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1. 发明授权

US09561131B2 Implant delivery system and methods thereof for treating ocular disorders 有权
标题翻译：植入物递送系统及其治疗眼部疾病的方法
公开(公告)号：US09561131B2
公开(公告)日：2017-02-07
申请号：US11455598
申请日：2006-06-19
申请人： Hosheng Tu , David Steven Haffner , Gregory T. Smedley , Barbara A. Niksch , Morteza Gharib , Thomas W. Burns , Richard Lindstrom
发明人： Hosheng Tu , David Steven Haffner , Gregory T. Smedley , Barbara A. Niksch , Morteza Gharib , Thomas W. Burns , Richard Lindstrom
IPC分类号： A61F9/007 , A61M27/00
CPC分类号： A61F9/00781 , A61M27/002
摘要： Surgical methods and related medical devices for treating glaucoma are disclosed. The method comprises trabecular bypass surgery, which involves bypassing diseased trabecular meshwork with the use of a stent implant. The stent implant is inserted into an opening created in the trabecular meshwork by a piercing member that is slidably advanceable through the lumen of the stent implant for supporting the implant insertion. The stent implant is positioned through the trabecular meshwork so that an inlet end of the stent implant is exposed to the anterior chamber of the eye and an outlet end is positioned into fluid collection channels at about an exterior surface of the trabecular meshwork or up to the level of aqueous veins.
摘要翻译：公开了用于治疗青光眼的手术方法和相关的医疗装置。该方法包括小梁旁路手术，其涉及利用支架植入物绕过患病的小梁网。支架植入物通过刺穿构件插入在小梁网中形成的开口中，该刺穿构件可滑动地前进通过支架植入物的内腔，用于支撑植入物插入。支架植入物定位穿过小梁网，使得支架植入物的入口端暴露于眼睛的前房，并且出口端被定位在围绕小梁网的外表面的流体收集通道中，或直到水静脉水平。

2. 发明授权

US07879079B2 Implant delivery system and methods thereof for treating ocular disorders 有权
标题翻译：植入物递送系统及其治疗眼部疾病的方法
公开(公告)号：US07879079B2
公开(公告)日：2011-02-01
申请号：US11455391
申请日：2006-06-19
申请人： Hosheng Tu , David S. Haffner , Gregory T. Smedley , Barbara A. Niksch , Morteza Gharib
发明人： Hosheng Tu , David S. Haffner , Gregory T. Smedley , Barbara A. Niksch , Morteza Gharib
IPC分类号： A61F2/06
CPC分类号： A61F9/00781 , A61M27/002
摘要： Surgical methods and related medical devices for treating glaucoma are disclosed. The method comprises trabecular bypass surgery, which involves bypassing diseased trabecular meshwork with the use of a stent implant. The stent implant is inserted into an opening created in the trabecular meshwork by a piercing member that is slidably advanceable through the lumen of the stent implant for supporting the implant insertion. The stent implant is positioned through the trabecular meshwork so that an inlet end of the stent implant is exposed to the anterior chamber of the eye and an outlet end is positioned into fluid collection channels at about an exterior surface of the trabecular meshwork or up to the level of aqueous veins.
摘要翻译：公开了用于治疗青光眼的手术方法和相关的医疗装置。该方法包括小梁旁路手术，其涉及利用支架植入物绕过患病的小梁网。支架植入物通过刺穿构件插入在小梁网中形成的开口中，该刺穿构件可滑动地前进通过支架植入物的内腔，用于支撑植入物插入。支架植入物定位穿过小梁网，使得支架植入物的入口端暴露于眼睛的前房，并且出口端被定位在围绕小梁网的外表面的流体收集通道中，或直到水静脉水平。

