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1. 发明专利

JP2013126487A Apparatus for evaluating vascular endothelial function 有权
标题翻译：评估血管内皮功能的装置
公开(公告)号：JP2013126487A
公开(公告)日：2013-06-27
申请号：JP2011276925
申请日：2011-12-19
申请人： Hiroshima Univ , 国立大学法人広島大学 , Nippon Koden Corp , 日本光電工業株式会社
发明人： TSUJI TOSHIO , YOSHIZUMI MASAO , AZUMA YUKITO , KAWAMOTO MASASHI , OZAWA HIDEO , UGAWA SADAJI , TAKAYANAGI TSUNEO , MORIMOTO YOKA , KUBO RYOSUKE
IPC分类号： A61B5/02 , A61B5/022
CPC分类号： A61B5/02007 , A61B5/02108 , A61B5/02233 , A61B5/0225 , A61B5/7242 , A61B5/7278
摘要： PROBLEM TO BE SOLVED: To enable a highly accurate vascular endothelial function evaluation even when the change in a blood vessel viscosity is caused.SOLUTION: An apparatus for evaluating a vascular endothelial function includes: cuffs 11 and 51 that are wrapped around the predetermined part of the body of a subject; a controlling unit 20 that controls the pressurization and the depressurization of the cuffs; a cuff pressure detecting unit 31 that detects a cuff pressure from an output of a pressure sensor 54 connected to the cuffs; a pulse wave detecting unit 32 that detects a pulse wave from the output of the pressure sensor; and an analyzing unit 33 that analyzes the detected pulse wave, wherein the cuff pressure controlling unit 20 performs continuous pressure stimulation on the predetermined part of the body of a subject for a predetermined time by the cuffs, and the analyzing unit 33 evaluates the vascular endothelial function by making comparison using vessel viscoelastic indexes which are obtained from the pulse wave detected in two of zones before, during, and after the pressure stimulation, and which exclude an amplitude of the pulse wave.
摘要翻译：要解决的问题：即使当引起血管粘度的变化时，也能够进行高度精确的血管内皮功能评估。解决方案：一种用于评估血管内皮功能的装置包括：缠绕在受试者身体的预定部分周围的袖带11和51; 控制单元20，其控制袖带的加压和减压; 袖带压检测单元31，其从连接到袖带的压力传感器54的输出检测袖带压力; 脉波检测单元32，其从压力传感器的输出检测脉波; 以及分析检测出的脉波的分析部33，袖带压力控制部20通过袖带对被检体的预定部位的规定时间进行持续的压力刺激，分析部33评价血管内皮通过使用从在压力刺激之前，期间和之后的两个区域中检测到的脉搏波获得的血管粘弹性指数进行比较，并且不包括脉搏波的幅度来进行比较。版权所有（C）2013，JPO＆INPIT

2. 发明专利

JP2010284517A Abdominal aortic aneurysm detector 有权
标题翻译： ABDOMINAL AORTIC ANEURYSM DETECTOR
公开(公告)号：JP2010284517A
公开(公告)日：2010-12-24
申请号：JP2010112372
申请日：2010-05-14
申请人： Delta Tooling Co Ltd , Hiroshima Univ , 国立大学法人広島大学 , 株式会社デルタツーリング
发明人： YOSHIZUMI MASAO , TSUJI TOSHIO , FUJITA YOSHINORI , OGURA YUMI , MAEDA SHINICHIRO
IPC分类号： A61B5/0245
摘要： PROBLEM TO BE SOLVED: To provide a detector that easily enables it to determine whether there is an abdominal aortic aneurysm. SOLUTION: The detector has the following construction. An air cushion 10 is applied to at least two abdominal positions left and right of the middle of a human body near the navel; the degree of differences between the signal waveforms output from a sensor 14 to detect air pressure changes arising from pulse waves at the positions where the air cushions 10 are applied; and determining whether an abdominal aortic aneurysm exists, based on the degree of differences between the signal waveforms detected by the sensor. If there should be an abdominal aortic aneurysm, the blood vessels of the affected part are winding in and out or projecting left or right compared with normal conditions. As a result, the signal waveforms of air pressure changes are substantially not the same at least between the left and right air cushions 10 the air pressure amplitude grows larger or is more disturbed in one air cushion than the other. Based on the degree of these signal waveform differences, it is easy to determine whether there is any abdominal aortic aneurysm. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供能够容易地确定是否存在腹主动脉瘤的检测器。
解决方案：检测器具有以下结构。将气垫10施加到靠近肚脐的人体中部左右的至少两个腹部位置; 从传感器14输出的信号波形之间的差异程度，以检测在施加空气垫10的位置处由脉冲波引起的空气压力变化; 并且基于由传感器检测到的信号波形之间的差异程度来确定是否存在腹主动脉瘤。如果应该有腹主动脉瘤，受影响部位的血管与正常情况相比左右弯曲或向外突出。结果，空气压力变化的信号波形至少在左右气垫10之间基本上不相同，空气压力振幅在一个气垫中比另一个气垫增大或者更多的干扰。根据这些信号波形差异的程度，很容易确定是否存在任何腹主动脉瘤。版权所有（C）2011，JPO＆INPIT

