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1. 发明申请

US20060292623A1 Signature genes in chronic myelogenous leukemia 审中-公开
公开(公告)号：US20060292623A1
公开(公告)日：2006-12-28
申请号：US11510798
申请日：2006-08-25
申请人： Peter Linsley , Mao Mao , Hongyue Dai , Yudong He , Jerald Radich
发明人： Peter Linsley , Mao Mao , Hongyue Dai , Yudong He , Jerald Radich
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： G01N33/57426 , C12Q1/6837 , C12Q1/6886 , C12Q2600/158 , G16B25/00
摘要： The present invention relates to genetic markers whose expression is correlated with progression of CML. Specifically, the invention provides sets of markers whose expression patterns can be used to differentiate chronic phase individuals from those in blast crisis. The invention relates to methods of using these markers to distinguish these conditions. The invention also relates to kits containing ready-to-use microarrays and computer software for data analysis using the statistical methods disclosed herein.

2. 发明申请

US20070154931A1 Genes associate with progression and response in chronic myeloid leukemia and uses thereof 失效
标题翻译：与慢性骨髓性白血病中进展和反应相关的基因及其用途
公开(公告)号：US20070154931A1
公开(公告)日：2007-07-05
申请号：US11640517
申请日：2006-12-14
申请人： Jerald Radich , Hongyue Dai , Mao Mao , Janell Schelter , Peter Linsley
发明人： Jerald Radich , Hongyue Dai , Mao Mao , Janell Schelter , Peter Linsley
IPC分类号： C12Q1/68 , G06F19/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , Y02A90/26
摘要： The invention provides molecular markers that are associated with the progression of chronic myeloid leukemia (CML), and methods and computer systems for monitoring the progression of CML in a patient based on measurements of these molecular markers. The present invention also provides CML target genes, and methods and compositions for treating CML patients by modulating the expression or activity of these CML target genes and/or their encoded proteins. The invention also provides genes that are associated with resistance to imatinib mesylate (Gleevec™) treatment in CML patients, and methods and compositions for determining the responsiveness of a CML patient to imatinib mesylate treatment based on measurements of these genes and/or their encoded proteins. The invention also provides methods and compositions for enhancing the effect of Gleevec™ by modulating the expression or activity of these genes and/or their encoded proteins.
摘要翻译：本发明提供了与慢性骨髓性白血病（CML）进展相关的分子标记，以及用于基于这些分子标记物的测量来监测患者中CML进展的方法和计算机系统。本发明还提供CML靶基因，以及通过调节这些CML靶基因和/或其编码蛋白的表达或活性来治疗CML患者的方法和组合物。本发明还提供了与CML患者中对甲磺酸伊马替尼（Gleevec TM）的抗药性相关的基因，以及基于这些基因和/或它们的测量来确定CML患者对甲磺酸伊马替尼治疗的反应性的方法和组合物编码的蛋白质。本发明还提供了通过调节这些基因和/或其编码的蛋白质的表达或活性来增强Gleevec TM的作用的方法和组合物。

3. 发明申请

US20110166200A1 METHODS OF USING MIR210 AS A BIOMARKER FOR HYPOXIA AND AS A THERAPEUTIC AGENT FOR TREATING CANCER 审中-公开
标题翻译：使用MIR210作为生物标记物用于HYPOXIA的方法和作为治疗癌症的治疗剂
公开(公告)号：US20110166200A1
公开(公告)日：2011-07-07
申请号：US12989198
申请日：2009-04-16
申请人： Zhan Zhang , Sun Hong , Hongyue Dai , Jan Schelter , Julia Burchard , Xudong Dai , Michael Carleton , Michael Cleary , Peter Linsley , Carla Grandori
发明人： Zhan Zhang , Sun Hong , Hongyue Dai , Jan Schelter , Julia Burchard , Xudong Dai , Michael Carleton , Michael Cleary , Peter Linsley , Carla Grandori
IPC分类号： A61K31/713 , C12Q1/68 , C12N5/09 , A61P35/00
CPC分类号： C12Q1/6886 , C12Q2600/106 , C12Q2600/178
摘要： The present invention provides compositions and methods for predicting the hypoxia response in tumor cells, methods for predicting the likelihood of cancer metastasis, and methods for inhibiting tumor cell proliferation using a microRNA comprising miR-210.
摘要翻译：本发明提供用于预测肿瘤细胞中的缺氧反应的组合物和方法，用于预测癌症转移的可能性的方法，以及使用包含miR-210的微小RNA抑制肿瘤细胞增殖的方法。

