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1. 发明授权

US08500795B2 Retrievable devices for improving cardiac function 有权
标题翻译：用于改善心脏功能的可检索装置
公开(公告)号：US08500795B2
公开(公告)日：2013-08-06
申请号：US12198010
申请日：2008-08-25
申请人： Alexander Khairkhahan , Serjan D. Nikolic , Hugh R. Sharkey
发明人： Alexander Khairkhahan , Serjan D. Nikolic , Hugh R. Sharkey
IPC分类号： A61F2/06
CPC分类号： A61F2/2427 , A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B17/3468 , A61B2017/00243 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00632 , A61B2017/00867 , A61B2017/0649 , A61B2017/12054 , A61B2017/12095 , A61F2/2487 , A61F2002/2484 , A61F2250/0003
摘要： Removable cardiac implants, applicators for inserting, repositioning and/or removing them, and methods of using them are described. In particular, removable or repositionable ventricular partitioning devices are described. Systems including removable implants and applicators for inserting and/or removing them are also described.
摘要翻译：描述了可移除的心脏植入物，用于插入，重新定位和/或去除它们的施用器以及使用它们的方法。特别地，描述了可拆卸或可重新定位的心室分配装置。还描述了包括用于插入和/或移除它们的可移除植入物和施用器的系统。

2. 发明申请

US20090254195A1 SYSTEM FOR IMPROVING CARDIAC FUNCTION BY SEALING A PARTITIONING MEMBRANE WITHIN A VENTRICLE 有权
标题翻译：通过密封隔离膜在心脏中改善心脏功能的系统
公开(公告)号：US20090254195A1
公开(公告)日：2009-10-08
申请号：US12422144
申请日：2009-04-10
申请人： Alexander Khairkhahan , Serjan D. Nikolic , Hugh R. Sharkey
发明人： Alexander Khairkhahan , Serjan D. Nikolic , Hugh R. Sharkey
IPC分类号： A61F2/04
CPC分类号： A61F2/2487 , A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/1214 , A61B17/12172 , A61B17/12195 , A61B2017/00243 , A61B2017/00557 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00615 , A61B2017/00632 , A61B2017/00867 , A61B2017/0649 , A61B2017/12095
摘要： Partitioning devices that may be secured and sealed within a heart chamber for separating a patient's heart chamber into a productive portion and a non-productive portion are described herein. The partitioning devices described herein may include a reinforced membrane with outwardly biased members. The reinforced membrane may have a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. These devices may be secured within the heart chamber by sealing them to the wall of the heart chamber, for example, by inflating an inflatable element on the periphery of the device. The non-productive portion may be filled with a material, including occlusive materials. Sealing and/or filling the non-productive portion formed by the devices described herein may help prevent leakage from the non-productive region. Also described herein are systems including these devices and methods of using them, which may be suitable for treating patients with heart disease, particularly congestive heart failure.
摘要翻译：本文描述了可以在心室内固定和密封以将患者的心室分离成生产部分和非生产性部分的分隔装置。本文所述的分隔装置可以包括具有向外偏置构件的增强膜。增强膜可以具有中心毂，其具有远端延伸的支撑杆，其具有从中心线轴线径向延伸的多个脚，并且优选地具有在公共平面中对准的端部。这些装置可以通过将它们密封到心室的壁来固定在心脏腔室内，例如通过使装置的周边上的可充气元件膨胀。非生产性部分可以填充材料，包括封闭材料。密封和/或填充由本文所述的装置形成的非生产性部分可以有助于防止从非生产性区域泄漏。本文还描述了包括这些装置和使用它们的方法的系统，其可适用于治疗心脏病患者，特别是充血性心力衰竭。