3. 发明授权

US07331984B2 Glaucoma stent for treating glaucoma and methods of use 有权
标题翻译：用于治疗青光眼的青光眼支架及其使用方法
公开(公告)号：US07331984B2
公开(公告)日：2008-02-19
申请号：US10231342
申请日：2002-08-28
申请人： Hosheng Tu , David S. Haffner , Gregory T. Smedley , Barbara A. Niksch , Morteza Gharib
发明人： Hosheng Tu , David S. Haffner , Gregory T. Smedley , Barbara A. Niksch , Morteza Gharib
IPC分类号： A61F2/06
CPC分类号： A61F9/00781 , A61M27/002
摘要： Surgical methods and related medical devices for treating glaucoma are disclosed. The method comprises trabecular bypass surgery, which involves bypassing diseased trabecular meshwork with the use of a stent implant. The stent implant is inserted into an opening created in the trabecular meshwork by a piercing member that is slidably advanceable through the lumen of the stent implant for supporting the implant insertion. The stent implant is positioned through the trabecular meshwork so that an inlet end of the stent implant is exposed to the anterior chamber of the eye and an outlet end is positioned into fluid collection channels at about an exterior surface of the trabecular meshwork or up to the level of aqueous veins.
摘要翻译：公开了用于治疗青光眼的手术方法和相关的医疗装置。该方法包括小梁旁路手术，其涉及利用支架植入物绕过患病的小梁网。支架植入物通过刺穿构件插入在小梁网中形成的开口中，该刺穿构件可滑动地前进通过支架植入物的内腔，用于支撑植入物插入。支架植入物定位穿过小梁网，使得支架植入物的入口端暴露于眼睛的前房，并且出口端被定位在围绕小梁网的外表面的流体收集通道中，或直到水静脉水平。

4. 发明授权

US09301875B2 Ocular disorder treatment implants with multiple opening 有权
标题翻译：眼部疾病治疗植入物多次开放
公开(公告)号：US09301875B2
公开(公告)日：2016-04-05
申请号：US11084314
申请日：2005-03-18
申请人： Hosheng Tu , Jason Artof , David Steven Haffner , Gregory T. Smedley , Barbara A. Niksch
发明人： Hosheng Tu , Jason Artof , David Steven Haffner , Gregory T. Smedley , Barbara A. Niksch
IPC分类号： A61F2/14 , A61F9/007 , A61M27/00
CPC分类号： A61F9/00781 , A61M27/002 , A61M27/006
摘要： Intraocular stents and applicators are disclosed for treating glaucoma. The stents are configured to extend between the anterior chamber of the eye and Schlemm's canal for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The stents can have features for anchoring the stent into Schlemm's canal as well as preventing the walls of Schlemm's canal from closing the outlet of the stents. The applicators can be steerable so as to make implantation easier. Additionally, the applicators can be configured to hold a plurality of stents so that multiple stents can be implanted through one incision without removing the applicator from the incision between serial implantations.
摘要翻译：公开了用于治疗青光眼的眼内支架和敷贴器。支架构造成在眼前房和施乐姆氏管之间延伸，以增强从前房的水流出，以便降低眼内压。支架可以具有用于将支架锚定到施乐姆运河中的特征，以及阻止施莱姆运河的墙壁关闭支架的出口。施加器可以是可操纵的，以便使植入更容易。此外，施用器可以被配置成保持多个支架，使得可以通过一个切口植入多个支架，而不会从串联注入之间的切口移除施加器。

5. 发明授权

US09155654B2 Ocular system with anchoring implant and therapeutic agent 有权
标题翻译：具有锚固植入物和治疗剂的眼科系统
公开(公告)号：US09155654B2
公开(公告)日：2015-10-13
申请号：US13399760
申请日：2012-02-17
申请人： Hosheng Tu , Jason Artof , David Steven Haffner , Gregory T. Smedley , Barbara A. Niksch
发明人： Hosheng Tu , Jason Artof , David Steven Haffner , Gregory T. Smedley , Barbara A. Niksch
IPC分类号： A61M19/00 , A61F9/007 , A61K31/215
CPC分类号： A61F9/00781 , A61F9/0017 , A61F2220/0008 , A61F2230/0069 , A61F2250/0067 , A61K31/215
摘要： Ocular implants, delivery devices and methods for treating ocular disorders are disclosed. One method involves inserting an implant on one side of an eye. The implant has an anchor on a distal end portion and an outlet opening that is disposed proximal of the anchor. The implant is advanced across the eye to the other side of the eye. The anchor is inserted into eye tissue on the other side of the eye. A therapeutic agent is eluted using the implant.
摘要翻译：公开了眼部植入物，递送装置和治疗眼部疾病的方法。一种方法是将植入物插入眼睛的一侧。植入物具有位于锚固件近侧的远端部分上的锚固件和出口开口。植入物通过眼睛前进到眼睛的另一侧。将锚固体插入眼睛另一侧的眼睛组织中。使用植入物洗脱治疗剂。

