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1. 发明申请

US20090291461A1 METHOD OF SELECTIVELY ASSAYING ADIPONECTIN MULTIMERS 有权
标题翻译：选择ADIPONECTIN多聚体的方法
公开(公告)号：US20090291461A1
公开(公告)日：2009-11-26
申请号：US12468440
申请日：2009-05-19
申请人： Hiroyuki EBINUMA , Hirokazu Yago , Yuka Akimoto , Osamu Miyazaki , Takashi Kadowaki , Toshimasa Yamauchi , Kazuo Hara
发明人： Hiroyuki EBINUMA , Hirokazu Yago , Yuka Akimoto , Osamu Miyazaki , Takashi Kadowaki , Toshimasa Yamauchi , Kazuo Hara
IPC分类号： G01N33/53
CPC分类号： G01N33/74 , G01N2800/042 , G01N2800/32
摘要： Kits and methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of adiponectin multimers and provide information that cannot be obtained through measurement of the total amount of adiponectin alone. A method for selectively assaying a target adiponectin multimer in a biological sample comprising distinguishing target adiponectin multimer from the other adiponectin multimers by using a protease and/or an antibody.
摘要翻译：用于选择性测定生物样品中目标脂联素多聚体的试剂盒和方法。这种方法通过脂联素多聚体的选择性测定来准确地评估疾病与脂联素之间的关系，并提供通过单独测量脂连蛋白的总量不能获得的信息。一种用于选择性测定生物样品中的目标脂联素多聚体的方法，包括通过使用蛋白酶和/或抗体将目标脂连蛋白多聚体与其它脂联素多聚体区分开。

2. 发明授权

US08039223B2 Method of selectively assaying adiponectin multimers 有权
标题翻译：选择性测定脂连蛋白多聚体的方法
公开(公告)号：US08039223B2
公开(公告)日：2011-10-18
申请号：US12468440
申请日：2009-05-19
申请人： Hiroyuki Ebinuma , Hirokazu Yago , Yuka Akimoto , Osamu Miyazaki , Takashi Kadowaki , Toshimasa Yamauchi , Kazuo Hara
发明人： Hiroyuki Ebinuma , Hirokazu Yago , Yuka Akimoto , Osamu Miyazaki , Takashi Kadowaki , Toshimasa Yamauchi , Kazuo Hara
IPC分类号： G01N33/53
CPC分类号： G01N33/74 , G01N2800/042 , G01N2800/32
摘要： Kits and methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of adiponectin multimers and provide information that cannot be obtained through measurement of the total amount of adiponectin alone. A method for selectively assaying a target adiponectin multimer in a biological sample comprising distinguishing target adiponectin multimer from the other adiponectin multimers by using a protease and/or an antibody.
摘要翻译：用于选择性测定生物样品中目标脂联素多聚体的试剂盒和方法。这种方法通过脂联素多聚体的选择性测定来准确地评估疾病与脂联素之间的关系，并提供通过单独测量脂连蛋白的总量不能获得的信息。一种用于选择性测定生物样品中的目标脂联素多聚体的方法，包括通过使用蛋白酶和/或抗体将目标脂连蛋白多聚体与其它脂联素多聚体区分开。

3. 发明授权

US07608405B2 Method of selectively assaying adiponectin multimers 有权
标题翻译：选择性测定脂连蛋白多聚体的方法
公开(公告)号：US07608405B2
公开(公告)日：2009-10-27
申请号：US10575931
申请日：2004-10-15
申请人： Hiroyuki Ebinuma , Hirokazu Yago , Yuka Akimoto , Osamu Miyazaki , Takashi Kadowaki , Toshimasa Yamauchi , Kazuo Hara
发明人： Hiroyuki Ebinuma , Hirokazu Yago , Yuka Akimoto , Osamu Miyazaki , Takashi Kadowaki , Toshimasa Yamauchi , Kazuo Hara
IPC分类号： G01N33/53 , G01N33/543 , A61K39/395
CPC分类号： G01N33/74 , G01N2800/042 , G01N2800/32
摘要： Methods for selectively assaying a target adiponectin multimer in a biological sample. Such methods accurately evaluate the relationship between a disease and adiponectin through selective assay of adiponectin multimers and provide information that cannot be obtained through measurement of the total amount of adiponectin alone. A method for selectively assaying of a target adiponectin multimer in a biological sample comprising distinguishing target adiponectin multimer from the other adiponectin multimers by using a protease and/or an antibody.
摘要翻译：用于选择性测定生物样品中目标脂联素多聚体的方法。这种方法通过脂联素多聚体的选择性测定来准确地评估疾病与脂联素之间的关系，并提供通过单独测量脂连蛋白的总量不能获得的信息。一种用于选择性测定生物样品中的目标脂联素多聚体的方法，包括通过使用蛋白酶和/或抗体将目标脂连蛋白多聚体与其他脂联素多聚体区分开。