4. 发明申请

US20050181385A1 Synthetic lethal screen using RNA interference 审中-公开
标题翻译：合成致死屏幕采用RNA干扰
公开(公告)号：US20050181385A1
公开(公告)日：2005-08-18
申请号：US10947637
申请日：2004-09-22
申请人： Peter Linsley , Mao Mao , Annette Kim , Stephen Friend , Steven Bartz , Michele Cleary
发明人： Peter Linsley , Mao Mao , Annette Kim , Stephen Friend , Steven Bartz , Michele Cleary
IPC分类号： C07H21/02 , C12N15/11 , C12N15/85 , C12Q1/68
CPC分类号： C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2320/12
摘要： The invention provides a method for identifying one or more genes in a cell of a cell type which interact with, e.g., modulate the effect of, an agent, e.g., a drug. For example, an identified gene may confer resistance or sensitivity to a drug, i.e., reduces or enhances the effect of the drug. The invention also provides STK6 and TPX2 as a gene that exhibits synthetic lethal interactions with KSP encoding a kinesin-like motor protein, and methods and compositions for treatment of diseases, e.g., cancers, by modulating the expression of STK6 or TPX2 gene and/or the activity of STK6 or TPX2 gene product. The invention also provides genes involved in cellular response to DNA damage, and their therapeutic uses.
摘要翻译：本发明提供了一种用于鉴定与例如药物的作用相互作用的细胞类型的细胞中的一种或多种基因的方法。例如，鉴定的基因可赋予药物抗药性或敏感性，即降低或增强药物的作用。本发明还提供STK6和TPX2作为与编码驱动蛋白样运动蛋白的KSP呈现合成的致死相互作用的基因，以及通过调节STK6或TPX2基因的表达和/或治疗疾病例如癌症的方法和组合物 STK6或TPX2基因产物的活性。本发明还提供涉及对DNA损伤的细胞反应及其治疗用途的基因。

5. 发明申请

US20070134660A1 Methods for identifying modulators of kinesin activity 审中-公开
标题翻译：识别驱动蛋白活性调节剂的方法
公开(公告)号：US20070134660A1
公开(公告)日：2007-06-14
申请号：US10558463
申请日：2004-05-28
申请人： Mao Mao , Peter Linsley , Carolyn Buser , Christopher Marshall
发明人： Mao Mao , Peter Linsley , Carolyn Buser , Christopher Marshall
IPC分类号： C12Q1/68 , G01N33/574 , A61K31/175
CPC分类号： G01N33/5011 , A61K31/175 , A61K38/00 , C12Q1/34 , G01N33/573 , G01N33/57415
摘要： In a first aspect, the invention provides methods for screening for modulators of a target protein, comprising the steps of contacting a target protein with a candidate agent and determining whether the candidate agent modulates the activity of the target protein, wherein the target protein comprises a sequence that has more than 80% amino acid sequence identity to KIF14 (SEQ ID NO:2) or the KIF14 motor domain (SEQ ID NO:3). In a second aspect, the invention provides methods for modulating cell proliferation comprising administering to a cell an effective amount of a modulator of the activity of a target protein. Some embodiments of this aspect provide methods for treating a subject with a cellular hyperproliferation disorder, such as cancer. In a third aspect, the invention provides methods for identifying candidate subjects for treatment with an inhibitor of the activity of a target protein.
摘要翻译：在第一方面，本发明提供了筛选靶蛋白的调节剂的方法，包括以下步骤：使靶蛋白与候选试剂接触并确定候选试剂是否调节靶蛋白的活性，其中靶蛋白包含与KIF14（SEQ ID NO：2）或KIF14运动结构域（SEQ ID NO：3）具有80％以上氨基酸序列同一性的序列。在第二方面，本发明提供了调节细胞增殖的方法，包括向细胞施用有效量的靶蛋白活性的调节剂。该方面的一些实施方案提供了用细胞过度增殖病症如癌症治疗受试者的方法。在第三方面，本发明提供用于鉴定候选受试者用靶蛋白活性抑制剂治疗的方法。

