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1. 发明授权

US07582051B2 Peripheral seal for a ventricular partitioning device 有权
标题翻译：心室分隔装置的外围密封
公开(公告)号：US07582051B2
公开(公告)日：2009-09-01
申请号：US11151164
申请日：2005-06-10
申请人： Alexander Khairkhahan , Hugh R. Sharkey , Serjan D. Nikolic , Branislav Radovancevic
发明人： Alexander Khairkhahan , Hugh R. Sharkey , Serjan D. Nikolic , Branislav Radovancevic
IPC分类号： A61F2/00
CPC分类号： A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B17/1219 , A61B2017/00243 , A61B2017/12095 , A61B2017/22061
摘要： A partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion which is suitable for treating patients with heart disease, particularly congestive heart failure. The partitioning device has a reinforced membrane with outwardly biased members to help seal the periphery of the membrane against the wall of the patient's heart chamber. In one embodiment, the outwardly biased member is an expansive strand that extends between adjacent ribs of an expandable frame which reinforces the membrane. In another embodiment, the outwardly biased member is a hydrophilic body such as foam which swells upon contact with body fluid such as blood in the heart chamber. The reinforced membrane has a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. The ends of the pods which extend radially away from the centerline axis may be interconnected by flexible struts and/or webs.
摘要翻译：一种用于将患者心室分离为生产部分和非生产性部分的分配装置，其适用于治疗患有心脏病，特别是充血性心力衰竭的患者。分隔装置具有增强的膜，其具有向外偏置的构件，以帮助将膜的周边密封抵靠患者心室的壁。在一个实施例中，向外偏置的构件是在可扩展框架的相邻肋之间延伸的膨胀股线，其可加强膜。在另一个实施方案中，向外偏压的构件是亲水体，例如泡沫，当与心液室中的体液如血液接触时膨胀。加强膜具有中心毂，其具有远端延伸的支撑杆，多个脚从中心线径向延伸，并且优选地具有在公共平面中对准的端部。从径向远离中心线轴线延伸的荚的端部可通过柔性支柱和/或腹板相互连接。

2. 发明申请

US20080228205A1 VENTRICULAR PARTITIONING DEVICE 审中-公开
标题翻译：静脉分隔装置
公开(公告)号：US20080228205A1
公开(公告)日：2008-09-18
申请号：US12125015
申请日：2008-05-21
申请人： Hugh R. Sharkey , Alexander Khairkhahan , Serjan D. Nikolic , Branislav Radovancevic
发明人： Hugh R. Sharkey , Alexander Khairkhahan , Serjan D. Nikolic , Branislav Radovancevic
IPC分类号： A61B17/08 , A61M29/00 , A61B19/00
CPC分类号： A61B17/12022 , A61B17/12122 , A61B17/12136 , A61B17/12172 , A61B17/12186 , A61B2017/12095 , A61F2/2487
摘要： This invention is directed to a partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion. The device is particularly suitable for treating patients with congestive heart failure. The partitioning device has a reinforced, expandable membrane which separates the productive and non-productive portions of the heart chamber and a support or spacing member extending between the reinforced membrane and the wall of the patient's heart chamber. The support or spacing member has a non-traumatic distal end to engage the ventricular wall.
摘要翻译：本发明涉及一种用于将患者的心室分离成生产部分和非生产性部分的分隔装置。该装置特别适用于治疗充血性心力衰竭患者。分隔装置具有加强的可扩张的膜，其分离心室的生产和非生产部分以及在增强膜和患者心室的壁之间延伸的支撑或间隔构件。支撑或间隔构件具有非创伤性远端以接合心室壁。