4. 发明申请

US20070042424A1 Method of selectively assaying adiponectin multimers 有权
标题翻译：选择性测定脂连蛋白多聚体的方法
公开(公告)号：US20070042424A1
公开(公告)日：2007-02-22
申请号：US10575931
申请日：2004-10-15
申请人： Hiroyuki Ebinuma , Hirokazu Yago , Yuka Akimoto , Osamu Miyazaki , Takashi Kadowaki , Toshimasa Yamauchi , Kazuo Hara
发明人： Hiroyuki Ebinuma , Hirokazu Yago , Yuka Akimoto , Osamu Miyazaki , Takashi Kadowaki , Toshimasa Yamauchi , Kazuo Hara
IPC分类号： G01N33/53 , C12Q1/37
CPC分类号： G01N33/74 , G01N2800/042 , G01N2800/32
摘要： We have discovered a “human adiponectin ELISA kit”, which can specifically measure adiponectin in human blood serum (or blood plasma) or in extracted fluid from lipocytes or culture supernatant fluid. After fractioning human serum by use of gel filtration column, each fraction was measured by the present kit, and as a result, adiponectin immunity activity was detected as a plurality of peaks at above 670 kD of molecular weight. From the results, it is presumed that adiponectin is present in the blood as a polymer or forms a complex with polymer proteins.
摘要翻译：我们已经发现了一种“人类脂联素ELISA试剂盒”，可以特异性地测量人血清（或血浆）中的脂联素或来自脂肪细胞或培养上清液的提取液。通过使用凝胶过滤柱对人血清进行分馏后，通过本试剂盒测定各级分，结果，在670kD以上的分子量下检测出多个峰的脂联素免疫活性。从结果可以推测，脂联素作为聚合物存在于血液中，或与聚合物蛋白形成复合物。

5. 发明申请

US20130236893A1 METHOD OF DETECTING TYPE II DIABETES 审中-公开
标题翻译：检测II型糖尿病的方法
公开(公告)号：US20130236893A1
公开(公告)日：2013-09-12
申请号：US13819821
申请日：2011-09-02
申请人： Shiro Maeda , Takashi Kadowaki , Toshimasa Yamauchi , Kazuo Hara
发明人： Shiro Maeda , Takashi Kadowaki , Toshimasa Yamauchi , Kazuo Hara
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/156
摘要： A single-nucleotide polymorphism in the UBE2E2 locus or C2CD4A-C2CD4B locus is analyzed and type II diabetes is examined based on the results of the analysis.
摘要翻译：分析UBE2E2位点或C2CD4A-C2CD4B位点的单核苷酸多态性，并根据分析结果检查II型糖尿病。

6. 发明授权

US07308964B2 Vehicle steering apparatus 有权
标题翻译：车辆转向装置
公开(公告)号：US07308964B2
公开(公告)日：2007-12-18
申请号：US10952917
申请日：2004-09-30
申请人： Kazuo Hara , Noriki Kubokawa , Tetsuya Osonoi , Takaaki Eguchi , Kiyotaka Shitamitsu , Hitoshi Ono
发明人： Kazuo Hara , Noriki Kubokawa , Tetsuya Osonoi , Takaaki Eguchi , Kiyotaka Shitamitsu , Hitoshi Ono
IPC分类号： B62D5/04
CPC分类号： B62D5/003 , B62D1/163 , B62D5/008 , B62D7/09
摘要： A vehicle steering apparatus includes a steering input section having at least a steering wheel to which steering input is applied, and a steering output section having at least a steering rack shaft and operatively associated with left and right steered wheels for steering the steered wheels by steering-rack-shaft movement produced by a steering force determined based on the steering input and transmitted directly or indirectly to the steering rack shaft. The steering rack shaft is split into left and right movable rack shaft portions. Also provided is a steer angle converter enabling a differential rack stroke between left and right rack strokes of the left and right movable rack shaft portions. The steer angle converter is constructed by at least one of a variable-pitch dual rack arrangement and a dual taper-pulley arrangement of a cable back-up mechanism.
摘要翻译：车辆转向装置包括至少具有转向输入的方向盘的转向输入部分和至少具有转向齿条轴的转向输出部分，并且可操作地与左右转向轮相关联，用于通过转向转向转向轮由基于转向输入确定并且直接或间接地传递到转向齿条轴的转向力产生的轨道轴运动。转向齿条轴分为左右可动齿条轴部分。还提供了一种转向角转换器，其能够实现左右可移动齿条轴部分的左右齿条行程之间的差速齿条行程。转向角转换器由可变间距双齿条布置和电缆支撑机构的双锥形滑轮布置中的至少一个构成。