3. 发明专利

JP2011056200A Apparatus for evaluating vascular endothelial function 有权
标题翻译：评估血管内皮功能的装置
公开(公告)号：JP2011056200A
公开(公告)日：2011-03-24
申请号：JP2009212533
申请日：2009-09-14
申请人： Hiroshima Univ , Nippon Koden Corp , 国立大学法人広島大学 , 日本光電工業株式会社
发明人： TSUJI TOSHIO , YOSHIZUMI MASAO , AZUMA YUKITO , KAWAMOTO MASASHI , OZAWA HIDEO , UGAWA SADAJI , TAKAYANAGI TSUNEO
IPC分类号： A61B5/0245 , A61B5/02 , A61B5/022
CPC分类号： A61B5/02 , A61B5/02007
摘要： PROBLEM TO BE SOLVED: To provide an apparatus and a method for simply and easily evaluating vascular endothelial functions with high precision.
SOLUTION: The apparatus includes: a first cuff 11, to be wound around a first site of the body of a subject; a second cuff 51, to be wound around a second site of the body of the subject; a controller 20 that is a cuff controller for controlling a pressurization and decompression of the cuff; a cuff pressure detector 31 for detecting the cuff pressure from an output of a pressure sensor 54 connected to the second cuff 51; a pulse wave detector 32 for detecting a pulse wave from the output of the pressure sensor 54; and an analyzer 33 for analyzing the detected pulse wave. The controller 20 performs continuous pressure stimulation on the first site of the body of the subject for predetermined time of period using the first cuff 11, and the analyzer 33 evaluates the vascular endothelial function by comparing the pulse waves detected before and after the continuous pressure stimulation is performed.
COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：提供用于简单且容易地以高精度评价血管内皮功能的装置和方法。解决方案：该装置包括：要缠绕在被检体的身体的第一部位上的第一箍11; 第二箍51围绕被检体的身体的第二部位缠绕; 控制器20，其是用于控制袖带的加压和减压的袖带控制器; 袖带压力检测器31，用于从连接到第二袖带51的压力传感器54的输出端检测袖带压力; 用于从压力传感器54的输出检测脉波的脉波检测器32; 以及用于分析所检测的脉搏波的分析器33。控制器20使用第一袖带11对预定时间段的对象的身体的第一部位进行持续的压力刺激，并且分析器33通过比较连续压力刺激之前和之后检测到的脉搏波来评估血管内皮功能被执行。版权所有（C）2011，JPO＆INPIT

