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1. 发明授权

US06313214B1 Melanin inhibiting and cell growth activating compositions containing compounds having labdane structure 有权
标题翻译：黑色素抑制和细胞生长激活组合物含有具有实验组织结构的化合物
公开(公告)号：US06313214B1
公开(公告)日：2001-11-06
申请号：US09294875
申请日：1999-04-20
申请人： Eiko Tamai , Katsuyoshi Tsuchiya , Yoichiro Nishizawa , Minoru Hanada , Kazuhiko Tokoro
发明人： Eiko Tamai , Katsuyoshi Tsuchiya , Yoichiro Nishizawa , Minoru Hanada , Kazuhiko Tokoro
IPC分类号： A61K31215
CPC分类号： A61Q15/00 , A61K8/0212 , A61K8/34 , A61K8/345 , A61K8/36 , A61K8/37 , A61K8/97 , A61K31/045 , A61K31/19 , A61K31/192 , A61K31/215 , A61K31/216 , A61K2800/70 , A61Q1/02 , A61Q5/006 , A61Q11/00 , A61Q17/005 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61Q19/10 , A61K2300/00
摘要： The present invention provides compounds which have, particularly, an inhibitory activity on production of melanin, a cell activating activity and an anti-bacterial activity, are derived from natural sources, and are safe and not harmful. One or more compounds represented by the following general formula are contained: wherein R1 represents —CH2OH, —COOR6 or —COOX, whereupon X is a group capable forming a salt and R6 represents hydrogen or a C1 to C3 lower alkyl group; R2 to R5 each represent hydrogen or a methyl group; and . . . A . . . represents ═C(CH3)—, —C(CH3)═, —C(═CH2)—, —CH(CH3)— or —C(OH) (CH3)—.
摘要翻译：本发明提供特别是对黑素生成抑制活性，细胞活化活性和抗细菌活性的化合物来源于天然来源，是安全且无害的。含有下列通式表示的一种或多种化合物：其中R1表示-CH2OH，-COOR6或-COOX，其中X为能形成盐的基团，R6表示氢或C1至C3低级烷基; R2至R5各自表示氢或甲基; 和。。。一个。。。表示= C（CH 3） - ， - C（CH 3）=， - C（= CH 2） - ， - CH（CH 3） - 或-C（OH）

2. 发明授权

US06280754B1 Dermal topical formulations 有权
标题翻译：皮肤局部制剂
公开(公告)号：US06280754B1
公开(公告)日：2001-08-28
申请号：US09432100
申请日：1999-11-02
申请人： Minoru Hanada , Eiko Tamai , Kazuhiko Tokoro
发明人： Minoru Hanada , Eiko Tamai , Kazuhiko Tokoro
IPC分类号： A61K900
CPC分类号： A61K8/34 , A61K8/498 , A61K8/602 , A61Q19/02 , Y10S514/946 , Y10S514/947
摘要： A dermal topical formulation containing p-menthane-3,8-diol and a whitening component such as arbutin, kojic acid, ellagic acid, ascorbic acid or its derivative, lactic acid, glycolic acid, tartaric acid, and an essence or an absolute extracted from a plant such as labdanum, jasmine and mugwort (T.vulgare). The dermal topical formulation is highly safe and capable of promoting the percutaneous absorption of the whitening component.
摘要翻译：包含对薄荷烷-3,8-二醇和美白组分如熊果苷，曲酸，鞣花酸，抗坏血酸或其衍生物，乳酸，乙醇酸，酒石酸和精华或绝对提取的真皮局部制剂来自植物如labdanum，茉莉花和艾蒿（T.vulgare）。真皮局部制剂是高度安全的并且能够促进美白组分的经皮吸收。

