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1. 发明授权

US5869507A Azatyrosine analogues 失效
标题翻译：酪氨酸类似物
公开(公告)号：US5869507A
公开(公告)日：1999-02-09
申请号：US899859
申请日：1997-07-24
申请人： Hui-Po Wang , On Lee , Jin-Yuh Shew , Shui-Jane Lee
发明人： Hui-Po Wang , On Lee , Jin-Yuh Shew , Shui-Jane Lee
IPC分类号： A61K31/44 , A61K31/4418 , A61P35/00 , C07D213/65
CPC分类号： C07D213/65
摘要： A novel anti-oncogenic azatyrosine analogues of formula (I) ##STR1## wherein R.sub.1 is C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, benzyl, or (C.sub.1-6 alkyl)carbonyl; R.sub.2 is C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, or C.sub.1-6 alkoxyl; and R.sub.3 is CONR.sub.4 R.sub.5, CONHNR.sub.4 R.sub.5, or COOR.sub.6, wherein each R.sub.4 and R.sub.5 independently is a hydrogen, C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, or C.sub.3-6 cycloalkyl, or R.sub.4 and R.sub.5 taken together with the nitrogen attached thereto form a C.sub.3-8 heterocyclic group; R.sub.6 is C.sub.1-6 alkyl, C.sub.1-6 haloalkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, or benzyl. Also disclosed is a method of preparing such a novel anti-oncogenic azatyrosine analogues, as well as a pharmaceutical composition containing a compound of formula (I).
摘要翻译：式（I）的新型抗致癌性酪氨酸类似物其中R 1为C 1-6烷基，C 1-6卤代烷基，苄基或（C 1-6烷基）羰基; R2是C1-6烷基，C1-6卤代烷基或C1-6烷氧基; 并且R 3是CONR 4 R 5，CONHR 4 R 5或COOR 6，其中每个R 4和R 5独立地是氢，C 1-6烷基，C 2-6烯基，C 2-6炔基或C 3-6环烷基，或者R 4和R 5与氮一起附着其形成C 3-8杂环基; R 6是C 1-6烷基，C 1-6卤代烷基，C 2-6烯基，C 2-6炔基，C 3-6环烷基或苄基。还公开了制备这种新型抗致癌性酪氨酸类似物的方法，以及含有式（I）化合物的药物组合物。

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