4. 发明专利

JP2007007078A Blood vessel state measuring instrument, control program and recording medium 有权
标题翻译：血管状态测量仪器，控制程序和记录介质
公开(公告)号：JP2007007078A
公开(公告)日：2007-01-18
申请号：JP2005190474
申请日：2005-06-29
申请人： Hiroshima Univ , 国立大学法人広島大学
发明人： TSUJI TOSHIO , SHIBA KENJI , YOSHIZUMI MASAO , AZUMA YUKITO , SAKANE AKIRA , TERAO YUZURU
IPC分类号： A61B5/02 , A61B5/0205 , A61B5/0456
摘要： PROBLEM TO BE SOLVED: To provide a blood vessel state measuring instrument, a control program and a recording medium surely evaluating the vascular lesion such as the arteriosclerosis and the like. SOLUTION: This blood vessel state measuring instrument is provided with an electrocardiograph 2 for measuring and outputting an electrocardiogram of a subject 1. This instrument is further provided with a plethysmographic apparatus 3 for measuring a change in the outer circumferential length of a front arm 1a, or a part including the artery 1b in the subject 1. This instrument is also provided with a hemodynamometer 4 for detecting the blood pressure value in the artery 1b. This instrument has a computer part 5 for measuring the blood vessel state of the artery 1b by calculating at least one of the viscosity and rigidity of the artery 1b based on the electrocardiogram, the change in the outer circumferential length and the blood pressure value. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：提供血管状态测量仪器，控制程序和可靠地评估血管病变如动脉硬化等的记录介质。解决方案：该血管状态测量仪器设置有用于测量和输出被检体1的心电图的心电图仪2.该仪器还设置有用于测量前方的外周长度变化的体积描记法装置3 或者包括受试者1中的动脉1b的部分。该仪器还设置有用于检测动脉1b中的血压值的血液动力学计量器4。该仪器具有用于通过基于心电图，外周长度和血压值的变化计算动脉1b的粘度和刚度中的至少一个来测量动脉1b的血管状态的计算机部件5。版权所有（C）2007，JPO＆INPIT

5. 发明专利

JP2011110206A Vessel wall monitoring apparatus, vessel wall monitoring program, and computer readable recording medium 有权
标题翻译：船舶监控装置，船舶监控程序和计算机可读记录介质
公开(公告)号：JP2011110206A
公开(公告)日：2011-06-09
申请号：JP2009268901
申请日：2009-11-26
申请人： Hiroshima Univ , Nippon Koden Corp , 国立大学法人広島大学 , 日本光電工業株式会社
发明人： TSUJI TOSHIO , YOSHIZUMI MASAO , KAWAMOTO MASASHI , AZUMA YUKITO , SAEKI NOBORU , NAKAMURA TAKAHARU , KUTLUK ABDUGHENI , KONO YOCHO , HORIUCHI TETSUYA , UGAWA SADAJI
IPC分类号： A61B5/02 , A61B5/0205 , A61B5/0215 , A61B8/00
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/0402 , A61B5/0452 , A61B8/0891 , A61B8/485
摘要： PROBLEM TO BE SOLVED: To faithfully estimate the mechanical characteristic of a vessel even when the blood pressure of a subject is changed, without having dependence on the blood pressure. SOLUTION: A vessel wall monitoring apparatus includes: a vessel diameter information detecting unit which detects vessel diameter information, based on first biological information obtained from a subject; a blood pressure detecting unit for detecting blood pressure, based on second biological information obtained from a subject; a logarithmic blood pressure function producing unit 51 which performs a logarithmic operation on the blood pressure detected by the blood pressure detecting unit, to produce a logarithmic blood pressure function; a vessel diameter function producing unit 55 which differentiates the vessel diameter information detected by the vessel diameter information detecting unit, to produce a function concerning a vessel diameter; and a regression operating unit 26 which produces an impedance model expression by using mechanical characteristic values including a stiffness, viscosity, and inertia, and which calculates and outputs at least one of the stiffness, the viscosity, and the inertia, based on the produced impedance model expression. COPYRIGHT: (C)2011,JPO&INPIT
摘要翻译：要解决的问题：即使当受试者的血压改变而不依赖于血压时，也忠实地估计血管的机械特性。解决方案：血管壁监测装置包括：血管直径信息检测单元，其基于从受试者获得的第一生物信息来检测血管直径信息; 基于从被检体获取的第二生物信息，检测血压的血压检测部; 对数血压函数生成部51对由血压检测部检测出的血压进行对数运算，生成对数血压函数; 容器直径函数产生单元55，其区分由血管直径信息检测单元检测的血管直径信息，以产生关于血管直径的功能; 以及通过使用包括刚度，粘度和惯性的机械特性值来产生阻抗模型表达式的回归运算单元26，其基于所产生的阻抗来计算和输出刚度，粘度和惯性中的至少一个模型表达。版权所有（C）2011，JPO＆INPIT

