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1. 发明授权

US06759557B2 Melanin production inhibitors and skincare products containing such inhibitors 失效
标题翻译：黑色素生成抑制剂和含有这些抑制剂的护肤品
公开(公告)号：US06759557B2
公开(公告)日：2004-07-06
申请号：US10164702
申请日：2002-06-10
申请人： Hiroyuki Matsuda , Hiroyasu Kumamoto , Eiko Tamai , Misao Yagi , Kenichi Yamamoto , Toshimitsu Hagiwara , Shinya Watanabe
发明人： Hiroyuki Matsuda , Hiroyasu Kumamoto , Eiko Tamai , Misao Yagi , Kenichi Yamamoto , Toshimitsu Hagiwara , Shinya Watanabe
IPC分类号： C07C49105
CPC分类号： C07C49/703 , A61K8/35 , A61K2800/782 , A61Q19/02 , C07C45/45 , C07C45/62 , C07C49/385 , C07C49/487 , C07C49/587
摘要： A melanin synthesis inhibitor composition containing at least one macrocyclic compound represented by Formula (1) wherein X is a group selected among the groups consisting of C═O; CH—OH and O═C—CHOH; R being a chain hydrocarbon having 13 to 24 carbon atoms, R forms a ring with X and may be saturated or contain 1 to 3 unsaturated bonds and may be substituted by a lower alkyl group of 1 to 3 carbon atoms.
摘要翻译：含有至少一种由式（1）表示的大环化合物的黑色素合成抑制剂组合物，其中X是选自由C = O组成的组中的基团; CH-OH和O = C-CHOH; R是具有13-24个碳原子的链烃，R与X形成具有X的环并且可以是饱和的或含有1-3个不饱和键，并且可以被1至3个碳原子的低级烷基取代。

2. 发明授权

US06440400B1 Trimethylcylohexane derivatives and melanin-formation inhibitors and perfumeholding agents with the use of the same 失效
标题翻译：三甲基环己烷衍生物和黑色素形成抑制剂和使用其的香料保持剂
公开(公告)号：US06440400B1
公开(公告)日：2002-08-27
申请号：US09601508
申请日：2000-08-02
申请人： Takashi Aida , Hiroyuki Matsuda , Kenya Ishida , Tetsuro Yamasaki , Eiko Tamai , Kazuhiko Tokoro
发明人： Takashi Aida , Hiroyuki Matsuda , Kenya Ishida , Tetsuro Yamasaki , Eiko Tamai , Kazuhiko Tokoro
IPC分类号： A61K742
CPC分类号： C11B9/0034 , A61K8/34 , A61K8/35 , A61Q13/00 , A61Q19/02 , C07C31/1355 , C07C33/14 , C07C49/11 , C07C49/15 , C07C403/08 , C07C403/16 , C07C2601/14
摘要： The present invention is a trimethylcyclohexane derivative represented by Formula (1): wherein A represents C═O or CH—OH, n represents 2, R1 represents hydrogen or a methyl group, R2 represents a straight or branched, saturated or unsaturated hydrocarbon group having 3 to 10 carbon atoms, and a dotted line represents a saturated or unsaturated carbon-carbon bond, a melanin production inhibitor and a fragrance fixative comprising one or more of the trimethylcyclohexane derivatives, and a dermal formulation comprising one or more of the melanin production inhibitors and/or fragrance fixatives.
摘要翻译：本发明是由式（1）表示的三甲基环己烷衍生物：其中A表示C = O或CH-OH，n表示2，R1表示氢或甲基，R2表示直链或支链，饱和或不饱和的烃基， 3至10个碳原子，虚线表示饱和或不饱和碳 - 碳键，黑色素产生抑制剂和包含一种或多种三甲基环己烷衍生物的香料固定剂和包含一种或多种黑色素产生抑制剂的皮肤制剂和/或香料固定剂。