3. 发明授权

US07582051B2 Peripheral seal for a ventricular partitioning device 有权
标题翻译：心室分隔装置的外围密封
公开(公告)号：US07582051B2
公开(公告)日：2009-09-01
申请号：US11151164
申请日：2005-06-10
申请人： Alexander Khairkhahan , Hugh R. Sharkey , Serjan D. Nikolic , Branislav Radovancevic
发明人： Alexander Khairkhahan , Hugh R. Sharkey , Serjan D. Nikolic , Branislav Radovancevic
IPC分类号： A61F2/00
CPC分类号： A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B17/1219 , A61B2017/00243 , A61B2017/12095 , A61B2017/22061
摘要： A partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion which is suitable for treating patients with heart disease, particularly congestive heart failure. The partitioning device has a reinforced membrane with outwardly biased members to help seal the periphery of the membrane against the wall of the patient's heart chamber. In one embodiment, the outwardly biased member is an expansive strand that extends between adjacent ribs of an expandable frame which reinforces the membrane. In another embodiment, the outwardly biased member is a hydrophilic body such as foam which swells upon contact with body fluid such as blood in the heart chamber. The reinforced membrane has a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. The ends of the pods which extend radially away from the centerline axis may be interconnected by flexible struts and/or webs.
摘要翻译：一种用于将患者心室分离为生产部分和非生产性部分的分配装置，其适用于治疗患有心脏病，特别是充血性心力衰竭的患者。分隔装置具有增强的膜，其具有向外偏置的构件，以帮助将膜的周边密封抵靠患者心室的壁。在一个实施例中，向外偏置的构件是在可扩展框架的相邻肋之间延伸的膨胀股线，其可加强膜。在另一个实施方案中，向外偏压的构件是亲水体，例如泡沫，当与心液室中的体液如血液接触时膨胀。加强膜具有中心毂，其具有远端延伸的支撑杆，多个脚从中心线径向延伸，并且优选地具有在公共平面中对准的端部。从径向远离中心线轴线延伸的荚的端部可通过柔性支柱和/或腹板相互连接。

4. 发明申请

US20090054723A1 RETRIEVABLE DEVICES FOR IMPROVING CARDIAC FUNCTION 有权
标题翻译：用于改善心脏功能的可检测设备
公开(公告)号：US20090054723A1
公开(公告)日：2009-02-26
申请号：US12198010
申请日：2008-08-25
申请人： Alexander Khairkhahan , Serjan D. Nikolic , Hugh R. Sharkey
发明人： Alexander Khairkhahan , Serjan D. Nikolic , Hugh R. Sharkey
IPC分类号： A61F2/00
CPC分类号： A61F2/2427 , A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B17/3468 , A61B2017/00243 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00632 , A61B2017/00867 , A61B2017/0649 , A61B2017/12054 , A61B2017/12095 , A61F2/2487 , A61F2002/2484 , A61F2250/0003
摘要： Removable cardiac implants, applicators for inserting, repositioning and/or removing them, and methods of using them are described. In particular, removable or repositionable ventricular partitioning devices are described. Systems including removable implants and applicators for inserting and/or removing them are also described.
摘要翻译：描述了可移除的心脏植入物，用于插入，重新定位和/或去除它们的施用器以及使用它们的方法。特别地，描述了可拆卸或可重新定位的心室分配装置。还描述了包括用于插入和/或移除它们的可移除植入物和施用器的系统。

5. 发明申请

US20080228205A1 VENTRICULAR PARTITIONING DEVICE 审中-公开
标题翻译：静脉分隔装置
公开(公告)号：US20080228205A1
公开(公告)日：2008-09-18
申请号：US12125015
申请日：2008-05-21
申请人： Hugh R. Sharkey , Alexander Khairkhahan , Serjan D. Nikolic , Branislav Radovancevic
发明人： Hugh R. Sharkey , Alexander Khairkhahan , Serjan D. Nikolic , Branislav Radovancevic
IPC分类号： A61B17/08 , A61M29/00 , A61B19/00
CPC分类号： A61B17/12022 , A61B17/12122 , A61B17/12136 , A61B17/12172 , A61B17/12186 , A61B2017/12095 , A61F2/2487
摘要： This invention is directed to a partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion. The device is particularly suitable for treating patients with congestive heart failure. The partitioning device has a reinforced, expandable membrane which separates the productive and non-productive portions of the heart chamber and a support or spacing member extending between the reinforced membrane and the wall of the patient's heart chamber. The support or spacing member has a non-traumatic distal end to engage the ventricular wall.
摘要翻译：本发明涉及一种用于将患者的心室分离成生产部分和非生产性部分的分隔装置。该装置特别适用于治疗充血性心力衰竭患者。分隔装置具有加强的可扩张的膜，其分离心室的生产和非生产部分以及在增强膜和患者心室的壁之间延伸的支撑或间隔构件。支撑或间隔构件具有非创伤性远端以接合心室壁。

