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1. 发明授权

US06512004B2 Promoters of neural regeneration 失效
公开(公告)号：US06512004B2
公开(公告)日：2003-01-28
申请号：US09900268
申请日：2001-07-06
申请人： Hong-jun Song , Mu-ming Poo , Guo-li Ming , Marc Tessier-Lavigne , Zhigang He
发明人： Hong-jun Song , Mu-ming Poo , Guo-li Ming , Marc Tessier-Lavigne , Zhigang He
IPC分类号： A61K3135
CPC分类号： A61K31/70
摘要： The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent protein kinase a neural cell subject to growth repulsion mediated by a neural cell growth repulsion factor. The activator may comprise a direct or an indirect activator of the protein kinase; the repulsion factor typically comprises one or more natural, endogenous proteins mediating localized repulsion or inhibition of neural cell growth; and the target cells are generally vertebrate neurons, typically injured mammalian neurons. The subject compositions include mixtures comprising a neural cell, an activator of a cyclic nucleotide dependent protein kinase and a neural cell growth repulsion factor.

2. 发明授权

US06268352B1 Promoters of neural regeneration 失效
标题翻译：神经再生的启动子
公开(公告)号：US06268352B1
公开(公告)日：2001-07-31
申请号：US09145820
申请日：1998-09-02
申请人： Hong-jun Song , Mu-Ming Poo , Guo-li Ming , Marc Tessier-Lavigne , Zhigang He
发明人： Hong-jun Song , Mu-Ming Poo , Guo-li Ming , Marc Tessier-Lavigne , Zhigang He
IPC分类号： A61K3170
CPC分类号： A61K31/70
摘要： The invention provides methods and compositions for promoting neural cell growth and/or regeneration. The general methods involve contacting with an activator of a cyclic nucleotide dependent protein kinase a neural cell subject to growth repulsion mediated by a neural cell growth repulsion factor. The activator may comprise a direct or an indirect activator of the protein kinase; the repulsion factor typically comprises one or more natural, endogenous proteins mediating localized repulsion or inhibition of neural cell growth; and the target cells are generally vertebrate neurons, typically injured mammalian neurons. The subject compositions include mixtures comprising a neural cell, an activator of a cyclic nucleotide dependent protein kinase and a neural cell growth repulsion factor.
摘要翻译：本发明提供促进神经细胞生长和/或再生的方法和组合物。一般方法包括与环核苷酸依赖性蛋白激酶的激活剂接触受到由神经细胞生长排斥因子介导的生长排斥的神经细胞的接触。活化剂可以包含蛋白激酶的直接或间接激活剂; 排斥因子通常包含介导局部排斥或抑制神经细胞生长的一种或多种天然的内源性蛋白质; 并且靶细胞通常是脊椎动物神经元，通常是受损的哺乳动物神经元。主题组合物包括包含神经细胞，环核苷酸依赖性蛋白激酶的激活剂和神经细胞生长排斥因子的混合物。

3. 发明授权

US06623738B1 Semaphorin receptors 有权
标题翻译：信号素受体
公开(公告)号：US06623738B1
公开(公告)日：2003-09-23
申请号：US09439711
申请日：1999-11-12
申请人： Marc Tessier-Lavigne , Zhigang He , Hang Chen
发明人： Marc Tessier-Lavigne , Zhigang He , Hang Chen
IPC分类号： A61K39395
CPC分类号： C07K14/7056 , A61K38/00
摘要： The invention provides methods and compositions relating to two classes of semaphorin receptors, SR1 and SR2. The polypeptides may be produced recombinantly from transformed host cells from the disclosed SR encoding nucleic acids or purified from human cells. The invention provides isolated SR hybridization probes and primers, capable of specifically hybridizing with the disclosed SR genes. SR-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译：本发明提供了与两类信号素受体SR1和SR2相关的方法和组合物。可以从所公开的SR编码核酸的转化的宿主细胞重组产生多肽或从人细胞纯化。本发明提供了能够与所公开的SR基因特异性杂交的分离的SR杂交探针和引物。 SR特异性结合剂，例如特异性抗体，以及在诊断，治疗和生物制药工业中制备和使用本发明组合物的方法。