3. 发明授权

US06384074B1 Cell growth activating composition containing compound having labdane structure 失效
标题翻译：细胞生长活化组合物含有具有实验组织结构的化合物
公开(公告)号：US06384074B1
公开(公告)日：2002-05-07
申请号：US09765590
申请日：2001-01-22
申请人： Eiko Tamai , Katsuyoshi Tsuchiya , Yoichiro Nishizawa , Minoru Hanada , Kazuhiko Tokoro
发明人： Eiko Tamai , Katsuyoshi Tsuchiya , Yoichiro Nishizawa , Minoru Hanada , Kazuhiko Tokoro
IPC分类号： A01N3700
CPC分类号： A61Q15/00 , A61K8/0212 , A61K8/34 , A61K8/345 , A61K8/36 , A61K8/37 , A61K8/97 , A61K31/045 , A61K31/19 , A61K31/192 , A61K31/215 , A61K31/216 , A61K2800/70 , A61Q1/02 , A61Q5/006 , A61Q11/00 , A61Q17/005 , A61Q19/00 , A61Q19/02 , A61Q19/08 , A61Q19/10 , A61K2300/00
摘要： The present invention provides compounds which have, particularly, an inhibitory activity on production of melanin, a cell activating activity and an anti-bacterial activity, are derived from natural sources, and are safe and not harmful. One or more compounds represented by the following general formula are contained: wherein R1 represents —CH2OH, —COOR6 or —COOX, whereupon X is a group capable forming a salt and R6 represents hydrogen or a C1 to C3 lower alkyl group; R2 to R5 each represent hydrogen or a methyl group; and . . . A . . . represents ═C(CH3)—, —C(CH3)═, —C(═CH2)—, —CH(CH3)— or —C(OH)(CH3)—.
摘要翻译：本发明提供特别是对黑素生成抑制活性，细胞活化活性和抗细菌活性的化合物来源于天然来源，是安全且无害的。含有下列通式表示的一种或多种化合物：其中R1表示-CH2OH，-COOR6或-COOX，其中X为能形成盐的基团，R6表示氢或C1至C3低级烷基; R2至R5各自表示氢或甲基; 和。。。一个。。。表示= C（CH 3） - ， - C（CH 3）=， - C（= CH 2） - ， - CH（CH 3） - 或-C（OH）

4. 发明授权

US06723501B2 Methods of judging mouth odor 失效
标题翻译：口臭鉴别方法
公开(公告)号：US06723501B2
公开(公告)日：2004-04-20
申请号：US10041455
申请日：2002-01-10
申请人： Kazutoshi Sakurai , Sadahiko Yamazaki , Minoru Hanada , Kiyohito Sawano
发明人： Kazutoshi Sakurai , Sadahiko Yamazaki , Minoru Hanada , Kiyohito Sawano
IPC分类号： C02Q100
CPC分类号： C12Q1/04 , G01N33/487
摘要： Convenient methods for judging mouth odor with the use of an artificial mouth odor prepared by a convenient method which load any burdens neither on the operator nor on the subjects. Saliva collected immediately after wake-up is cultured under anaerobic conditions and head space components of the thus cultured saliva are analyzed, or anaerobic bacteria contained in the collected saliva are counted.
摘要翻译：使用通过方便的方法制备的人造口腔气味来判断口腔气味的方便方法，既不对操作者也不对受试者负担任何负担。唤醒后立即收集的唾液在厌氧条件下进行培养，分析由此培养的唾液的头部空间组分，或计数收集的唾液中含有的厌氧菌。

5. 发明授权

US6121343A Perfume-containing controlled release biodegradable resin composition 失效
标题翻译：含香料的控释生物降解树脂组合物
公开(公告)号：US6121343A
公开(公告)日：2000-09-19
申请号：US162506
申请日：1998-09-29
申请人： Hideyuki Hongo , Yoji Hori , Yasuo Fujiwara , Seiichi Abe , Minoru Hanada
发明人： Hideyuki Hongo , Yoji Hori , Yasuo Fujiwara , Seiichi Abe , Minoru Hanada
IPC分类号： A61K8/00 , A61K8/85 , A61K8/90 , A61K31/765 , A61Q13/00 , C08L67/04 , C08L101/16 , C11B9/00
CPC分类号： A61K8/85 , A61Q13/00 , A61K2800/56
摘要： A perfume-containing controlled release biodegradable resin composition which can release aroma of the included perfume gradually without changing its perfume tone and can be used in such applications as deodorants, etc. The resin composition includes a biodegradable resin which is a random or block copolymer polyester represented by the following formula (1): ##STR1## wherein R.sup.1 is a hydrocarbon radical having 1 to 15 carbon atoms, which is a divalent organic group that may be have a double bond or an oxygen atom but does not have a group represented by the formula ##STR2## wherein the symbol "*" is an asymmetric carbon atom. Each of m and n is 0 or an integer of 100 to 9,000, provided that m+n is within the range of 200 to 10,000. The molar ratio of the structural units [I] and [II] is 1-99:99-1 when m and n are not 0 and the number average molecular weight is 5,000 to 1,000,000, and a perfume such as a cyclic ether, a natural plant perfume, etc., is held in the biodegradable resin.
摘要翻译：一种含香料的控释生物降解性树脂组合物，其可以逐渐释放所含香料的香味，而不改变其香料色调，并且可用于除臭剂等的应用中。树脂组合物包括可生物降解的树脂，其是无规或嵌段共聚物聚酯由下式（1）表示：其中R 1是具有1至15个碳原子的烃基，其是可以具有双键或氧原子但不具有由下式表示的基团的二价有机基团：其中符号“*”是不对称碳原子。 m和n分别为0或100〜9000的整数，条件是m + n在200〜10000的范围内。当m和n不为0且数均分子量为5,000至1,000,000时，结构单元[I]和[II]的摩尔比为1-99:99-1，环状醚，天然植物香料等保存在可生物降解的树脂中。

