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1. 发明申请

US20100032061A1 METHOD FOR MANUFACTURING A Ni-BASED ALLOY ARTICLE AND PRODUCT THEREFROM 审中-公开
标题翻译：制造镍基合金制品及其制品的方法
公开(公告)号：US20100032061A1
公开(公告)日：2010-02-11
申请号：US12538385
申请日：2009-08-10
申请人： Hiroyuki Anada , Shoji Kinomura , Noriaki Hirohata , Manabu Kanzaki , Kazuyuki Kitamura
发明人： Hiroyuki Anada , Shoji Kinomura , Noriaki Hirohata , Manabu Kanzaki , Kazuyuki Kitamura
IPC分类号： C23C8/10
CPC分类号： C23C8/10 , C23C8/16
摘要： A method for manufacturing a Ni-based alloy article which elutes little Ni even when used in a high-temperature water environment for a long period comprises heating the Ni-based alloy in a carbon dioxide-containing atmosphere for a set period of time at an elevated temperature to form an oxide film comprising chromium oxide on a surface thereof. Using carbon dioxide as an oxidizing gas produces an oxide film of generally uniform thickness along a length of the article being treated so that resistance to nickel elution is more uniform over the entire article.
摘要翻译：即使长时间在高温水环境中使用也可以洗脱少量Ni的Ni系合金制品的制造方法包括在含二氧化碳的气氛中将Ni系合金在一定时间内加热升高温度以在其表面上形成包含氧化铬的氧化物膜。使用二氧化碳作为氧化气体，沿着待处理的制品的长度产生大致均匀厚度的氧化膜，使得在整个制品上耐镍洗脱更均匀。

2. 发明申请

US20060177679A1 Method for manufacturing a Ni-based alloy article and product therefrom 审中-公开
标题翻译：镍基合金制品及其制品的制造方法
公开(公告)号：US20060177679A1
公开(公告)日：2006-08-10
申请号：US11055198
申请日：2005-02-04
申请人： Hiroyuki Anada , Shoji Kinomura , Noriaki Hirohata , Manabu Kanzakli , Kazuyuki Kitamura
发明人： Hiroyuki Anada , Shoji Kinomura , Noriaki Hirohata , Manabu Kanzakli , Kazuyuki Kitamura
IPC分类号： C23C8/10
CPC分类号： C23C8/10 , C23C8/16
摘要： A method for manufacturing a Ni-based alloy article which elutes little Ni even when used in a high-temperature water environment for a long period comprises heating the Ni-based alloy in a carbon dioxide-containing atmosphere for a set period of time at an elevated temperature to form an oxide film comprising chromium oxide on a surface thereof. Using carbon dioxide as an oxidizing gas produces an oxide film of generally uniform thickness along a length of the article being treated so that resistance to nickel elution is more uniform over the entire article.
摘要翻译：即使长时间在高温水环境中使用也可以洗脱少量Ni的Ni系合金制品的制造方法包括在含二氧化碳的气氛中将Ni系合金在一定时间内加热升高温度以在其表面上形成包含氧化铬的氧化物膜。使用二氧化碳作为氧化气体，沿着待处理的制品的长度产生大致均匀厚度的氧化膜，使得在整个制品上耐镍洗脱更均匀。

