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1. 发明授权

US5530145A Anticholesteremic compounds 失效
标题翻译：抗胆碱化合物
公开(公告)号：US5530145A
公开(公告)日：1996-06-25
申请号：US350425
申请日：1994-12-06
申请人： Hui-Po Wang , On Lee , Chin-Tsai Fan
发明人： Hui-Po Wang , On Lee , Chin-Tsai Fan
IPC分类号： C07C59/68 , C07C67/03 , C07C69/712 , C07D305/12 , C07C69/76 , C07C59/48
CPC分类号： C07C59/68 , C07C67/03 , C07C69/712 , C07D305/12
摘要： Novel anticholesteremic compounds capable of reducing blood cholesterol levels. Also included in this invention are (i) intermediates from which the abovementioned anticholesteremic compounds can be prepared, and (ii) methods for preparing both the intermediates and the anticholesteremic compounds.
摘要翻译：能够降低血液胆固醇水平的新型抗胆固醇化合物。本发明还包括（i）可以制备上述抗胆固醇化合物的中间体，和（ii）制备中间体和抗胆固醇化合物的方法。

2. 发明授权

US5412112A Derivatives and preparation of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids 失效
标题翻译：衍生物和2,2-二甲基-5-取代的苯氧基 - 戊酸的制备
公开(公告)号：US5412112A
公开(公告)日：1995-05-02
申请号：US259537
申请日：1994-06-14
申请人： Hui-Po Wang , On Lee , Chin-Tsai Fan
发明人： Hui-Po Wang , On Lee , Chin-Tsai Fan
IPC分类号： C07C59/68 , C07C67/03 , C07C69/712 , C07D305/12 , C07C59/48 , C07C69/76
CPC分类号： C07D305/12 , C07C59/68 , C07C67/03 , C07C69/712
摘要： Novel 3-substituted derivatives of 2,2-dimethyl-5-substituted phenoxy-pentanoic acids of formula (I) are prepared. These compouds are prepared from 2,2-dimethyl-5-substituted phenoxy-3-hydroxy-pentanoic acid-.beta.-lactones (formula II). The .beta.-lactones are prepared by condensing relevant phenoxypropanals with dimethylketene.
摘要翻译：制备式（I）的2,2-二甲基-5-取代的苯氧基 - 戊酸的3-取代衍生物。这些化合物由2,2-二甲基-5-取代的苯氧基-3-羟基 - 戊酸-β-内酯（式II）制备。 β-内酯通过将相关苯氧基丙醛与二甲基烯酮缩合而制备。

3. 发明申请

US20090169508A1 OPIOID AND OPIOID-LIKE COMPOUNDS AND USES THEREOF 有权
标题翻译： OPIOID和类似阿片类似物的化合物及其用途
公开(公告)号：US20090169508A1
公开(公告)日：2009-07-02
申请号：US12400344
申请日：2009-03-09
申请人： Edwin S.C. Wu , Mao-Hsiung Yen , Chin-Tsai Fan
发明人： Edwin S.C. Wu , Mao-Hsiung Yen , Chin-Tsai Fan
IPC分类号： A61K31/485 , C07D489/00 , A61K38/21 , A61P25/04
CPC分类号： C07D221/28 , A61K31/485 , A61K38/21 , A61K45/06 , C07D453/00 , C07D489/00 , C07D489/02 , C07D489/08 , Y10S514/893 , Y10S514/894 , A61K2300/00
摘要： The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of disorders such as septic shock and organ damage.
摘要翻译：本发明涉及阿片样物质和阿片样物质化合物及其药物制剂及其用于预防和治疗诸如败血性休克和器官损害的病症的用途。

4. 发明授权

US08557784B2 Glycyrrhizinates of morphinan derivatives 有权
标题翻译：吗啡喃衍生物的甘草酸盐
公开(公告)号：US08557784B2
公开(公告)日：2013-10-15
申请号：US13178215
申请日：2011-07-07
申请人： Chin-Tsai Fan , Cheng-Shun Lai , Wen-Yen Yeh , Yu-Ying Liu
发明人： Chin-Tsai Fan , Cheng-Shun Lai , Wen-Yen Yeh , Yu-Ying Liu
IPC分类号： A61K31/70 , A61K31/44 , C07H15/24 , C07H15/06 , C13K5/00 , C07D221/22
CPC分类号： C07H15/24
摘要： The present invention provides a pharmaceutically acceptable compound, a pharmaceutical composition comprising the above-mentioned pharmaceutically acceptable compound. The pharmaceutically acceptable compound provided by the present invention is a salt of a basic group-containing morphinan derivative and a carboxyl group-containing glycyrrhizinic acid and has the ability to be used to manufacture medicaments for treating and/or preventing cough, ameliorating pains, treating respiratory system diseases, treating cardiovascular diseases and treating liver diseases.
摘要翻译：本发明提供药学上可接受的化合物，包含上述药学上可接受的化合物的药物组合物。本发明提供的药学上可接受的化合物是含有碱性基团的吗啡喃衍生物和含羧基的甘草酸的盐，并且具有用于制备治疗和/或预防咳嗽，改善疼痛，治疗呼吸系统疾病，治疗心血管疾病和治疗肝病。