6. 发明专利

JP2009273870A Device for evaluating vascular endothelium function and method for evaluating vascular endothelium function 有权
标题翻译：用于评估血管内皮功能的装置和评估血管内皮功能的方法
公开(公告)号：JP2009273870A
公开(公告)日：2009-11-26
申请号：JP2008322586
申请日：2008-12-18
申请人： Hiroshima Univ , Nippon Koden Corp , 国立大学法人広島大学 , 日本光電工業株式会社
发明人： TSUJI TOSHIO , YOSHIZUMI MASAO , AZUMA YUKITO , KAWAMOTO MASASHI , UGAWA SADAJI
IPC分类号： A61B5/02 , A61B5/022
CPC分类号： A61B5/022 , A61B5/02007 , A61B5/02116
摘要： PROBLEM TO BE SOLVED: To provide a device and method for simply and easily evaluating vascular endothelium functions with high precision.
SOLUTION: The device includes a cuff 11 wrapped around a part of the body of the subject to be tested, a cuff pressure controller 20 for controlling the pressing and depressing of the cuff 11, a cuff pressure detector 31 for detecting a cuff pressure from the output of a pressure sensor 14 connected to the cuff 11, a pulse wave detector 32 for detecting a pulse wave from the output of the pressure sensor 14 and an analyzer 33 for analyzing the detected pulse wave, wherein the cuff pressure controller 20 performs a continuous pressure sensation for a predetermined period on the body part of the subject to be tested, the analyzer 33 evaluates the vascular endothelium functions on the basis of comparison of the pulse waves before and after the pressurized sensation.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：提供用于简单且容易地以高精度评估血管内皮功能的装置和方法。解决方案：该装置包括围绕待测试对象的身体的一部分的袖带11，用于控制袖带11的按压和压下的袖带压力控制器20，用于检测袖带的袖带压力检测器31 连接于袖带11的压力传感器14的输出的压力，用于检测来自压力传感器14的输出的脉搏波的脉波检测器32和分析检测出的脉搏波的分析器33，其中袖带压力控制器20 在待测试对象的身体部分上进行一段持续的压力感觉，分析器33基于加压感觉之前和之后的脉搏波的比较来评估血管内皮功能。版权所有（C）2010，JPO＆INPIT

7. 发明专利

JP2008272387A Instrument and method for measuring blood vessel viscoelasticity, program, computer readable recording medium, large-scale integrated circuit, and fpga 审中-公开
标题翻译：用于测量血管粘弹性，程序，计算机可读记录介质，大规模集成电路和FPGA的仪器和方法
公开(公告)号：JP2008272387A
公开(公告)日：2008-11-13
申请号：JP2007126086
申请日：2007-05-10
申请人： Hiroshima Univ , Mizoue Project Japan:Kk , 国立大学法人広島大学 , 有限会社Mizoue Project Japan
发明人： TSUJI TOSHIO , SHIBA KENJI , YOSHIZUMI MASAO , AZUMA YUKITO , MITSUNARI TAKAHIRO , TERAO YUZURU , MIZOGAMI KOJI , KONISHI TAKASHI
IPC分类号： A61B5/02 , A61B5/11 , A61B8/08
摘要： PROBLEM TO BE SOLVED: To easily correct a phase deviation between a stress signal and a distortion signal with a simple configuration without performing determination after comparison with a catheter whose phase characteristic is previously known. SOLUTION: A blood vessel viscoelasticity measuring instrument 1 includes: a calculating part 9 for correcting the phase deviation between the stress signal and the distortion signal, based on a shift time with the maximum determination coefficient, which expresses a multiple correlation coefficient between an estimation stress signal, obtained by performing regression calculation, based on the distortion signal expressing the distortion of a blood vessel along the radial direction of a blood vessel wall, and the stress signal, expressing the stress of the blood vessel along the radial direction of the blood vessel wall; an instrument control part 10; and a timing control part 11. COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了容易地以简单的配置校正应力信号和失真信号之间的相位偏差，而不是在与先前已知相位特性的导管比较之后进行确定。解决方案：血管粘弹性测量仪1包括：计算部分9，用于基于具有最大确定系数的移位时间来校正应力信号和失真信号之间的相位偏差，其表示多个相关系数基于表示血管壁沿血管壁的径向的血管畸变的失真信号，通过进行回归计算获得的估计应力信号和表示血管沿径向的应力的应力信号血管壁; 仪器控制部10; 和时间控制部分11.版权所有（C）2009，JPO＆INPIT

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