6. 发明授权

US06757565B2 Electrosurgical instrument having a predetermined heat profile 失效
标题翻译：具有预定热分布的电外科器械
公开(公告)号：US06757565B2
公开(公告)日：2004-06-29
申请号：US10071470
申请日：2002-02-08
申请人： Hugh R. Sharkey , John E. Ashley , Kobi Iki
发明人： Hugh R. Sharkey , John E. Ashley , Kobi Iki
IPC分类号： A61F712
CPC分类号： A61B18/148
摘要： An electrosurgical instrument is provided, having a holding formation, an elongated probe, an electrode, and a conductor. The elongated probe is connected to and extends from the holding formation. The electrode is located on an end of the elongated probe opposing the holding formation, and has a leading edge and a face. The electrode is locatable so that the face is substantially in a horizontal plane and the leading edge is above the horizontal plane. The conductor extends along the elongated probe and has a portion connected to the electrode to provide RF power thereto. The electrode creates a temperature profile with a temperature adjacent to the leading edge being higher than a temperature adjacent to the face.
摘要翻译：提供了一种具有保持结构，细长探针，电极和导体的电外科器械。细长的探针连接到保持结构并从保持结构延伸。电极位于与保持结构相对的细长探针的端部上，并且具有前缘和面。电极是可定位的，使得所述面基本上处于水平面并且前缘在水平面之上。导体沿着细长的探针延伸并且具有连接到电极的部分以向其提供RF功率。电极产生温度曲线，其中与前缘相邻的温度高于与面相邻的温度。

7. 发明授权

US06749605B2 Catheter for delivery of energy to a surgical site 有权
标题翻译：导管将能量输送到手术部位
公开(公告)号：US06749605B2
公开(公告)日：2004-06-15
申请号：US09776186
申请日：2001-02-01
申请人： John E. Ashley , Hugh R. Sharkey , Joel Saal , Jeffrey A. Saal
发明人： John E. Ashley , Hugh R. Sharkey , Joel Saal , Jeffrey A. Saal
IPC分类号： A61B1818
CPC分类号： A61B18/082 , A61B10/02 , A61B17/00491 , A61B17/1671 , A61B17/29 , A61B17/320016 , A61B17/3203 , A61B17/3421 , A61B17/3496 , A61B18/00 , A61B18/14 , A61B18/148 , A61B18/1482 , A61B18/1485 , A61B18/1492 , A61B18/18 , A61B18/24 , A61B34/20 , A61B2017/00022 , A61B2017/00084 , A61B2017/0011 , A61B2017/00119 , A61B2017/00261 , A61B2017/00274 , A61B2017/003 , A61B2017/00336 , A61B2017/00455 , A61B2017/00867 , A61B2017/22044 , A61B2017/22049 , A61B2017/22082 , A61B2017/22087 , A61B2017/2905 , A61B2017/2927 , A61B2017/320008 , A61B2017/320044 , A61B2017/32113 , A61B2017/3445 , A61B2017/3488 , A61B2018/00011 , A61B2018/00267 , A61B2018/00434 , A61B2018/0044 , A61B2018/00547 , A61B2018/00625 , A61B2018/00654 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797 , A61B2018/046 , A61B2018/1266 , A61B2018/1405 , A61B2018/1407 , A61B2018/1412 , A61B2018/1425 , A61B2018/1435 , A61B2018/1455 , A61B2018/1472 , A61B2018/1807 , A61B2090/0454 , A61B2090/061 , A61B2090/064 , A61B2090/3937 , A61B2217/005 , A61B2217/007 , A61B2218/002 , A61B2218/007 , A61F2/442 , A61F2002/30677 , A61F2007/0298 , A61M25/0144 , A61M25/0155 , A61M25/0158 , A61M2025/0063 , A61M2025/0064 , A61M2025/0163 , A61N1/06 , A61N1/40
摘要： A catheter for delivering energy to a surgical site is disclosed. The catheter includes at a proximal end a handle and at a distal end a probe. The catheter includes at least one energy delivery device and an activation element. The at least one energy delivery device is located at the distal end of the catheter to deliver energy to portions of the surgical site. The activation element is located at the distal end of the catheter, to transition the probe from a linear to a multi-dimensional shape, within the surgical site. Methods for deploying the probe from the linear to multi-dimensional shape are disclosed. In another embodiment of the invention, the catheter includes a heating element fabricated on a substrate by photo-etching to deliver thermal energy to portions of the surgical site. In another embodiment of the invention, the catheter includes an energy delivery element, a tip and a blade. The energy delivery element is located at the distal end of the catheter to deliver energy to portions of the intervertebral disc. The blade is positioned within a first lumen of the tip and is extensible beyond the tip, to cut selected portions within the intervertebral disc. In another embodiment of the invention, a catheter includes both energy and material transfer elements and an interface on the handle thereof. The interface couples the energy delivery element and the material transfer element to external devices for energy and material transfer to and from the intervertebral disc.
摘要翻译：公开了一种用于向外科手术部位输送能量的导管。导管在近端处包括手柄，并且在远端处包括探针。导管包括至少一个能量输送装置和激活元件。所述至少一个能量输送装置位于所述导管的远端，以将能量传递到手术部位的部分。激活元件位于导管的远端，以将探针从线性过渡到多维形状，在手术部位内。公开了将探针从线性部分展开到多维形状的方法。在本发明的另一个实施例中，导管包括通过光蚀刻在基底上制造的加热元件，以将热能传递到手术部位的部分。在本发明的另一个实施例中，导管包括能量输送元件，尖端和一个刀片。能量输送元件位于导管的远端，以将能量传递给椎间盘的部分。刀片定位在尖端的第一内腔内并且可延伸超过尖端，以切割椎间盘内的所选部分。在本发明的另一个实施例中，导管包括能量和材料转移元件以及手柄上的界面。该界面将能量输送元件和材料传递元件耦合到外部装置，以将能量和材料转移到椎间盘和从椎间盘传递。

