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    • 4. 发明申请
    • TRANSPORTER VEHICLE
    • 运输车辆
    • US20110308882A1
    • 2011-12-22
    • US13203276
    • 2010-07-01
    • Katsumi TamuraKazumasa HoriiKnud Jensen Meldgaard
    • Katsumi TamuraKazumasa HoriiKnud Jensen Meldgaard
    • B62D5/08
    • B62D5/06F15B21/042
    • There is provided a circulation line (39) for circulating pressurized oil from an accumulator (11) into a housing (15) of a steering valve (14). An orifice joint (41) is provided along the path of the circulation line (39). The orifice joint (41) is removably mounted on the housing (15) of the steering valve (14) from outside. An orifice portion (42) of the orifice joint (41) applies a throttling function to the circulating oil liquid whereby a frictional heat is generated therein. The oil liquid in a warm state flows through a communication passage (21), passages in a spool valve (16), and a low pressure side passage (18B), thus enabling the steering valve (14) to be always in a warm state.
    • 设置有用于将加压油从蓄能器(11)循环到转向阀(14)的壳体(15)中的循环管线(39)。 沿着循环管线(39)的路径设置节流孔接头(41)。 节流孔接头(41)从外部可拆卸地安装在转向阀(14)的壳体(15)上。 节流孔接头(41)的孔口部分(42)向循环油液体施加节流功能,从而在其中产生摩擦热。 处于暖状态的油液流过连通路21,通过滑阀16和低压侧通路18B,从而使转向阀14始终处于暖状态 。
    • 10. 发明授权
    • Carbostyril derivative
    • 碳青霉烯衍生物
    • US5401740A
    • 1995-03-28
    • US273624
    • 1994-07-12
    • Takao NishiMakoto KomatsuYasuo KogaYoshio ShuKatsumi Tamura
    • Takao NishiMakoto KomatsuYasuo KogaYoshio ShuKatsumi Tamura
    • C07D215/22C07D215/227C07D401/12C07D401/14C07D405/12C07D405/14C07D411/12C07D417/12C07D521/00A61K31/47A61K31/505C07D403/12
    • C07D215/227C07D231/12C07D233/56C07D249/08C07D401/12C07D401/14C07D405/12C07D405/14C07D411/12C07D417/12
    • The novel carbostyril derivative represented by the general formula (1) ##STR1## [in the formula, A, R.sup.1, R.sup.2 and the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton have the same definitions as above] has an excellent platelet aggregation inhibitory activity, a phosphodiesterase inhibitory activity, a venticular contraction activity (a positive contraction activity), an anti-ulcer activity, an anti-inflammatory activity, a cerebral blood flow increasing activity, a thrombus dissociation activity, a thromboxane A.sub.2 antagonism activity, etc. The carbostyril derivative of the present invention is characterized in that it exhibits the above activities for a long time, is low in toxicity (particularly low in toxicity to hearts of cardiovascular hyperplasia, myocardipathy, etc.), and is low in circulation activities such as heart rate increasing activity, blood pressure decreasing activity and the like. Also, the carbostyril derivative of the present invention has advantages in that it is easily absorbed by the intestinal tract and easily migrates into blood. Therefore, the carbostyril derivative of the present invention can be used most suitably as a preventive and remedy for thrombi such as apoplexia, cerebral infarction, myocardial infarction and the like, a cerebral circulation improving agent, an anti-inflammatory agent, an anti-asthmatic agent, a cardiotonic agent and a phosphodiesterase inhibitory agent.
    • 由通式(1)表示的新型喹诺酮衍生物(1)[在式中,A,R1,R2和喹诺酮骨架中3-和4-位之间的碳 - 碳键具有相同的定义 上述]具有优异的血小板聚集抑制活性,磷酸二酯酶抑制活性,通气收缩活性(正收缩活性),抗溃疡活性,抗炎活性,脑血流增加活性,血栓解离活性, 血栓素A2拮抗活性等。本发明的喹诺酮衍生物的特征在于其长时间显示上述活性,毒性低(对心脏心脏增生,心肌病等的心脏毒性特别低), 并且循环活动低,如心率增加活动,降血压活动等。 此外,本发明的喹诺酮衍生物具有容易被肠道吸收并易于迁移到血液中的优点。 因此,本发明的喹诺酮衍生物可以最适合地用作血栓形成的预防和治疗方法,例如复杂不良,脑梗死,心肌梗塞等,脑循环改善剂,抗炎剂,抗哮喘 药剂,强心剂和磷酸二酯酶抑制剂。