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1. 发明授权

US08105777B1 Methods for diagnosis and/or prognosis of colon cancer 失效
标题翻译：结肠癌诊断和/或预后的方法
公开(公告)号：US08105777B1
公开(公告)日：2012-01-31
申请号：US12370264
申请日：2009-02-12
申请人： Hongyue Dai , Laura J. Van't Veer , Yudong He
发明人： Hongyue Dai , Laura J. Van't Veer , Yudong He
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/118 , C12Q2600/158
摘要： The present invention relates to genetic markers whose expression is correlated with colon cancer. In one aspect, the invention provides sets of markers whose expression can be used for classifying colon cancer patients into different prognostic categories. In another aspect, the invention provides kits containing marker sets for determining prognosis of colon cancer. In another aspect, the invention provides methods of classifying cancer patients with regard to prognosis.
摘要翻译：本发明涉及其表达与结肠癌相关的遗传标记。一方面，本发明提供了一组标志物，其表达可用于将结肠癌患者分类为不同的预后类别。另一方面，本发明提供了包含用于确定结肠癌预后的标记物组的试剂盒。另一方面，本发明提供了关于预后的癌症患者分类方法。

2. 发明授权

US08019552B2 Classification of breast cancer patients using a combination of clinical criteria and informative genesets 失效
标题翻译：乳腺癌患者使用临床标准和信息基因组合的分类
公开(公告)号：US08019552B2
公开(公告)日：2011-09-13
申请号：US10591800
申请日：2005-03-07
申请人： Hongyue Dai , Laura J. Van't Veer , John Lamb , Roland Stoughton , Stephen H. Friend , Yudong He
发明人： Hongyue Dai , Laura J. Van't Veer , John Lamb , Roland Stoughton , Stephen H. Friend , Yudong He
IPC分类号： G01N33/48 , G01N33/50
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , Y10T436/143333
摘要： The present invention provides prognostic methods for conditions such as cancer, for example, breast cancer, comprising classifying an individual by a plurality of phenotypic, genotypic or clinical characteristics of the condition into a plurality of patient subsets, and analyzing the pattern of expression of prognosis-informative genes identified for that subset in a sample from the individual. The present invention also provides methods for constructing such patient subsets and of identifying prognosis-informative genesets for such subsets. The invention further provides methods of assigning a therapeutic regimen to an individual, microarrays useful for performing prognosis, kits comprising these microarrays, and computer systems and programs for implementing the methods of the invention.
摘要翻译：本发明提供了诸如癌症例如乳腺癌的病症的预后方法，包括将个体的多个表型，基因型或临床特征分类为多个患者子集，并分析预后表达模式在来自个体的样品中识别该子集的信息基因。本发明还提供了用于构建这样的患者子集以及鉴定这样的子集的预后信息性基因组的方法。本发明进一步提供了将个体的治疗方案分配给用于进行预后的微阵列，包括这些微阵列的试剂盒以及用于实施本发明的方法的计算机系统和程序的方法。

3. 发明申请

US20090239214A1 Prognosis of breast cancer patients 审中-公开
标题翻译：乳腺癌患者预后
公开(公告)号：US20090239214A1
公开(公告)日：2009-09-24
申请号：US11658605
申请日：2005-08-01
申请人： Hongyue Dai , Yudong He , Mao Mao , Bernard Fine , Laura J. van't Veer , Marc J. van de Vijver
发明人： Hongyue Dai , Yudong He , Mao Mao , Bernard Fine , Laura J. van't Veer , Marc J. van de Vijver
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G01N33/57415 , B01J2219/00378 , B01J2219/00385 , B01J2219/00527 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00641 , B01J2219/00675 , B01J2219/00677 , B01J2219/00693 , B01J2219/00711 , B01J2219/00722 , B82Y30/00 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , G16B25/00 , G16B40/00
摘要： The present invention relates to sets of genetic markers whose expression is correlated with prognosis of breast cancer in individuals having breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate individuals having a good prognosis, e.g., no reoccurrence or metastasis within five years of initial diagnosis, and individuals having a poor prognosis, e.g., reoccurrence or metastasis within five years of initial diagnosis. The invention relates to methods of prognosis using these markers. The invention also relates to microarrays containing probes to these markers, and to kits containing ready-to-use microarrays and computer software for data analysis using the prognostic and statistical methods disclosed herein.
摘要翻译：本发明涉及具有乳腺癌个体的表达与乳腺癌预后相关的遗传标记组。具体地，本发明提供了一组标志物，其表达模式可用于区分具有良好预后的个体，例如在初始诊断的五年内不再发生或转移，以及在五年内具有差的预后，例如再发生或转移的个体的初步诊断。本发明涉及使用这些标记物的预后方法。本发明还涉及含有这些标记物的探针的微阵列，以及包含即用型微阵列的试剂盒和用于使用本文公开的预后和统计学方法进行数据分析的计算机软件。