7. 发明授权

US07200457B2 Component and material traceability control apparatus, control method, control program, and control program memory medium 有权
标题翻译：组件和材料可追溯性控制装置，控制方法，控制程序和控制程序存储介质
公开(公告)号：US07200457B2
公开(公告)日：2007-04-03
申请号：US11282452
申请日：2005-11-17
申请人： Satoshi Ohishi , Kazuo Hara , Yoshifumi Morioka , Katsumi Otani , Makoto Kogai
发明人： Satoshi Ohishi , Kazuo Hara , Yoshifumi Morioka , Katsumi Otani , Makoto Kogai
IPC分类号： G06F19/00 , G06F17/30
CPC分类号： G06Q10/06 , H05K3/00 , H05K13/084 , Y10S707/99945 , Y10S707/99948
摘要： The present invention is related to a component and material traceability control apparatus for controlling manufacturing lot identification information of any of a component and material constituting a product manufactured according to a process where a manufacturing apparatus with not less than one component and material reserve unit picks up a needed amount out of the component and material reserved in the component and material reserve unit and manufactures the product, and the component and material traceability control apparatus is equipped with at least a processing unit, a memory unit used as a work area by the processing unit, a manufacturing performance information memory unit, a component and material supply performance information memory unit, and a manufacturing lot trace information memory unit.
摘要翻译：本发明涉及一种用于控制构成产品的部件和材料的制造批次识别信息的组件和材料可追溯性控制装置，该组件和材料根据其中具有不少于一个部件和材料储备单元拾取的制造装置的工艺制造从部件和材料备料单元中保留的部件和材料中所需的量，并制造产品，并且部件和材料可追溯性控制装置至少配备有处理单元，通过处理用作工作区的存储单元单元，制造性能信息存储单元，组件和材料供应性能信息存储单元，以及制造批次跟踪信息存储单元。

8. 发明申请

US20050045413A1 Vehicle steering system 失效
标题翻译：车辆转向系统
公开(公告)号：US20050045413A1
公开(公告)日：2005-03-03
申请号：US10886702
申请日：2004-07-09
申请人： Kiyotaka Shitamitsu , Hitoshi Ono , Kazuo Hara
发明人： Kiyotaka Shitamitsu , Hitoshi Ono , Kazuo Hara
IPC分类号： B62D5/00 , B62D5/04
CPC分类号： B62D5/0409 , B62D5/003 , B62D5/0487
摘要： A vehicle steering system is provided with a primary steering system, a backup steering system and a control system that switches from the primary steering system to the backup steering system when a defect is determined in the primary steering system such as a defeat in a steering reaction force actuator. The vehicle steering system has a pair of clutches that mechanically disconnect the steering wheel from the steerable vehicle wheels in normal situations, and connect them when the steering reaction force actuator is determined to be defective. The control system has a steering malfunction detection section that detects a malfunction in the steering reaction force actuator, and a steering control limiting section that limits the control commands to the steering gear unit actuator from when the steering reaction force actuator is determined to be malfunctioning to when both the clutches are connected.
摘要翻译：车辆转向系统设有初级转向系统，后备转向系统和控制系统，当在主转向系统中确定缺陷时（例如转向反作用中的失败），从主转向系统切换到备用转向系统力致动器。车辆转向系统具有一对离合器，其在正常情况下机械地将方向盘与可转向车轮分离，并且当转向反作用力致动器被确定为有缺陷时将其连接。控制系统具有检测转向反作用力致动器的故障的转向故障检测部，以及转向控制限制部，其将来自转向反作用力促动器的转向反作用力致动器判定为发生故障的转向控制限制部，当两个离合器连接时。

