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1. 发明授权

US07060821B2 Osteoclast differentiation inhibitors 失效
标题翻译：破骨细胞分化抑制剂
公开(公告)号：US07060821B2
公开(公告)日：2006-06-13
申请号：US10506975
申请日：2003-03-06
申请人： Hiroyuki Kumagai , Tomohiro Sameshima , Motoko Matsufuji , Naoto Kawamura , Kunio Isshiki , Hiroyuki Inoue , Tetsuya Someno , Masaaki Ishizuka , Tomio Takeuchi
发明人： Hiroyuki Kumagai , Tomohiro Sameshima , Motoko Matsufuji , Naoto Kawamura , Kunio Isshiki , Hiroyuki Inoue , Tetsuya Someno , Masaaki Ishizuka , Tomio Takeuchi
IPC分类号： C07D498/02 , C07D295/02
CPC分类号： C07D265/38 , C12P17/14 , C12P17/188 , C12R1/645
摘要： A compound represented by formula (I); a process for producing a compound (substance F-1490) of formula (I), wherein X represents —O— and R represents a hydroxyl group, by using a microorganism belonging to the genus Cunninghamella; and a Cunninghamella sp. F-1490 strain (FERM BP-8287) capable of producing the substance F-1490; and an osteoclast differentiation inhibitory agent containing as an active ingredient the compound represented by formula (I): wherein X represents —O— or —CH2—, and R represents a hydroxyl group when X represents —O—, or a hydrogen atom when X represents —CH2—.
摘要翻译：由式（I）表示的化合物; 通过使用属于葫芦科属的微生物，制备式（I）化合物（F-1490物质）的方法，其中X表示-O-，R表示羟基; 和unning ella ella 能够生产物质F-1490的F-1490菌株（FERM BP-8287）; 和破骨细胞分化抑制剂，其含有作为活性成分的式（I）表示的化合物：其中X表示-O-或-CH 2 - ，当X表示-O时，R表示羟基 - 或当X代表-CH 2 - 2时为氢原子。

2. 发明申请

US20050124050A1 Osteoclast differentiation inhibitors 失效
标题翻译：破骨细胞分化抑制剂
公开(公告)号：US20050124050A1
公开(公告)日：2005-06-09
申请号：US10506975
申请日：2003-03-06
申请人： Hiroyuki Kumagai , Tomohiro Sameshima , Motoko Matsufuji , Naoto Kawamura , Kunio Isshiki , Hiroyuki Inoue , Tetsuya Someno , Masaaki Sihizuka , Tomio Takeuchi
发明人： Hiroyuki Kumagai , Tomohiro Sameshima , Motoko Matsufuji , Naoto Kawamura , Kunio Isshiki , Hiroyuki Inoue , Tetsuya Someno , Masaaki Sihizuka , Tomio Takeuchi
IPC分类号： A61P19/02 , A61P19/10 , A61P29/00 , A61P35/00 , A61P35/04 , A61P43/00 , C07D265/38 , C07D498/04 , C12P17/14 , C12P17/18 , C12P17/16 , C07D498/02 , C12N1/21
CPC分类号： C07D265/38 , C12P17/14 , C12P17/188 , C12R1/645
摘要： A compound represented by formula (I); a process for producing a compound (substance F-1490) of formula (I), wherein X represents —O— and R represents a hydroxyl group, by using a microorganism belonging to the genus Cunninghamella; and a Cunninghamella sp. F-1490 strain (FERM BP-8287) capable of producing the substance F-1490; and an osteoclast differentiation inhibitory agent containing as an active ingredient the compound represented by formula (I): wherein X represents —O— or —CH2—, and R represents a hydroxyl group when X represents —O—, or a hydrogen atom when X represents —CH2—.
摘要翻译：由式（I）表示的化合物; 通过使用属于葫芦科属的微生物，制备式（I）化合物（F-1490物质）的方法，其中X表示-O-，R表示羟基; 和unning ella ella 能够生产物质F-1490的F-1490菌株（FERM BP-8287）; 和破骨细胞分化抑制剂，其含有作为活性成分的式（I）表示的化合物：其中X表示-O-或-CH 2 - ，当X表示-O时，R表示羟基 - 或当X代表-CH 2 - 2时为氢原子。