3. 发明授权

US07862500B2 Multiple partitioning devices for heart treatment 有权
标题翻译：用于心脏治疗的多重分隔装置
公开(公告)号：US07862500B2
公开(公告)日：2011-01-04
申请号：US11151156
申请日：2005-06-10
申请人： Alexander Khairkhahan , Serjan D. Nikolic , Branislav Radovancevic , Hugh R. Sharkey
发明人： Alexander Khairkhahan , Serjan D. Nikolic , Branislav Radovancevic , Hugh R. Sharkey
IPC分类号： A61N1/362
CPC分类号： A61N1/3627 , A61B17/12022 , A61B17/12122 , A61B17/12168 , A61B17/12172 , A61B2017/0084 , A61B2017/12095
摘要： This invention is directed to a system and method for partitioning a patient's heart chamber into a productive portion and a non-productive portion which are particularly suitable for treating patients with congestive heart failure. The partitioning system has a plurality of partitioning devices with reinforced, expandable membranes which separate the productive and non-productive portions of the heart chamber. When deployed within the patient's heart chamber, the second partitioning device is off-set from the deployed first partitioning device to cover a region of the wall defining the patient's heart chamber which is not covered by the first partitioning device. The multiple partitioning devices may be independent from each other or may be interconnected, e.g. a tether or strand.
摘要翻译：本发明涉及一种用于将患者的心脏室分成生产部分和非生产性部分的系统和方法，其特别适用于治疗患有充血性心力衰竭的患者。分隔系统具有多个具有加强的可扩张膜的分隔装置，其分离心室的生产和非生产性部分。当部署在患者的心室内时，第二分隔装置从展开的第一分隔装置偏离，以覆盖限定不被第一分隔装置覆盖的患者心室的壁的区域。多个分割装置可以彼此独立，或者可以相互连接。系绳或股绳。

4. 发明申请

US20090287040A1 PERIPHERAL SEAL FOR A VENTRICULAR PARTITIONING DEVICE 有权
标题翻译：用于静脉分隔装置的外周密封
公开(公告)号：US20090287040A1
公开(公告)日：2009-11-19
申请号：US12509289
申请日：2009-07-24
申请人： Alexander Khairkhahan , Hugh R. Sharkey , Serjan D. Nikolic , Branislav Radovancevic
发明人： Alexander Khairkhahan , Hugh R. Sharkey , Serjan D. Nikolic , Branislav Radovancevic
IPC分类号： A61F2/02
CPC分类号： A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/12095 , A61B2017/22061
摘要： A partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion which is suitable for treating patients with heart disease, particularly congestive heart failure. The partitioning device has a reinforced membrane with outwardly biased members to help seal the periphery of the membrane against the wall of the patient's heart chamber. In one embodiment, the outwardly biased member is an expansive strand that extends between adjacent ribs of an expandable frame which reinforces the membrane. In another embodiment, the outwardly biased member is a hydrophilic body such as foam which swells upon contact with body fluid such as blood in the heart chamber. The reinforced membrane has a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. The ends of the pods which extend radially away from the centerline axis may be interconnected by flexible struts and/or webs.
摘要翻译：一种用于将患者心室分离为生产部分和非生产性部分的分配装置，其适用于治疗患有心脏病，特别是充血性心力衰竭的患者。分隔装置具有增强的膜，其具有向外偏置的构件，以帮助将膜的周边密封抵靠患者心室的壁。在一个实施例中，向外偏置的构件是在可扩展框架的相邻肋之间延伸的膨胀股线，其可加强膜。在另一个实施方案中，向外偏压的构件是亲水体，例如泡沫，当与心液室中的体液如血液接触时膨胀。加强膜具有中心毂，其具有远端延伸的支撑杆，多个脚从中心线径向延伸，并且优选地具有在公共平面中对准的端部。从径向远离中心线轴线延伸的荚的端部可通过柔性支柱和/或腹板相互连接。

5. 发明授权

US07399271B2 Ventricular partitioning device 有权
标题翻译：心室分配装置
公开(公告)号：US07399271B2
公开(公告)日：2008-07-15
申请号：US10754182
申请日：2004-01-09
申请人： Alexander Khairkhahan , Serjan D. Nikolic , Branislav Radovancevic , Hugh R. Sharkey
发明人： Alexander Khairkhahan , Serjan D. Nikolic , Branislav Radovancevic , Hugh R. Sharkey
IPC分类号： A61F2/00
CPC分类号： A61B17/12022 , A61B17/12122 , A61B17/12136 , A61B17/12172 , A61B17/12186 , A61B2017/12095 , A61F2/2487
摘要： This invention is directed to a partitioning device for separating a patient's heart chamber into a productive portion and a non-productive portion. The device is particularly suitable for treating patients with congestive heart failure. The partitioning device has a reinforced, expandable membrane which separates the productive and non-productive portions of the heart chamber and a support or spacing member extending between the reinforced membrane and the wall of the patient's heart chamber. The support or spacing member has a non-traumatic distal end to engage the ventricular wall.
摘要翻译：本发明涉及一种用于将患者的心室分离成生产部分和非生产性部分的分隔装置。该装置特别适用于治疗充血性心力衰竭患者。分隔装置具有加强的可扩张的膜，其分离心室的生产和非生产部分以及在增强膜和患者心室的壁之间延伸的支撑或间隔构件。支撑或间隔构件具有非创伤性远端以接合心室壁。