6. 发明授权

US5071957A Antibiotic BU-4061T 失效
标题翻译：抗生素BU-4061T
公开(公告)号：US5071957A
公开(公告)日：1991-12-10
申请号：US593170
申请日：1990-10-04
申请人： Masataka Konishi , Minoru Hanada , Yuji Nishiyama
发明人： Masataka Konishi , Minoru Hanada , Yuji Nishiyama
IPC分类号： A61K38/00 , C07K5/083
CPC分类号： C12R1/01 , C07K5/0808 , A61K38/00
摘要： The antibiotic designated BU-4061T is produced by fermentation of actinomycete strain Q996-17 (ATCC-53904). The BU-4061T antibiotic exhibits both in vitro and in vivo antitumor activity.
摘要翻译：命名为BU-4061T的抗生素通过放线菌菌株Q996-17（ATCC-53904）的发酵产生。 BU-4061T抗生素具有体外和体内抗肿瘤活性。

7. 发明授权

US4009237A Process for producing shaped synthetic resin articles varying in shape of longitudinal section 失效
标题翻译：用于生产纵向形状变化的成型合成树脂制品的方法
公开(公告)号：US4009237A
公开(公告)日：1977-02-22
申请号：US584877
申请日：1975-06-09
申请人： Takashi Kimura , Giichi Kawashima , Minoru Nagami , Minoru Hanada
发明人： Takashi Kimura , Giichi Kawashima , Minoru Nagami , Minoru Hanada
IPC分类号： B29C43/00 , B29C33/00 , B29C43/24 , B29C43/32 , B29C44/00 , B29C47/02 , B29C53/24 , B29C69/00 , B29D1/00 , B29D27/00 , B29F3/012
CPC分类号： B29C67/20 , B29C47/02 , B29C53/24 , B29C47/0016 , B29C47/0023 , B29C47/0033 , Y10S264/14
摘要： A shaped synthetic resin article varying in cross-sectional area and shape of longitudinal section along at least a part of the length is continuously produced by introducing a molten synthetic resin composition, extruded from an extruder die, between at least one pair of rolls rotating in the direction of extrusion so that the rolls of each pair contact each other on their periphery, the peripheral surfaces of the rolls being engraved so as to form a cavity corresponding to the shape of said shaped article when the rolls of each pair contact each other while being rotated, in which cavity the molten resin composition is remolded into an article having the desired shape and at the same time the surplus resin composition overflowing from said cavity is cut off by the edges of said rolls contacting each other, and then cooling the molded article to solidify the same. According to the above process, the diameter of the minimum cross-section of the article can be made much smaller than the outer diameter of the die or nozzle.

8. 发明申请

US20080102043A1 ANTIMICROBIAL FLAVOR AND ORAL CARE COMPOSITON CONTAINING THE SAME 审中-公开
标题翻译：抗菌药和口服护理组合物
公开(公告)号：US20080102043A1
公开(公告)日：2008-05-01
申请号：US11947549
申请日：2007-11-29
申请人： Minoru Hanada , Haruo Arai
发明人： Minoru Hanada , Haruo Arai
IPC分类号： A61K8/33 , A61P1/02 , A61Q11/00
CPC分类号： A61K8/342 , A61K8/02 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/97 , A61Q11/00 , A61Q19/04
摘要： The present invention provides antimicrobial flavors and flavor compositions which are of high safety and little influential on intestinal bacteria, as well as oral care compositions and foods containing the same. The flavor is selected from dihydrofarnesol, isocamphylcyclohexanol, levosandol, bacdanol, Santalinol, methyl atrarate, 10-undecen-1-ol, 2-methyl undecanal, sandalol, dodecanal, brahmanol, neroridol, o-methoxycinnamic aldehyde, methyl sandeflor, 9-decen-1-ol, 3-dodecenal, etc.
摘要翻译：本发明提供了具有高度安全性且对肠细菌影响小的抗微生物风味剂和风味组合物，以及口腔护理组合物和含有它们的食品。风味剂选自二氢法呢醇，异坎蔻胺环己醇，左旋肉豆蔻醇，巴豆醇，马来亚醇，十一碳烯醇，2-甲基十一烷醛，檀香醇，十二烷醛，婆罗门醇，橙花醇，邻甲氧基肉桂醛，甲基三氟乙酸 -1-醇，3-十二烯醛等