9. 发明授权

US6127564A Semicarbazine/manganese complex and gas generator for air bag 失效
标题翻译：用于气囊的缩氨基胺/锰络合物和气体发生器
公开(公告)号：US6127564A
公开(公告)日：2000-10-03
申请号：US331774
申请日：1999-06-24
申请人： Tadao Yoshida , Shiro Chijiwa , Yasuo Shimizu , Kazuo Hara , Takashi Kazumi , Keisuke Matsuda , Kenichi Fukase
发明人： Tadao Yoshida , Shiro Chijiwa , Yasuo Shimizu , Kazuo Hara , Takashi Kazumi , Keisuke Matsuda , Kenichi Fukase
IPC分类号： C06D5/06 , C07F1/00 , C07F3/00 , C07F5/06 , C07F15/02 , C07F13/00 , B60R21/26 , C05D5/06
CPC分类号： C06D5/06 , C07F1/005 , C07F15/025 , C07F3/003 , C07F5/069
摘要： The manganese complex of the invention is one represented by the formula (1)[Mn(H.sub.2 NNHCONH.sub.2).sub.3 ](NO.sub.3).sub.2 (1)and showing weight loss of not higher than 1% after heating at 107.degree. C. for 400 hours. The manganese complex has high heat stability and is used as an active component of an air bag gas generating composition. The air bag gas generating composition of the invention contains the above-mentioned manganese complex. The air bag gas generating composition comprising a complex mixture of the manganese complex and magnesium complex of semicarbazide and/or carbohydrazide features a high rate of combustion residue in an inflator.
摘要翻译： PCT No.PCT / JP97 / 04733 Sec。 371日期1999年6月24日第 102（e）1999年6月24日PCT 1997年12月22日PCT公布。第WO98 / 29425号公报日期1998年7月9日本发明的锰络合物为式（1）[Mn（H2NNHCONH2）3]（NO3）2（1）表示的锰配合物，107℃加热后的重量损失为1％以下 400小时锰络合物具有高的热稳定性，并且用作气囊气体发生组合物的活性组分。本发明的气囊气发生剂组合物含有上述锰配合物。包含锰络合物和氨基脲和/或碳酰肼的镁络合物的复合混合物的气囊气产生组合物在充气机中具有高的燃烧残余率。

10. 发明授权

US5751247A Fixed earth station 失效
标题翻译：固定地球站
公开(公告)号：US5751247A
公开(公告)日：1998-05-12
申请号：US797860
申请日：1997-02-10
申请人： Shinichi Nomoto , Hideo Kobayashi , Teruhiko Honda , Kazuo Hara
发明人： Shinichi Nomoto , Hideo Kobayashi , Teruhiko Honda , Kazuo Hara
IPC分类号： H01Q15/16 , H01Q3/02 , H01Q3/08 , H01Q21/28 , H04B7/155 , H04B7/185 , H01Q3/00
CPC分类号： H04B7/18517 , H01Q3/02
摘要： It is the object of the present invention to provide a fixed earth station in which many antennas can be placed in a site area limited to one-several tenth of the conventional one. On a rotatable base 2, a plurality of antennas 1a to 1e are mounted. A control unit 4 controls the rotation angle of a drive unit for driving the base by the previously known orbital parameters of communication satellites. Further, the azimuth angle and the elevation angle of the respective antennas are controlled by antenna control units 5a to 5e, and the antennas catch and track communication satellites having appeared in the sky. As a result, the rotation angle of the base 2 can be set so that a beam accessing a satellite of a low elevation angle is not intercepted by other antennas. In addition, the area in which the antennas are placed can be reduced to about 1/50 of the conventional one. As other embodiments, there are an embodiment in which the antenna height is varied, an embodiment in which antennas are mounted on vehicles to change the position thereof, an embodiment in which antennas are made to travel on previously laid rails, etc.
摘要翻译：本发明的目的是提供一种固定的地球站，其中可以将许多天线放置在限于常规天线的十分之一的位置区域中。在可旋转底座2上安装有多个天线1a至1e。控制单元4通过先前已知的通信卫星的轨道参数来控制用于驱动基座的驱动单元的旋转角度。此外，天线控制单元5a至5e控制各天线的方位角和仰角，并且天线捕获并跟踪出现在天空中的通信卫星。结果，基座2的旋转角度可以被设定为使得接近低仰角的卫星的波束不被其他天线截取。此外，将天线放置的区域可以减小到常规的天线的大约+ E，fra 1/50 + EE。作为其他实施例，存在天线高度变化的实施例，其中天线安装在车辆上以改变其位置的实施例，其中使天线在先前铺设的轨道上行进的实施例等。

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