3. 发明授权

US06313214B1 Melanin inhibiting and cell growth activating compositions containing compounds having labdane structure 有权
标题翻译：黑色素抑制和细胞生长激活组合物含有具有实验组织结构的化合物
公开(公告)号：US06313214B1
公开(公告)日：2001-11-06
申请号：US09294875
申请日：1999-04-20
申请人： Eiko Tamai , Katsuyoshi Tsuchiya , Yoichiro Nishizawa , Minoru Hanada , Kazuhiko Tokoro
发明人： Eiko Tamai , Katsuyoshi Tsuchiya , Yoichiro Nishizawa , Minoru Hanada , Kazuhiko Tokoro
IPC分类号： A61K31215
CPC分类号： A61Q15/00 , A61K8/0212 , A61K8/34 , A61K8/345 , A61K8/36 , A61K8/37 , A61K8/97 , A61K31/045 , A61K31/19 , A61K31/192 , A61K31/215 , A61K31/216 , A61K2800/70 , A61Q1/02 , A61Q5/006 , A61Q11/00 , A61Q17/005 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61Q19/10 , A61K2300/00
摘要： The present invention provides compounds which have, particularly, an inhibitory activity on production of melanin, a cell activating activity and an anti-bacterial activity, are derived from natural sources, and are safe and not harmful. One or more compounds represented by the following general formula are contained: wherein R1 represents —CH2OH, —COOR6 or —COOX, whereupon X is a group capable forming a salt and R6 represents hydrogen or a C1 to C3 lower alkyl group; R2 to R5 each represent hydrogen or a methyl group; and . . . A . . . represents ═C(CH3)—, —C(CH3)═, —C(═CH2)—, —CH(CH3)— or —C(OH) (CH3)—.
摘要翻译：本发明提供特别是对黑素生成抑制活性，细胞活化活性和抗细菌活性的化合物来源于天然来源，是安全且无害的。含有下列通式表示的一种或多种化合物：其中R1表示-CH2OH，-COOR6或-COOX，其中X为能形成盐的基团，R6表示氢或C1至C3低级烷基; R2至R5各自表示氢或甲基; 和。。。一个。。。表示= C（CH 3） - ， - C（CH 3）=， - C（= CH 2） - ， - CH（CH 3） - 或-C（OH）

4. 发明授权

US07576125B2 Melanogenesis inhibitor and skin preparation containing the same 失效
标题翻译：黑素生成抑制剂和含有相同的皮肤制剂
公开(公告)号：US07576125B2
公开(公告)日：2009-08-18
申请号：US10545006
申请日：2004-02-12
申请人： Kenya Ishida , Eiko Tamai
发明人： Kenya Ishida , Eiko Tamai
IPC分类号： A61K31/357
CPC分类号： A61Q19/02 , A61K8/4973
摘要： A melanogenesis inhibitor characterized by containing at least one kind of piperonyl alcohol represented by the following general formula (1) wherein R is a straight chain or branched chain alkyl group having 3 to 18 carbon atoms, a straight chain or branched chain alkenyl group having 3 to 18 carbon atoms, or an optionally substituted alicyclic alkyl group. The melanogenesis inhibitor is superior in stability and safety and has a high melanogenesis-inhibiting effect; and a skin preparation containing the melanogenesis inhibitor is very stable, safe, and has a sufficient fair skin effect and a sufficient effect for curing skin dyspigmentation.
摘要翻译：一种黑素生成抑制剂，其特征在于含有以下通式（1）表示的至少一种胡椒醇，其中R是具有3至18个碳原子的直链或支链烷基，具有3个碳原子的直链或支链烯基至18个碳原子，或任选取代的脂环族烷基。黑素生成抑制剂的稳定性和安全性优越，具有高的黑素生成抑制作用; 含有黑素生成抑制剂的皮肤制剂非常稳定，安全，具有足够的良好的皮肤效果和足够的治疗皮肤色素沉着的作用。

