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1. 发明授权

US5530145A Anticholesteremic compounds 失效
标题翻译：抗胆碱化合物
公开(公告)号：US5530145A
公开(公告)日：1996-06-25
申请号：US350425
申请日：1994-12-06
申请人： Hui-Po Wang , On Lee , Chin-Tsai Fan
发明人： Hui-Po Wang , On Lee , Chin-Tsai Fan
IPC分类号： C07C59/68 , C07C67/03 , C07C69/712 , C07D305/12 , C07C69/76 , C07C59/48
CPC分类号： C07C59/68 , C07C67/03 , C07C69/712 , C07D305/12
摘要： Novel anticholesteremic compounds capable of reducing blood cholesterol levels. Also included in this invention are (i) intermediates from which the abovementioned anticholesteremic compounds can be prepared, and (ii) methods for preparing both the intermediates and the anticholesteremic compounds.
摘要翻译：能够降低血液胆固醇水平的新型抗胆固醇化合物。本发明还包括（i）可以制备上述抗胆固醇化合物的中间体，和（ii）制备中间体和抗胆固醇化合物的方法。

2. 发明授权

US5412112A Derivatives and preparation of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids 失效
标题翻译：衍生物和2,2-二甲基-5-取代的苯氧基 - 戊酸的制备
公开(公告)号：US5412112A
公开(公告)日：1995-05-02
申请号：US259537
申请日：1994-06-14
申请人： Hui-Po Wang , On Lee , Chin-Tsai Fan
发明人： Hui-Po Wang , On Lee , Chin-Tsai Fan
IPC分类号： C07C59/68 , C07C67/03 , C07C69/712 , C07D305/12 , C07C59/48 , C07C69/76
CPC分类号： C07D305/12 , C07C59/68 , C07C67/03 , C07C69/712
摘要： Novel 3-substituted derivatives of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids of formula (I) are prepared. These compouds are prepared from 2,2-dimethyl-5-substituted phenoxy-3-hydroxy-pentanoic acid-.beta.-lactones (formula II). The .beta.-lactones are prepared by condensing relevant phenoxypropanals with dimethylketene.
摘要翻译：制备式（I）的2,2-二甲基-5-取代的苯氧基 - 戊酸的3-取代衍生物。这些化合物由2,2-二甲基-5-取代的苯氧基-3-羟基 - 戊酸-β-内酯（式II）制备。 β-内酯通过将相关苯氧基丙醛与二甲基烯酮缩合而制备。

3. 发明授权

US5869507A Azatyrosine analogues 失效
标题翻译：酪氨酸类似物
公开(公告)号：US5869507A
公开(公告)日：1999-02-09
申请号：US899859
申请日：1997-07-24
申请人： Hui-Po Wang , On Lee , Jin-Yuh Shew , Shui-Jane Lee
发明人： Hui-Po Wang , On Lee , Jin-Yuh Shew , Shui-Jane Lee
IPC分类号： A61K31/44 , A61K31/4418 , A61P35/00 , C07D213/65
CPC分类号： C07D213/65
摘要： A novel anti-oncogenic azatyrosine analogues of formula (I) ##STR1## wherein R.sub.1 is C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, benzyl, or (C.sub.1-6 alkyl)carbonyl; R.sub.2 is C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, or C.sub.1-6 alkoxyl; and R.sub.3 is CONR.sub.4 R.sub.5, CONHNR.sub.4 R.sub.5, or COOR.sub.6, wherein each R.sub.4 and R.sub.5 independently is a hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, or C.sub.3-6 cycloalkyl, or R.sub.4 and R.sub.5 taken together with the nitrogen attached thereto form a C.sub.3-8 heterocyclic group; R.sub.6 is C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, or benzyl. Also disclosed is a method of preparing such a novel anti-oncogenic azatyrosine analogues, as well as a pharmaceutical composition containing a compound of formula (I).
摘要翻译：式（I）的新型抗致癌性酪氨酸类似物其中R 1为C 1-6烷基，C 1-6卤代烷基，苄基或（C 1-6烷基）羰基; R2是C1-6烷基，C1-6卤代烷基或C1-6烷氧基; 并且R 3是CONR 4 R 5，CONHR 4 R 5或COOR 6，其中每个R 4和R 5独立地是氢，C 1-6烷基，C 2-6烯基，C 2-6炔基或C 3-6环烷基，或者R 4和R 5与氮一起附着其形成C 3-8杂环基; R 6是C 1-6烷基，C 1-6卤代烷基，C 2-6烯基，C 2-6炔基，C 3-6环烷基或苄基。还公开了制备这种新型抗致癌性酪氨酸类似物的方法，以及含有式（I）化合物的药物组合物。