3. 发明申请

US20050131061A1 Angiogenesis inhibitors 审中-公开
标题翻译：血管生成抑制剂
公开(公告)号：US20050131061A1
公开(公告)日：2005-06-16
申请号：US10506976
申请日：2003-03-06
申请人： Hiroyuki Kumagai , Tomohiro Sameshima , Motoko Matsufuji , Naoto Kawamura , Tetsuya Someno , Masaaki Ishiduka , Tomio Takeuchi
发明人： Hiroyuki Kumagai , Tomohiro Sameshima , Motoko Matsufuji , Naoto Kawamura , Tetsuya Someno , Masaaki Ishiduka , Tomio Takeuchi
IPC分类号： A61P17/06 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D303/32 , C07D493/04 , C12P17/02 , C12P17/18 , C12R1/66 , C12N1/16 , A61K31/336 , C07D303/12
CPC分类号： C07D493/04 , C07D303/32 , C12P17/02 , C12P17/181 , C12R1/66
摘要： Compounds represented by formula (I) below; a process for producing the compounds by culturing a microorganism belonging to the genus Aspergillus and isolating the above-mentioned compounds from the culture; an angiogenesis inhibitory agent containing as an active ingredient the compounds; and an Aspergillus sp. F-1491 (FERM BP-8288) strain capable of producing the compounds. In formula (I), R represents a methyl group or an ethyl group, R1 represents a hydrogen atom, a chlorine atom, a hydroxyl group or a methoxy group, R2 represents a hydroxyl group, or R1 and R2 taken together form an epoxy ring structure.
摘要翻译：由下式（I）表示的化合物; 通过培养属于曲霉属的微生物并从培养物中分离上述化合物来生产化合物的方法; 含有化合物作为活性成分的血管发生抑制剂; 和曲霉属（Aspergillus sp。）能够生产化合物的F-1491（FERM BP-8288）菌株。式（I）中，R表示甲基或乙基，R 1表示氢原子，氯原子，羟基或甲氧基，R 2 O >表示羟基，或R 1和R 2一起形成环氧环结构。

4. 发明授权

US5096924A Anticancer antibiotic MI43-37F11 substance 失效
标题翻译： ANTICANCER抗生素MI43-37F11物质
公开(公告)号：US5096924A
公开(公告)日：1992-03-17
申请号：US531109
申请日：1990-05-31
申请人： Masaaki Ishizuka , Hiroyuki Kumagai , Tsutomu Sawa , Hiroshi Naganawa , Hironobu Iinuma , Kunio Isshiki , Masa Hamada , Kenji Maeda , Tomio Takeuchi
发明人： Masaaki Ishizuka , Hiroyuki Kumagai , Tsutomu Sawa , Hiroshi Naganawa , Hironobu Iinuma , Kunio Isshiki , Masa Hamada , Kenji Maeda , Tomio Takeuchi
IPC分类号： A61K31/35 , A61K31/352 , A61P35/00 , C07D311/76 , C12N1/20 , C12P17/06 , C12R1/625
CPC分类号： C12P17/06 , C07D311/76
摘要： As a new antibiotic is provided a compound, now nominated as MI43-37F11 substance, which has formula ##STR1## This MI43-37F11 substance has an antitumor activity, an activity to enhance the production of interleukin-1 in vivo in a mammalian, and an activity to activate a macrophage in vivo in a mammalian. MI43-37F11 substance may be produced by cultivation of Streptoverticillium eurocidicum MI43-37F11 strain identified as FERM BP-2783.

5. 发明授权

US06589981B2 Tumor radiosensitization and/or chemopotentiation using isocoumarin derivatives 失效
公开(公告)号：US06589981B2
公开(公告)日：2003-07-08
申请号：US09794417
申请日：2001-02-27
申请人： Corinne L. Reimer , Naoki Agata , Tomio Takeuchi , Hiroyuki Kumagai , Takeo Yoshioka , Masaaki Ishizuka , Donald W. Kufe , Ralph R. Weichselbaum
发明人： Corinne L. Reimer , Naoki Agata , Tomio Takeuchi , Hiroyuki Kumagai , Takeo Yoshioka , Masaaki Ishizuka , Donald W. Kufe , Ralph R. Weichselbaum
IPC分类号： A61K3135
CPC分类号： A61K41/0038
摘要： A method for enhancing the efficacy of chemotherapy and/or radiation in the treatment of cancer in animals, particularly humans, is provided wherein certain isocoumarin derivatives which exhibit unique radiosensitization activity and/or chemopotentiation properties are employed in a combination treatment with ionizing radiation and/or chemotherapy.