3. 发明申请

US20090123775A1 Method for producing Cr containing nickel-base alloy tube and Cr containing nickel-base alloy tube 审中-公开
标题翻译：含Cr的镍基合金管和含镍的镍基合金管的生产方法
公开(公告)号：US20090123775A1
公开(公告)日：2009-05-14
申请号：US12285644
申请日：2008-10-10
申请人： Manabu Kanzaki , Kazuyuki Kitamura , Noriaki Hirohata
发明人： Manabu Kanzaki , Kazuyuki Kitamura , Noriaki Hirohata
IPC分类号： B29D23/00 , B05D7/22 , B32B1/08
CPC分类号： C23C8/16 , C22C19/05 , C22F1/10 , F22B37/002 , F22B37/04 , Y10T428/12292
摘要： To form a chromium oxide film on the inner surface of a Cr containing nickel-base alloy tube inexpensively and uniformly, the Cr containing nickel-base alloy tube is heated in atmospheric gas of carbon dioxide gas and non-oxidation gas to form an oxide film consisting of chromium oxide having a thickness of 0.2 to 1.5 μm on the inner surface of the Cr containing nickel-base alloy tube. The atmospheric gas may contain oxygen gas of 5 vol % or less and/or water vapor of 7.5 vol % or less.
摘要翻译：为了廉价且均匀地在含Cr的镍基合金管的内表面上形成氧化铬膜，将含Cr的镍基合金管在二氧化碳气体和非氧化气体的大气中加热，形成氧化膜在含Cr的镍基合金管的内表面上由厚度为0.2-1.5μm的氧化铬组成。气氛气体可以含有5体积％以下的氧气和/或7.5体积％以下的水蒸汽。

4. 发明授权

US07037390B2 Method of heat treatment for Ni-base alloy tube 有权
标题翻译：镍基合金管热处理方法
公开(公告)号：US07037390B2
公开(公告)日：2006-05-02
申请号：US10681117
申请日：2003-10-09
申请人： Osamu Miyahara , Toshihiro Imoto , Hiroyuki Anada , Kazuyuki Kitamura
发明人： Osamu Miyahara , Toshihiro Imoto , Hiroyuki Anada , Kazuyuki Kitamura
IPC分类号： C22C1/10
CPC分类号： C22C19/058 , C21D1/74 , C21D9/08 , C22F1/02 , C22F1/10 , C23C8/10 , C23C8/16
摘要： A method of heat treatment for an efficient forming of two-layered oxide film on the inside surface of a Ni-base alloy tube. The oxide film suppresses the Ni release in a high-temperature water environment.At least two gas supplying devices are provided on the outlet side of a continuous heat treatment furnace; or one gas supplying device is provided respectively on the outlet side and the inlet side thereof. The tube is put into the furnace while supplying an atmospheric gas into the tube from the front end of the tube moving direction with one of these gas supplying devices and a gas introducing pipe, which is arranged inside the furnace, and this tube is maintained at 650 to 1200° C. for 1 to 1200 minutes. The atmospheric gas consists of hydrogen or a mixture of hydrogen and argon, whose dew point is in a range of from −60° C. to +20° C. After the front end of the Ni-base alloy tube reaches the outlet side of the furnace, the supply of atmospheric gas into the tube is switched to the supply from other gas supplying device. The operations are repeated.
摘要翻译：一种用于在Ni基合金管的内表面上有效形成双层氧化膜的热处理方法。该氧化物膜在高温水环境中抑制Ni释放。在连续热处理炉的出口侧设置至少两个供气装置; 或者在其出口侧和入口侧分别设置一个气体供给装置。将管放入炉中，同时从管移动方向的前端向气体供给装置和气体导入管中的一个供给大气气体，并将该管保持在炉内 650〜1200℃1〜1200分钟。气氛气体由氢气或氢气和氩气的混合物组成，其露点在-60℃至+ 20℃的范围内。在Ni基合金管的前端到达出口侧炉子中，将大气气体供应到管中被切换到来自其他气体供应装置的供应。重复操作。