6. 发明申请

US20100113577A1 ISOLATED NUCLEIC ACID MOLECULES CORRESPONDING TO MICRO RNA 145 (MIRNA-145) AND THEIR USE IN TREATING COLON CANCER 审中-公开
标题翻译：与MICRO RNA 145（MIRNA-145）相关的分离的核酸分子及其在治疗结肠癌中的应用
公开(公告)号：US20100113577A1
公开(公告)日：2010-05-06
申请号：US12594962
申请日：2008-04-07
申请人： Bin Shi , Laura Sepp-Lorenzino , Peter Linsley , Renato Baserga
发明人： Bin Shi , Laura Sepp-Lorenzino , Peter Linsley , Renato Baserga
IPC分类号： A61K31/7088 , C12Q1/68
CPC分类号： C07K14/47 , A61K48/00
摘要： Provided herein are isolated nucleic acid molecule corresponding to miR145 that are useful in treating colon cancer. The disclosed miR145 nucleic acids specifically bind the 3′ UTR within endogenous IRS-I such as to suppress or inhibit colon cell proliferation.
摘要翻译：本文提供了对应于可用于治疗结肠癌的miR145的分离的核酸分子。公开的miR145核酸特异性结合内源IRS-1内的3'UTR，以抑制或抑制结肠细胞增殖。

7. 发明申请

US20070048320A1 Method for indentifying modulators of PPIL2 useful for treating Alzheimer's disease 审中-公开
标题翻译：用于鉴定治疗阿尔茨海默病的PPIL2调节剂的方法
公开(公告)号：US20070048320A1
公开(公告)日：2007-03-01
申请号：US11514737
申请日：2006-08-31
申请人： Amy Espeseth , Daria Hazuda , Peter Linsley , Qian Huang
发明人： Amy Espeseth , Daria Hazuda , Peter Linsley , Qian Huang
IPC分类号： A61K39/395 , G01N33/567 , A61K39/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K16/40 , C12N9/90 , G01N33/6896 , G01N2333/4709 , G01N2500/10
摘要： Methods for identifying modulators of PPIL2 are described. The methods are particularly useful for identifying analytes that antagonize PPIL2's effect on processing of amyloid precursor protein to Aβ peptide and thus useful for identifying analytes that can be used for treating Alzheimer disease.
摘要翻译：描述了用于鉴定PPIL2调节剂的方法。该方法特别适用于鉴定拮抗PPIL2对淀粉样蛋白前体蛋白加工成Abeta肽的影响的分析物，因此可用于鉴定可用于治疗阿尔茨海默病的分析物。