4. 发明授权

US07288545B2 Piperazinedione compounds 失效
公开(公告)号：US07288545B2
公开(公告)日：2007-10-30
申请号：US10689865
申请日：2003-10-20
申请人： Che-Ming Teng , Hui-Po Wang , Eric I. C. Li , On Lee , Jih-Hwa Guh , Huei-Ting Chen , Ya-Bing Fan , Ya-Lan Chen
发明人： Che-Ming Teng , Hui-Po Wang , Eric I. C. Li , On Lee , Jih-Hwa Guh , Huei-Ting Chen , Ya-Bing Fan , Ya-Lan Chen
IPC分类号： A61K31/496 , C07D405/14
CPC分类号： C07D401/06 , C07D409/14
摘要： This invention relates to a method for treating an angiogenesis-related disease. The method includes administering to a subject in need thereof an effective amount of a piperazinedione compound having the formula: In the above formula, each of and , independently, is a single bond or a double bond; A is H or CH(RaRb) when is a single bond, or C(RaRb) when is a double bond; Z is CH(RcRd) when is a single bond, or C(RcRd) when is a double bond; each of R1 and R2, independently, is H, C(O)Re, C(O)ORe, C(O)NReRf, or SO2Re; and each of Ra, Rb, Rc, Rd, Re, and Rf, independently, is H, C1-C6 alkyl, aryl, heteroaryl, C3-C8 cycloalkyl, or C3-C8 heterocycloalkyl; or Ra and Rb taken together are C3-C8 cycloalkyl, C3-C8 heterocycloalkyl, aryl, or heteroaryl; or R1 and Ra or R1 and Rb taken together are C3-C8 cycloalkyl, C3-C8 heterocycloalkyl, aryl, or heteroaryl; provided that one of Rc and Rd is aryl or heteroaryl.

5. 发明授权

US06635649B2 Piperazinedione compounds 失效
标题翻译：哌嗪二酮化合物
公开(公告)号：US06635649B2
公开(公告)日：2003-10-21
申请号：US09851077
申请日：2001-05-08
申请人： Che-Ming Teng , Hui-Po Wang , Eric I. C. Li , On Lee , Jih-Hwa Guh , Huei-Ting Chen , Ya-Bing Fan , Ya-Lan Chen
发明人： Che-Ming Teng , Hui-Po Wang , Eric I. C. Li , On Lee , Jih-Hwa Guh , Huei-Ting Chen , Ya-Bing Fan , Ya-Lan Chen
IPC分类号： A61K31496
CPC分类号： C07D401/06 , C07D409/14
摘要： Piperazinedione compounds of the formula: Each of and and independently, is a single bond or a double bond; A is H or CH(RaRb) when is a single bond, or C(RaRb) when is a double bond; Z is R3O—(Ar)—B, in which B is CH(Rc) when is a single bond, or C(Rc) when is a double bond; Ar is heteroaryl; and R3 is H, alkyl, aryl, heteroaryl, C(O)Rd, C(O)ORd, C(O)NRdRe, or SO2Rd; each of R1 and R2, independently, is H, C(O)Rd, C(O)ORd, C(O)NRdRe, or SO2Rd; and each of Ra, Rb, Rc, Rd, and Re, independently, is H, alkyl, aryl, heteroaryl, cyclyl, or heterocyclyl. Optionally, Ra and Rb taken together are cyclyl or heterocyclyl; and, also optionally, R1 and Ra or R1 and Rb taken together are cyclyl or heterocyclyl. Also disclosed is a method for treating tumor with the above described piperazinedione compounds.
摘要翻译：哌嗪二酮化合物，分别为：＆lt; CUSTOM-CHARACTER FILE =“US06635649-20031021-P00900.TIF”ALT =“custom character”HE =“20”WI =“20”ID =“CUSTOM-CHARACTER-00001”/ >和或双键; 当是单键，或C（R a R b）当为双键时; 当是单键或C（R ）”ALT =“自定义字符”HE =“20”WI =“20”ID =“CUSTOM-CHARACTER-00005”/>是双键; Ar是杂芳基; 且R 3为H，烷基，芳基，杂芳基，C（O）R d，C（O）OR d，C（O）NR d R e或SO 2 R d; R 1和R 2各自独立地是H，C（O）R d，C（O）OR d，C（O）NR d R e或SO 2 R ; R a，R b，R c，R d和R e各自独立地是H，烷基，芳基，杂芳基，环基或杂环基。任选地，R 5和R b一起是环基或杂环基; 并且还可任选地，R 1和R 5'或R 1和R b一起是环基或杂环基。还公开了用上述哌嗪二酮化合物治疗肿瘤的方法。

