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    • 1. 发明授权
    • Carbostyril derivative
    • 碳青霉烯衍生物
    • US5227381A
    • 1993-07-13
    • US929097
    • 1992-08-13
    • Takao NishiMakoto KomatsuYasuo KogaYoshio ShuKatsumi Tamura
    • Takao NishiMakoto KomatsuYasuo KogaYoshio ShuKatsumi Tamura
    • C07D215/22C07D215/227C07D401/12C07D401/14C07D405/12C07D405/14C07D411/12C07D417/12C07D521/00
    • C07D215/227C07D231/12C07D233/56C07D249/08C07D401/12C07D401/14C07D405/12C07D405/14C07D411/12C07D417/12
    • Carbostyril compounds or salts thereof of the formula ##STR1## wherein A is a C.sub.1 -C.sub.6 alkylene group; R.sup.1 is a C.sub.3 -C.sub.8 cycloalkyl-C.sub.1 -C.sub.6 alkyl group which may have, as a substituent, a group selected from the group consisting of C.sub.1 -C.sub.6 alkoxycarbonyl groups, a carboxy group, C.sub.2 -C.sub.6 alkanoyloxy-C.sub.1 -C.sub.6 alkyl groups, amino-C.sub.1 -C.sub.6 alkyl groups, C.sub.1 -C.sub.6 alkylamino-C.sub.1 -C.sub.6 alkyl groups and hydroxy-C.sub.1 -C.sub.6 alkyl groups, a C.sub.3 -C.sub.8 cycloalkyl group, a tetrahydropyranyl-C.sub.1 -C.sub.6 alkyl group, a C.sub.1 -C.sub.3 alkylenedioxy group-substituted C.sub.1 -C.sub.6 alkyl group, a phenyl-C.sub.1 -C.sub.6 alkyl group having, as a substituent on the phenyl ring, 1 to 3 groups selected from the group consisting of C.sub.1 -C.sub.6 alkyl groups and a hydroxyl group, or a piperidinyl-C.sub.1 -C.sub.6 alkyl group having a C.sub.1 -C.sub.6 alkyl group as a substituent; R.sup.2 is a 5-membered or 6-membered saturated or unsaturated heterocyclic-C.sub.1 -C.sub.6 alkyl group, said heterocyclic being selected from the group consisting of pyrrolidinyl, morpholino, piperidinyl, thiomorpholino, imidazolyl, 1,2,4-triazolyl, furyl, piperazinyl, pyridyl, tetrahydropyranyl and 1,3-oxathiolranyl groups which may have, as a substituent thereon 1 to 3 groups selected from the group consisting of hydroxy-C.sub. 1 -C.sub.6 alkyl groups, C.sub.2 -C.sub.6 alkanoyloxy-C.sub.1 -C.sub.6 alkyl groups, a hydroxyl group, C.sub.1 -C.sub.6 alkyl groups, amino-C.sub.1 -C.sub.6 alkyl groups, C.sub.1 -C.sub.6 alkylamino-C.sub.1 -C.sub.6 alkyl groups, C.sub.1 -C.sub.6 alkoxy groups, C.sub.1 -C.sub.6 alkoxy-C.sub.1 -C.sub.6 alkoxy groups, C.sub.1 -C.sub.6 alkoxy-C.sub.1 -C.sub.6 alkyl groups, a thio group and C.sub.1 -C.sub.6 alkylamido groups; the carbon-carbon bond between the 3- and 4-positions in the carbostyril skeleton being a single bond or a double bond and pharmaceutical compositions containing the compound as the active ingredient.