6. 发明授权

US6030951A Chrysomycin derivative compounds and use as antitumor agents 失效
标题翻译：赤霉素衍生物，用作抗肿瘤剂
公开(公告)号：US6030951A
公开(公告)日：2000-02-29
申请号：US308710
申请日：1999-07-08
申请人： Takashi Nakashima , Tadashi Fujii , Kazuya Sakai , Tomohiro Sameshima , Hiroyuki Kumagai , Takeo Yoshioka
发明人： Takashi Nakashima , Tadashi Fujii , Kazuya Sakai , Tomohiro Sameshima , Hiroyuki Kumagai , Takeo Yoshioka
IPC分类号： C07D311/78 , C07D407/04 , C12P17/06 , A61K31/70 , C07H7/04
CPC分类号： C07D407/04 , C07D311/78 , C12P17/06
摘要： Disclosed are the novel C-glycoside compounds Mer-1020dA, Mer-1020dB, Mer-1020dC and Mer-1020dD which have a chromophore group in common with well-known chrysomycins A and B, but can be distinguished from the chrysomycins and the like in that the novel C-glycoside compounds have a sugar residue having a higher degree of oxidation, as well as the compound Mer-1020dE comprising only the chromophore thereof. Among these compounds, the C-glycoside compounds are antibiotics which have low toxicity and can strongly inhibit the growth of solid cancer cells in particular.
摘要翻译： PCT No.PCT / JP97 / 04007 Sec。 371日期：1999年7月8日 102（e）1999年7月8日PCT PCT 1997年11月4日PCT公布。公开号WO98 / 22612 PCT 日期1998年5月28日公开了具有发色团组的新颖的C-糖苷化合物Mer-1020dA，Mer-1020dB，Mer-1020dC和Mer-1020dD，与着名的科莫昔霉素A和B相同，但可以区别于科莫昔霉素因为新型C-糖苷化合物具有较高氧化度的糖残基以及仅包含其发色团的化合物Mer-1020dE。在这些化合物中，C-糖苷化合物是具有低毒性并特别强烈地抑制固体癌细胞生长的抗生素。

7. 发明授权

US6020363A Isocoumarin derivatives and use thereof in drugs 失效
标题翻译：异香豆素衍生物及其在药物中的应用
公开(公告)号：US6020363A
公开(公告)日：2000-02-01
申请号：US202606
申请日：1998-12-17
申请人： Shin-ichi Hirano , Toshiyuki Mase , Naoki Agata , Hiroshi Iguchi , Naoki Matsumoto , Takeo Yoshioka , Hiroshi Tone , Hiroyuki Kumagai , Masaaki Ishizuki , Tomio Takeuchi
发明人： Shin-ichi Hirano , Toshiyuki Mase , Naoki Agata , Hiroshi Iguchi , Naoki Matsumoto , Takeo Yoshioka , Hiroshi Tone , Hiroyuki Kumagai , Masaaki Ishizuki , Tomio Takeuchi
IPC分类号： A61K31/35 , A61K31/352 , A61K31/366 , A61P1/04 , A61P9/00 , A61P17/06 , A61P19/02 , A61P29/00 , A61P37/00 , A61P37/02 , A61P37/06 , C07D311/76
CPC分类号： C07D311/76
摘要： Compounds of the formula (I) ##STR1## wherein R is a hydrogen atom or a C.sub.1-6 alkyl group and n is an integer of 0 or 1, and pharmaceutical preparations thereof are provided. These pharmaceutical preparations are useful for the prevention or treatment of diseases associated with an abnormality in immunological regulatory function or vascularization.
摘要翻译： PCT No.PCT / JP96 / 01657 Sec。 371日期1998年12月17日第 102（e）1998年12月17日PCT PCT 1996年6月17日PCT公布。出版物WO97 / 48693 日期1997年12月24日其中R为氢原子或C1-6烷基且n为0或1的整数的式（I）化合物及其药物制剂。这些药物制剂可用于预防或治疗与免疫调节功能或血管形成异常有关的疾病。