4. 发明授权

US6054293A Semaphorin receptors 失效
标题翻译：信号素受体
公开(公告)号：US6054293A
公开(公告)日：2000-04-25
申请号：US936135
申请日：1997-09-24
申请人： Marc Tessier-Lavigne , Zhigang He , Hang Chen
发明人： Marc Tessier-Lavigne , Zhigang He , Hang Chen
IPC分类号： G01N33/50 , A61K38/00 , A61P25/00 , A61P43/00 , C07K14/435 , C07K14/705 , C07K16/18 , C07K16/28 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , G01N33/15 , G01N33/53 , C07H21/04 , C12N15/63
CPC分类号： C07K14/7056 , A61K38/00
摘要： The invention provides methods and compositions relating to two classes of semaphorin receptors, SR1 and SR2. The polypeptides may be produced recombinantly from transformed host cells from the disclosed SR encoding nucleic acids or purified from human cells. The invention provides isolated SR hybridization probes and primers capable of specifically hybridizing with the disclosed SR genes, SR-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
摘要翻译：本发明提供了与两类信号素受体SR1和SR2相关的方法和组合物。可以从所公开的SR编码核酸的转化的宿主细胞重组产生多肽或从人细胞纯化。本发明提供能够与所公开的SR基因，SR-特异性结合剂如特异性抗体特异性杂交的分离的SR杂交探针和引物，以及在诊断，治疗和生物制药工业中制备和使用该主题组合物的方法。

5. 发明申请

US20110223630A1 METHOD FOR SCREENING FOR COMPOUNDS THAT INHIBIT NEURODEGENERATION 审中-公开
标题翻译：用于筛选不抑制神经元的化合物的方法
公开(公告)号：US20110223630A1
公开(公告)日：2011-09-15
申请号：US12997297
申请日：2009-06-12
申请人： Anatoly Nikolaev , Marc Tessier-Lavigne
发明人： Anatoly Nikolaev , Marc Tessier-Lavigne
IPC分类号： C12Q1/02
CPC分类号： G01N33/5058 , G01N33/6896
摘要： Methods for screening for compounds that inhibit neurodegeneration are presented. Shedding of APP can be a useful marker for neurodegeneration and compounds that inhibit shedding of APP are useful as inhibitors of neurodegeneration. Such compounds may be useful in treatment and/or prevention of various neurological diseases, disorders and neuronal damage and may enhance growth, regeneration or survival of mammalian neuronal cells or tissue.
摘要翻译：提出了筛选抑制神经变性的化合物的方法。 APP的脱落可能是神经变性的有用标志物，并且抑制APP脱落的化合物可用作神经退行性抑制剂。这样的化合物可用于治疗和/或预防各种神经疾病，病症和神经元损伤，并且可以增强哺乳动物神经细胞或组织的生长，再生或存活。

6. 发明申请

US20100203044A1 DR6 ANTAGONISTS AND USES THEREOF IN TREATING NEUROLOGICAL DISORDERS 审中-公开
标题翻译： DR6拮抗剂及其在治疗神经疾病中的应用
公开(公告)号：US20100203044A1
公开(公告)日：2010-08-12
申请号：US12520044
申请日：2007-12-21
申请人： Anatoly Nikolaev , Marc Tessier-Lavigne
发明人： Anatoly Nikolaev , Marc Tessier-Lavigne
IPC分类号： A61K39/395 , C12N5/00 , A61K38/16 , A61P25/00 , G01N33/53 , C07K16/00 , C07K14/00 , G01N33/68
CPC分类号： C07K16/18 , A61K38/00 , C07K14/70578 , C07K16/2878 , C07K2317/76 , C07K2319/02 , C07K2319/30 , C07K2319/61 , C12N15/1138 , C12N2310/14
摘要： Methods and compositions comprising DR6 antagonists for use in treating neurological disorders, including Alzheimer's disease, are provided. The DR6 antagonists include anti-APP antibodies, anti-DR6 antibodies, DR6 immunoadhesins and DR6 variants (and fusion proteins thereof) which enhance growth, regeneration or survival of mammalian neuronal cells or tissue.
摘要翻译：提供了包含用于治疗神经障碍（包括阿尔茨海默氏病）的DR6拮抗剂的方法和组合物。 DR6拮抗剂包括增强哺乳动物神经细胞或组织的生长，再生或存活的抗APP抗体，抗DR6抗体，DR6免疫粘附素和DR6变体（及其融合蛋白）。

7. 发明申请

US20090232794A1 Modulators of neuronal regeneration 审中-公开
标题翻译：神经元再生调节剂
公开(公告)号：US20090232794A1
公开(公告)日：2009-09-17
申请号：US12316130
申请日：2008-12-09
申请人： Marc Tessier-Lavigne , Jasvinder Atwal , Julie Pinkston-Gosse
发明人： Marc Tessier-Lavigne , Jasvinder Atwal , Julie Pinkston-Gosse
IPC分类号： A61K39/395 , G01N33/566 , G01N33/567 , C07K16/00 , C07H21/02 , C12N5/06 , A61K31/7105
CPC分类号： G01N33/5058 , G01N33/5073 , G01N2333/525 , G01N2333/705 , G01N2500/00
摘要： The present invention provides methods and compositions related to CNS function and diseases.
摘要翻译：本发明提供了与CNS功能和疾病有关的方法和组合物。

