays. Embodiments of the invention also provide tools for real-time tomography-based analyses.
摘要翻译：本发明涉及医学成像领域。更具体地，本发明的实施例涉及用于成像的方法，系统和装置，包括用于基于层析摄影的应用。本发明的实施例包括例如基于计算机断层摄影的成像系统，包括：（a）至少一个能够执行对象的全局扫描并获取与该对象有关的投影数据的宽光束灰度级成像链; （b）至少一个能够执行感兴趣区域（ROI）的光谱内部扫描并获取与该对象有关的投影数据的窄束真彩色成像链; （c）可操作地配置用于：（1）接收投影数据的处理模块; （2）通过在包括ROI的整个视场（FOV）的个体化灰度重建的辅助下，利用颜色内部层析成像算法分析数据，将ROI重建成图像; 和（d）用于执行处理模块的处理器。本应用中提出的用于光谱，光学和光声成像的扩展内部方法和系统可以通过提供具有更高分辨率或质量的图像来导致更好的医学诊断，并且可以通过提供能够减少患者的暴露时间的系统来导致更安全的程序，因此可能有害x射线的数量。本发明的实施例还提供用于基于实时断层摄影的分析的工具。

3. 发明申请

US20070244395A1 SYSTEMS AND METHODS FOR MULTI-SPECTRAL BIOLUMINESCENCE TOMOGRAPHY 有权
标题翻译：多光谱生物荧光光谱的系统与方法
公开(公告)号：US20070244395A1
公开(公告)日：2007-10-18
申请号：US11619495
申请日：2007-01-03
申请人： Ge Wang , Alexander Cong , Weimin Han , Ming Jiang , Haiou Shen , Wenxiang Cong
发明人： Ge Wang , Alexander Cong , Weimin Han , Ming Jiang , Haiou Shen , Wenxiang Cong
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0077 , A61B6/03 , A61B6/4488 , A61B6/482 , A61B6/508 , A61B6/5247 , A61B2503/40
摘要： Bioluminescent imaging has proven to be a valuable tool for monitoring physiological and pathological activities at cellular and molecular levels in living small animals. Using biological techniques, target cells can be tagged with reporters which generate characteristic photons in a wide spectrum covering the infra-red range. Part of the diffused light can reach the body surface of a subject/specimen (e.g., a small animal), be separated into several spectral bands using optical means, and collected by a sensitive camera. Systems and methods are disclosed herein for multi-spectral bioluminescence tomography (MBLT), in which an image of an underlying 3D bioluminescent source distribution is synergistically reconstructed from spectrally resolved datasets externally measured. This MBLT process involves two or multiple imaging modalities that produce structural information of the object and optical properties of the object as well to enable and improve the quality of MBLT.
摘要翻译：已经证明生物发光成像是监测活的小动物细胞和分子水平的生理和病理活动的有价值的工具。使用生物学技术，靶细胞可以用记录器进行标记，记者在覆盖红外范围的广谱中产生特征光子。扩散光的一部分可以到达对象/标本（例如，小动物）的身体表面，使用光学装置分离成若干光谱带，并由敏感摄像机收集。本文公开了用于多光谱生物发光断层摄影（MBLT）的系统和方法，其中底层3D生物发光源分布的图像从外部测量的光谱解析数据集协同地重建。该MBLT过程涉及产生物体的结构信息和对象的光学性质的两个或多个成像模态，以及实现和提高MBLT的质量。

4. 发明授权

US08676302B2 Systems and methods for multi-spectral bioluminescence tomography 有权
标题翻译：多光谱生物发光断层扫描的系统和方法
公开(公告)号：US08676302B2
公开(公告)日：2014-03-18
申请号：US11619495
申请日：2007-01-03
申请人： Ge Wang , Alexander X. Cong , Weimin Han , Ming Jiang , Haiou Shen , Wenxiang Cong
发明人： Ge Wang , Alexander X. Cong , Weimin Han , Ming Jiang , Haiou Shen , Wenxiang Cong
IPC分类号： A61B6/00
CPC分类号： A61B5/0059 , A61B5/0077 , A61B6/03 , A61B6/4488 , A61B6/482 , A61B6/508 , A61B6/5247 , A61B2503/40
摘要： Bioluminescent imaging has proven to be a valuable tool for monitoring physiological and pathological activities at cellular and molecular levels in living small animals. Using biological techniques, target cells can be tagged with reporters which generate characteristic photons in a wide spectrum covering the infra-red range. Part of the diffused light can reach the body surface of a subject/specimen (e.g., a small animal), be separated into several spectral bands using optical means, and collected by a sensitive camera. Systems and methods are disclosed herein for multi-spectral bioluminescence tomography (MBLT), in which an image of an underlying 3D bioluminescent source distribution is synergistically reconstructed from spectrally resolved datasets externally measured. This MBLT process involves two or multiple imaging modalities that produce structural information of the object and optical properties of the object as well to enable and improve the quality of MBLT.
摘要翻译：已经证明生物发光成像是监测活的小动物细胞和分子水平的生理和病理活动的有价值的工具。使用生物学技术，靶细胞可以用记录器进行标记，记者在覆盖红外范围的广谱中产生特征光子。扩散光的一部分可以到达对象/标本（例如，小动物）的身体表面，使用光学装置分离成若干光谱带，并由敏感摄像机收集。本文公开了用于多光谱生物发光断层摄影（MBLT）的系统和方法，其中底层3D生物发光源分布的图像从外部测量的光谱解析数据集协同地重建。该MBLT过程涉及产生物体的结构信息和对象的光学性质的两个或多个成像模态，以及实现和提高MBLT的质量。

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