    • 其中A为C1-C6亚烷基的卡波斯特尔化合物或其盐, R1是可以具有选自C1-C6烷氧基羰基,羧基,C2-C6烷酰氧基-C1-C6烷基的基团作为取代基的C3-C8环烷基-C1-C6烷基, 氨基-C 1 -C 6烷基,C 1 -C 6烷基氨基-C 1 -C 6烷基和羟基-C 1 -C 6烷基,C 3 -C 8环烷基,四氢吡喃基-C 1 -C 6烷基,C 1 -C 3亚烷基二氧基 - 取代的C 1 -C 6烷基,作为苯环上的取代基的苯基-C 1 -C 6烷基,选自C 1 -C 6烷基和羟基的1至3个基团或哌啶基-C 1 具有C 1 -C 6烷基的-C 6烷基作为取代基; R2是5元或6元饱和或不饱和杂环-C 1 -C 6烷基,所述杂环选自吡咯烷基,吗啉代,哌啶基,硫代吗啉代,咪唑基,1,2,4-三唑基,呋喃基, 哌嗪基,吡啶基,四氢吡喃基和1,3-氧硫杂环戊酰基,其可以具有1至3个选自羟基-C 1 -C 6烷基,C 2 -C 6烷酰氧基-C 1 -C 6烷基, 羟基,C 1 -C 6烷基,氨基-C 1 -C 6烷基,C 1 -C 6烷基氨基-C 1 -C 6烷基,C 1 -C 6烷氧基,C 1 -C 6烷氧基-C 1 -C 6烷氧基,C 1 -C 6烷氧基 -C 1 -C 6烷基,硫基和C 1 -C 6烷基酰胺基; 喹诺酮骨架中3-和4-位之间的碳 - 碳键是单键或双键,以及含有该化合物作为活性成分的药物组合物。
    • 2. 发明授权
    • Carbostyril derivative
    • 碳青霉烯衍生物
    • US5401740A
    • 1995-03-28
    • US273624
    • 1994-07-12
    • Takao NishiMakoto KomatsuYasuo KogaYoshio ShuKatsumi Tamura
    • Takao NishiMakoto KomatsuYasuo KogaYoshio ShuKatsumi Tamura
    • C07D215/22C07D215/227C07D401/12C07D401/14C07D405/12C07D405/14C07D411/12C07D417/12C07D521/00A61K31/47A61K31/505C07D403/12
    • C07D215/227C07D231/12C07D233/56C07D249/08C07D401/12C07D401/14C07D405/12C07D405/14C07D411/12C07D417/12
    • The novel carbostyril derivative represented by the general formula (1) ##STR1## [in the formula, A, R.sup.1, R.sup.2 and the carbon-carbon bond between 3- and 4-positions in the carbostyril skeleton have the same definitions as above] has an excellent platelet aggregation inhibitory activity, a phosphodiesterase inhibitory activity, a venticular contraction activity (a positive contraction activity), an anti-ulcer activity, an anti-inflammatory activity, a cerebral blood flow increasing activity, a thrombus dissociation activity, a thromboxane A.sub.2 antagonism activity, etc. The carbostyril derivative of the present invention is characterized in that it exhibits the above activities for a long time, is low in toxicity (particularly low in toxicity to hearts of cardiovascular hyperplasia, myocardipathy, etc.), and is low in circulation activities such as heart rate increasing activity, blood pressure decreasing activity and the like. Also, the carbostyril derivative of the present invention has advantages in that it is easily absorbed by the intestinal tract and easily migrates into blood. Therefore, the carbostyril derivative of the present invention can be used most suitably as a preventive and remedy for thrombi such as apoplexia, cerebral infarction, myocardial infarction and the like, a cerebral circulation improving agent, an anti-inflammatory agent, an anti-asthmatic agent, a cardiotonic agent and a phosphodiesterase inhibitory agent.
    • 由通式(1)表示的新型喹诺酮衍生物(1)[在式中,A,R1,R2和喹诺酮骨架中3-和4-位之间的碳 - 碳键具有相同的定义 上述]具有优异的血小板聚集抑制活性,磷酸二酯酶抑制活性,通气收缩活性(正收缩活性),抗溃疡活性,抗炎活性,脑血流增加活性,血栓解离活性, 血栓素A2拮抗活性等。本发明的喹诺酮衍生物的特征在于其长时间显示上述活性,毒性低(对心脏心脏增生,心肌病等的心脏毒性特别低), 并且循环活动低,如心率增加活动,降血压活动等。 此外,本发明的喹诺酮衍生物具有容易被肠道吸收并易于迁移到血液中的优点。 因此,本发明的喹诺酮衍生物可以最适合地用作血栓形成的预防和治疗方法,例如复杂不良,脑梗死,心肌梗塞等,脑循环改善剂,抗炎剂,抗哮喘 药剂,强心剂和磷酸二酯酶抑制剂。
    • 6. 发明申请
    • POWDER CONTAINER, POWDER SUPPLY DEVICE AND IMAGE FORMING APPARATUS
    • 粉末容器,粉末供应装置和图像形成装置
    • US20130272750A1
    • 2013-10-17
    • US13991250
    • 2011-12-02
    • Junichi MatsumotoTsukuru KaiHiroshi HosokawaMakoto KomatsuTadashi HayakawaYuzuru Ozawa
    • Junichi MatsumotoTsukuru KaiHiroshi HosokawaMakoto KomatsuTadashi HayakawaYuzuru Ozawa
    • G03G15/08
    • G03G15/0886G03G15/0832G03G15/0865G03G15/0872G03G15/0879G03G2215/0132
    • Provided is a powder container having a new structure capable of stable discharge and transport of a powder contained in a container by enabling the powder to be reliably discharged to the outside of the package while preventing the powder from spilling and flying out of the container. The powder container has a container body (138) for transporting powder contained therein from a first end side (138a) to a second end side (138b) thereof by self-rotating; a nozzle receiver (139) having a nozzle receiving hole (insertion section) (139a) arranged inside the second end side of the container body and configured to allow a transport nozzle (162) having a powder receiving inlet (170) to be inserted therein, and a supply port 139b arranged in at least a part of the nozzle receiver (139) and configured to supply the powder in the container body (138) to the powder receiving inlet (170): and a shutter (140) supported by the nozzle receiver 139 and configured to open and close the nozzle receiving hole (insertion section) 139a by sliding in response to insertion of the transport nozzle 162 into the nozzle receiver (139).