5. 发明授权

US06482528B2 Nickel-base alloy product and method of producing the same 有权
标题翻译：镍基合金制品及其制造方法
公开(公告)号：US06482528B2
公开(公告)日：2002-11-19
申请号：US10119085
申请日：2002-04-10
申请人： Hiroyuki Anada , Kazuyuki Kitamura , Toshihiro Imoto , Osamu Miyahara
发明人： Hiroyuki Anada , Kazuyuki Kitamura , Toshihiro Imoto , Osamu Miyahara
IPC分类号： C22C1905
CPC分类号： C23C28/044 , C23C8/10 , C23C8/80 , C23C28/048 , Y10T428/12618 , Y10T428/12944
摘要： (1) A nickel-base alloy product having, on the surface thereof, an oxide film comprising at least two layers, namely a first layer mainly composed of Cr2O3 and having a chromium content of not less than 50% relative to the total amount of metal elements and a second layer occurring outside the first layer and mainly composed of MnCr2O4, wherein the grain size of Cr2O3 crystals in the first layer is 50 to 1,000 nm and the total oxide film thickness is 180 to 1,500 nm. (2) A method of producing the nickel-base alloy product as specified above under (1) which comprises subjecting a nickel-base alloy product to oxide film formation treatment by maintaining the same at a temperature of 650 to 1,200° C. in a hydrogen atmosphere or hydrogen-argon mixed atmosphere showing a dew point of −60° C. to +20° C. for 1 to 1,200 minutes. The product mentioned above (1) allows only a very low level of Ni release in a high-temperature water environment over a long period of time and is particularly suited for use as a nuclear reactor member.
摘要翻译：（1）一种镍基合金制品，其表面上具有包含至少两层的氧化物膜，即主要由Cr 2 O 3组成的第一层，铬含量不低于50％金属元素和第二层，其主要由MnCr 2 O 4构成，其中第一层中的Cr 2 O 3晶体的晶粒尺寸为50〜1000nm，氧化膜的总厚度为180〜1500nm。（2）（1）所述的镍基合金制品的制造方法，其特征在于，在氢气氛中，在氢气氛中，在氢气氛中，在650〜1200℃的温度下，使镍基合金制品进行氧化膜形成处理，氩气混合气氛，露点为-60°C至+ 20°C，持续1〜1,200分钟。上述（1）所述的产品在高温水环境中仅允许非常低的Ni释放量很长一段时间，尤其适合用作核反应堆构件。

6. 发明授权

US5726148A Method of treating metabolic bone diseases with an IL-1 receptor 失效
标题翻译：用IL-1受体治疗代谢性骨疾病的方法
公开(公告)号：US5726148A
公开(公告)日：1998-03-10
申请号：US487646
申请日：1995-06-07
申请人： Masakazu Katoh , Kazuyuki Kitamura
发明人： Masakazu Katoh , Kazuyuki Kitamura
IPC分类号： A61K38/00 , A61K38/17 , A61P19/10 , A61P43/00 , A61K45/05
CPC分类号： A61K38/1793
摘要： A method of treating metabolic bone diseases comprising using a pharmaceutical composition which comprises as an active ingredient IL-1 receptor, a soluble fragment consisting of an extracellular domain of IL-1R or a fragment thereof derived from mammals. The composition has a bone resorption inhibiting activity and is useful for the therapy and prophylaxis of metabolic bone diseases.
摘要翻译：一种治疗代谢性骨疾病的方法，包括使用包含作为活性成分IL-1受体的由IL-1R的细胞外结构域或其衍生自哺乳动物的片段组成的可溶性片段的药物组合物。该组合物具有骨吸收抑制活性，可用于治疗和预防代谢性骨疾病。