9. 发明授权

US06960350B2 Antifungal fragrance composition 有权
标题翻译：抗真菌香精组合物
公开(公告)号：US06960350B2
公开(公告)日：2005-11-01
申请号：US10012365
申请日：2001-12-12
申请人： Minoru Hanada , Hisao Iwai , Jun Fujigasaki
发明人： Minoru Hanada , Hisao Iwai , Jun Fujigasaki
IPC分类号： A01N31/02 , A01N31/04 , A01N31/08 , A01N35/02 , A01N35/04 , A01N43/08 , A61K9/00 , A61K31/045 , C11B9/00 , A01N25/08 , A01N25/34 , A61K7/46
CPC分类号： A61Q13/00 , A01N31/02 , A01N31/04 , A01N31/08 , A01N35/02 , A01N35/04 , A01N37/40 , A01N43/08 , A01N49/00 , A01N65/00 , A61K8/33 , A61K8/34 , A61K8/342 , A61K8/347 , A61K8/37 , A61K2800/77 , Y10S514/957 , Y10T428/13 , Y10T428/1334 , Y10T428/1341 , Y10T428/1345 , Y10T428/1352 , Y10T428/1362 , Y10T428/1366 , Y10T428/1379 , A01N2300/00 , A01N25/04 , A01N31/16
摘要： An antifungal fragrance composition containing as its active ingredients: (a) at least one type of fragrance component selected from the group consisting of an aliphatic or aromatic aldehyde having 5 to 16 carbon atoms and an aliphatic or aromatic alcohol having 5 to 16 carbon atoms, and (b) at least one type of compound different from component (a) and selected from the group consisting of an aliphatic or aromatic aldehyde, an aliphatic or aromatic alcohol, acetal and ester that produces synergistic antifungal effects in the presence of said fragrance component (a). The present antifungal fragrance composition demonstrates antifungal activity by adding a small amount of oils and fragrant chemical products that have a minimal effect on the scent of the fragrance composition.
摘要翻译：一种抗真菌香料组合物，其含有活性成分：（a）至少一种选自碳原子数为5〜16的脂肪族或芳香族醛和碳原子数为5〜16的脂肪族或芳香族醇的香料成分，和（b）至少一种类型的不同于组分（a）的化合物，并且选自在所述香料组分存在下产生协同抗真菌作用的脂族或芳族醛，脂族或芳族醇，缩醛和酯的组（一个）。本发明的抗真菌香料组合物通过加入对香料组合物的香味影响最小的少量油和芳香化学产品来显示抗真菌活性。

10. 发明申请

US20050201953A1 Antibacterial flavor and fragrance composition and halitosis-inhibition flavor and fragrance composition and oral care composition containing the same 审中-公开
标题翻译：抗菌风味和香味成分以及口臭抑制香精和香料组成及含有相同的口腔护理组合物
公开(公告)号：US20050201953A1
公开(公告)日：2005-09-15
申请号：US10514129
申请日：2003-06-18
申请人： Minoru Hanada , Fumihiro Yanaka , Yukihiro Kawakami
发明人： Minoru Hanada , Fumihiro Yanaka , Yukihiro Kawakami
IPC分类号： A23G3/00 , A23G3/34 , A23G4/00 , A61K8/00 , A61K8/18 , A61K8/30 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/49 , A61K8/92 , A61K8/97 , A61Q11/00 , A61Q13/00 , C11B9/00 , A61K7/26
CPC分类号： A61K8/30 , A61K8/922 , A61Q11/00
摘要： A flavor and fragrance composition possessing an antibacterial activity effective against periodontal disease-causing bacteria and/or a halitosis-inhibition action capable of controlling production of volatile sulfides, which is safe for the human body, and containing at least one or more substances selected from food fragrance materials such as hexylaldehyde, caryophyllene alcohol, cinnamicaldehyde, dihydroeugenol, farnesol, dihydrofarnesol, hinokitiol, isoeugenol, γ-undecalactone, d-limonene, o-methoxycinnamicaldehyde, β-pinene, γ-terpinene, terpinolene, orange oil, nutmeg oil, and grapefruit oil, and an oral care composition containing the same.
摘要翻译：具有对牙周病引起的细菌有效的抗菌活性和/或能够控制对人体安全的挥发性硫化物的生产的口臭防止作用的香料和香料组合物，并含有至少一种或多种选自食用香料如己醛，石竹烯醇，肉桂醛，二氢丁子香酚，法呢醇，二氢法呢醇，桧醇，异丁子香酚，γ-十一内酯，d-柠檬烯，邻甲氧基肉桂醛，β-蒎烯，γ-萜品烯，萜品油烯，橙油，肉豆蔻油，和葡萄柚油，以及含有其的口腔护理组合物。

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