    • 本发明提供一种粉末容器,其具有通过使粉末能够可靠地排出到包装外部而能够稳定地排出和运送容器中的粉末的结构,同时防止粉末溢出并从容器中飞出。 该粉末容器具有:容纳体,用于通过自转旋转从第一端侧(138a)向第二端侧(138b)输送其中所含的粉末; 喷嘴接收器(139),其具有布置在容器主体的第二端侧内侧的喷嘴接收孔(插入部)(139a),并且构造成允许具有粉末接收入口(170)的输送喷嘴(162)插入其中 以及布置在喷嘴接收器(139)的至少一部分中并被配置为将粉末容纳在容器主体(138)中的粉末供应到粉末接收入口(170)的供应口139b,以及由所述容器主体 喷嘴接收器139,并且构造成响应于将输送喷嘴162插入喷嘴接收器(139)而滑动来打开和关闭喷嘴接收孔(插入部)139a。
    • 9. 发明申请
    • Grafted Material, and Method of Manufacturing the Same
    • 接合材料及其制造方法
    • US20080214690A1
    • 2008-09-04
    • US11663927
    • 2005-09-22
    • Makoto KomatsuJunichi Kanno
    • Makoto KomatsuJunichi Kanno
    • C08J7/16C08F291/18
    • C08F255/02C08F255/00C08F291/18C08F291/185
    • There is provided a technique for introducing grafted side chains having a narrow molecular weight distribution onto a molded organic polymer substrate, for example polyolefin substrate, while maintaining the form of the substrate. One aspect of the present invention relates to a method of manufacturing a grafted material, comprising the steps of (a) irradiating an organic polymer substrate with ionizing radiation, and then bringing a polymerizable monomer and a polymerization initiating group-introducing agent into contact with the substrate, thus introducing grafted side chains having polymerization initiating groups on ends thereof onto trunk polymer of the substrate, and (b) then bringing a polymerizable monomer into contact with the substrate, thus causing the grafted side chains to grow.
    • 提供了一种在保持基材形式的同时将具有窄分子量分布的接枝侧链引入到模塑的有机聚合物基材(例如聚烯烃基材)上的技术。 本发明的一个方面涉及一种接枝材料的制造方法,包括以下步骤:(a)用电离辐射照射有机聚合物基材,然后使可聚合单体和聚合引发基团引入剂与 从而将其端部具有聚合引发基团的接枝侧链引入到基材的树脂聚合物上,和(b)然后使可聚合单体与基材接触,从而使接枝的侧链生长。
    • 10. 发明申请
    • Brushless-motor driving control device, image reading apparatus, and image forming apparatus
    • 无刷马达驱动控制装置,图像读取装置和图像形成装置
    • US20070247092A1
    • 2007-10-25
    • US11705834
    • 2007-02-14
    • Makoto KomatsuHiroshi Koide
    • Makoto KomatsuHiroshi Koide
    • H02P6/08
    • H02P6/06
    • A drive control device for a brushless motor having a rotor and a plurality of coils with different phases can be included in an image reading apparatus or an image forming apparatus. The drive control device may include a detection target configured to rotate in synchronization with rotation of the rotor and having formed thereon a pattern representing modulation information, a detector configured to read the pattern and to output modulated output signals, a demodulator configured to demodulate the modulated output signals and to obtain demodulated information, and a controller configured to control rotation of the rotor on the basis of at least the demodulated information obtained by the demodulator.
    • 具有转子和具有不同相位的多个线圈的无刷电动机的驱动控制装置可以包括在图像读取装置或图像形成装置中。 驱动控制装置可以包括被配置为与转子的旋转同步地旋转并且在其上形成有表示调制信息的图案的检测目标,被配置为读取图案并输出调制输出信号的检测器,被配置为解调调制信号的解调器 输出信号并获得解调信息;以及控制器,被配置为至少基于由解调器获得的解调信息来控制转子的旋转。