6. 发明授权

US09987472B2 Ocular implant delivery systems 有权
公开(公告)号：US09987472B2
公开(公告)日：2018-06-05
申请号：US12979249
申请日：2010-12-27
申请人： Hosheng Tu , Gregory T. Smedley , David Steven Haffner , Barbara A. Niksch , Richard A. Hill , Olav B. Bergheim
发明人： Hosheng Tu , Gregory T. Smedley , David Steven Haffner , Barbara A. Niksch , Richard A. Hill , Olav B. Bergheim
IPC分类号： A61B19/00 , A61F11/00 , A61M27/00 , A61F9/007
CPC分类号： A61M27/00 , A61F9/00781
摘要： Systems and methods for treating ocular disorders are disclosed. One system has a delivery instrument, with a non-linear axis, configured to be inserted into an anterior chamber of an eye and moved to a location proximate a physiologic outflow pathway of the eye. The delivery instrument carries an implant that has a distal end sized for insertion into tissue such that aqueous humor drains from the anterior chamber to the physiologic outflow pathway. One method involves inserting a non-linear portion of a delivery device into the anterior chamber to position an implant within the eye. Another method involves using a delivery device with a curved distal portion to implant an implant at a location communicating with the physiologic outflow pathway. The delivery can be through a corneal incision and the implant can comprise a drug.

7. 发明授权

US09597230B2 Devices and methods for glaucoma treatment 有权
公开(公告)号：US09597230B2
公开(公告)日：2017-03-21
申请号：US11836112
申请日：2007-08-08
申请人： David Steven Haffner , Gregory T Smedley , Hosheng Tu , Thomas W. Burns
发明人： David Steven Haffner , Gregory T Smedley , Hosheng Tu , Thomas W. Burns
IPC分类号： A61M1/00 , A61F9/007
CPC分类号： A61F9/00781
摘要： Intraocular implants and delivery instruments are disclosed for treating ophthalmic conditions and ocular disorders, such as glaucoma. The implants are configured to extend between the anterior chamber of the eye and a fluid outflow path or physiologic outflow pathway, such as Schlemm's canal, of the eye for enhancing outflow of aqueous from the anterior chamber so as to reduce intraocular pressure. The implants can have features for anchoring the implant into the physiologic outflow pathway as well as preventing the walls of the physiologic outflow pathway from closing the outlet of the implants. The delivery instruments can be steerable so as to make implantation easier. Additionally, the delivery instruments can be configured to hold a plurality of implants so that multiple implants can be implanted through one incision without removing the delivery instrument from the incision between serial implantations.

8. 发明授权

US08579846B2 Ocular implant systems 有权
标题翻译：眼植入系统
公开(公告)号：US08579846B2
公开(公告)日：2013-11-12
申请号：US13301648
申请日：2011-11-21
申请人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
发明人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
IPC分类号： A61B19/00 , A61F11/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： Implants and methods for treating ocular disorders are disclosed. One implant has a tubular member, with inlet and outlet ends, and a cutting member connected thereto. The tubular member is configured to extend through eye tissue such that the inlet and outlet ends reside respectively in an anterior chamber and a physiologic outflow pathway of the eye. Desirably, the cutting member is configured to make an incision in the eye tissue for receiving at least a portion of the tubular member. One method involves introducing an implant, with proximal and distal ends, into the anterior chamber and penetrating eye tissue using an implant distal portion. The implant is advanced from the anterior chamber into the penetrated eye tissue to locate the distal and proximal ends respectively in the physiologic outflow pathway and the anterior chamber. Aqueous humor is conducted between the proximal and distal ends.
摘要翻译：公开了用于治疗眼部疾病的植入物和方法。一个植入物具有管状构件，其具有入口端和出口端以及与其连接的切割构件。管状构件构造成延伸穿过眼睛组织，使得入口端和出口端分别位于眼睛的前房和生理流出路径中。期望地，切割构件被配置为在眼组织中进行切口以接收管状构件的至少一部分。一种方法包括使用植入物远端部分将具有近端和远端的植入物引入前房和穿透眼组织。植入物从前房进入穿透的眼组织，将远端和近端分别定位在生理流出道和前房中。在近端和远端之间进行水性幽默。