7. 发明授权

US5169861A Benzothiophene compounds 失效
标题翻译：苯并噻吩化合物
公开(公告)号：US5169861A
公开(公告)日：1992-12-08
申请号：US645433
申请日：1991-01-24
申请人： Tameo Iwasaki , Masaki Sugiura , Yuzo Matsuoka , Mamoru Matsumoto , Kazuyuki Kitamura
发明人： Tameo Iwasaki , Masaki Sugiura , Yuzo Matsuoka , Mamoru Matsumoto , Kazuyuki Kitamura
IPC分类号： C07D493/04 , C07D495/04
CPC分类号： C07D493/04 , C07D495/04 , Y10S514/893 , Y10S514/894
摘要： A novel biphenyl derivative of the formula: ##STR1## wherein Ring A is a substituted or unsubstituted sulfur-containing or oxygen-containing heteromonocyclic ring; Ring B is a ring of the formula: ##STR2## each of R.sup.1 to R.sup.3 is hydrogen atom, a halogen atom or a lower alkoxy group, or R.sup.1 is hydrogen atom, and R.sup.2 and R.sup.3 are combined together to form a lower alkylenedioxy group; R.sup.4 is a lower alkyl group which may have a substituent selected from a lower alkoxy group and a lower alkoxycarbonyl group; Y is methylene group or carbonyl group, and a pharmaceutically acceptable salt thereof are disclosed. Said derivative and a pharmaceutically acceptable salt thereof are useful as a therapeutic or prophylactic agent for hepatic diseases.
摘要翻译：一种下式的新型联苯衍生物：其中环A是取代或未取代的含硫或含氧杂环; 环B是下式的环：R1至R3各自为氢原子，卤素原子或低级烷氧基，或R1为氢原子，R2和R3组合在一起形成低级亚烷基二氧基; R4是可以具有选自低级烷氧基和低级烷氧基羰基的取代基的低级烷基; Y是亚甲基或羰基，并且其药学上可接受的盐被公开。所述衍生物及其药学上可接受的盐可用作肝脏疾病的治疗或预防剂。

8. 发明授权

US06509462B2 Estradiol derivative and immunoassy using the same 失效
标题翻译：雌二醇衍生物和免疫应用使用它们
公开(公告)号：US06509462B2
公开(公告)日：2003-01-21
申请号：US09905945
申请日：2001-07-17
申请人： Noboru Yanaihara , Ikuo Kato , Kazuyuki Kitamura , Tsukasa Kodaira
发明人： Noboru Yanaihara , Ikuo Kato , Kazuyuki Kitamura , Tsukasa Kodaira
IPC分类号： C07J4300
CPC分类号： C07J43/00 , Y10S436/811 , Y10S436/815 , Y10S436/817
摘要： The present invention provides a highly sensitive immunoassay system for estrogens, which utilizes as a labeled compound a biotinylated estradiol derivative of the formula (1) wherein one of R1 and R2 is hydrogen and the other is a group represented by wherein R3s are the same or different and represent an arginine residue or a lysine residue, x is 0 or 1, y is an integer from 1 to 5, and z is an integer from 1 to 3.
摘要翻译：本发明提供了一种用于雌激素的高度灵敏的免疫测定系统，其利用标记化合物作为式（1）的生物素化雌二醇衍生物，其中R 1和R 2之一是氢，另一个是由其中R3表示的基团相同或不同并且表示精氨酸残基或赖氨酸残基，x为0或1，y为1〜5的整数，z为1〜3的整数。

9. 发明授权

US06194380B1 Agents for promoting bone formation 有权
标题翻译：促进骨形成的药剂
公开(公告)号：US06194380B1
公开(公告)日：2001-02-27
申请号：US09077714
申请日：1999-04-20
申请人： Kazuyuki Kitamura , Osamu Komiyama , Mizuho Inazu , Roland Baron , Thomas R. Gadek , Hans-Ulrich Stilz , Volkmar Wehner , Jochen Knolle , Robert S. McDowell
发明人： Kazuyuki Kitamura , Osamu Komiyama , Mizuho Inazu , Roland Baron , Thomas R. Gadek , Hans-Ulrich Stilz , Volkmar Wehner , Jochen Knolle , Robert S. McDowell
IPC分类号： A01N3718
CPC分类号： C07K5/0821 , A61K38/04 , A61K38/05 , A61K38/07 , A61K38/12 , A61K38/1703 , A61K38/39 , C07C271/22 , C07C279/08 , C07C279/20 , C07K5/0202 , C07K5/0817 , C07K5/1019 , C07K5/1024 , C07K14/46 , C07K14/745 , C07K14/78
摘要： The object is to provide a promoting agent for bone formation, a therapeutic method for bone formation and a process for preparing a promoting agent for bone formation. A promoting agent for bone formation which comprises at least one of kistrin, echstatin, a peptide or polypeptide containing the amino acid sequence ArgGlyAsp in the molecule such as a peptide represented by Gly-Arg-Gly-Asp-Ser or a compound represented by the following general formula (IX) and so on, as well as a biologically acceptable salt thereof wherein R16 represents —N(R20)2 (R20 represents a hydrogen atom or a C1-C4 alkyl group), R17 represents a hydrogen atom or a C1-C4 alkyl group, R18 represents a hydrogen atom, a C1-C4 alkyl group and so on, R19 represents OH, NH2 and so on, Y represents —NH—, —O— or a direct bond, a represents 1-3, b represents 1 or 2, c represents 0 or 1 and d represents 0 or 1.
摘要翻译：本发明的目的是提供骨形成促进剂，骨形成用治疗剂和骨形成促进剂的制备方法.1，一种骨形成促进剂，其特征在于，含有丝ist药，e嗪，肽或多肽中的至少一种包含分子中的氨基酸序列ArgGlyAsp，例如由Gly-Arg-Gly-Asp-Ser表示的肽或由以下通式（IX）表示的化合物等，以及其生物可接受的盐，其中R 16表示 -N（R 20）2（R 20表示氢原子或C 1 -C 4烷基），R 17表示氢原子或C 1〜C 4烷基，R 18表示氢原子，C 1〜C 4烷基等， R 19表示OH，NH 2等，Y表示-NH-，-O-或直接键，a表示1-3，b表示1或2，c表示0或1，d表示0或1。