5. 发明授权

US08202995B2 Pharmaceutically acceptable salts of aporphine derivatives and carboxyl group-containing agents and methods for preparing the same 有权
标题翻译：阿托啡衍生物和含羧基试剂的药学上可接受的盐及其制备方法
公开(公告)号：US08202995B2
公开(公告)日：2012-06-19
申请号：US12457713
申请日：2009-06-19
申请人： Chin-Tsai Fan , Cheng-Shun Lai , Mei-Jung Lin
发明人： Chin-Tsai Fan , Cheng-Shun Lai , Mei-Jung Lin
IPC分类号： C07D221/18 , C07D221/02
CPC分类号： A61K31/4184 , A61K31/192 , A61K31/197 , A61K31/216 , A61K31/40 , A61K31/401 , A61K31/41 , A61K31/4453 , A61K31/473 , A61K45/06 , A61K2300/00
摘要： The present invention discloses novel pharmaceutically acceptable salts of aporphine compounds and carboxyl-group containing agents. Also, the present invention discloses methods for preparing the pharmaceutically acceptable salts. These pharmaceutically acceptable salts are suitable for use in treating and/or preventing hyperglycemic disease and/or several oxidative stress related diseases.
摘要翻译：本发明公开了阿托啡化合物和含羧基试剂的新药学上可接受的盐。此外，本发明公开了制备药学上可接受的盐的方法。这些药学上可接受的盐适用于治疗和/或预防高血糖疾病和/或几种与氧化应激相关的疾病。

6. 发明申请

US20090005570A1 Method for preparing 2- (2-pyridinylmethylsulfinyl) benzimidazoles 有权
标题翻译：制备2-（2-吡啶基甲基亚磺酰基）苯并咪唑的方法
公开(公告)号：US20090005570A1
公开(公告)日：2009-01-01
申请号：US11819179
申请日：2007-06-26
申请人： Chin-Tsai Fan
发明人： Chin-Tsai Fan
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： The present invention provides a method for preparing an antiulcer agent, 2-(2-pyridinylmethylsulfinyl)benzimidazoles, such as Omeprazole, Lansoprazole, Pantoprazole and Rabeprazole, which includes oxidizing an intermediate having a linkage of methylthio group (—CH2S—) to methylsulfinyl (—CH2S(O)—) in the presence of an oxidation catalyst of an alkali metal salt of tungstate at a temperature of 10-50° C.
摘要翻译：本发明提供了制备抗溃疡剂的方法，其包括将奥美拉唑，兰索拉唑，泮托拉唑和雷贝拉唑等的2-（2-吡啶基甲基亚磺酰基）苯并咪唑氧化成甲氧基硫基（-CH 2 S-）与甲基亚磺酰基 -CH 2 S（O） - ），在10-50℃的温度下，在钨酸碱金属盐的氧化催化剂存在下，

7. 发明授权

US08404706B2 Opioid and opioid-like compounds and uses thereof 有权
标题翻译：阿片样物质和阿片样物质化合物及其用途
公开(公告)号：US08404706B2
公开(公告)日：2013-03-26
申请号：US13081179
申请日：2011-04-06
申请人： Edwin S. C. Wu , Mao-Hsiung Yen , Chin-Tsai Fan
发明人： Edwin S. C. Wu , Mao-Hsiung Yen , Chin-Tsai Fan
IPC分类号： A61K31/4748 , C07D221/28
CPC分类号： A61K31/485 , C07D221/28 , C07D489/00 , C07D489/02 , C07D489/08
摘要： The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations containing the same and methods of use thereof. Uses of the present invention include, but are not limited to, use for the prevention and treatment of septic shock and other disorders. The compounds described herein can be water soluble and can act through mechanisms mediated through pathways other than opiate receptors.
摘要翻译：本发明涉及阿片样物质和阿片样物质化合物，以及含有其的药物制剂及其使用方法。本发明的用途包括但不限于用于预防和治疗败血性休克和其它疾病的用途。本文所述的化合物可以是水溶性的，并且可以通过除阿片受体之外的途径介导的机制起作用。