8. 发明申请

US20050169919A1 CTLA4 molecules and IL4-binding molecules and uses thereof 失效
标题翻译： CTLA4分子和IL4结合分子及其用途
公开(公告)号：US20050169919A1
公开(公告)日：2005-08-04
申请号：US10461000
申请日：2003-06-13
申请人： Peter Linsley , Jeffrey Ledbetter , Nitin Damle , William Brady
发明人： Peter Linsley , Jeffrey Ledbetter , Nitin Damle , William Brady
IPC分类号： A61K38/00 , C07K14/705 , C07K14/715 , C07K16/00 , C07K16/28 , A61K39/395 , C07K14/74
CPC分类号： C07K16/247 , A61K38/00 , A61K2039/505 , C07K14/70521 , C07K14/7155 , C07K16/00 , C07K16/2818 , C07K16/2827 , C07K2317/34 , C07K2317/73 , C07K2319/00 , C07K2319/30 , Y10S514/885
摘要： The invention identifies the CTLA4 receptor as a ligand for the B7 antigen. The complete amino acid sequence encoding human CTLA4 receptor gene is provided. Methods are provided for expressing CTLA4 as an immunoglobulin fusion protein, for preparing hybrid CTLA4 fusion proteins, and for using the soluble fusion proteins, fragments and derivatives thereof, including monoclonal antibodies reactive with B7 and CTLA4, to regulate T cell interactions and immune responses mediated by such interactions.
摘要翻译：本发明鉴定CTLA4受体作为B7抗原的配体。提供编码人CTLA4受体基因的完整氨基酸序列。提供用于表达CTLA4作为免疫球蛋白融合蛋白的方法，用于制备杂合CTLA4融合蛋白，并使用可溶性融合蛋白，其片段和衍生物，包括与B7和CTLA4反应的单克隆抗体调节T细胞相互作用和免疫应答介导通过这种互动。

9. 发明授权

US08713172B1 Identification of websites that break out of frames 有权
标题翻译：识别出框架的网站
公开(公告)号：US08713172B1
公开(公告)日：2014-04-29
申请号：US13468322
申请日：2012-05-10
申请人： Peter Linsley
发明人： Peter Linsley
IPC分类号： G06F15/16 , G06F12/00
CPC分类号： G06F17/30905
摘要： Websites or webpages that break frames may be automatically detected by determining a first value, based on a number of occurrences, that a child webpage and a container webpage are provided for presentation, the child webpage being presented within a frame of the container webpage. A second value may be determined, based on a number of occurrences, of user interaction data, indicating user interaction with the container webpage. The method may further include calculating a frame break score for the child webpage based on the first value and the second value and comparing the frame break score to a threshold. The method may further include identifying, based on the comparison to the threshold, the child webpage as a webpage that breaks frames.
摘要翻译：可以通过基于出现次数确定子网页和容器网页用于呈现来确定第一个值来自动检测出框架的网站或网页，该子网页被呈现在容器网页的框架内。可以基于多次出现的用户交互数据来确定第二个值，指示用户与容器网页的交互。该方法还可以包括基于第一值和第二值计算子网页的帧间分数，并将帧间分数与阈值进行比较。该方法还可以包括基于与阈值的比较来识别作为中断帧的网页的子网页。

10. 发明申请

US20130117258A1 Previewing Search Results 有权
标题翻译：预览搜索结果
公开(公告)号：US20130117258A1
公开(公告)日：2013-05-09
申请号：US13288859
申请日：2011-11-03
申请人： Peter Linsley , Kenneth W. Dauber
发明人： Peter Linsley , Kenneth W. Dauber
IPC分类号： G06F17/30
CPC分类号： G06F17/30277 , G06F17/30572 , G06F17/30864
摘要： Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for previewing search results. In one aspect, a method includes receiving a query from a client device. One or more image search results are provided to the client device, each of the one or more image search results identifying a corresponding image resource and each of the one or more image search results including an image representation of the corresponding image resource. One or more related queries are provided to the client device, the one or more related queries having been determined to be related to the query, wherein each of the one or more related queries includes a preview image to be displayed at the client device, the preview image representing an image search result responsive to the related query.
摘要翻译：方法，系统和装置，包括在计算机存储介质上编码的计算机程序，用于预览搜索结果。一方面，一种方法包括从客户端设备接收查询。将一个或多个图像搜索结果提供给客户端设备，所述一个或多个图像搜索结果中的每一个标识对应的图像资源，并且所述一个或多个图像搜索结果中的每一个包括对应的图像资源的图像表示。将一个或多个相关查询提供给客户端设备，所述一个或多个相关查询已被确定为与查询相关，其中所述一个或多个相关查询中的每一个包括要在客户端设备处显示的预览图像，响应于相关查询的表示图像搜索结果的预览图像。

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