8. 发明授权

US06699244B2 Electrosurgical instrument having a chamber to volatize a liquid 有权
标题翻译：电外科器械具有使液体挥发的室
公开(公告)号：US06699244B2
公开(公告)日：2004-03-02
申请号：US10124954
申请日：2002-04-17
申请人： J. Remberto Carranza , Hugh R. Sharkey , John E. Ashley , Gary S. Fanton
发明人： J. Remberto Carranza , Hugh R. Sharkey , John E. Ashley , Gary S. Fanton
IPC分类号： A61B1814
CPC分类号： A61B18/148 , A61B18/1482 , A61B18/1492 , A61B2017/320008 , A61B2018/00434 , A61B2018/00625 , A61B2018/00654 , A61B2018/00702 , A61B2018/00791 , A61B2018/00797 , A61B2018/1472 , A61B2218/002 , A61N1/06 , A61N1/40
摘要： An electrosurgical instrument is provided which includes a holding formation, a probe shaft, an electric conductor, and a probe tip. The probe shaft is secured to the holding formation and has an elongated section extending therefrom. The electric conductor extends along the elongated section. The probe tip is located on a distal end of the probe shaft opposing the holding formation. The probe tip defines a volatization chamber with a mouth out of the probe tip. The probe tip includes an electrode, to which RF current is provided through the electric conductor. The electrode heats an area adjacent to the probe tip. The electrode also heats a liquid in the first volatization chamber to evaporate the liquid into a vapor pocket that ejects from the first volatization chamber through the mouth out of the probe tip. A pump effect is created so that the liquid maintains the probe tip at a more stable temperature.
摘要翻译：提供了一种电外科器械，其包括保持结构，探针轴，电导体和探针尖端。探头轴固定在保持结构上，并具有从其延伸的细长部分。电导体沿着细长部分延伸。探针尖端位于与保持结构相对的探针轴的远端上。探针尖端限定了具有探针尖端的口的挥发室。探针尖端包括电极，通过电导体提供RF电流。电极加热与探针尖端相邻的区域。电极还加热第一挥发室中的液体以将液体蒸发成从第一挥发室通过探针尖端喷出的蒸气袋。产生泵效应，使得液体将探针尖端保持在更稳定的温度。