8. 发明授权

US08071781B2 Process for preparing rabeprazole sodium 有权
标题翻译：雷贝拉唑钠制备方法
公开(公告)号：US08071781B2
公开(公告)日：2011-12-06
申请号：US12268580
申请日：2008-11-11
申请人： Chin-Tsai Fan , Chen-Ming Hsiao , Rong-Bin Hsieh
发明人： Chin-Tsai Fan , Chen-Ming Hsiao , Rong-Bin Hsieh
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： The present invention provides a process for preparing the amorphous rabeprazole sodium. The process comprises the following steps: (a) Contacting rabeprazole sodium compound with a solvent system to thereby obtain a clear solution under a first temperature, wherein said solvent system is a mixture of at least two categories of organic solvents; (b) Stirring said clear solution of step (a) under a second temperature for a certain time period to obtain a solution containing resultant separated solid, wherein said second temperature is equal to or lower than said first temperature; (c) Filtering said solution containing resultant separated solid obtained from step (b) to obtain a wet solid; and (d) Drying said wet solid to obtain an amorphous rabeprazole sodium compound.
摘要翻译：本发明提供了制备无定形雷贝拉唑钠的方法。该方法包括以下步骤：（a）用溶剂体系接触雷贝拉唑钠化合物，从而在第一温度下获得澄清溶液，其中所述溶剂体系是至少两类有机溶剂的混合物; （b）在第二温度下将所述步骤（a）的澄清溶液搅拌一定时间以获得含有所得分离固体的溶液，其中所述第二温度等于或低于所述第一温度; （c）将从步骤（b）获得的含有所得分离固体的所述溶液过滤，得到湿固体; 和（d）干燥所述湿固体以获得无定形雷贝拉唑钠化合物。

9. 发明授权

US07531666B2 Method for preparing 2-(2-pyridinylmethylsulfinyl) benzimidazoles 有权
标题翻译：制备2-（2-吡啶基甲基亚磺酰基）苯并咪唑的方法
公开(公告)号：US07531666B2
公开(公告)日：2009-05-12
申请号：US11819179
申请日：2007-06-26
申请人： Chin-Tsai Fan
发明人： Chin-Tsai Fan
IPC分类号： C07D401/12
CPC分类号： C07D401/12
摘要： The present invention provides a method for preparing an antiulcer agent, 2-(2-pyridinylmethylsulfinyl)benzimidazoles, such as Omeprazole, Lansoprazole, Pantoprazole and Rabeprazole, which includes oxidizing an intermediate having a linkage of methylthio group (—CH2S—) to methylsulfinyl (—CH2S(O)—) in the presence of an oxidation catalyst of an alkali metal salt of tungstate at a temperature of 10-50° C.
摘要翻译：本发明提供了制备抗溃疡剂的方法，其包括将奥美拉唑，兰索拉唑，泮托拉唑和雷贝拉唑等的2-（2-吡啶基甲基亚磺酰基）苯并咪唑氧化成甲氧基硫基（-CH 2 S-）与甲基亚磺酰基 -CH 2 S（O） - ），在10-50℃的温度下，在钨酸碱金属盐的氧化催化剂存在下，

10. 发明授权

US09776971B2 Opioid and opioid-like compounds and uses thereof 有权
公开(公告)号：US09776971B2
公开(公告)日：2017-10-03
申请号：US13228527
申请日：2011-09-09
申请人： Edwin S. C. Wu , Mao-Hsiung Yen , Chin-Tsai Fan
发明人： Edwin S. C. Wu , Mao-Hsiung Yen , Chin-Tsai Fan
IPC分类号： A61K31/485 , C07D221/28 , C07D489/00 , C07D489/02 , C07D489/08 , A61K38/21 , A61K45/06 , C07D453/00
CPC分类号： C07D221/28 , A61K31/485 , A61K38/21 , A61K45/06 , C07D453/00 , C07D489/00 , C07D489/02 , C07D489/08 , Y10S514/893 , Y10S514/894 , A61K2300/00
摘要： The present invention relates to opioid and opioid-like compounds, and pharmaceutical formulations thereof, and use thereof for prevention and treatment of disorders such as septic shock and organ damage.

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