5. 发明授权

US06384074B1 Cell growth activating composition containing compound having labdane structure 失效
标题翻译：细胞生长活化组合物含有具有实验组织结构的化合物
公开(公告)号：US06384074B1
公开(公告)日：2002-05-07
申请号：US09765590
申请日：2001-01-22
申请人： Eiko Tamai , Katsuyoshi Tsuchiya , Yoichiro Nishizawa , Minoru Hanada , Kazuhiko Tokoro
发明人： Eiko Tamai , Katsuyoshi Tsuchiya , Yoichiro Nishizawa , Minoru Hanada , Kazuhiko Tokoro
IPC分类号： A01N3700
CPC分类号： A61Q15/00 , A61K8/0212 , A61K8/34 , A61K8/345 , A61K8/36 , A61K8/37 , A61K8/97 , A61K31/045 , A61K31/19 , A61K31/192 , A61K31/215 , A61K31/216 , A61K2800/70 , A61Q1/02 , A61Q5/006 , A61Q11/00 , A61Q17/005 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61Q19/10 , A61K2300/00
摘要： The present invention provides compounds which have, particularly, an inhibitory activity on production of melanin, a cell activating activity and an anti-bacterial activity, are derived from natural sources, and are safe and not harmful. One or more compounds represented by the following general formula are contained: wherein R1 represents —CH2OH, —COOR6 or —COOX, whereupon X is a group capable forming a salt and R6 represents hydrogen or a C1 to C3 lower alkyl group; R2 to R5 each represent hydrogen or a methyl group; and . . . A . . . represents ═C(CH3)—, —C(CH3)═, —C(═CH2)—, —CH(CH3)— or —C(OH)(CH3)—.
摘要翻译：本发明提供特别是对黑素生成抑制活性，细胞活化活性和抗细菌活性的化合物来源于天然来源，是安全且无害的。含有下列通式表示的一种或多种化合物：其中R1表示-CH2OH，-COOR6或-COOX，其中X为能形成盐的基团，R6表示氢或C1至C3低级烷基; R2至R5各自表示氢或甲基; 和。。。一个。。。表示= C（CH 3） - ， - C（CH 3）=， - C（= CH 2） - ， - CH（CH 3） - 或-C（OH）

6. 发明申请

US20060088485A1 Melanogenesis inhibitor and skin preparation containing the same 失效
公开(公告)号：US20060088485A1
公开(公告)日：2006-04-27
申请号：US10545006
申请日：2004-02-12
申请人： Kenya Ishida , Eiko Tamai
发明人： Kenya Ishida , Eiko Tamai
IPC分类号： A61K8/49 , C07D317/44
CPC分类号： A61Q19/02 , A61K8/4973
摘要： A melanogenesis inhibitor characterized by containing at least one kind of piperonyl alcohol represented by the following general formula (1) wherein R is a straight chain or branched chain alkyl group having 3 to 18 carbon atoms, a straight chain or branched chain alkenyl group having 3 to 18 carbon atoms, or an optionally substituted alicyclic alkyl group. The melanogenesis inhibitor is superior in stability and safety and has a high melanogenesis-inhibiting effect; and a skin preparation containing the melanogenesis inhibitor is very stable, safe, and has a sufficient fair skin effect and a sufficient effect for curing skin dyspigmentation.

7. 发明授权

US06280754B1 Dermal topical formulations 有权
标题翻译：皮肤局部制剂
公开(公告)号：US06280754B1
公开(公告)日：2001-08-28
申请号：US09432100
申请日：1999-11-02
申请人： Minoru Hanada , Eiko Tamai , Kazuhiko Tokoro
发明人： Minoru Hanada , Eiko Tamai , Kazuhiko Tokoro
IPC分类号： A61K900
CPC分类号： A61K8/34 , A61K8/498 , A61K8/602 , A61Q19/02 , Y10S514/946 , Y10S514/947
摘要： A dermal topical formulation containing p-menthane-3,8-diol and a whitening component such as arbutin, kojic acid, ellagic acid, ascorbic acid or its derivative, lactic acid, glycolic acid, tartaric acid, and an essence or an absolute extracted from a plant such as labdanum, jasmine and mugwort (T.vulgare). The dermal topical formulation is highly safe and capable of promoting the percutaneous absorption of the whitening component.
摘要翻译：包含对薄荷烷-3,8-二醇和美白组分如熊果苷，曲酸，鞣花酸，抗坏血酸或其衍生物，乳酸，乙醇酸，酒石酸和精华或绝对提取的真皮局部制剂来自植物如labdanum，茉莉花和艾蒿（T.vulgare）。真皮局部制剂是高度安全的并且能够促进美白组分的经皮吸收。

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