8. 发明授权

US06309638B1 Netrins 有权
标题翻译：网吧
公开(公告)号：US06309638B1
公开(公告)日：2001-10-30
申请号：US09490517
申请日：2000-01-25
申请人： Marc Tessier-Lavigne , Tito Serafini , Timothy Kennedy , Marysia Placzek , Thomas Jessell , Jane Dodd
发明人： Marc Tessier-Lavigne , Tito Serafini , Timothy Kennedy , Marysia Placzek , Thomas Jessell , Jane Dodd
IPC分类号： A61K39395
CPC分类号： G01N33/6896 , A61K38/00 , C07K14/4705 , C07K14/475 , C07K14/705 , C07K14/71 , G01N2500/04
摘要： Netrin proteins, nucleic acids which encode netrin proteins and hybridization reagents, probes and primers capable of hybridizing with netrin genes and methods for screening chemical libraries for lead compounds for pharmacological agents are provided.
摘要翻译：提供了Netrin蛋白质，编码netrin蛋白质的核酸和杂交试剂，能够与netrin基因杂交的探针和引物以及用于筛选用于药理学试剂的铅化合物化学文库的方法。

9. 发明授权

US06248934B1 Gene trap vectors 有权
标题翻译：基因陷阱载体
公开(公告)号：US06248934B1
公开(公告)日：2001-06-19
申请号：US09191652
申请日：1998-11-13
申请人： Marc Tessier-Lavigne , William C. Skarnes , Kevin Mitchell , Philip A. Leighton
发明人： Marc Tessier-Lavigne , William C. Skarnes , Kevin Mitchell , Philip A. Leighton
IPC分类号： C12N1500
CPC分类号： C12N15/1051 , A01K2217/05 , C07K2319/02 , C07K2319/03 , C07K2319/04 , C07K2319/60 , C12N15/62 , C12N15/85 , C12N2800/60 , C12N2840/203 , C12N2840/44 , C12Q1/6897
摘要： The invention provides methods and compositions for expressing targeted gene products in vertebrate neurons. The compositions include gene trap vectors comprising a polynucleotide comprising promoterless selectable marker and axon reporter encoding sequences, which may be operatively joined to an internal ribosome-entry site, and may comprise a splice acceptor site located 5′ to the selectable marker and axon reporter encoding sequences. The methods include methods of expressing an axon reporter in a cell by transferring the subject vectors into an embryonic stem cell and incubating the cell under conditions whereby the cell or a progeny of the cell differentiates into a neuron comprising an axon or dendrites, and the neuron expresses the axon reporter under the transcriptional control of the gene; and specifically detecting the axon reporter in the axon or dendrites. Neuronal specific expression may also be effected in disclosed binary systems.
摘要翻译：本发明提供用于在脊椎动物神经元中表达靶基因产物的方法和组合物。组合物包括基因捕获载体，其包含多核苷酸，其包含无启动子选择标记和轴突报道子编码序列，其可以可操作地连接到内部核糖体进入位点，并且可以包含位于选择性标记5'的剪接受体位点和轴突报告基因编码序列。所述方法包括通过将受试载体转移到胚胎干细胞中并在细胞或细胞的后代分化为包含轴突或树突的神经元和神经元的条件下孵育细胞来在细胞中表达轴突报告物的方法在基因的转录控制下表达轴突记者; 并具体检测轴突或树突中的轴突记录。神经元特异性表达也可以在公开的二元系统中进行。

10. 发明申请

US20120076785A1 METHOD FOR INHIBITING NEURODEGENERATION 审中-公开
标题翻译：抑制神经元的方法
公开(公告)号：US20120076785A1
公开(公告)日：2012-03-29
申请号：US13202144
申请日：2010-02-17
申请人： Anatoly J. Nikolaev , Julie Pinkston-Gosse , Marc Tessier-Lavigne
发明人： Anatoly J. Nikolaev , Julie Pinkston-Gosse , Marc Tessier-Lavigne
IPC分类号： A61K39/395 , A61P25/00 , A61P25/16 , A61K38/17 , C12N5/0793 , A61P25/28
CPC分类号： C07K16/2878 , A61K2039/505 , C07K16/18 , C07K2317/74 , C07K2317/76
摘要： Methods for screening for compounds that inhibit neurodegeneration are presented. Shedding of APP can be a useful marker for neurodegeneration and compounds that inhibit shedding of APP are useful as inhibitors of neurodegeneration. Such compounds may be useful in treatment and/or prevention of various neurological diseases, disorders and neuronal damage and may enhance growth, regeneration or survival of mammalian neuronal cells or tissue.
摘要翻译：提出了筛选抑制神经变性的化合物的方法。 APP的脱落可能是神经变性的有用标志物，并且抑制APP脱落的化合物可用作神经退行性抑制剂。这样的化合物可用于治疗和/或预防各种神经疾病，病症和神经元损伤，并且可以增强哺乳动物神经细胞或组织的生长，再生或存活。

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