9. 发明授权

US08075511B2 System for treating ocular disorders and methods thereof 有权
标题翻译：用于治疗眼部疾病的系统及其方法
公开(公告)号：US08075511B2
公开(公告)日：2011-12-13
申请号：US12111033
申请日：2008-04-28
申请人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
发明人： Hosheng Tu , Gregory T. Smedley , David Haffner , Barbara A. Niksch
IPC分类号： A61M5/00
CPC分类号： A61M27/00 , A61F9/00781
摘要： Systems and methods for treating ocular disorders are disclosed. One system has an implant and a delivery device. The implant has inlet and outlet portions, a lumen extending therebetween and communicating with inlet and outlet ports. The implant is sized so that in use aqueous humor flows from an anterior chamber of an eye through the implant and into a uveal scleral outflow path of the eye. The delivery device is configured to advance the implant from within the anterior chamber, with the outlet portion leading the inlet portion, to a location where the outlet and inlet ports respectively communicate with the uveal scleral outflow path and the anterior chamber. One method involves advancing an implant from within the anterior chamber, and draining fluid from therein such that fluid flows into an implant inlet port and out through an implant outlet port and into the uveal scleral outflow path.
摘要翻译：公开了用于治疗眼部疾病的系统和方法。一个系统具有植入物和递送装置。植入物具有入口和出口部分，在其间延伸并与入口和出口连通的内腔。植入物的大小使得在使用中，房水从眼睛的前房通过植入物流入眼睛的葡萄膜巩膜流出道。输送装置构造成使得植入物从前室中前进，出口部分将入口部分引导到出口和入口分别与葡萄膜巩膜流出道和前房连通的位置。一种方法包括从前房中推进植入物，并从其中排出流体，使得流体流入植入物入口并通过植入物出口并流入葡萄膜巩膜流出道。

10. 发明授权

US08337445B2 Ocular implant with double anchor mechanism 有权
标题翻译：双锚机构眼植入
公开(公告)号：US08337445B2
公开(公告)日：2012-12-25
申请号：US11860785
申请日：2007-09-25
申请人： Hosheng Tu , Gregory T Smedley , Barbara A Niksch , David S Haffner
发明人： Hosheng Tu , Gregory T Smedley , Barbara A Niksch , David S Haffner
IPC分类号： A61M5/00 , A61M25/00 , A61M31/00 , A61M29/00 , A61F2/14 , A61F2/82 , A61F2/94
CPC分类号： A61F2/16 , A61F9/00781 , A61K9/0048
摘要： The invention relates generally to medical devices and methods for the treatment of ocular disorders. One method provides an implant having an inlet portion with a first anchor and an outlet portion with a second anchor. The implant is implanted in tissue of an eye such the implant conducts fluid from an anterior chamber of the eye to a physiological outflow pathway of the eye. The implanting involves positioning the first anchor adjacent eye tissue, positioning the second anchor within the physiological outflow pathway, and deploying the second anchor such that the second anchor secures the implant within the physiological outflow pathway and a distal end of the second anchor is positioned further into the physiological outflow pathway than an outlet of the outlet portion.
摘要翻译：本发明一般涉及用于治疗眼部疾病的医疗装置和方法。一种方法提供了一种具有入口部分的植入体，该入口部分具有第一锚固件和具有第二锚固件的出口部分将植入物植入眼睛的组织中，使得植入物将流体从眼睛的前房传导到眼睛的生理流出路径。所述植入涉及将所述第一锚固件邻近眼睛组织定位，将所述第二锚固件定位在所述生理流出路径内，以及展开所述第二锚固件，使得所述第二锚固件将所述植入物固定在所述生理流出路径内，并且所述第二锚固件的远端进一步定位进入生理流出路径而不是出口部分的出口。

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