4. 发明申请

US20080187909A1 Classification of Breast Cancer Patients Using a Combination of Clinical Criteria and Informative Genesets 失效
标题翻译：乳腺癌患者使用临床标准和信息基因组合的分类
公开(公告)号：US20080187909A1
公开(公告)日：2008-08-07
申请号：US10591800
申请日：2005-03-07
申请人： Hongyue Dai , Laura J. Van't Veer , John Lamb , Roland Stoughton , Stephen H. Friend , Yudong He
发明人： Hongyue Dai , Laura J. Van't Veer , John Lamb , Roland Stoughton , Stephen H. Friend , Yudong He
IPC分类号： C12Q1/68 , C40B40/06
CPC分类号： G01N33/57415 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , Y10T436/143333
摘要： The present invention provides prognostic methods for conditions such as cancer, for example, breast cancer, comprising classifying an individual by a plurality of phenotypic, genotypic or clinical characteristics of the condition into a plurality of patient subsets, and analyzing the pattern of expression of prognosis-informative genes identified for that subset in a sample from the individual. The present invention also provides methods for constructing such patient subsets and of identifying prognosis-informative genesets for such subsets. The invention further provides methods of assigning a therapeutic regimen to an individual, microarrays useful for performing prognosis, kits comprising these microarrays, and computer systems and programs for implementing the methods of the invention.
摘要翻译：本发明提供了诸如癌症例如乳腺癌的病症的预后方法，包括将个体的多个表型，基因型或临床特征分类为多个患者子集，并分析预后表达模式在来自个体的样品中识别该子集的信息基因。本发明还提供了用于构建这样的患者子集以及鉴定这样的子集的预后信息性基因组的方法。本发明进一步提供了将个体的治疗方案分配给用于进行预后的微阵列，包括这些微阵列的试剂盒以及用于实施本发明的方法的计算机系统和程序的方法。

5. 发明授权

US07171311B2 Methods of assigning treatment to breast cancer patients 有权
标题翻译：为乳腺癌患者分配治疗方法
公开(公告)号：US07171311B2
公开(公告)日：2007-01-30
申请号：US10342887
申请日：2003-01-15
申请人： Hongyue Dai , Yudong He , Peter S. Linsley , Mao Mao , Christopher J. Roberts , Laura Johanna Van't Veer , Marc J. Van de Vijver , Rene Bernards , A. A. M. Hart
发明人： Hongyue Dai , Yudong He , Peter S. Linsley , Mao Mao , Christopher J. Roberts , Laura Johanna Van't Veer , Marc J. Van de Vijver , Rene Bernards , A. A. M. Hart
IPC分类号： G01N33/48 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/158
摘要： The present invention relates to genetic markers whose expression is correlated with breast cancer. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate clinical conditions associated with breast cancer, such as the presence or absence of the estrogen receptor ESR1, and BRCA1 and sporadic tumors, and to provide information on the likelihood of tumor distant metastases within five years of initial diagnosis. The invention relates to methods of using these markers to distinguish these conditions. The invention also provides methods of classifying and treating patients based on prognosis. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the diagnostic, prognostic and statistical methods disclosed herein.
摘要翻译：本发明涉及其表达与乳腺癌相关的遗传标记。具体地，本发明提供了一组标志物，其表达模式可用于区分与乳腺癌相关的临床病症，例如雌激素受体ESR1和BRCA1和散发性肿瘤的存在或不存在，并提供关于肿瘤可能性的信息初步诊断五年内远处转移。本发明涉及使用这些标记来区分这些条件的方法。本发明还提供了基于预后对患者进行分类和治疗的方法。本发明还涉及包含即用型微阵列的试剂盒和用于使用本文公开的诊断，预后和统计学方法进行数据分析的计算机软件。