9. 发明授权

US06610054B1 Medical probe device and method 失效
标题翻译：医疗探针装置及方法
公开(公告)号：US06610054B1
公开(公告)日：2003-08-26
申请号：US08757282
申请日：1996-11-27
申请人： Stuart D. Edwards , Ronald G. Lax , Ingemar H. Lundquist , Hugh R. Sharkey
发明人： Stuart D. Edwards , Ronald G. Lax , Ingemar H. Lundquist , Hugh R. Sharkey
IPC分类号： A61B1736
CPC分类号： A61N5/02 , A61B10/02 , A61B10/0241 , A61B18/00 , A61B18/082 , A61B18/1206 , A61B18/1477 , A61B18/148 , A61B18/1485 , A61B18/18 , A61B18/1815 , A61B18/24 , A61B2017/00084 , A61B2017/00092 , A61B2017/00106 , A61B2017/00274 , A61B2017/00292 , A61B2017/003 , A61B2017/00867 , A61B2017/22072 , A61B2017/22077 , A61B2017/22082 , A61B2017/248 , A61B2017/2939 , A61B2017/3488 , A61B2018/00005 , A61B2018/00011 , A61B2018/00083 , A61B2018/00095 , A61B2018/00196 , A61B2018/0022 , A61B2018/00547 , A61B2018/00577 , A61B2018/00678 , A61B2018/00702 , A61B2018/00726 , A61B2018/00744 , A61B2018/0075 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00869 , A61B2018/00886 , A61B2018/0091 , A61B2018/00916 , A61B2018/00946 , A61B2018/00982 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/128 , A61B2018/1412 , A61B2018/1425 , A61B2018/1861 , A61B2018/2238 , A61B2090/0814 , A61B2090/3614 , A61B2090/3782 , A61B2090/3925 , A61F2007/0054 , A61M3/0279 , A61M25/0068 , A61M25/0069 , A61M25/008 , A61M25/0082 , A61M2025/0086 , A61M2025/0087 , A61M2025/0089 , A61M2025/009 , A61M2025/0096 , A61M2025/018 , A61N1/06 , A61N1/40 , A61N1/403 , A61N5/04 , A61N5/045
摘要： A medical probe device comprises a catheter having a stylet guide housing with one or more stylet ports in a side wall thereof and a stylet guide for directing a flexible stylet outward through the stylet port and through intervening tissue at a preselected, adjustable angle to a target tissue. The total catheter assembly includes a stylet guide lumen communicating with the stylet port and a stylet positioned in said stylet guide lumen for longitudinal movement from the port through intervening tissue to a target tissue. The stylet can be an electrical conductor enclosed within a non-conductive layer, the electrical conductor being a radiofrequency electrode. Preferably, the non-conductive layer is a sleeve which is axially moveable on the electrical conductor to expose a selected portion of the electrical conductor surface in the target tissue. The stylet can also be a microwave antenna. The stylet can also be a hollow tube for delivering treatment fluid to the target tissue. It can also include a fiber optic cable for laser treatment. The catheter can include one or more inflatable balloons located adjacent to the stylet port for anchoring the catheter or dilation. Ultrasound transponders and temperature sensors can be attached to the probe end and/or stylet. The stylet guide can define a stylet path from an axial orientation in the catheter through a curved portion to a lateral orientation at the stylet port.
摘要翻译：医疗探针装置包括导管，其具有在其侧壁中具有一个或多个管心针端口的探针引导壳体和用于将柔性探针向外引导通过探针端口的探针引导件，并且以与预定的可调节角度相对的目标通过介入组织组织。总导管组件包括与通管孔端口连通的探针引导腔和位于所述探针引导腔中的探针，用于从端口到介入组织到目标组织的纵向移动。探针可以是封闭在非导电层内的电导体，电导体是射频电极。优选地，非导电层是可在电导体上轴向移动以暴露目标组织中电导体表面的选定部分的套筒。探针也可以是微波天线。探针也可以是用于将治疗流体输送到靶组织的中空管。它还可以包括用于激光治疗的光纤电缆。导管可以包括一个或多个位于探针端口附近的可充气气囊，用于锚定导管或扩张。超声波转发器和温度传感器可以连接到探针端和/或探针。探针引导件可以从导管中的轴向方向定义探针路径，通过弯曲部分到探针端口处的横向取向。

10. 发明授权

US06358273B1 Soft tissue heating apparatus with independent, cooperative heating sources 有权
标题翻译：软组织加热装置具有独立的协调加热源
公开(公告)号：US06358273B1
公开(公告)日：2002-03-19
申请号：US09289459
申请日：1999-04-09
申请人： Bruno Strul , Hugh R. Sharkey , Daren L. Stewart
发明人： Bruno Strul , Hugh R. Sharkey , Daren L. Stewart
IPC分类号： A61F700
CPC分类号： A61B18/148 , A61B18/1492 , A61B2018/00005 , A61B2018/00714 , A61B2018/00791 , A61B2018/00815 , A61B2018/1253
摘要： A medical probe for the heating of soft tissue, such as collagen tissue, wherein the medical probe has an elongated body with a proximal and distal end, a heating source, an RF electrode. Optional components include a thermocouple, and an insulative sleeve. The probe's elongated body is preferably hollow and flexible. The RF electrode and the heating source are powered by independently controlled power sources and cooperate to maintain a constant and smooth temperature to the distal end of the RF electrode. The heating source may be a contained liquid, such as saline, or an electrothermal mass, such as a ferrite, a toroid, a resistive element, or the like. Current induced from the conductor to the heating source creates heat in the heating source. The thermocouple measures the temperature of the heating source and adjusts the power to the conductor to maintain the heating source's temperature.
摘要翻译：用于加热软组织（例如胶原组织）的医疗探针，其中医疗探针具有带近端和远端的细长体，加热源，RF电极。可选组件包括热电偶和绝缘套管。探头的细长体优选是中空的和柔性的。 RF电极和加热源由独立控制的电源供电，并协调以保持恒定且平稳的温度到RF电极的远端。加热源可以是诸如盐水的包含的液体，或诸如铁氧体，环形线圈，电阻元件等的电热物质。从导体引导到加热源的电流在加热源中产生热量。热电偶测量加热源的温度，并调整导体的功率以保持加热源的温度。

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