6. 发明授权

US07303526B2 Device for improving cardiac function 有权
标题翻译：改善心脏功能的装置
公开(公告)号：US07303526B2
公开(公告)日：2007-12-04
申请号：US10212033
申请日：2002-08-01
申请人： Hugh R. Sharkey , Serjan D. Nikolic , Branislav Radovancevic
发明人： Hugh R. Sharkey , Serjan D. Nikolic , Branislav Radovancevic
IPC分类号： A61F2/00
CPC分类号： A61B17/12022 , A61B17/00234 , A61B17/0057 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00632 , A61B2017/044 , A61B2017/048 , A61B2017/1205 , A61N1/05 , Y10S623/904 , Y10S623/91
摘要： A method and a device for improving cardiac function are provided. The device is packaged in a collapsed state in an end of a catheter. Portions of a frame construction of the device spring outwardly when the catheter is withdrawn from the device. Anchoring formations on the frame construction secure the frame construction to a myocardium of the heart. A membrane secured to the frame construction then forms a division between volumes of an endocardial cavity of the heart on opposing sides of the membrane.
摘要翻译：提供了一种用于改善心脏功能的方法和装置。该装置在导管的末端以折叠状态包装。当导管从装置中取出时，装置的框架结构的一部分向外弹起。框架结构上的锚固结构将框架结构固定到心脏的心肌。固定在框架结构上的膜然后在膜的相对侧上形成心脏心内膜的体积之间的分隔。

7. 发明授权

US07279007B2 Method for improving cardiac function 有权
标题翻译：改善心脏功能的方法
公开(公告)号：US07279007B2
公开(公告)日：2007-10-09
申请号：US10212032
申请日：2002-08-01
申请人： Serjan D. Nikolic , Hugh R. Sharkey , Branislav Radovancevic
发明人： Serjan D. Nikolic , Hugh R. Sharkey , Branislav Radovancevic
IPC分类号： A61F2/02 , A61F2/00 , A61F13/00 , A61B17/08
CPC分类号： A61B17/12022 , A61B17/00234 , A61B17/0057 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00632 , A61B2017/044 , A61B2017/048 , A61B2017/1205 , A61N1/05 , Y10S623/904 , Y10S623/91
摘要： A method and a device for improving cardiac function are provided. The device is packaged in a collapsed state in an end of a catheter. Portions of a frame construction of the device spring outwardly when the catheter is withdrawn from the device. Anchoring formations on the frame construction secure the frame construction to a myocardium of the heart. A membrane secured to the frame construction then forms a division between volumes of an endocardial cavity of the heart on opposing sides of the membrane.
摘要翻译：提供了一种用于改善心脏功能的方法和装置。该装置在导管的末端以折叠状态包装。当导管从装置中取出时，装置的框架结构的一部分向外弹起。框架结构上的锚固结构将框架结构固定到心脏的心肌。固定在框架结构上的膜然后在膜的相对侧上形成心脏心内膜的体积之间的分隔。

8. 发明授权

US06852076B2 Method for improving cardiac function 有权
标题翻译：改善心脏功能的方法
公开(公告)号：US06852076B2
公开(公告)日：2005-02-08
申请号：US10382962
申请日：2003-03-06
申请人： Serjan D. Nikolic , Hugh R. Sharkey , Branislav Radovancevic
发明人： Serjan D. Nikolic , Hugh R. Sharkey , Branislav Radovancevic
IPC分类号： A61F2/82 , A61B17/00 , A61B17/12 , A61F2/04 , A61F2/24 , A61M29/00 , A61N1/05 , A61F2/00 , A61B17/08
CPC分类号： A61B17/12022 , A61B17/00234 , A61B17/0057 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00632 , A61B2017/044 , A61B2017/048 , A61B2017/1205 , A61N1/05 , Y10S623/904 , Y10S623/91
摘要： A method and a device for improving cardiac function are provided. The device is packaged in a collapsed state in an end of a catheter. Portions of a frame construction of the device spring outwardly when the catheter is withdrawn from the device. Anchoring formations on the frame construction secure the frame construction to a myocardium of the heart. A membrane secured to the frame construction then forms a division between volumes of an endocardial cavity of the heart on opposing sides of the membrane.
摘要翻译：提供了一种用于改善心脏功能的方法和装置。该装置在导管的末端以折叠状态包装。当导管从装置中取出时，装置的框架结构的一部分向外弹起。框架结构上的锚固结构将框架结构固定到心脏的心肌。固定在框架结构上的膜然后在膜的相对侧上形成心脏心内膜的体积之间的分隔。