6. 发明申请

US20050143628A1 Methods for characterizing tissue or organ condition or status 审中-公开
标题翻译：表征组织或器官状况或状态的方法
公开(公告)号：US20050143628A1
公开(公告)日：2005-06-30
申请号：US10872157
申请日：2004-06-17
申请人： Xudong Dai , Yudong He , Hongyue Dai , Roger Ulrich , Jeffrey Waring
发明人： Xudong Dai , Yudong He , Hongyue Dai , Roger Ulrich , Jeffrey Waring
IPC分类号： A61B5/00 , G01N33/567 , G06F19/00 , G01N33/48 , G01N33/50
CPC分类号： G01N33/567 , A61B5/00 , A61B5/416 , A61B5/726 , A61B5/7267 , G01N2500/00 , G16B40/00
摘要： The invention provides methods for characterizing the condition or status of a tissue or organ in a multicellular organism, e.g., an animal, by combining a plurality of clinical measures are combined into a composite clinical score (CCS) and using such a CCS to represent the condition or status of the tissue or organ. The invention provides methods for predicting the condition or status of a tissue or organ in a multicellular organism, e.g., an animal, based on measurements of a set of cellular constituent markers, e.g., measured expression levels of a set of marker genes. The invention also provides methods for selecting the set of marker genes whose expression levels can be used in determining the CCS.
摘要翻译：本发明提供用于表征多细胞生物（例如动物）中的组织或器官的状况或状态的方法，通过组合多个临床措施组合成复合临床评分（CCS）并使用这样的CCS来表示条件或状态。本发明提供了用于基于一组细胞构成标志物的测量，例如一组标记基因的测量的表达水平来预测多细胞生物体（例如动物）中的组织或器官的状态或状态的方法。本发明还提供了用于选择其表达水平可以用于确定CCS的标记基因的集合的方法。

7. 发明申请

US20060292623A1 Signature genes in chronic myelogenous leukemia 审中-公开
公开(公告)号：US20060292623A1
公开(公告)日：2006-12-28
申请号：US11510798
申请日：2006-08-25
申请人： Peter Linsley , Mao Mao , Hongyue Dai , Yudong He , Jerald Radich
发明人： Peter Linsley , Mao Mao , Hongyue Dai , Yudong He , Jerald Radich
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G01N33/57426 , C12Q1/6837 , C12Q1/6886 , C12Q2600/158 , G16B25/00
摘要： The present invention relates to genetic markers whose expression is correlated with progression of CML. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate chronic phase individuals from those in blast crisis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.

8. 发明申请

US20100169025A1 METHODS AND GENE EXPRESSION SIGNATURE FOR WNT/B-CATENIN SIGNALING PATHWAY 审中-公开
标题翻译： WNT / B-CATENIN信号通路的方法和基因表达标志
公开(公告)号：US20100169025A1
公开(公告)日：2010-07-01
申请号：US12641486
申请日：2009-12-18
申请人： William T. Arthur , Brian Roberts , Rachel Needham , Hongyue Dai
发明人： William T. Arthur , Brian Roberts , Rachel Needham , Hongyue Dai
IPC分类号： G06F19/00 , C12Q1/68 , G06N5/02
CPC分类号： C12Q1/6876 , C12Q2600/158 , G16B25/00
摘要： Methods, biomarkers, and expression signatures are disclosed for assessing the regulation status of Wnt/β-catenin signaling pathway in a cell sample or subject. More specifically, several aspects of the invention provide a set of genes which can be used as biomarkers and gene signatures for evaluating Wnt/β-catenin pathway deregulation status in a sample; classifying a cell sample as having a deregulated or regulated Wnt/β-catenin signaling pathway; determining whether an agent modulates the Wnt/β-catenin signaling pathway in sample; predicting response of a subject to an agent that modulates the Wnt/β-catenin signaling pathway; assigning treatment to a subject; and evaluating the pharmacodynamic effects of therapies designed to regulate Wnt/β-catenin pathway signaling.
摘要翻译：公开了方法，生物标志物和表达特征，用于评估细胞样品或受试者中Wnt / / bgr-catenin信号通路的调节状态。更具体地，本发明的几个方面提供了一组基因，其可以用作用于评估样品中Wnt / bgr-连接蛋白通路去调节状态的生物标志物和基因特征; 将细胞样品分类为具有失调或调节的Wnt / / bgr-catenin信号通路; 确定试剂是否调节样品中的Wnt / bgr-catenin信号通路; 预测受试者对调节Wnt / bgr-catenin信号通路的药剂的反应; 为受试者分配治疗; 并评估旨在调节Wnt / bgr-catenin途径信号传导的疗法的药效学作用。