10. 发明授权

US06177474B1 Polyhydroxyphenol derivatives and preventive and therapeutic agents for bone and cartilage diseases containing the same 失效
标题翻译：聚羟基苯酚衍生物以及含有其的骨和软骨疾病的预防和治疗剂
公开(公告)号：US06177474B1
公开(公告)日：2001-01-23
申请号：US09180756
申请日：1998-12-10
申请人： Kunikazu Sakai , Yusuke Satoh , Kazuyuki Doi , Kazuyuki Kitamura
发明人： Kunikazu Sakai , Yusuke Satoh , Kazuyuki Doi , Kazuyuki Kitamura
IPC分类号： A61K3112
CPC分类号： C07C49/84 , C07C45/00 , C07C45/46 , C07C45/512 , C07C45/62 , C07C45/68 , C07C45/71 , C07C49/713 , C07C49/743 , C07C49/747 , C07C49/825 , C07C49/83 , C07C49/835
摘要： Compounds useful as preventive and therapeutic agents for bone and cartilage diseases; and drug compositions containing the same. The compounds are polyhydroxyphenol derivatives of general formula (I) and quinione analogues derived therefrom (wherein R1 is alkyl, optionally substituted benzyl or optionally substituted aryl; R2 is hydrogen, alkyl, alkenyl or optionally substituted benzyl; R3 is hydrogen, alkyl, alkenyl, optionally substituted benzyl, hydroxyl, alkoxy, alkenyloxy or optionally substituted benzyloxy; R4 is hydrogen, alkyl, alkenyl, optionally substituted benzyl or hydroxyl; and R5 and R6 are each independently hydrogen, alkyl, alkenyl or optionally substituted benzyl). The polyhydroxyphenol derivatives and the quinone analogues exhibit a potent inhibitory activity against bone resorption and are useful as preventive and therapeutic agents for bone and cartilage diseases.
摘要翻译：用作骨和软骨疾病的预防和治疗剂的化合物; 和含有它们的药物组合物。化合物是通式（I）的多羟基苯酚衍生物和由其衍生的醌基类似物（其中R1是烷基，任意取代的苄基或任意取代的芳基; R 2是氢，烷基，烯基或任选取代的苄基; R 3是氢，烷基，链烯基，任选取代的苄基，羟基，烷氧基，烯氧基或任选取代的苄氧基; R 4是氢，烷基，烯基，任选取代的苄基或羟基;且R 5和R 6各自独立地为氢，烷基，烯基或任选取代的苄基。多羟基苯酚衍生物和醌类似物表现出对骨吸收的有效抑制活性，并且可用作骨和软骨疾病的预防和治疗剂。

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