6. 发明授权

US5686423A Di-and tri-peptide mimetic compounds for Parkinson's disease 失效
标题翻译：用于帕金森病的二肽和三肽模拟物质
公开(公告)号：US5686423A
公开(公告)日：1997-11-11
申请号：US602361
申请日：1996-02-16
申请人： Hui-Po Wang , Jia-Shuai Lee , Ming-Cheng Tsai , Hsiao-Hwa Lu , Oliver Yoa-Pu Hu , Wen-Lin Luo
发明人： Hui-Po Wang , Jia-Shuai Lee , Ming-Cheng Tsai , Hsiao-Hwa Lu , Oliver Yoa-Pu Hu , Wen-Lin Luo
IPC分类号： A61K38/00 , C07K5/065 , C07K5/087 , A61K38/05 , A61K38/06 , C07K5/00
CPC分类号： C07K5/0812 , C07K5/06078 , A61K38/00
摘要： A series of di- and tri-peptide mimetic dopamine prodrugs are synthesized in which D-phenylglycine or D-p-hydroxyphenylglycine is attached as tools for delivery of L-dopa through the intestine via the intestinal dipeptide-mediated carrier transport system. These compounds are found useful as an active ingredient for the treatment of Parkinson's disease.
摘要翻译：合成一系列二 - 和三肽模拟多巴胺前药，其中D-苯基甘氨酸或D-对羟基苯基甘氨酸作为用于通过肠二肽介导的载体转运系统通过肠递送L-多巴的工具。发现这些化合物可用作治疗帕金森病的活性成分。

7. 发明申请

US20120232088A1 PIPERAZINEDIONE COMPOUNDS 失效
标题翻译：哌嗪化合物
公开(公告)号：US20120232088A1
公开(公告)日：2012-09-13
申请号：US13404534
申请日：2012-02-24
申请人： Hui-Po Wang , Che-Ming Teng , Chun-Li Wang , Jih-hwa Guh , Shiow-Lin Pan , Yuan-Yi Wang , Jang-Feng Lian
发明人： Hui-Po Wang , Che-Ming Teng , Chun-Li Wang , Jih-hwa Guh , Shiow-Lin Pan , Yuan-Yi Wang , Jang-Feng Lian
IPC分类号： A61K31/496 , C07D401/06 , A61P35/00 , C07D401/14
CPC分类号： C07D401/06 , C07D401/14
摘要： This invention relates to piperazinedione compounds shown in the specification. These compounds are tyrosine kinase inhibitors and can be used to treat cancer.
摘要翻译：本发明涉及说明书中所示的哌嗪二酮化合物。这些化合物是酪氨酸激酶抑制剂，可用于治疗癌症。

8. 发明授权

US5670508A 2-amino-6-alkyl-5-(4-substituted-1-piperazinyl) pyrimidin-4-ones, the preparation and use thereof 失效
标题翻译： 2-氨基-6-烷基-5-（4-取代-1-哌嗪基）嘧啶-4-酮，其制备和用途
公开(公告)号：US5670508A
公开(公告)日：1997-09-23
申请号：US548211
申请日：1995-10-25
申请人： Hui-Po Wang , Tung-Shing Bai
发明人： Hui-Po Wang , Tung-Shing Bai
IPC分类号： C07D239/48 , A61K31/535 , C07D403/02
CPC分类号： C07D239/48
摘要： A series of 2-amino-6-alkyl-5-(4-substituted-1-piperazinyl)pyrimidin-4-ones that have selective cytotoxicity on human CNS tumor cells.
摘要翻译：一系列对人CNS肿瘤细胞具有选择性细胞毒性的2-氨基-6-烷基-5-（4-取代-1-哌嗪基）嘧啶-4-酮。

9. 发明授权

US5498787A Method for preparing cephalosporin derivatives 失效
标题翻译：头孢菌素衍生物的制备方法
公开(公告)号：US5498787A
公开(公告)日：1996-03-12
申请号：US230475
申请日：1994-04-20
申请人： Hui-Po Wang , Jia-Shuai Lee
发明人： Hui-Po Wang , Jia-Shuai Lee
IPC分类号： C07D501/00 , C07D501/04
CPC分类号： C07D501/00
摘要： A method for preparing cephalosporm derivatives by reacting cephalosporin alkaline metal salts with organic halide in the presence of quaternary ammonium salts catalyst is disclosed. .DELTA..sup.3 .fwdarw..DELTA..sup.2 isomerization, a side reaction commonly reported in preparation of cephalosporin derivatives was successfully eliminated. The desired .DELTA..sup.3 was obtained as a sole product in the reaction.
摘要翻译：公开了一种通过在季铵盐催化剂存在下使头孢菌素碱金属盐与有机卤化物反应来制备头孢菌素衍生物的方法。 DELTA 3-> DELTA 2异构化，在头孢菌素衍生物制备中通常报道的副反应成功消除。在反应中作为唯一的产物获得所需的DELTA 3。

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