9. 发明申请

US20050084872A1 Methods for determining whether an agent possesses a defined biological activity 审中-公开
标题翻译：用于确定试剂是否具有确定的生物活性的方法
公开(公告)号：US20050084872A1
公开(公告)日：2005-04-21
申请号：US10764420
申请日：2004-01-23
申请人： Pek Lum , Yejun Tan , Hongyue Dai , Eric Muise , Joel Berger , John Thompson
发明人： Pek Lum , Yejun Tan , Hongyue Dai , Eric Muise , Joel Berger , John Thompson
IPC分类号： G01N33/48 , G01N33/50 , G06F19/00 , C12Q1/68
CPC分类号： G01N33/5014 , G01N33/48 , G01N2333/70567 , G16B25/00
摘要： In one aspect, the present invention provides methods for determining whether an agent (e.g., candidate drug) possesses a biological activity. In another aspect, the present invention provides populations of nucleic acid molecules useful in the practice of the present invention as probes for measuring the level of expression of populations of genes.
摘要翻译：一方面，本发明提供了用于确定试剂（例如候选药物）是否具有生物活性的方法。另一方面，本发明提供了可用于本发明实践的核酸分子群体，作为用于测量基因群体表达水平的探针。

10. 发明申请

US20050033520A1 Methods and compositions for utilizing changes of hybridization signals during approach to equilibrium 审中-公开
标题翻译：在平衡过程中利用杂交信号变化的方法和组合物
公开(公告)号：US20050033520A1
公开(公告)日：2005-02-10
申请号：US10475960
申请日：2002-04-24
申请人： Hongyue Dai , Michael Meyer , Roland Stoughton
发明人： Hongyue Dai , Michael Meyer , Roland Stoughton
IPC分类号： C12Q1/68 , G06F19/20 , G06F19/00
CPC分类号： C12Q1/6816 , C12Q1/6837 , G16B25/00 , C12Q2527/113
摘要： The present invention provides methods for utilizing the changes of hybridization levels in time during approach to equilibrium duplex formation for identifying specific hybridization to polynucleotide probes. In the invention, the changes of hybridization levels at one or more polynucleotide probes by a sample comprising a plurality of nucleic acid molecules having different sequences are monitored during their progress towards equilibrium and the continuing increase of hybridization signals beyond cross-hybridization is used as an indication of specific binding. The invention also provides methods of comparing specificities of different polynucleotides probes. The invention further provides methods for ranking and selecting polynucleotide probes that are specific to particular nucleic acids and methods for enhancing the detection of nucleic acids. The invention further provides methods for determining the orientation of nucleotide sequences.
摘要翻译：本发明提供了在平衡双相形成过程中利用杂交水平随时间变化的方法，用于鉴定与多核苷酸探针的特异性杂交。在本发明中，在包含具有不同序列的多个核酸分子的样品的一个或多个多核苷酸探针处的杂交水平的变化在其进展到平衡期间被监测，并且超越交叉杂交的杂交信号的持续增加用作指示具体绑定。本发明还提供了比较不同多核苷酸探针的特异性的方法。本发明还提供了用于评估和选择对特定核酸特异性的多核苷酸探针的方法和用于增强核酸检测的方法。本发明还提供了确定核苷酸序列取向的方法。

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