9. 发明授权

US08388672B2 System for improving cardiac function by sealing a partitioning membrane within a ventricle 有权
标题翻译：通过密封心室内的分隔膜来改善心脏功能的系统
公开(公告)号：US08388672B2
公开(公告)日：2013-03-05
申请号：US12422144
申请日：2009-04-10
申请人： Alexander Khairkhahan , Serjan D. Nikolic , Hugh R. Sharkey
发明人： Alexander Khairkhahan , Serjan D. Nikolic , Hugh R. Sharkey
IPC分类号： A61F2/06 , A61M29/08
CPC分类号： A61F2/2487 , A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/1214 , A61B17/12172 , A61B17/12195 , A61B2017/00243 , A61B2017/00557 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00601 , A61B2017/00615 , A61B2017/00632 , A61B2017/00867 , A61B2017/0649 , A61B2017/12095
摘要： Partitioning devices that may be secured and sealed within a heart chamber for separating a patient's heart chamber into a productive portion and a non-productive portion are described herein. The partitioning devices described herein may include a reinforced membrane with outwardly biased members. The reinforced membrane may have a central hub with a distally extending support stem with a plurality of feet which extend radially from a centerline axis and preferably have ends that are aligned in a common plane. These devices may be secured within the heart chamber by sealing them to the wall of the heart chamber, for example, by inflating an inflatable element on the periphery of the device. The non-productive portion may be filled with a material, including occlusive materials. Sealing and/or filling the non-productive portion formed by the devices described herein may help prevent leakage from the non-productive region. Also described herein are systems including these devices and methods of using them, which may be suitable for treating patients with heart disease, particularly congestive heart failure.
摘要翻译：本文描述了可以在心室内固定和密封以将患者的心室分离成生产部分和非生产性部分的分隔装置。本文所述的分隔装置可以包括具有向外偏置构件的增强膜。增强膜可以具有中心毂，其具有远端延伸的支撑杆，其具有从中心线轴线径向延伸的多个脚，并且优选地具有在公共平面中对准的端部。这些装置可以通过将它们密封到心室的壁来固定在心脏腔室内，例如通过使装置的周边上的可充气元件膨胀。非生产性部分可以填充材料，包括封闭材料。密封和/或填充由本文所述的装置形成的非生产性部分可以有助于防止从非生产性区域泄漏。本文还描述了包括这些装置和使用它们的方法的系统，其可适用于治疗心脏病患者，特别是充血性心力衰竭。

10. 发明授权

US08257428B2 System for improving cardiac function 有权
标题翻译：改善心脏功能的系统
公开(公告)号：US08257428B2
公开(公告)日：2012-09-04
申请号：US10436959
申请日：2003-05-12
申请人： Alexander Khairkhahan , Hugh R. Sharkey , Serjan D. Nikolic
发明人： Alexander Khairkhahan , Hugh R. Sharkey , Serjan D. Nikolic
IPC分类号： A61F2/06
CPC分类号： A61B17/0057 , A61B17/12022 , A61B17/12122 , A61B17/12172 , A61B2017/00243 , A61B2017/00575 , A61B2017/00579 , A61B2017/00592 , A61B2017/00597 , A61B2017/00615 , A61B2017/00632 , A61B2017/00867 , A61B2017/0649 , A61B2017/12095
摘要： A system for improving cardiac function is provided. A foldable and expandable frame having at least one anchoring formation is attached to an elongate manipulator and placed in a catheter tube while folded. The tube is inserted into a left ventricle of a heart where the frame is ejected from the tube and expands in the left ventricle. Movements of the elongate manipulator cause the anchor to penetrate the heart muscle and the elongate manipulator to release the frame. The installed frame minimizes the effects of an akinetic portion of the heart forming an aneurysmic bulge.
摘要翻译：提供了一种改善心脏功能的系统。具有至少一个锚固结构的可折叠和可扩张的框架附接到细长的操纵器并且在折叠时放置在导管中。将管插入心脏的左心室，其中框架从管中弹出并在左心室中扩张。细长机械手的运动导致锚固体穿透心脏肌肉和细长操纵器以释放框架。安装的框架最小化形成动脉瘤隆起的心脏的运动部分的影响。

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