8. 发明授权

US5691687A Contactless magnetic slip ring 失效
标题翻译：非接触式磁滑环
公开(公告)号：US5691687A
公开(公告)日：1997-11-25
申请号：US520865
申请日：1995-07-03
申请人： Hiroyuki Kumagai , Joe D. Deardon
发明人： Hiroyuki Kumagai , Joe D. Deardon
IPC分类号： H01F38/18 , H01F21/06
CPC分类号： H01F38/18
摘要： A contactless magnetic slip ring is disclosed having a primary coil and a secondary coil. The primary and secondary coils are preferably magnetically coupled together, in a highly reliable efficient manner, by a magnetic layered core. One of the secondary and primary coils is rotatable and the contactless magnetic slip ring provides a substantially constant output.
摘要翻译：公开了一种具有初级线圈和次级线圈的非接触式磁性滑环。初级和次级线圈优选通过磁性分层芯以高度可靠的有效方式磁耦合在一起。次级和初级线圈中的一个可旋转，非接触式磁滑环提供基本恒定的输出。

9. 发明申请

US20060090131A1 Multi-media user terminal for a presentation medium 审中-公开
标题翻译：用于演示介质的多媒体用户终端
公开(公告)号：US20060090131A1
公开(公告)日：2006-04-27
申请号：US11059176
申请日：2005-02-15
申请人： Hiroyuki Kumagai
发明人： Hiroyuki Kumagai
IPC分类号： G06F3/00 , G06F17/00 , G06F9/00
CPC分类号： H04N21/812 , G06Q30/02 , H04N7/17318 , H04N21/2393 , H04N21/2542 , H04N21/4622 , H04N21/4722 , H04N21/4755
摘要： Mass electronic-commerce (e-commerce) user terminal is disclosed, which enables mass television (TV) viewers to participate in e-commerce using new and existing business infrastructures. The multi-media user terminal makes a direct, real-time, instantaneous connection between products featured in TV commercials/programs (or other event such as a movie in a theater) and the existing web-based business infrastructure directly through the multi-media user terminal device. The multi-media user terminal provides real-time two-way communication with the TV viewers and the business entities. The device will also provide the TV viewing information for TV rating on real-time basis.
摘要翻译：公开了大众电子商务（电子商务）用户终端，其使大众电视（TV）观众能够使用新的和现有的商业基础设施参与电子商务。多媒体用户终端直接通过多媒体直接实时地连接电视广告/节目（或其他事件，例如剧院中的电影）和现有的基于网络的商业基础设施之间的连接用户终端设备。多媒体用户终端提供与电视观众和业务实体的实时双向通信。该设备还将实时为电视评级提供电视观看信息。

10. 发明申请

US20060200286A1 Mileage logging apparatus 审中-公开
标题翻译：里程测井仪
公开(公告)号：US20060200286A1
公开(公告)日：2006-09-07
申请号：US11317291
申请日：2005-12-23
申请人： Hiroyuki Kumagai , Scott Christa
发明人： Hiroyuki Kumagai , Scott Christa
IPC分类号： G06F19/00
CPC分类号： G01C21/005
摘要： A system and a method for a mileage (or other distance measurement) logging apparatus (or portable mileage logger) is configured as an electronic device, which keeps track of the vehicle's mileage. The mileage logger is independent of the vehicle's electrical and sensor systems, although it may also be configured to tap a vehicle's power connection. The mileage logger is configured for portability. Hence, it can be transferred from one vehicle to another and removed from the vehicle without the need for disabling and re-wiring. Moreover, the mileage logger may be configured with input/output ports to connect with a personal computer to download data from the apparatus. Alternative embodiments of the mileage logger may also be configured to include wireless network capabilities with an electronic mail protocol that allows for automatic wireless transmission of e-mailing capability to a user's computer, utilizing wireless network connections.
摘要翻译：用于里程（或其他距离测量）测井装置（或便携式里程记录器）的系统和方法被配置为跟踪车辆里程的电子设备。里程记录器独立于车辆的电气和传感器系统，尽管它也可以被配置为点击车辆的电源连接。里程记录器配置为可移植性。因此，它可以从一个车辆转移到另一个车辆并从车辆中移除，而不需要禁用和重新布线。此外，里程记录器可以配置有输入/输出端口以与个人计算机连接以从设备下载数据。里程记录器的替代实施例还可以被配置为包括使用电子邮件协议的无线网络功能，其允许利用无线网络连接自动地将电子邮件发送到用户的计算机。

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